Professor Claude Wischik

Degeneration of basal and limbic networks is a core feature of behavioural variant frontotemporal dementia

Vuksanovic, V., Staff, R., Morson, S., Ahearn, T., Bracoud, L., Murray, A. D., Bentham, P., Kipps, C. M., Harrington, C., Wischik, C.

Brain Communications

Contributions to Journals: Articles

Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates

Maina, M. B., Al-Hilaly, Y. K., Burra, G., Rickard, J. E., Harrington, C. R., Wischik, C. M., Serpell, L. C.

Cells, vol. 10, no. 3, 703

Contributions to Journals: Articles

Digital Object Identifier

https://doi.org/10.3390/cells10030703

Open Access

http://aura.abdn.ac.uk/bitstream/2164/16165/1/Maina_etal_CELLS_Oxidative_Stress_Conditions_VoR.pdf

Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the Line 66 model of frontotemporal dementia

Lemke, N., Melis, V., Lauer, D., Magbagbeolu, M., Neumann, B., Harrington, C. R., Riedel, G., Wischik, C. M., Theuring, F., Schwab, K.

Journal of Biological Chemistry, vol. 295, no. 52, pp. 18508-18523

Contributions to Journals: Articles

Digital Object Identifier

https://doi.org/10.1074/jbc.RA120.014890

Open Access

http://aura.abdn.ac.uk/bitstream/2164/15308/2/Lemke_etal_Differential_compartmental_VOR.pdf

Additional Links

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Adaptive neurological testing method.

Shiells, H. C., Morson, S., Schelter, B., Wischik, D. J., Wischik, C.

Patents: Patents

Current Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer’s Disease

Arastoo, M., Lofthouse, R., Penny, L. K., Harrington, C. R., Porter, A., Wischik, C. M., Palliyil, S.

International Journal of Molecular Sciences, vol. 21, no. 22, pp. 1-19

Contributions to Journals: Articles

Digital Object Identifier

https://doi.org/10.3390/ijms21228673

Open Access

http://aura.abdn.ac.uk/bitstream/2164/15385/1/Arastoo_et_al_IJMS_CurrentProgressAndFuture_VoR.pdf

Additional Links

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Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target.

Oakley, S., Maina, M. B., Marshall, K. E., Al-Hilaly, Y. K., Harrington, C. R., Wischik, C. M., Serpell, L. C.

Frontiers in Neurology, vol. 11, 590754

Contributions to Journals: Articles

Digital Object Identifier

https://doi.org/10.3389/fneur.2020.590754

Open Access

http://aura.abdn.ac.uk/bitstream/2164/15357/1/Oakley_et_al_Fneur_TauFilamentSelf_Assembly_VoR.pdf

Additional Links

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Paired helical filament forming region of tau (297-391) influences endogenous tau protein and accumulates in acidic compartments in human neuronal cells

Pollack, S. J., Trigg, J., Khanom, T., Biasetti, L., Marshall, K. E., Al-Hilaly, Y. K., Rickard, J. E., Harrington, C. R., Wischik, C. M., Serpell, L. C.

Journal of Molecular Biology, vol. 432, no. 17, pp. 4891-4907

Contributions to Journals: Articles

Digital Object Identifier

https://doi.org/10.1016/j.jmb.2020.05.027

Open Access

http://aura.abdn.ac.uk/bitstream/2164/14862/1/Pollack_etal_Paired_helical_VOR.pdf

Additional Links

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Analysis of the Relationship Between Metalloprotease-9 and Tau Protein in Alzheimer's Disease

Hernandes-Alejandro, M., Montaño, S., Harrington, C. R., Wischik, C. M., Salas-Casas, A., Cortes-Reynosa, P., Pérez Salazar, E., Cazares-Apatiga, J., Apatiga-Perez, R., Ontiveros Torres, M. Ã., Perry, G., Pacheco-Herrero, M., Luna-Muñoz, J.

Journal of Alzheimer's Disease, vol. 76, no. 2, pp. 553-569

Contributions to Journals: Articles

Digital Object Identifier

https://doi.org/10.3233/JAD-200146

Additional Links

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Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

Shiells, H., Schelter, B. O., Bentham, P., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Wischik, D. J., Riedel, G., Gauthier, S., Jia, J., Moebius, H. J., Hardlund, J., Kipps, C. M., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.

Journal of Alzheimer's Disease, vol. 75, no. 2, pp. 501-519

Contributions to Journals: Articles

Digital Object Identifier

https://doi.org/10.3233/JAD-191173

Open Access

http://aura.abdn.ac.uk/bitstream/2164/14427/2/Shiells_et_al_JAD_ConcentrationDependentActivity_VoR.pdf

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Mechanisms of anticholinesterase interference with tau aggregation inhibitor activity in a tau-transgenic mouse model

Riedel, G., Klein, J., Niewiadomska, G., Kondak, C., Schwab, K., Lauer, D., Magbagbeolu, M., Steczkowska, M., Zadrozny, M., Wydrych, M., Cranston, A., Melis, V., Santos, R. X., Theuring, F., Harrington, C. R., Wischik, C. M.

Current Alzheimer Research, vol. 17, no. 3, pp. 285-296

Contributions to Journals: Articles

Digital Object Identifier

https://doi.org/10.2174/1567205017666200224120926

Open Access

http://aura.abdn.ac.uk/bitstream/2164/15752/1/Riedel_et_al_CAR_MechanismsOfAnticholinesterase_AAM.pdf

Additional Links

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