Professor M Carmen Romano

Professor M Carmen Romano

Personal Chair

Overview

Contact Details

Telephone
work +44 (0)1224 272507
Email
Address
The University of Aberdeen Office 337, Institute for Complex Systems and Mathematical Biology, Department of Physics, Meston Building, Old Aberdeen

Office 3:47, Institute of Medical Sciences, Foresterhill
Research

Research Interests

I am interested in the understanding of fundamental biological processes using theoretical approaches based on nonlinear dynamics and statistical physics and combining them with experimental data. In particular, I am interested in the process of translation or synthesis of proteins, the coupling between transcription and translation, how ribosomes, the molecular machines that manufacture proteins, are synthesised, and its relationship to the cell cycle. I am furthermore interested in the effect of combinatorial stresses in yeast, as well as the effects of different types of stress on the cell cycle.

Research Grants

SULSA studentship (modeling of translation)/ SABR grant (Combinatorial Responses In Stress Pathways)/BBSRC grant (Ribosome Traffic Flow on the mRNA as a Regulator of Cellular Protein Production)
Teaching

Teaching Responsibilities

Electromagnetism (PX3008, 3rd year Physics) and Introduction to Mathematics and Modelling of Biological Systems (SB5005, MSc in Cell and Molecular Systems Biology)

Publications

Publications 

Currently viewing:

Page 1 of 7 Results 1 to 10 of 70

  • McFarland, MR, Keller, CD, Childers, BM, Adeniyi, SA, Corrigall, H, Raguin, A, Romano, MC & Stansfield, I 2020, 'The molecular aetiology of tRNA synthetase depletion: induction of a GCN4 amino acid starvation response despite homeostatic maintenance of charged tRNA levels', Nucleic Acids Research, vol. 48, no. 6, pp. 3071-3088. [Online] DOI: https://doi.org/10.1101/610790
  • Kompella, VPS, Stansfield, I, Romano, MC & Mancera, RL 2019, 'Definition Of The Minimal Contents For The Molecular Simulation Of The Yeast Cytoplasm', Frontiers in Molecular Biosciences, vol. 6, 97. [Online] DOI: https://doi.org/10.3389/fmolb.2019.00097
  • Wang, L, Romano, MC & Davidson, FA 2019, 'Translational control of gene expression via interacting feedback loops', Physical Review. E, Statistical, Nonlinear and Soft Matter Physics, vol. 100, no. 5, 050402(R). [Online] DOI: https://doi.org/10.1103/PhysRevE.100.050402
  • Szavits-Nossan, J, Ciandrini, L & Romano, MC 2018, 'Deciphering mRNA Sequence Determinants of Protein Production Rate', Physical Review Letters, vol. 120, no. 12, 128101. [Online] DOI: https://doi.org/10.1103/PhysRevLett.120.128101
  • Szavits-Nossan, J, Romano, MC & Ciandrini, L 2018, 'Power series solution of the inhomogeneous exclusion process', Physical Review. E, Statistical, Nonlinear and Soft Matter Physics, vol. 97, no. 5, 052139. [Online] DOI: https://doi.org/10.1103/PhysRevE.97.052139
  • Bonnin, P, Kern, N, Young, NT, Stansfield, I & Romano, MC 2017, 'Novel mRNA-specific effects of ribosome drop-off on translation rate and polysome profile', PLoS Computational Biology , vol. 13, no. 5, e1005555. [Online] DOI: https://doi.org/10.1371/journal.pcbi.1005555
  • Gorgoni, B, Ciandrini, L, McFarland, MR, Romano, MC & Stansfield, I 2016, 'Identification of the mRNA targets of tRNA-specific regulation using genome-wide simulation of translation', Nucleic Acids Research, vol. 44, no. 19, pp. 9231-9244. [Online] DOI: https://doi.org/10.1093/nar/gkw630
  • Nesbeth, DN, Zaikin, A, Saka, Y, Romano, MC, Giuraniuc, CV, Kanakov, O & Laptyeva, T 2016, 'Synthetic biology routes to bio-artificial intelligence', Essays in Biochemistry, vol. 60, no. 4, pp. 381-391. [Online] DOI: https://doi.org/10.1042/EBC20160014
  • Chandrasekaran, K, Kaloriti, D, Tillmann, AT, Yin, Z, Herrero De Dios, C, Jacobsen, MD, Belmonte, RC, Cameron, G, Haynes, K, Grebogi, C, de Moura, APS, Gow, NAR, Thiel, M, Quinn, J, Brown, AJP & Romano, MC 2015, 'Integrative Model of Oxidative Stress Adaptation in the Fungal Pathogen Candida albicans', PloS ONE, vol. 10, no. 9, 0137750. [Online] DOI: https://doi.org/10.1371/journal.pone.0137750
  • Gorgoni, B, Marshall, E, McFarland, MR, Romano, MC & Stansfield, I 2014, 'Controlling translation elongation efficiency: tRNA regulation of ribosome flux on the mRNA', Biochemical Society Transactions, vol. 42, no. 1, pp. 160-165. [Online] DOI: https://doi.org/10.1042/BST20130132
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