Professor Claude Wischik
Chair in Mental Health (Clin)
- About
-
- Email Address
- c.m.wischik@abdn.ac.uk
- Office Address
TauRx Therapeutics Ltd
1st Floor, Sir Moir Lockhead Building
395 King Street
Aberdeen
AB24 5RP
United Kingdom
- School/Department
- School of Medicine, Medical Sciences and Nutrition
- Research
-
Research Overview
Molecular Neuropathology of Alzheimer's Disease, and in particular the therapeutic intervention of tau pathology
- Publications
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Page 1 of 12 Results 1 to 10 of 112
Effects of hydromethylthionine mesylate and rivastigmine in a pharmacological mouse model of Alzheimer's disease
Behavioural Pharmacology, pp. 64-69Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1097/FBP.0000000000000865
Clinical, imaging and blood biomarker outcomes in a Phase 3 clinical trial of tau aggregation inhibitor hydromethylthionine mesylate in mild cognitive impairment and mild to moderate dementia due to Alzheimer’s disease
The Journal of Prevention of Alzheimer's Disease, vol. 13, no. 3, 100480Contributions to Journals: ArticlesInhibiting disulphide bonding in truncated tau297-391 results in enhanced self-assembly of tau into seed-competent assemblies
ACS Chemical Neuroscience, vol. 17, no. 1, pp. 124-138Contributions to Journals: ArticlesQuantification of plasma tau species containing the proline-rich region as a biomarker in Alzheimer’s disease
Scientific Reports, vol. 15, 41881Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/s41598-025-25864-x
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/82867189-e587-4cae-9b66-e8593ec53c83/download
- [ONLINE] View publication in Scopus
A key region of Tau that is able to drive assembly and modulate inhibition by Hydromethylthionine
Journal of Molecular Biology, vol. 437, no. 17, 169231Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jmb.2025.169231
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/7a09658e-98e2-46e0-b61c-ea4a48f823ab/download
- [ONLINE] View publication in Scopus
Proteomic and non-proteomic changes of presynaptic proteins in animal models of Alzheimer’s disease: A meta-analysis 2015-2023
Journal of Alzheimer's Disease, vol. 107, no. 2, pp. 452-476Contributions to Journals: ArticlesRole of 18F-florzolotau PET in diagnostic and therapeutic decision-making for cognitive impairment
Alzheimer's & dementia : the journal of the Alzheimer's Association, vol. 21, no. 8, e70563Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/alz.70563
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/019992bc-c02d-48ce-afa4-a00b14c06599/download
FDG-PET Image Classification in Alzheimer’s Disease: from Traditional Visual Analysis to Advanced Transfer Learning
Nuclear Medicine and Molecular Imaging, vol. 59, pp. 201-208Contributions to Journals: Articles- [ONLINE] https://pubmed.ncbi.nlm.nih.gov/40385367/
- [ONLINE] DOI: https://doi.org/10.1007/s13139-025-00908-2
Hydromethylthionine sustains truncated tau-dependent inflammation-lowering effects in mouse brain
FEBS Journal, vol. 292, no. 10, pp. 2602-2623Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/febs.70021
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/372a1f89-dc2a-4be5-a64e-19083dc6d8d6/download
- [ONLINE] View publication in Scopus
Inhibiting disulphide bonding in truncated tau297-391 results in enhanced self-assembly of tau into seed-competent assemblies
Working Papers: Preprint Papers- [ONLINE] DOI: https://doi.org/10.1101/2025.02.05.636249