Professor Anne Kiltie

Professor Anne Kiltie
Professor Anne Kiltie

Professor Anne Kiltie

MA DM DSc MRCP(UK) FRCR

Clinical Chair in Oncology

About

Biography

I qualified in medicine from the Universities of Cambridge and Oxford and trained in Clinical Oncology at the Christie Hospital, Manchester, and Cookridge Hospital, Leeds. I undertook my DM at the Paterson Institute, University of Manchester and was a Clinical Research Fellow at ICRF Clare Hall before taking up a Senior Lecturer/Honorary Consultant Clinical Oncologist appointment at the University of Leeds in 2001. I moved to the Department of Oncology, University of Oxford in 2009, and obtained my DSc and personal chair in 2016.

I took up my appointment as Clinical Chair of Oncology at the University of Aberdeen in June 2021.

My research focusses on exploiting dietary fibre manipulation and its effects on the gut microbiome as an ‘endogenous’ means of radiosensitising tumours without increasing radiation toxicity to the surrounding normal tissues including the intestines.

 

Qualifications

  • DSc Medical Sciences 
    2016 - University of Oxford 
  • DM Medical Sciences 
    1999 - University of Oxford 
  • BM BCh Medicine 
    1988 - University of Oxford 
  • BA Medical Sciences 
    1985 - University of Cambridge 
  • MRCP(UK) General Medicine 
    1992 - Royal College of Physicians of England 
  • FRCR Clinical Oncology 
    1995 - Royal College of Radiologists 
  • MA Medicine 
    1989 - University of Cambridge 
  • MA Medicine 
    1999 - University of Oxford 

Memberships and Affiliations

Internal Memberships

Jul 2021 - present      Member of the Rowett Institute Ethics Panel

External Memberships

Oct 2018 - present     Bladder Cancer Advocacy Network (BCAN) Bladder Cancer Research

                                          Network Management Committee

Dec 2017 - present    Member of Editorial Board of European Urology Oncology

Oct 2016 - present     Associate Editor of Bladder Cancer

2014 - present             Grant reviewer for Italian Association for Cancer Research (AIRC)

Sept 2012 - present   British Uro-oncology Group Executive Committee Trustee

Jan 2012 - present     Royal College of Radiologists representative on

                                           Advisory Appointments Committees

Research

Research Overview

Tumours in the pelvis, including bladder, prostate and colorectal cancer and gynaecological cancers may be treated by surgical removal or organ-preserving radiotherapy-based treatments. Current organ-preservation standard of care for most tumour sites includes addition of radiosensitising chemotherapy to improve tumour control. However, this often comes at the expense of increased radiotherapy-induced side effects to the surrounding normal tissues, including the intestines. Furthermore, such combined treatments are often not tolerated by elderly patients. With the proportion of over 75-year olds set to double by 2050, there is an urgent need to find alternative approaches to radiosensitisation.

Having worked on histone deacetylase inhibitors, which we showed to be effective tumour radiosensitisers without additional acute and late small intestinal toxicity in in vivo models, we are now working to exploit dietary fibre manipulation and the gut microbiome as an ‘endogenous’ means of radiosensitising tumours without increasing radiation toxicity to the surrounding normal tissues including the intestines.

Research Areas

Applied Health Sciences

Biomedical Sciences

Nutrition and Health

Research Specialisms

  • Medicine
  • Food Science
  • Bacteriology
  • Oncology

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Supervision

Daniel Sescu, Cyril and Margaret Gates Trust ASRS summer scholarship

Publications

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  • The role of dietary supplements, including biotics, glutamine, polyunsaturated fatty acids and polyphenols, in reducing gastrointestinal side effects in patients undergoing pelvic radiotherapy: A systematic review and meta-analysis

    Bartsch, B., Then, C. K., Harriss, E., Kartsonaki, C., Kiltie, A. E.
    Clinical and Translational Radiation Oncology, vol. 29, pp. 11-19
    Contributions to Journals: Articles
  • Evaluation of Loading Strategies to Improve Tumor Uptake of Gemcitabine in a Murine Orthotopic Bladder Cancer Model Using Ultrasound and Microbubbles

    Ruan, J. L., Browning, R. J., Yildiz, Y. O., Bau, L., Kamila, S., Gray, M. D., Folkes, L., Hampson, A., McHale, A. P., Callan, J. F., Vojnovic, B., Kiltie, A. E., Stride, E.
    Ultrasound in Medicine and Biology, vol. 47, no. 6, pp. 1596-1615
    Contributions to Journals: Articles
  • p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation

    Kilgas, S., Singh, A. N., Paillas, S., Then, C. K., Torrecilla, I., Nicholson, J., Browning, L., Vendrell, I., Konietzny, R., Kessler, B. M., Kiltie, A. E., Ramadan, K.
    Cell Reports, vol. 35, no. 8, 109153
    Contributions to Journals: Articles
  • Ultrasound-Mediated Gemcitabine Delivery Reduces the Normal-Tissue Toxicity of Chemoradiation Therapy in a Muscle-Invasive Bladder Cancer Model

    Ruan, J. L., Browning, R. J., Yildiz, Y. O., Gray, M., Bau, L., Kamila, S., Thompson, J., Elliott, A., Smart, S., McHale, A. P., Callan, J. F., Vojnovic, B., Stride, E., Kiltie, A. E.
    International Journal of Radiation Oncology Biology Physics, vol. 109, no. 5, pp. 1472-1482
    Contributions to Journals: Articles
  • SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells

    Na, J., Newman, J. A., Then, C. K., Syed, J., Vendrell, I., Torrecilla, I., Ellermann, S., Ramadan, K., Fischer, R., Kiltie, A. E.
    Cell Death and Disease, vol. 12, no. 2, 165
    Contributions to Journals: Articles
  • Greater utility of molecular subtype rather than epithelial-to-mesenchymal transition (EMT) markers for prognosis in high-risk non-muscle-invasive (HGT1) bladder cancer

    Ottley, E. C., Pell, R., Brazier, B., Hollidge, J., Kartsonaki, C., Browning, L., O'Neill, E., Kiltie, A. E.
    Journal of Pathology: Clinical Research, vol. 6, no. 4, pp. 238-251
    Contributions to Journals: Articles
  • Association of Bacteroides acidifaciens relative abundance with high-fibre diet-associated radiosensitisation

    Then, C. K., Paillas, S., Wang, X., Hampson, A., Kiltie, A. E.
    BMC Biology, vol. 18, no. 1, 102
    Contributions to Journals: Articles
  • The Histone Deacetylase Inhibitor Romidepsin Spares Normal Tissues While Acting as an Effective Radiosensitizer in Bladder Tumors in Vivo

    Paillas, S., Then, C. K., Kilgas, S., Ruan, J. L., Thompson, J., Elliott, A., Smart, S., Kiltie, A. E.
    International Journal of Radiation Oncology Biology Physics, vol. 107, no. 1, pp. 212-221
    Contributions to Journals: Articles
  • EAU-ESMO Consensus Statements on the Management of Advanced and Variant Bladder Cancer-An International Collaborative Multistakeholder Effort: Under the Auspices of the EAU-ESMO Guidelines Committees

    Witjes, J. A., Babjuk, M., Bellmunt, J., Bruins, H. M., De Reijke, T. M., De Santis, M., Gillessen, S., James, N., Maclennan, S., Palou, J., Powles, T., Ribal, M. J., Shariat, S. F., Der Kwast, T. V., Xylinas, E., Agarwal, N., Arends, T., Bamias, A., Birtle, A., Black, P. C., Bochner, B. H., Bolla, M., Boormans, J. L., Bossi, A., Briganti, A., Brummelhuis, I., Burger, M., Castellano, D., Cathomas, R., Chiti, A., Choudhury, A., Compérat, E., Crabb, S., Culine, S., De Bari, B., De Blok, W., J L De Visschere, P., Decaestecker, K., Dimitropoulos, K., Dominguez-Escrig, J. L., Fanti, S., Fonteyne, V., Frydenberg, M., Futterer, J. J., Gakis, G., Geavlete, B., Gontero, P., Grubmüller, B., Hafeez, S., Hansel, D. E., Hartmann, A., Hayne, D., Henry, A. M., Hernandez, V., Herr, H., Herrmann, K., Hoskin, P., Huguet, J., Jereczek-Fossa, B. A., Jones, R., Kamat, A. M., Khoo, V., Kiltie, A. E., Krege, S., Ladoire, S., Lara, P. C., Leliveld, A., Linares-Espinós, E., Løgager, V., Lorch, A., Loriot, Y., Meijer, R., Mir, M. C., Moschini, M., Mostafid, H., Müller, A., Müller, C. R., N'Dow, J., Necchi, A., Neuzillet, Y., Oddens, J. R., Oldenburg, J., Osanto, S., J G Oyen, W., Pacheco-Figueiredo, L., Pappot, H., Patel, M. I., Pieters, B. R., Plass, K., Remzi, M., Retz, M., Richenberg, J., Rink, M., Roghmann, F., Rosenberg, J. E., Rouprêt, M., Rouvière, O., Salembier, C., Salminen, A., Sargos, P., Sengupta, S., Sherif, A., Smeenk, R. J., Smits, A., Stenzl, A., Thalmann, G. N., Tombal, B., Turkbey, B., Lauridsen, S. V., Valdagni, R., Der Heijden, A. G. V., Van Poppel, H., Vartolomei, M. D., Veskimäe, E., Vilaseca, A., Rivera, F. A. V., Wiegel, T., Wiklund, P., Williams, A., Zigeuner, R., Horwich, A., Willemse, P. M.
    European Urology, vol. 77, no. 2, pp. 223-250
    Contributions to Journals: Articles
  • The p97–Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8

    Singh, A. N., Oehler, J., Torrecilla, I., Kilgas, S., Li, S., Vaz, B., Guérillon, C., Fielden, J., Hernandez-Carralero, E., Cabrera, E., Tullis, I. D., Meerang, M., Barber, P. R., Freire, R., Parsons, J., Vojnovic, B., Kiltie, A. E., Mailand, N., Ramadan, K.
    EMBO Journal, vol. 38, no. 21, e102361
    Contributions to Journals: Articles

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