Professor Claude Wischik | The University of Aberdeen

Inhibiting disulphide bonding in truncated tau297-391 results in enhanced self-assembly of tau into seed-competent assemblies
2025 - Accepted/In press
Oakley, S. S., Marshall, K. E., Meisl, G., Copsey, A., Maina, M. B., Milton, R., Vorley, T., Storey, J., Harrington, C., Wischik, C., Xue, W., Serpell, L. C.
ACS Chemical Neuroscience
Contributions to Journals: Articles
A key region of Tau that is able to drive assembly and modulate inhibition by Hydromethylthionine
2025 - Published
Al-Hilaly, Y. K., Rickard, J. E., Simpson, M., Storey, J. M., Harrington, C. R., Wischik, C. M., Serpell, L. C.
Journal of Molecular Biology, vol. 437, no. 17, 169231
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.jmb.2025.169231
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/7a09658e-98e2-46e0-b61c-ea4a48f823ab/download
- [ONLINE] View publication in Scopus
Proteomic and non-proteomic changes of presynaptic proteins in animal models of Alzheimer’s disease: A meta-analysis 2015-2023
2025 - Published
Anschuetz, A., Schwab, K., Harrington, C., Wischik, C., Riedel, G.
Journal of Alzheimer's Disease, vol. 107, no. 2, pp. 452-476
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1177/13872877251362212
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/7a9cc0f7-7c67-4f4a-a8e5-c989c8f36970/download
Role of 18F-florzolotau PET in diagnostic and therapeutic decision-making for cognitive impairment
2025 - Published
Wang, J., Wang, Z., Chen, S., Wang, R., Chen, K., Lu, J., Xin, J., Huang, Y., Wang, M., Xie, F., Cheng, W., Yen, T., Wischik, C. M., Cui, M., Zuo, C., Zhao, Q., Wang, Y., Yu, J.
Alzheimer's & dementia : the journal of the Alzheimer's Association, vol. 21, no. 8, e70563
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1002/alz.70563
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/019992bc-c02d-48ce-afa4-a00b14c06599/download
FDG-PET Image Classification in Alzheimer’s Disease: from Traditional Visual Analysis to Advanced Transfer Learning
2025 - Published
Tripathi, S., McNeil, C., Staff, R., Murray, A., Wischik, C., Schelter, B., Waiter, G.
Nuclear Medicine and Molecular Imaging, vol. 59, pp. 201-208
Contributions to Journals: Articles
- [ONLINE] https://pubmed.ncbi.nlm.nih.gov/40385367/
- [ONLINE] DOI: https://doi.org/10.1007/s13139-025-00908-2
Hydromethylthionine sustains truncated tau-dependent inflammation-lowering effects in mouse brain
2025 - Published
Coelho Dos Santos, R., Lee, S. H., Lofthouse, R. A., Melis, V., Strachan, L., Leith, M., Dreesen, E., Armstrong, P., Vorley, T., Goatman, E., Hull, C., Riedel, G., Wischik, C., Harrington, C.
FEBS Journal, vol. 292, no. 10, pp. 2602-2623
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1111/febs.70021
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/372a1f89-dc2a-4be5-a64e-19083dc6d8d6/download
- [ONLINE] View publication in Scopus
Inhibiting disulphide bonding in truncated tau297-391 results in enhanced self-assembly of tau into seed-competent assemblies
2025 - Published
Oakley, S. S., Marshall, K. E., Meisl, G., Copsey, A., Maina, M. B., Milton, R., Vorley, T., Storey, J., Harrington, C., Wischik, C., Xue, W., Serpell, L. C.
Working Papers: Preprint Papers
- [ONLINE] DOI: https://doi.org/10.1101/2025.02.05.636249
Obtaining personalized predictions from a randomized controlled trial on Alzheimer’s disease
2025 - Published
Shen, D., Agarwal, A., Misra, V., Schelter, B., Shah, D., Shiells, H., Wischik, C.
Scientific Reports, vol. 15, 1671
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1038/s41598-024-84687-4
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/8573e799-c5aa-4089-ad2c-33affbb2f834/download
Rivastigmine interferes with the pharmacological activity of hydromethylthionine on presynaptic proteins in the line 66 model of frontotemporal dementia
2025 - Published
Schwab, K., Strachan, L., Anschuetz, A., Dreesen, E. S., Magbagbeolu, M., Melis, V., Theuring, F., Harrington, C., Wischik, C., Riedel, G.
Brain Research Bulletin, vol. 220, 111172
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.brainresbull.2024.111172
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/50808b59-567a-4211-a048-cd17a2095954/download
High-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer’s disease
2024 - Published
Arastoo, M., Penny, L. K., Lofthouse, R. A., Abdallah, A., Abrahamsson, A., Marini, P., Melis, V., Riedel, G., Harrington, C., Wischik, C., Porter, A., Palliyil, S.
Alzheimer's Research & Therapy, vol. 16, 209
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1186/s13195-024-01561-1
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/16d6fd7f-e75d-41e6-9988-873e405154e6/download
- [ONLINE] View publication in Scopus
Rescue of synaptosomal glutamate release defects in tau transgenic mice by the tau aggregation inhibitor hydromethylthionine
2024 - Published
Cranston, A., Kraev, I., Stewart, M. G., Horsley, D., Robinson, L., Dreesen, E. S., Armstrong, P., Palliyil, S., Harrington, C., Wischik, C., Riedel, G.
Cellular Signalling, vol. 121, 111269
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.cellsig.2024.111269
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/d54bb6ea-885a-4e6b-8bcd-28e50ba2fe67/download
Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: interference by cholinesterase inhibitors
2024 - Published
Schwab, K., Lauer, D., Magbagbeolu, M., Institute, M., Institute, M., Institute, M., Harrington, C. R., Wischik, C. M., Niewiadomska, G., Riedel, G.
Brain Research Bulletin, vol. 212, 110955
Contributions to Journals: Articles
- [ONLINE] https://www.sciencedirect.com/science/article/pii/S0361923024000881
- [ONLINE] DOI: https://doi.org/10.1016/j.brainresbull.2024.110955
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/911fd769-9219-463f-83d9-b5ff9071cb3d/download
Considerations for biomarker strategies in clinical trials investigating tau-targeting therapeutics for Alzheimer's disease
2024 - Published
Penny, L. K., Lofthouse, R., Arastoo, M., Porter, A., Palliyil, S., Harrington, C. R., Wischik, C. M.
Translational neurodegeneration, vol. 13, 25
Contributions to Journals: Review articles
- [ONLINE] DOI: https://doi.org/10.1186/s40035-024-00417-w
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/f480b0d8-1b60-4c10-9ca8-418e5f6d6762/download
LETC inhibits α-Syn aggregation and ameliorates motor deficiencies in the L62 mouse model of synucleinopathy
2024 - Published
Schwab, K., Frahm, S., Magbagbeolu, M., Horsley, D., Goatman, E., Melis, V., Theuring, F., Ishaq, A., Storey, J. M. D., Harrington, C., Wischik, C., Riedel, G.
European Journal of Pharmacology, vol. 970, 176505
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.ejphar.2024.176505
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/9d89be2d-c6b8-49cc-bb79-e013038af2ec/download
Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model
2024 - Published
Zadrozny, M., Drapich, P., Gasiorowska-Bien, A., Niewiadomski, W., Harrington, C. R., Wischik, C. M., Riedel, G., Niewiadomska, G.
Cells, vol. 13, no. 7, 642
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/cells13070642
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/ca875772-85c5-4a84-8836-b35df823e61b/download
Assays for the Screening and Characterization of Tau Aggregation Inhibitors
2024 - Published
Horsley, D., Rickard, J. E., Vorley, T., Leeper, M. F., Wischik, C. M., Harrington, C. R.
Tau Protein: Methods and Protocols. 2 edition, pp. 93-104, 12 pages
Chapters in Books, Reports and Conference Proceedings: Chapters (Peer-Reviewed)
- [ONLINE] DOI: https://doi.org/10.1007/978-1-0716-3629-9_5
Solubility of α-synuclein species in the L62 mouse model of synucleinopathy
2024 - Published
Schwab, K., Magbagbeolu, M., Theuring, F., Harrington, C., Wischik, C., Riedel, G.
Scientific Reports, vol. 14, 6239
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1038/s41598-024-56735-6
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/798dca69-b204-4811-bd11-ff81161eebce/download
Apathy-like behaviour in tau mouse models of Alzheimer’s disease and frontotemporal dementia
2024 - Published
Robinson, L., Dreesen, E., Mondesir, M., Harrington, C., Wischik, C., Riedel, G.
Behavioural Brain Research, vol. 456, 114707
Contributions to Journals: Articles
- [ONLINE] https://www.sciencedirect.com/science/article/pii/S0166432823004254
- [ONLINE] DOI: https://doi.org/10.1016/j.bbr.2023.114707
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/aea69e4a-9c79-4f34-a4e5-b40c41c74126/download
A Meta-Analysis on Presynaptic Changes in Alzheimer's Disease
2024 - Published
Anschuetz, A., Schwab, K., Harrington, C. R., Wischik, C. M., Riedel, G.
Journal of Alzheimer's Disease, vol. 97, no. 1, pp. 145-162
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3233/JAD-231034
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/3addf8f1-3f99-45b5-b850-d0bad61a2a40/download
Significant dose-dependent reduction in neurofilament light chain concentration in plasma with oral tau aggregation inhibitor hydromethylthionine mesylate
2023 - Published
Wischik, C. M., Schelter, B., Penny, L. K., Miller, S., Stefanacci, R., Heslegrave, A., Zetterberg, H.
Alzheimer's Dementia, vol. 19, no. S24, e083153
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1002/alz.083153
Exploring the Anti-Hypoxaemia Effect of Hydromethylthionine: A Prospective Study of Phase 3 Clinical Trial Participants
2023 - Published
Arastoo, M., Mazanetz, M. P., Miller, S., Shiells, H., Hull, C., Robinson, K., Storey, J. M., Harrington, C. R., Wischik, C. M.
International Journal of Molecular Sciences, vol. 24, no. 18, 13747
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/ijms241813747
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/029b2654-85f4-47f9-9fbb-53ce74475240/download
- [ONLINE] View publication in Scopus
Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice
2023 - Published
Kondak, C., Leith, M., Baddeley, T. C., Santos, R. X., Harrington, C. R., Wischik, C. M., Riedel, G., Klein, J.
International Journal of Molecular Sciences, vol. 24, no. 13, 10810
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/ijms241310810
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/f25eee8a-d88e-4932-8d2f-6574bcb547cf/download
Utility of Blood-Based Tau Biomarkers for Mild Cognitive Impairment and Alzheimer’s Disease: Systematic Review and Meta-Analysis
2023 - Published
Zabala-Findlay, A., Penny, L. K., Lofthouse, R. A., Porter, A. J., Palliyil, S., Harrington, C. R., Wischik, C. M., Arastoo, M.
Cells, vol. 12, no. 8, 1184
Contributions to Journals: Review articles
- [ONLINE] DOI: https://doi.org/10.3390/cells12081184
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/5a7834d0-3873-4ab0-8e73-39d8d3e700e3/download
- [ONLINE] View publication in Scopus
An Additive-Free Model for Tau Self-Assembly
2023 - Published
Al-Hilaly, Y. K., Marshall, K. E., Lutter, L., Biasetti, L., Mengham, K., Harrington, C. R., Xue, W. F., Wischik, C. M., Serpell, L. C.
Methods in molecular biology (Clifton, N.J.), vol. 2551, pp. 163-188
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1007/978-1-0716-2597-2_12
- [ONLINE] View publication in Scopus
Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391)
2022 - Published
Al-Hilaly, Y. K., Hurt, C., Rickard, J. E., Harrington, C. R., Storey, J. M., Wischik, C. M., Serpell, L. C., Siemer, A. B.
Frontiers in Neuroscience, vol. 16, 988074
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3389/fnins.2022.988074
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/7eef7824-8886-4023-91e6-06245d0a03c3/download
- [ONLINE] View publication in Scopus

Show 10 | 25 | 50 | 100 results per page

Refine

Chapters in Books, Reports and Conference Proceedings

Chapters (4)

Chapters (Peer-Reviewed) (2)

Contributions to Conferences

Abstracts (3)

Contributions to Journals

Abstracts (4)

Articles (74)

Review articles (3)

Patents

Patents (18)

Working Papers

Preprint Papers (1)

Update

Research Overview

Inhibiting disulphide bonding in truncated tau297-391 results in enhanced self-assembly of tau into seed-competent assemblies

A key region of Tau that is able to drive assembly and modulate inhibition by Hydromethylthionine

Proteomic and non-proteomic changes of presynaptic proteins in animal models of Alzheimer’s disease: A meta-analysis 2015-2023

Role of 18F-florzolotau PET in diagnostic and therapeutic decision-making for cognitive impairment

FDG-PET Image Classification in Alzheimer’s Disease: from Traditional Visual Analysis to Advanced Transfer Learning

Hydromethylthionine sustains truncated tau-dependent inflammation-lowering effects in mouse brain

Inhibiting disulphide bonding in truncated tau297-391 results in enhanced self-assembly of tau into seed-competent assemblies

Obtaining personalized predictions from a randomized controlled trial on Alzheimer’s disease

Rivastigmine interferes with the pharmacological activity of hydromethylthionine on presynaptic proteins in the line 66 model of frontotemporal dementia

High-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer’s disease

Rescue of synaptosomal glutamate release defects in tau transgenic mice by the tau aggregation inhibitor hydromethylthionine

Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: interference by cholinesterase inhibitors

Considerations for biomarker strategies in clinical trials investigating tau-targeting therapeutics for Alzheimer's disease

LETC inhibits α-Syn aggregation and ameliorates motor deficiencies in the L62 mouse model of synucleinopathy

Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model

Assays for the Screening and Characterization of Tau Aggregation Inhibitors

Solubility of α-synuclein species in the L62 mouse model of synucleinopathy

Apathy-like behaviour in tau mouse models of Alzheimer’s disease and frontotemporal dementia

A Meta-Analysis on Presynaptic Changes in Alzheimer's Disease

Significant dose-dependent reduction in neurofilament light chain concentration in plasma with oral tau aggregation inhibitor hydromethylthionine mesylate

Exploring the Anti-Hypoxaemia Effect of Hydromethylthionine: A Prospective Study of Phase 3 Clinical Trial Participants

Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice

Utility of Blood-Based Tau Biomarkers for Mild Cognitive Impairment and Alzheimer’s Disease: Systematic Review and Meta-Analysis

An Additive-Free Model for Tau Self-Assembly

Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391)

Refine

Chapters in Books, Reports and Conference Proceedings

Contributions to Conferences

Contributions to Journals

Patents

Working Papers