Professor Anne Kiltie

Professor Anne Kiltie
Professor Anne Kiltie
Professor Anne Kiltie

MA DM DSc MRCP(UK) FRCR

Friends of ANCHOR Clinical Chair in Oncology

About

Biography

I qualified in medicine from the Universities of Cambridge and Oxford and trained in Clinical Oncology at the Christie Hospital, Manchester, and Cookridge Hospital, Leeds. I undertook my DM at the Paterson Institute, University of Manchester and was a Clinical Research Fellow at ICRF Clare Hall before taking up a Senior Lecturer/Honorary Consultant Clinical Oncologist appointment at the University of Leeds in 2001. I moved to the Department of Oncology, University of Oxford in 2009, and obtained my DSc and personal chair in 2016.

I took up my appointment as Friends of ANCHOR Clinical Chair of Oncology at the University of Aberdeen in June 2021.

My research focusses on exploiting dietary fibre manipulation and its effects on the gut microbiome as an ‘endogenous’ means of radiosensitising tumours without increasing radiation toxicity to the surrounding normal tissues including the intestines.

 

Qualifications

  • DSc Medical Sciences 
    2016 - University of Oxford 
  • DM Medical Sciences 
    1999 - University of Oxford 
  • BM BCh Medicine 
    1988 - University of Oxford 
  • BA Medical Sciences 
    1985 - University of Cambridge 
  • MRCP(UK) General Medicine 
    1992 - Royal College of Physicians of England 
  • FRCR Clinical Oncology 
    1995 - Royal College of Radiologists 
  • MA Medicine 
    1989 - University of Cambridge 
  • MA Medicine 
    1999 - University of Oxford 

Memberships and Affiliations

Internal Memberships

Jul 2021 - present      Member of the Rowett Institute Ethics Panel

Oct 2021 - present     Member of Friends of ANCHOR Research Advisory Group

External Memberships

Jun 2023 - present    Member of RAIDER TrialTranslational Working Group 

Jan 2022 - present    Member of Scientific Review Group BCAN Bladder Cancer Research Innovation Award 2022

Jan 2022 - present    Member of Scottish Radiotherapy Research Forum Committee

Oct 2018 - present     Bladder Cancer Advocacy Network (BCAN) Bladder Cancer Network Management Committee

Dec 2017 - present    Member of Editorial Board of European Urology Oncology

Oct 2016 - present     Associate Editor of Bladder Cancer

2014 - present            Grant reviewer for Italian Association for Cancer Research (AIRC)

Sept 2012 - present   British Uro-oncology Group Executive Committee Trustee

Jan 2012 - present     Royal College of Radiologists representative on Advisory Appointments Committees

Research

Research Overview

Tumours in the pelvis, including bladder, prostate and colorectal cancer and gynaecological cancers may be treated by surgical removal or organ-preserving radiotherapy-based treatments. Current organ-preservation standard of care for most tumour sites includes addition of radiosensitising chemotherapy to improve tumour control. However, this often comes at the expense of increased radiotherapy-induced side effects to the surrounding normal tissues, including the intestines. Furthermore, such combined treatments are often not tolerated by elderly patients. With the proportion of over 75-year olds set to double by 2050, there is an urgent need to find alternative approaches to radiosensitisation.

Having worked on histone deacetylase inhibitors, which we showed to be effective tumour radiosensitisers without additional acute and late small intestinal toxicity in in vivo models, we are now working to exploit dietary fibre manipulation and the gut microbiome as an ‘endogenous’ means of radiosensitising tumours without increasing radiation toxicity to the surrounding normal tissues including the intestines.

Research Areas

Applied Health Sciences

Biomedical Sciences

Nutrition and Health

Research Specialisms

  • Medicine
  • Food Science
  • Bacteriology
  • Oncology

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Supervision

Supervisees

  • MS MEREL VAN DEN HAAK
  • MR ADAM POTTER
  • MR DANIEL SESCU
  • MISS ANAM WAJID
Teaching

Teaching Responsibilities

ME3013 MBChB SSC2: supervisor

BM4501 BSc Honours project: supervisor

RN5504 Nutrition and Health through the Life Stages: lecture

RN5505 Clinical Nutrition: lecture and seminar

RN5503 Clinical Nutrition for Disease Prevention: lecture

Non-course Teaching Responsibilities

I am a Regent for the MB ChB Regent Scheme.

Publications

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  • Recommendations for follow-up of muscle-invasive bladder cancer patients: A consensus by the international bladder cancer network

    Zuiverloon, T. C., van Kessel, K. E., Bivalacqua, T. J., Boormans, J. L., Ecke, T. H., Grivas, P. D., Kiltie, A. E., Liedberg, F., Necchi, A., van Rhijn, B. W., Roghmann, F., Sanchez-Carbayo, M., Schmitz-Dräger, B. J., Wezel, F., Kamat, A. M.
    Urologic Oncology: Seminars and Original Investigations, vol. 36, no. 9, pp. 423-431
    Contributions to Journals: Review articles
  • Harnessing citizen science through mobile phone technology to screen for immunohistochemical biomarkers in bladder cancer

    Smittenaar, P., Walker, A. K., McGill, S., Kartsonaki, C., Robinson-Vyas, R. J., McQuillan, J. P., Christie, S., Harris, L., Lawson, J., Henderson, E., Howat, W., Hanby, A., Thomas, G. J., Bhattarai, S., Browning, L., Kiltie, A. E.
    British Journal of Cancer, vol. 119, no. 2, pp. 220-229
    Contributions to Journals: Articles
  • Contemporary Patterns of Multidisciplinary Care in Patients With Muscle-invasive Bladder Cancer

    Harshman, L. C., Tripathi, A., Kaag, M., Efstathiou, J. A., Apolo, A. B., Hoffman-Censits, J. H., Stadler, W. M., Yu, E. Y., Bochner, B. H., Skinner, E. C., Downs, T., Kiltie, A. E., Bajorin, D. F., Guru, K., Shipley, W. U., Steinberg, G. D., Hahn, N. M., Sridhar, S. S.
    Clinical genitourinary cancer, vol. 16, no. 3, pp. 213-218
    Contributions to Journals: Articles
  • High Levels of Patient Satisfaction in Joint Uro-oncology Clinics to Assist Patient Choice in Early Prostate Cancer and Muscle-invasive Bladder Cancer

    Kiltie, A. E., Southby, R., LeMonnier, K., Binnee, J., Niederer, J., Kartsonaki, C., Camilleri, P., Sabharwal, A., Brewster, S., Crew, J., Hamdy, F. C.
    Clinical Oncology, vol. 30, no. 4, pp. e39
    Contributions to Journals: Letters
  • Radiosensitization in vivo by histone deacetylase inhibition with no increase in early normal tissue radiation toxicity

    Groselj, B., Ruan, J. L., Scott, H., Gorrill, J., Nicholson, J., Kelly, J., Anbalagan, S., Thompson, J., Stratford, M. R., Jevons, S. J., Hammond, E. M., Scudamore, C. L., Kerr, M., Kiltie, A. E.
    Molecular Cancer Therapeutics, vol. 17, no. 2, pp. 381-392
    Contributions to Journals: Articles
  • Genetic Alterations in the Molecular Subtypes of Bladder Cancer: Illustration in the Cancer Genome Atlas Dataset

    Choi, W., Ochoa, A., McConkey, D. J., Aine, M., Höglund, M., Kim, W. Y., Real, F. X., Kiltie, A. E., Milsom, I., Dyrskjøt, L., Lerner, S. P.
    European Urology, vol. 72, no. 3, pp. 354-365
    Contributions to Journals: Review articles
  • No additional prognostic value for MRE11 in squamous cell carcinomas of the anus treated with chemo-radiotherapy

    Walker, A. K., Kartsonaki, C., Collantes, E., Nicholson, J., Gilbert, D. C., Kiltie, A. E.
    British Journal of Cancer, vol. 117, no. 3, pp. 322-325
    Contributions to Journals: Articles
  • The Impact of Histological Variants of Urothelial Carcinoma on Clinical Outcomes Following Trimodality Bladder-sparing Chemoradiation

    Kiltie, A. E., Browning, L.
    European Urology, vol. 72, no. 1, pp. 61-63
    Contributions to Journals: Editorials
  • E3 ligase cIAP2 mediates downregulation of MRE11 and radiosensitization in response to HDAC inhibition in bladder cancer

    Nicholson, J., Jevons, S. J., Groselj, B., Ellermann, S., Konietzny, R., Kerr, M., Kessler, B. M., Kiltie, A. E.
    Cancer Research, vol. 77, no. 11, pp. 3027-3029
    Contributions to Journals: Articles
  • The National Institute for Health and Care Excellence (NICE) Guidance on Bladder Cancer; a Step in the Right Direction?

    Trainor, S., Choudhury, A., Huddart, R., Kiltie, A. E., Kockelbergh, R., Turner, W., Birtle, A., Crabb, S. J.
    Clinical Oncology, vol. 29, no. 6, pp. 344-347
    Contributions to Journals: Editorials
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