Professor Claude Wischik | The University of Aberdeen

Dityrosine Cross-links are Present in Alzheimer's Disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the Stability of the PHF-core Tau (297–391) In Vitro
2022 - Published
Maina, M. B., Al-Hilaly, Y. K., Oakley, S., Burra, G., Khanom, T., Biasetti, L., Mengham, K., Marshall, K., Harrington, C. R., Wischik, C. M., Serpell, L. C.
Journal of Molecular Biology, vol. 434, no. 19, 167785
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.jmb.2022.167785
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/0a8f0abd-6cef-4f77-98b1-76e0eabc280f/download
- [ONLINE] View publication in Scopus
Oral Tau Aggregation Inhibitor for Alzheimer’s Disease: Design, Progress and Basis for Selection of the 16 mg/day Dose in a Phase 3, Randomized, Placebo-Controlled Trial of Hydromethylthionine Mesylate
2022 - Published
Wischik, C. M., Bentham, P., Gauthier, S., Miller, S., Kook, K., Schelter, B. O.
Journal of Prevention of Alzheimer's Disease, vol. 9, pp. 780-790
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.14283/jpad.2022.63
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/4b8d981b-d1b0-43ab-bbbc-a90581c02b21/download
- [ONLINE] View publication in Scopus
Glutamatergic transmission and receptor expression in the synucleinopathy h-α-synL62 mouse model: Effects of hydromethylthionine
2022 - Published
Schwab, K., Chasapopoulou, Z., Frahm, S., Magbagbeolu, M., Cranston, A., Harrington, C. R., Wischik, C. M., Theuring, F., Riedel, G.
Cellular Signalling, vol. 97, 110386
Contributions to Journals: Articles
- [ONLINE] https://www.sciencedirect.com/science/article/pii/S0898656822001486
- [ONLINE] DOI: https://doi.org/10.1016/j.cellsig.2022.110386
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/ea4865a6-a9d9-45aa-9ac8-d93d5b4f39d9/download
Structural Identification of Individual Helical Amyloid Filaments by Integration of Cryo-Electron Microscopy-Derived Maps in Comparative Morphometric Atomic Force Microscopy Image Analysis
2022 - Published
Lutter, L., Al-Hilaly, Y. K., Serpell, C. J., Tuite, M. F., Wischik, C. M., Serpell, L. C., Xue, W. F.
Journal of Molecular Biology, vol. 434, no. 7, 167466
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.jmb.2022.167466
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/bf92d10c-6597-45ea-95e4-ac6e0c02758c/download
- [ONLINE] View publication in Scopus
HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine
2022 - Published
Santos, R. X., Melis, V., Goatman, E. A., Leith, M., Baddeley, T. C., Storey, J. M., Riedel, G., Wischik, C. M., Harrington, C. R.
Biomedicines, vol. 10, no. 4, 867
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/biomedicines10040867
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/161666d1-4323-45bc-9b3c-26c075dc2edd/download
- [ONLINE] View publication in Scopus
Crossed cerebellar diaschisis in Alzheimer's disease
2022 - Published
Tripathi, S. M., Murray, A. D., Wischik, C. M., Schelter, B.
Nuclear Medicine Communications, vol. 43, no. 4, pp. 423-427
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1097/MNM.0000000000001531
- [ONLINE] View publication in Scopus
Hydromethylthionine enhancement of central cholinergic signalling is blocked by rivastigmine and memantine
2022 - Published
Kondak, C., Riedel, G., Harrington, C. R., Wischik, C. M., Klein, J.
Journal of Neurochemistry, vol. 160, pp. 172-184
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1111/jnc.15553
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/fc77ddf0-6353-4dc8-9d8a-f5a80fccaf2f/download
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/f423b85f-86d6-463d-8ebd-4918b17aa99c/download
Degeneration of basal and limbic networks is a core feature of behavioural variant frontotemporal dementia
2021 - Published
Vuksanovic, V., Staff, R., Morson, S., Ahearn, T., Bracoud, L., Murray, A. D., Bentham, P., Kipps, C. M., Harrington, C., Wischik, C.
Brain Communications, vol. 3, no. 4, fcab241
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1093/braincomms/fcab241
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/197d4f7a-3474-4cfa-88b4-a062a62bb8d7/download
Long-term hydromethylthionine treatment is associated with delayed clinical onset and slowing of cerebral atrophy in a pre-symptomatic P301S MAPT mutation carrier
2021 - Published
Bentham, P., Staff, R. T., Schelter, B. O., Shiells, H., Harrington, C. R., Wischik, C. M.
Journal of Alzheimer's Disease, vol. 83, no. 3, pp. 1017-1023
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3233/JAD-210390
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/ef8b32b2-335b-468f-930e-a8e0751fbda2/download
- [ONLINE] View publication in Scopus
Proteomic analysis of hydromethylthionine in the line 66 model of frontotemporal dementia demonstrates actions on tau-dependent and tau-independent networks
2021 - Published
Schwab, K., Melis, V., Harrington, C. R., Wischik, C. M., Magbagbeolu, M., Theuring, F., Riedel, G.
Cells, vol. 10, no. 8, 2162
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/cells10082162
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/131e3534-c036-4040-a381-e552f642e322/download
- [ONLINE] View publication in Scopus
Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates
2021 - Published
Maina, M. B., Al-Hilaly, Y. K., Burra, G., Rickard, J. E., Harrington, C. R., Wischik, C. M., Serpell, L. C.
Cells, vol. 10, no. 3, 703
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/cells10030703
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/a40fa657-872d-40f9-907e-438d23fc9812/download
Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the Line 66 model of frontotemporal dementia
2020 - Published
Lemke, N., Melis, V., Lauer, D., Magbagbeolu, M., Neumann, B., Harrington, C. R., Riedel, G., Wischik, C. M., Theuring, F., Schwab, K.
Journal of Biological Chemistry, vol. 295, no. 52, pp. 18508-18523
Contributions to Journals: Articles
- [ONLINE] http://www.jbc.org/content/early/2020/10/30/jbc.RA120.014890.abstract
- [ONLINE] DOI: https://doi.org/10.1074/jbc.RA120.014890
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/1d3b8abd-011d-4410-8fc6-b164f3a5f092/download
- [ONLINE] View publication in Scopus
Adaptive neurological testing method
2020 - Published
Shiells, H. C., Morson, S., Schelter, B., Wischik, D. J., Wischik, C.
Patents: Patents
Current Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer’s Disease
2020 - Published
Arastoo, M., Lofthouse, R., Penny, L., Harrington, C. R., Porter, A., Wischik, C. M., Palliyil, S.
International Journal of Molecular Sciences, vol. 21, no. 22, pp. 1-19
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/ijms21228673
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/997e480f-f45a-476e-9038-4e42a8e187ac/download
- [ONLINE] View publication in Scopus
Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target.
2020 - Published
Oakley, S., Maina, M. B., Marshall, K. E., Al-Hilaly, Y. K., Harrington, C. R., Wischik, C. M., Serpell, L. C.
Frontiers in Neurology, vol. 11, 590754
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3389/fneur.2020.590754
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/e55ed5c9-07a3-4b04-acf1-8b62a320679c/download
- [ONLINE] View publication in Scopus
Paired helical filament forming region of tau (297-391) influences endogenous tau protein and accumulates in acidic compartments in human neuronal cells
2020 - Published
Pollack, S. J., Trigg, J., Khanom, T., Biasetti, L., Marshall, K. E., Al-Hilaly, Y. K., Rickard, J. E., Harrington, C. R., Wischik, C. M., Serpell, L. C.
Journal of Molecular Biology, vol. 432, no. 17, pp. 4891-4907
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.jmb.2020.05.027
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/1180919d-7bb9-4ef0-b615-bcead7669252/download
- [ONLINE] View publication in Scopus
Analysis of the Relationship Between Metalloprotease-9 and Tau Protein in Alzheimer's Disease
2020 - Published
Hernandes-Alejandro, M., Montaño, S., Harrington, C. R., Wischik, C. M., Salas-Casas, A., Cortes-Reynosa, P., Pérez Salazar, E., Cazares-Apatiga, J., Apatiga-Perez, R., Ontiveros Torres, M. ?., Perry, G., Pacheco-Herrero, M., Luna-Muñoz, J.
Journal of Alzheimer's Disease, vol. 76, no. 2, pp. 553-569
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3233/JAD-200146
- [ONLINE] View publication in Scopus
Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia
2020 - Published
Shiells, H., Schelter, B. O., Bentham, P., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Wischik, D. J., Riedel, G., Gauthier, S., Jia, J., Moebius, H. J., Hardlund, J., Kipps, C. M., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
Journal of Alzheimer's Disease, vol. 75, no. 2, pp. 501-519
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3233/JAD-191173
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/53b6ee0c-d5be-45c3-90a0-1afea8f620c4/download
- [ONLINE] View publication in Scopus
Mechanisms of anticholinesterase interference with tau aggregation inhibitor activity in a tau-transgenic mouse model
2020 - Published
Riedel, G., Klein, J., Niewiadomska, G., Kondak, C., Schwab, K., Lauer, D., Magbagbeolu, M., Steczkowska, M., Zadrozny, M., Wydrych, M., Cranston, A., Melis, V., Santos, R. X., Theuring, F., Harrington, C. R., Wischik, C. M.
Current Alzheimer Research, vol. 17, no. 3, pp. 285-296
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.2174/1567205017666200224120926
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/93bdbc3a-7cb1-4d17-a739-bf474576969a/download
- [ONLINE] View publication in Scopus
Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer’s Disease and Frontotemporal Lobar Degeneration
2020 - Published
Cranston, A. L., Wysocka, A., Steczkowska, M., Zadrozny, M., Palasz, E., Harrington, C. R., Theuring, F., Wischik, C., Riedel, G., Niewiadomska, G.
Brain Communications, vol. 2, no. 1, fcaa033
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1093/braincomms/fcaa033
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/e8bdcbaa-dd08-47da-af17-30697cf2e0ce/download
Tau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brain
2020 - Published
Al-Hilaly, Y. K., Foster, B. E., Biasetti, L., Lutter, L., Pollack, S. J., Rickard, J. E., Storey, J. M. D., Harrington, C. R., Xue, W., Wischik, C. M., Serpell, L. C.
FEBS LETTERS, vol. 594, no. 5, pp. 944-950
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1002/1873-3468.13675
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/a1e6143f-ac8d-4b86-9587-c72bbd87d69c/download
- [ONLINE] View publication in Scopus
Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease
2019 - Published
Schelter, B. O., Shiells, H., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Riedel, G., Gauthier, S., Jia, J., Bentham, P., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
Journal of Alzheimer's Disease, vol. 72, no. 3, pp. 931-946
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3233/JAD-190772
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/4bb2ba91-6ed8-4d4f-92e5-d6879822bf25/download
Phospho-Tau Protein Expression in the Cell Cycle of SH-SY5Y Neuroblastoma Cells: A Morphological Study
2019 - Published
Flores-Rodríguez, P., Harrington, C. R., Wischik, C. M., Ibarra-Bracamontes, V., Zarco, N., Navarrete, A., Martínez-Maldonado, A., Guadarrama-Ortíz, P., Villanueva-Fierro, I., Ontiveros-Torres, M. A., Perry, G., Alonso, A. D., Florán-Garduño, B., Segovia, J., Luna-Muñoz, J.
Journal of Alzheimer's Disease, vol. 71, no. 2, pp. 631-645
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3233/JAD-190155
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/9729b8a2-0e5b-43e3-84ac-9960eaa6a6fb/download
- [ONLINE] https://www.medra.org/servlet/aliasResolver?alias=iospress&doi=10.3233/JAD-190155
- [ONLINE] View publication in Mendeley
Cortical Thickness and Surface Area Networks in Healthy Aging, Alzheimer’s Disease and Behavioral Variant Fronto-Temporal Dementia
2019 - Published
Vuksanovic, V., Staff, R. T., Ahearn, T., Murray, A. D., Wischik, C. M.
International Journal of Neural Systems, vol. 29, no. 6, 1850055
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1142/S0129065718500557
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/8d52863b-34a5-4944-aa97-15d36af20879/download
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Increased Cholinergic Response in α-Synuclein Transgenic Mice (h-α-synL62)
2019 - Published
König, M., Berlin, B., Schwab, K., Frahm, S., Theuring, F., Wischik, C. M., Harrington, C. R., Riedel, G., Klein, J.
ACS Chemical Neuroscience, vol. 10, no. 4, pp. 1915-1922
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1021/acschemneuro.8b00274
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/3b748f24-8b93-40f4-846d-54a822947515/download
- [ONLINE] View publication in Mendeley

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Research Overview

Dityrosine Cross-links are Present in Alzheimer's Disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the Stability of the PHF-core Tau (297–391) In Vitro

Oral Tau Aggregation Inhibitor for Alzheimer’s Disease: Design, Progress and Basis for Selection of the 16 mg/day Dose in a Phase 3, Randomized, Placebo-Controlled Trial of Hydromethylthionine Mesylate

Glutamatergic transmission and receptor expression in the synucleinopathy h-α-synL62 mouse model: Effects of hydromethylthionine

Structural Identification of Individual Helical Amyloid Filaments by Integration of Cryo-Electron Microscopy-Derived Maps in Comparative Morphometric Atomic Force Microscopy Image Analysis

HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine

Crossed cerebellar diaschisis in Alzheimer's disease

Hydromethylthionine enhancement of central cholinergic signalling is blocked by rivastigmine and memantine

Degeneration of basal and limbic networks is a core feature of behavioural variant frontotemporal dementia

Long-term hydromethylthionine treatment is associated with delayed clinical onset and slowing of cerebral atrophy in a pre-symptomatic P301S MAPT mutation carrier

Proteomic analysis of hydromethylthionine in the line 66 model of frontotemporal dementia demonstrates actions on tau-dependent and tau-independent networks

Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates

Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the Line 66 model of frontotemporal dementia

Adaptive neurological testing method

Current Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer’s Disease

Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target.

Paired helical filament forming region of tau (297-391) influences endogenous tau protein and accumulates in acidic compartments in human neuronal cells

Analysis of the Relationship Between Metalloprotease-9 and Tau Protein in Alzheimer's Disease

Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

Mechanisms of anticholinesterase interference with tau aggregation inhibitor activity in a tau-transgenic mouse model

Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer’s Disease and Frontotemporal Lobar Degeneration

Tau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brain

Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

Phospho-Tau Protein Expression in the Cell Cycle of SH-SY5Y Neuroblastoma Cells: A Morphological Study

Cortical Thickness and Surface Area Networks in Healthy Aging, Alzheimer’s Disease and Behavioral Variant Fronto-Temporal Dementia

Increased Cholinergic Response in α-Synuclein Transgenic Mice (h-α-synL62)

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Chapters in Books, Reports and Conference Proceedings

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