Professor Claude Wischik | The University of Aberdeen

Inhibiting disulphide bonding in truncated tau297-391 results in enhanced self-assembly of tau into seed-competent assemblies
2025 - Accepted/In press
Oakley, S. S., Marshall, K. E., Meisl, G., Copsey, A., Maina, M. B., Milton, R., Vorley, T., Storey, J., Harrington, C., Wischik, C., Xue, W., Serpell, L. C.
ACS Chemical Neuroscience
Contributions to Journals: Articles
A key region of Tau that is able to drive assembly and modulate inhibition by Hydromethylthionine
2025 - Published
Al-Hilaly, Y. K., Rickard, J. E., Simpson, M., Storey, J. M., Harrington, C. R., Wischik, C. M., Serpell, L. C.
Journal of Molecular Biology, vol. 437, no. 17, 169231
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.jmb.2025.169231
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/7a09658e-98e2-46e0-b61c-ea4a48f823ab/download
- [ONLINE] View publication in Scopus
Proteomic and non-proteomic changes of presynaptic proteins in animal models of Alzheimer’s disease: A meta-analysis 2015-2023
2025 - Published
Anschuetz, A., Schwab, K., Harrington, C., Wischik, C., Riedel, G.
Journal of Alzheimer's Disease, vol. 107, no. 2, pp. 452-476
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1177/13872877251362212
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/7a9cc0f7-7c67-4f4a-a8e5-c989c8f36970/download
Role of 18F-florzolotau PET in diagnostic and therapeutic decision-making for cognitive impairment
2025 - Published
Wang, J., Wang, Z., Chen, S., Wang, R., Chen, K., Lu, J., Xin, J., Huang, Y., Wang, M., Xie, F., Cheng, W., Yen, T., Wischik, C. M., Cui, M., Zuo, C., Zhao, Q., Wang, Y., Yu, J.
Alzheimer's & dementia : the journal of the Alzheimer's Association, vol. 21, no. 8, e70563
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1002/alz.70563
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/019992bc-c02d-48ce-afa4-a00b14c06599/download
FDG-PET Image Classification in Alzheimer’s Disease: from Traditional Visual Analysis to Advanced Transfer Learning
2025 - Published
Tripathi, S., McNeil, C., Staff, R., Murray, A., Wischik, C., Schelter, B., Waiter, G.
Nuclear Medicine and Molecular Imaging, vol. 59, pp. 201-208
Contributions to Journals: Articles
- [ONLINE] https://pubmed.ncbi.nlm.nih.gov/40385367/
- [ONLINE] DOI: https://doi.org/10.1007/s13139-025-00908-2
Hydromethylthionine sustains truncated tau-dependent inflammation-lowering effects in mouse brain
2025 - Published
Coelho Dos Santos, R., Lee, S. H., Lofthouse, R. A., Melis, V., Strachan, L., Leith, M., Dreesen, E., Armstrong, P., Vorley, T., Goatman, E., Hull, C., Riedel, G., Wischik, C., Harrington, C.
FEBS Journal, vol. 292, no. 10, pp. 2602-2623
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1111/febs.70021
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/372a1f89-dc2a-4be5-a64e-19083dc6d8d6/download
- [ONLINE] View publication in Scopus
Inhibiting disulphide bonding in truncated tau297-391 results in enhanced self-assembly of tau into seed-competent assemblies
2025 - Published
Oakley, S. S., Marshall, K. E., Meisl, G., Copsey, A., Maina, M. B., Milton, R., Vorley, T., Storey, J., Harrington, C., Wischik, C., Xue, W., Serpell, L. C.
Working Papers: Preprint Papers
- [ONLINE] DOI: https://doi.org/10.1101/2025.02.05.636249
Obtaining personalized predictions from a randomized controlled trial on Alzheimer’s disease
2025 - Published
Shen, D., Agarwal, A., Misra, V., Schelter, B., Shah, D., Shiells, H., Wischik, C.
Scientific Reports, vol. 15, 1671
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1038/s41598-024-84687-4
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/8573e799-c5aa-4089-ad2c-33affbb2f834/download
Rivastigmine interferes with the pharmacological activity of hydromethylthionine on presynaptic proteins in the line 66 model of frontotemporal dementia
2025 - Published
Schwab, K., Strachan, L., Anschuetz, A., Dreesen, E. S., Magbagbeolu, M., Melis, V., Theuring, F., Harrington, C., Wischik, C., Riedel, G.
Brain Research Bulletin, vol. 220, 111172
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.brainresbull.2024.111172
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/50808b59-567a-4211-a048-cd17a2095954/download
High-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer’s disease
2024 - Published
Arastoo, M., Penny, L. K., Lofthouse, R. A., Abdallah, A., Abrahamsson, A., Marini, P., Melis, V., Riedel, G., Harrington, C., Wischik, C., Porter, A., Palliyil, S.
Alzheimer's Research & Therapy, vol. 16, 209
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1186/s13195-024-01561-1
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/16d6fd7f-e75d-41e6-9988-873e405154e6/download
- [ONLINE] View publication in Scopus
Rescue of synaptosomal glutamate release defects in tau transgenic mice by the tau aggregation inhibitor hydromethylthionine
2024 - Published
Cranston, A., Kraev, I., Stewart, M. G., Horsley, D., Robinson, L., Dreesen, E. S., Armstrong, P., Palliyil, S., Harrington, C., Wischik, C., Riedel, G.
Cellular Signalling, vol. 121, 111269
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.cellsig.2024.111269
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/d54bb6ea-885a-4e6b-8bcd-28e50ba2fe67/download
Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: interference by cholinesterase inhibitors
2024 - Published
Schwab, K., Lauer, D., Magbagbeolu, M., Institute, M., Institute, M., Institute, M., Harrington, C. R., Wischik, C. M., Niewiadomska, G., Riedel, G.
Brain Research Bulletin, vol. 212, 110955
Contributions to Journals: Articles
- [ONLINE] https://www.sciencedirect.com/science/article/pii/S0361923024000881
- [ONLINE] DOI: https://doi.org/10.1016/j.brainresbull.2024.110955
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/911fd769-9219-463f-83d9-b5ff9071cb3d/download
Considerations for biomarker strategies in clinical trials investigating tau-targeting therapeutics for Alzheimer's disease
2024 - Published
Penny, L. K., Lofthouse, R., Arastoo, M., Porter, A., Palliyil, S., Harrington, C. R., Wischik, C. M.
Translational neurodegeneration, vol. 13, 25
Contributions to Journals: Review articles
- [ONLINE] DOI: https://doi.org/10.1186/s40035-024-00417-w
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/f480b0d8-1b60-4c10-9ca8-418e5f6d6762/download
LETC inhibits α-Syn aggregation and ameliorates motor deficiencies in the L62 mouse model of synucleinopathy
2024 - Published
Schwab, K., Frahm, S., Magbagbeolu, M., Horsley, D., Goatman, E., Melis, V., Theuring, F., Ishaq, A., Storey, J. M. D., Harrington, C., Wischik, C., Riedel, G.
European Journal of Pharmacology, vol. 970, 176505
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.ejphar.2024.176505
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/9d89be2d-c6b8-49cc-bb79-e013038af2ec/download
Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model
2024 - Published
Zadrozny, M., Drapich, P., Gasiorowska-Bien, A., Niewiadomski, W., Harrington, C. R., Wischik, C. M., Riedel, G., Niewiadomska, G.
Cells, vol. 13, no. 7, 642
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/cells13070642
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/ca875772-85c5-4a84-8836-b35df823e61b/download
Assays for the Screening and Characterization of Tau Aggregation Inhibitors
2024 - Published
Horsley, D., Rickard, J. E., Vorley, T., Leeper, M. F., Wischik, C. M., Harrington, C. R.
Tau Protein: Methods and Protocols. 2 edition, pp. 93-104, 12 pages
Chapters in Books, Reports and Conference Proceedings: Chapters (Peer-Reviewed)
- [ONLINE] DOI: https://doi.org/10.1007/978-1-0716-3629-9_5
Solubility of α-synuclein species in the L62 mouse model of synucleinopathy
2024 - Published
Schwab, K., Magbagbeolu, M., Theuring, F., Harrington, C., Wischik, C., Riedel, G.
Scientific Reports, vol. 14, 6239
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1038/s41598-024-56735-6
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/798dca69-b204-4811-bd11-ff81161eebce/download
Apathy-like behaviour in tau mouse models of Alzheimer’s disease and frontotemporal dementia
2024 - Published
Robinson, L., Dreesen, E., Mondesir, M., Harrington, C., Wischik, C., Riedel, G.
Behavioural Brain Research, vol. 456, 114707
Contributions to Journals: Articles
- [ONLINE] https://www.sciencedirect.com/science/article/pii/S0166432823004254
- [ONLINE] DOI: https://doi.org/10.1016/j.bbr.2023.114707
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/aea69e4a-9c79-4f34-a4e5-b40c41c74126/download
A Meta-Analysis on Presynaptic Changes in Alzheimer's Disease
2024 - Published
Anschuetz, A., Schwab, K., Harrington, C. R., Wischik, C. M., Riedel, G.
Journal of Alzheimer's Disease, vol. 97, no. 1, pp. 145-162
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3233/JAD-231034
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/3addf8f1-3f99-45b5-b850-d0bad61a2a40/download
Significant dose-dependent reduction in neurofilament light chain concentration in plasma with oral tau aggregation inhibitor hydromethylthionine mesylate
2023 - Published
Wischik, C. M., Schelter, B., Penny, L. K., Miller, S., Stefanacci, R., Heslegrave, A., Zetterberg, H.
Alzheimer's Dementia, vol. 19, no. S24, e083153
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1002/alz.083153
Exploring the Anti-Hypoxaemia Effect of Hydromethylthionine: A Prospective Study of Phase 3 Clinical Trial Participants
2023 - Published
Arastoo, M., Mazanetz, M. P., Miller, S., Shiells, H., Hull, C., Robinson, K., Storey, J. M., Harrington, C. R., Wischik, C. M.
International Journal of Molecular Sciences, vol. 24, no. 18, 13747
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/ijms241813747
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/029b2654-85f4-47f9-9fbb-53ce74475240/download
- [ONLINE] View publication in Scopus
Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice
2023 - Published
Kondak, C., Leith, M., Baddeley, T. C., Santos, R. X., Harrington, C. R., Wischik, C. M., Riedel, G., Klein, J.
International Journal of Molecular Sciences, vol. 24, no. 13, 10810
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/ijms241310810
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/f25eee8a-d88e-4932-8d2f-6574bcb547cf/download
Utility of Blood-Based Tau Biomarkers for Mild Cognitive Impairment and Alzheimer’s Disease: Systematic Review and Meta-Analysis
2023 - Published
Zabala-Findlay, A., Penny, L. K., Lofthouse, R. A., Porter, A. J., Palliyil, S., Harrington, C. R., Wischik, C. M., Arastoo, M.
Cells, vol. 12, no. 8, 1184
Contributions to Journals: Review articles
- [ONLINE] DOI: https://doi.org/10.3390/cells12081184
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/5a7834d0-3873-4ab0-8e73-39d8d3e700e3/download
- [ONLINE] View publication in Scopus
An Additive-Free Model for Tau Self-Assembly
2023 - Published
Al-Hilaly, Y. K., Marshall, K. E., Lutter, L., Biasetti, L., Mengham, K., Harrington, C. R., Xue, W. F., Wischik, C. M., Serpell, L. C.
Methods in molecular biology (Clifton, N.J.), vol. 2551, pp. 163-188
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1007/978-1-0716-2597-2_12
- [ONLINE] View publication in Scopus
Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391)
2022 - Published
Al-Hilaly, Y. K., Hurt, C., Rickard, J. E., Harrington, C. R., Storey, J. M., Wischik, C. M., Serpell, L. C., Siemer, A. B.
Frontiers in Neuroscience, vol. 16, 988074
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3389/fnins.2022.988074
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/7eef7824-8886-4023-91e6-06245d0a03c3/download
- [ONLINE] View publication in Scopus
Dityrosine Cross-links are Present in Alzheimer's Disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the Stability of the PHF-core Tau (297–391) In Vitro
2022 - Published
Maina, M. B., Al-Hilaly, Y. K., Oakley, S., Burra, G., Khanom, T., Biasetti, L., Mengham, K., Marshall, K., Harrington, C. R., Wischik, C. M., Serpell, L. C.
Journal of Molecular Biology, vol. 434, no. 19, 167785
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.jmb.2022.167785
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/0a8f0abd-6cef-4f77-98b1-76e0eabc280f/download
- [ONLINE] View publication in Scopus
Oral Tau Aggregation Inhibitor for Alzheimer’s Disease: Design, Progress and Basis for Selection of the 16 mg/day Dose in a Phase 3, Randomized, Placebo-Controlled Trial of Hydromethylthionine Mesylate
2022 - Published
Wischik, C. M., Bentham, P., Gauthier, S., Miller, S., Kook, K., Schelter, B. O.
Journal of Prevention of Alzheimer's Disease, vol. 9, pp. 780-790
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.14283/jpad.2022.63
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/4b8d981b-d1b0-43ab-bbbc-a90581c02b21/download
- [ONLINE] View publication in Scopus
Glutamatergic transmission and receptor expression in the synucleinopathy h-α-synL62 mouse model: Effects of hydromethylthionine
2022 - Published
Schwab, K., Chasapopoulou, Z., Frahm, S., Magbagbeolu, M., Cranston, A., Harrington, C. R., Wischik, C. M., Theuring, F., Riedel, G.
Cellular Signalling, vol. 97, 110386
Contributions to Journals: Articles
- [ONLINE] https://www.sciencedirect.com/science/article/pii/S0898656822001486
- [ONLINE] DOI: https://doi.org/10.1016/j.cellsig.2022.110386
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/ea4865a6-a9d9-45aa-9ac8-d93d5b4f39d9/download
Structural Identification of Individual Helical Amyloid Filaments by Integration of Cryo-Electron Microscopy-Derived Maps in Comparative Morphometric Atomic Force Microscopy Image Analysis
2022 - Published
Lutter, L., Al-Hilaly, Y. K., Serpell, C. J., Tuite, M. F., Wischik, C. M., Serpell, L. C., Xue, W. F.
Journal of Molecular Biology, vol. 434, no. 7, 167466
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.jmb.2022.167466
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/bf92d10c-6597-45ea-95e4-ac6e0c02758c/download
- [ONLINE] View publication in Scopus
HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine
2022 - Published
Santos, R. X., Melis, V., Goatman, E. A., Leith, M., Baddeley, T. C., Storey, J. M., Riedel, G., Wischik, C. M., Harrington, C. R.
Biomedicines, vol. 10, no. 4, 867
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/biomedicines10040867
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/161666d1-4323-45bc-9b3c-26c075dc2edd/download
- [ONLINE] View publication in Scopus
Crossed cerebellar diaschisis in Alzheimer's disease
2022 - Published
Tripathi, S. M., Murray, A. D., Wischik, C. M., Schelter, B.
Nuclear Medicine Communications, vol. 43, no. 4, pp. 423-427
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1097/MNM.0000000000001531
- [ONLINE] View publication in Scopus
Hydromethylthionine enhancement of central cholinergic signalling is blocked by rivastigmine and memantine
2022 - Published
Kondak, C., Riedel, G., Harrington, C. R., Wischik, C. M., Klein, J.
Journal of Neurochemistry, vol. 160, pp. 172-184
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1111/jnc.15553
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/fc77ddf0-6353-4dc8-9d8a-f5a80fccaf2f/download
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/f423b85f-86d6-463d-8ebd-4918b17aa99c/download
Degeneration of basal and limbic networks is a core feature of behavioural variant frontotemporal dementia
2021 - Published
Vuksanovic, V., Staff, R., Morson, S., Ahearn, T., Bracoud, L., Murray, A. D., Bentham, P., Kipps, C. M., Harrington, C., Wischik, C.
Brain Communications, vol. 3, no. 4, fcab241
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1093/braincomms/fcab241
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/197d4f7a-3474-4cfa-88b4-a062a62bb8d7/download
Long-term hydromethylthionine treatment is associated with delayed clinical onset and slowing of cerebral atrophy in a pre-symptomatic P301S MAPT mutation carrier
2021 - Published
Bentham, P., Staff, R. T., Schelter, B. O., Shiells, H., Harrington, C. R., Wischik, C. M.
Journal of Alzheimer's Disease, vol. 83, no. 3, pp. 1017-1023
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3233/JAD-210390
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/ef8b32b2-335b-468f-930e-a8e0751fbda2/download
- [ONLINE] View publication in Scopus
Proteomic analysis of hydromethylthionine in the line 66 model of frontotemporal dementia demonstrates actions on tau-dependent and tau-independent networks
2021 - Published
Schwab, K., Melis, V., Harrington, C. R., Wischik, C. M., Magbagbeolu, M., Theuring, F., Riedel, G.
Cells, vol. 10, no. 8, 2162
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/cells10082162
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/131e3534-c036-4040-a381-e552f642e322/download
- [ONLINE] View publication in Scopus
Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates
2021 - Published
Maina, M. B., Al-Hilaly, Y. K., Burra, G., Rickard, J. E., Harrington, C. R., Wischik, C. M., Serpell, L. C.
Cells, vol. 10, no. 3, 703
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/cells10030703
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/a40fa657-872d-40f9-907e-438d23fc9812/download
Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the Line 66 model of frontotemporal dementia
2020 - Published
Lemke, N., Melis, V., Lauer, D., Magbagbeolu, M., Neumann, B., Harrington, C. R., Riedel, G., Wischik, C. M., Theuring, F., Schwab, K.
Journal of Biological Chemistry, vol. 295, no. 52, pp. 18508-18523
Contributions to Journals: Articles
- [ONLINE] http://www.jbc.org/content/early/2020/10/30/jbc.RA120.014890.abstract
- [ONLINE] DOI: https://doi.org/10.1074/jbc.RA120.014890
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/1d3b8abd-011d-4410-8fc6-b164f3a5f092/download
- [ONLINE] View publication in Scopus
Adaptive neurological testing method
2020 - Published
Shiells, H. C., Morson, S., Schelter, B., Wischik, D. J., Wischik, C.
Patents: Patents
Current Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer’s Disease
2020 - Published
Arastoo, M., Lofthouse, R., Penny, L., Harrington, C. R., Porter, A., Wischik, C. M., Palliyil, S.
International Journal of Molecular Sciences, vol. 21, no. 22, pp. 1-19
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/ijms21228673
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/997e480f-f45a-476e-9038-4e42a8e187ac/download
- [ONLINE] View publication in Scopus
Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target.
2020 - Published
Oakley, S., Maina, M. B., Marshall, K. E., Al-Hilaly, Y. K., Harrington, C. R., Wischik, C. M., Serpell, L. C.
Frontiers in Neurology, vol. 11, 590754
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3389/fneur.2020.590754
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/e55ed5c9-07a3-4b04-acf1-8b62a320679c/download
- [ONLINE] View publication in Scopus
Paired helical filament forming region of tau (297-391) influences endogenous tau protein and accumulates in acidic compartments in human neuronal cells
2020 - Published
Pollack, S. J., Trigg, J., Khanom, T., Biasetti, L., Marshall, K. E., Al-Hilaly, Y. K., Rickard, J. E., Harrington, C. R., Wischik, C. M., Serpell, L. C.
Journal of Molecular Biology, vol. 432, no. 17, pp. 4891-4907
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.jmb.2020.05.027
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/1180919d-7bb9-4ef0-b615-bcead7669252/download
- [ONLINE] View publication in Scopus
Analysis of the Relationship Between Metalloprotease-9 and Tau Protein in Alzheimer's Disease
2020 - Published
Hernandes-Alejandro, M., Montaño, S., Harrington, C. R., Wischik, C. M., Salas-Casas, A., Cortes-Reynosa, P., Pérez Salazar, E., Cazares-Apatiga, J., Apatiga-Perez, R., Ontiveros Torres, M. ?., Perry, G., Pacheco-Herrero, M., Luna-Muñoz, J.
Journal of Alzheimer's Disease, vol. 76, no. 2, pp. 553-569
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3233/JAD-200146
- [ONLINE] View publication in Scopus
Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia
2020 - Published
Shiells, H., Schelter, B. O., Bentham, P., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Wischik, D. J., Riedel, G., Gauthier, S., Jia, J., Moebius, H. J., Hardlund, J., Kipps, C. M., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
Journal of Alzheimer's Disease, vol. 75, no. 2, pp. 501-519
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3233/JAD-191173
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/53b6ee0c-d5be-45c3-90a0-1afea8f620c4/download
- [ONLINE] View publication in Scopus
Mechanisms of anticholinesterase interference with tau aggregation inhibitor activity in a tau-transgenic mouse model
2020 - Published
Riedel, G., Klein, J., Niewiadomska, G., Kondak, C., Schwab, K., Lauer, D., Magbagbeolu, M., Steczkowska, M., Zadrozny, M., Wydrych, M., Cranston, A., Melis, V., Santos, R. X., Theuring, F., Harrington, C. R., Wischik, C. M.
Current Alzheimer Research, vol. 17, no. 3, pp. 285-296
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.2174/1567205017666200224120926
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/93bdbc3a-7cb1-4d17-a739-bf474576969a/download
- [ONLINE] View publication in Scopus
Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer’s Disease and Frontotemporal Lobar Degeneration
2020 - Published
Cranston, A. L., Wysocka, A., Steczkowska, M., Zadrozny, M., Palasz, E., Harrington, C. R., Theuring, F., Wischik, C., Riedel, G., Niewiadomska, G.
Brain Communications, vol. 2, no. 1, fcaa033
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1093/braincomms/fcaa033
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/e8bdcbaa-dd08-47da-af17-30697cf2e0ce/download
Tau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brain
2020 - Published
Al-Hilaly, Y. K., Foster, B. E., Biasetti, L., Lutter, L., Pollack, S. J., Rickard, J. E., Storey, J. M. D., Harrington, C. R., Xue, W., Wischik, C. M., Serpell, L. C.
FEBS LETTERS, vol. 594, no. 5, pp. 944-950
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1002/1873-3468.13675
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/a1e6143f-ac8d-4b86-9587-c72bbd87d69c/download
- [ONLINE] View publication in Scopus
Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease
2019 - Published
Schelter, B. O., Shiells, H., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Riedel, G., Gauthier, S., Jia, J., Bentham, P., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
Journal of Alzheimer's Disease, vol. 72, no. 3, pp. 931-946
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3233/JAD-190772
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/4bb2ba91-6ed8-4d4f-92e5-d6879822bf25/download
Phospho-Tau Protein Expression in the Cell Cycle of SH-SY5Y Neuroblastoma Cells: A Morphological Study
2019 - Published
Flores-Rodríguez, P., Harrington, C. R., Wischik, C. M., Ibarra-Bracamontes, V., Zarco, N., Navarrete, A., Martínez-Maldonado, A., Guadarrama-Ortíz, P., Villanueva-Fierro, I., Ontiveros-Torres, M. A., Perry, G., Alonso, A. D., Florán-Garduño, B., Segovia, J., Luna-Muñoz, J.
Journal of Alzheimer's Disease, vol. 71, no. 2, pp. 631-645
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3233/JAD-190155
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/9729b8a2-0e5b-43e3-84ac-9960eaa6a6fb/download
- [ONLINE] https://www.medra.org/servlet/aliasResolver?alias=iospress&doi=10.3233/JAD-190155
- [ONLINE] View publication in Mendeley
Cortical Thickness and Surface Area Networks in Healthy Aging, Alzheimer’s Disease and Behavioral Variant Fronto-Temporal Dementia
2019 - Published
Vuksanovic, V., Staff, R. T., Ahearn, T., Murray, A. D., Wischik, C. M.
International Journal of Neural Systems, vol. 29, no. 6, 1850055
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1142/S0129065718500557
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/8d52863b-34a5-4944-aa97-15d36af20879/download
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Increased Cholinergic Response in α-Synuclein Transgenic Mice (h-α-synL62)
2019 - Published
König, M., Berlin, B., Schwab, K., Frahm, S., Theuring, F., Wischik, C. M., Harrington, C. R., Riedel, G., Klein, J.
ACS Chemical Neuroscience, vol. 10, no. 4, pp. 1915-1922
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1021/acschemneuro.8b00274
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/3b748f24-8b93-40f4-846d-54a822947515/download
- [ONLINE] View publication in Mendeley

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Research Overview

Inhibiting disulphide bonding in truncated tau297-391 results in enhanced self-assembly of tau into seed-competent assemblies

A key region of Tau that is able to drive assembly and modulate inhibition by Hydromethylthionine

Proteomic and non-proteomic changes of presynaptic proteins in animal models of Alzheimer’s disease: A meta-analysis 2015-2023

Role of 18F-florzolotau PET in diagnostic and therapeutic decision-making for cognitive impairment

FDG-PET Image Classification in Alzheimer’s Disease: from Traditional Visual Analysis to Advanced Transfer Learning

Hydromethylthionine sustains truncated tau-dependent inflammation-lowering effects in mouse brain

Inhibiting disulphide bonding in truncated tau297-391 results in enhanced self-assembly of tau into seed-competent assemblies

Obtaining personalized predictions from a randomized controlled trial on Alzheimer’s disease

Rivastigmine interferes with the pharmacological activity of hydromethylthionine on presynaptic proteins in the line 66 model of frontotemporal dementia

High-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer’s disease

Rescue of synaptosomal glutamate release defects in tau transgenic mice by the tau aggregation inhibitor hydromethylthionine

Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: interference by cholinesterase inhibitors

Considerations for biomarker strategies in clinical trials investigating tau-targeting therapeutics for Alzheimer's disease

LETC inhibits α-Syn aggregation and ameliorates motor deficiencies in the L62 mouse model of synucleinopathy

Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model

Assays for the Screening and Characterization of Tau Aggregation Inhibitors

Solubility of α-synuclein species in the L62 mouse model of synucleinopathy

Apathy-like behaviour in tau mouse models of Alzheimer’s disease and frontotemporal dementia

A Meta-Analysis on Presynaptic Changes in Alzheimer's Disease

Significant dose-dependent reduction in neurofilament light chain concentration in plasma with oral tau aggregation inhibitor hydromethylthionine mesylate

Exploring the Anti-Hypoxaemia Effect of Hydromethylthionine: A Prospective Study of Phase 3 Clinical Trial Participants

Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice

Utility of Blood-Based Tau Biomarkers for Mild Cognitive Impairment and Alzheimer’s Disease: Systematic Review and Meta-Analysis

An Additive-Free Model for Tau Self-Assembly

Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391)

Dityrosine Cross-links are Present in Alzheimer's Disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the Stability of the PHF-core Tau (297–391) In Vitro

Oral Tau Aggregation Inhibitor for Alzheimer’s Disease: Design, Progress and Basis for Selection of the 16 mg/day Dose in a Phase 3, Randomized, Placebo-Controlled Trial of Hydromethylthionine Mesylate

Glutamatergic transmission and receptor expression in the synucleinopathy h-α-synL62 mouse model: Effects of hydromethylthionine

Structural Identification of Individual Helical Amyloid Filaments by Integration of Cryo-Electron Microscopy-Derived Maps in Comparative Morphometric Atomic Force Microscopy Image Analysis

HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine

Crossed cerebellar diaschisis in Alzheimer's disease

Hydromethylthionine enhancement of central cholinergic signalling is blocked by rivastigmine and memantine

Degeneration of basal and limbic networks is a core feature of behavioural variant frontotemporal dementia

Long-term hydromethylthionine treatment is associated with delayed clinical onset and slowing of cerebral atrophy in a pre-symptomatic P301S MAPT mutation carrier

Proteomic analysis of hydromethylthionine in the line 66 model of frontotemporal dementia demonstrates actions on tau-dependent and tau-independent networks

Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates

Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the Line 66 model of frontotemporal dementia

Adaptive neurological testing method

Current Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer’s Disease

Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target.

Paired helical filament forming region of tau (297-391) influences endogenous tau protein and accumulates in acidic compartments in human neuronal cells

Analysis of the Relationship Between Metalloprotease-9 and Tau Protein in Alzheimer's Disease

Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

Mechanisms of anticholinesterase interference with tau aggregation inhibitor activity in a tau-transgenic mouse model

Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer’s Disease and Frontotemporal Lobar Degeneration

Tau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brain

Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

Phospho-Tau Protein Expression in the Cell Cycle of SH-SY5Y Neuroblastoma Cells: A Morphological Study

Cortical Thickness and Surface Area Networks in Healthy Aging, Alzheimer’s Disease and Behavioral Variant Fronto-Temporal Dementia

Increased Cholinergic Response in α-Synuclein Transgenic Mice (h-α-synL62)

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