Professor Claude Wischik

Chair in Mental Health (Clin)

Overview

Contact Details

Telephone: work +44 (0)1224 438558; work +44 (0)1224 438559
Email: c.m.wischik@abdn.ac.uk
Address: The University of Aberdeen
TauRx Therapeutics Ltd
1st Floor, Sir Moir Lockhead Building
395 King Street
Aberdeen
AB24 5RP
United Kingdom

Research

Research Overview

Molecular Neuropathology of Alzheimer's Disease, and in particular the therapeutic intervention of tau pathology

Publications

Publications

Currently viewing:

Page 1 of 7 Results 1 to 10 of 70

Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the Line 66 model of frontotemporal dementia
2020
Lemke, N., Melis, V., Lauer, D., Magbagbeolu, M., Neumann, B., Harrington, C. R., Riedel, G., Wischik, C. M., Theuring, F., Schwab, K.

Journal of Biological Chemistry, vol. 295, no. 52, pp. 18508-18523

Contributions to Journals: Articles

Digital Object Identifier

https://doi.org/10.1074/jbc.RA120.014890

Open Access

http://aura.abdn.ac.uk/bitstream/2164/15308/1/Lemke_etal_JBC_Differential_compartmental_AAM.pdf

Additional Links

View publication in Scopus
Current Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer’s Disease
2020
Arastoo, M., Lofthouse, R., Penny, L. K., Harrington, C. R., Porter, A., Wischik, C. M., Palliyil, S.

International Journal of Molecular Sciences, vol. 21, no. 22, pp. 1-19

Contributions to Journals: Articles

Digital Object Identifier

https://doi.org/10.3390/ijms21228673

Open Access

http://aura.abdn.ac.uk/bitstream/2164/15385/1/Arastoo_et_al_IJMS_CurrentProgressAndFuture_VoR.pdf

Additional Links

View publication in Scopus
Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target.
2020
Oakley, S., Maina, M. B., Marshall, K. E., Al-Hilaly, Y. K., Harrington, C. R., Wischik, C. M., Serpell, L. C.

Frontiers in Neurology, vol. 11, 590754

Contributions to Journals: Articles

Digital Object Identifier

https://doi.org/10.3389/fneur.2020.590754

Open Access

http://aura.abdn.ac.uk/bitstream/2164/15357/1/Oakley_et_al_Fneur_TauFilamentSelf_Assembly_VoR.pdf

Additional Links

View publication in Scopus
Paired helical filament forming region of tau (297-391) influences endogenous tau protein and accumulates in acidic compartments in human neuronal cells
2020
Pollack, S. J., Trigg, J., Khanom, T., Biasetti, L., Marshall, K. E., Al-Hilaly, Y. K., Rickard, J. E., Harrington, C. R., Wischik, C. M., Serpell, L. C.

Journal of Molecular Biology, vol. 432, no. 17, pp. 4891-4907

Contributions to Journals: Articles

Digital Object Identifier

https://doi.org/10.1016/j.jmb.2020.05.027

Open Access

http://aura.abdn.ac.uk/bitstream/2164/14862/1/Pollack_etal_Paired_helical_VOR.pdf

Additional Links

View publication in Scopus
Analysis of the Relationship Between Metalloprotease-9 and Tau Protein in Alzheimer's Disease
2020
Hernandes-Alejandro, M., Montaño, S., Harrington, C. R., Wischik, C. M., Salas-Casas, A., Cortes-Reynosa, P., Pérez Salazar, E., Cazares-Apatiga, J., Apatiga-Perez, R., Ontiveros Torres, M. �., Perry, G., Pacheco-Herrero, M., Luna-Muñoz, J.

Journal of Alzheimer's Disease, vol. 76, no. 2, pp. 553-569

Contributions to Journals: Articles

Digital Object Identifier

https://doi.org/10.3233/JAD-200146

Additional Links

View publication in Scopus
Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia
2020
Shiells, H., Schelter, B. O., Bentham, P., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Wischik, D. J., Riedel, G., Gauthier, S., Jia, J., Moebius, H. J., Hardlund, J., Kipps, C. M., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.

Journal of Alzheimer's Disease, vol. 75, no. 2, pp. 501-519

Contributions to Journals: Articles

Digital Object Identifier

https://doi.org/10.3233/JAD-191173

Open Access

http://aura.abdn.ac.uk/bitstream/2164/14427/2/Shiells_et_al_JAD_ConcentrationDependentActivity_VoR.pdf

Additional Links

View publication in Scopus
Mechanisms of anticholinesterase interference with tau aggregation inhibitor activity in a tau-transgenic mouse model
2020
Riedel, G., Klein, J., Niewiadomska, G., Kondak, C., Schwab, K., Lauer, D., Magbagbeolu, M., Steczkowska, M., Zadrozny, M., Wydrych, M., Cranston, A., Melis, V., Santos, R. X., Theuring, F., Harrington, C. R., Wischik, C. M.

Current Alzheimer Research, vol. 17, no. 3, pp. 285-296

Contributions to Journals: Articles

Digital Object Identifier

https://doi.org/10.2174/1567205017666200224120926

Additional Links

View publication in Scopus
Tau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brain
2020
Al-Hilaly, Y. K., Foster, B. E., Biasetti, L., Lutter, L., Pollack, S. J., Rickard, J. E., Storey, J. M. D., Harrington, C. R., Xue, W., Wischik, C. M., Serpell, L. C.

FEBS LETTERS, vol. 594, no. 5, pp. 944-950

Contributions to Journals: Articles

Digital Object Identifier

https://doi.org/10.1002/1873-3468.13675

Open Access

http://aura.abdn.ac.uk/bitstream/2164/13414/2/AlHilaly_etal_FEBS_VOR.pdf

Additional Links

View publication in Scopus
Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer’s Disease and Frontotemporal Lobar Degeneration
2020
Cranston, A. L., Wysocka, A., Steczkowska, M., Zadrozny, M., Palasz, E., Harrington, C. R., Theuring, F., Wischik, C., Riedel, G., Niewiadomska, G.

Brain Communications, vol. 2, no. 1, fcaa033

Contributions to Journals: Articles

Digital Object Identifier

https://doi.org/10.1093/braincomms/fcaa033

Open Access

http://aura.abdn.ac.uk/bitstream/2164/14871/1/Cranston_etal_BC_Cholinergenic_VOR.pdf
Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease
2019
Schelter, B. O., Shiells, H. C., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Riedel, G., Gauthier, S., Jia, J., Bentham, P., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.

Journal of Alzheimer's Disease, vol. 72, no. 3, pp. 931-946

Contributions to Journals: Articles

Digital Object Identifier

https://doi.org/10.3233/JAD-190772

Open Access

http://aura.abdn.ac.uk/bitstream/2164/13339/1/Schelter_et_al_JoAD_ConcentrationDependentActivity_VoR.pdf

1
2
3
4
5 ...

Show 10 | 25 | 50 | 100 results per page

Update

Contact Details

Research Overview

Publications

Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the Line 66 model of frontotemporal dementia

Current Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer’s Disease

Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target.

Paired helical filament forming region of tau (297-391) influences endogenous tau protein and accumulates in acidic compartments in human neuronal cells

Analysis of the Relationship Between Metalloprotease-9 and Tau Protein in Alzheimer's Disease

Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

Mechanisms of anticholinesterase interference with tau aggregation inhibitor activity in a tau-transgenic mouse model

Tau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brain

Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer’s Disease and Frontotemporal Lobar Degeneration

Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease