Professor Nicola Mutch

Professor Nicola Mutch
Professor Nicola Mutch
Professor Nicola Mutch

BSc (Hons), Molecular and Cellular Biology; PhD, Thrombosis & Haemostasis

Personal Chair

Accepting PhDs

About
Email Address
n.j.mutch@abdn.ac.uk
Telephone Number
+44 (0)1224 437492
Office Address

Lab 1.33          01224 437417

Office 5.16      01224 437492

School of Medicine, Medical Sciences and Nutrition,

Institute of Medical Sciences

University of Aberdeen

Foresterhill

Aberdeen

AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

Education

University of Aberdeen, Department of Molecular and Cellular Biology and Department of Medince and Therapeutics. Aberdeen, UK.                                                                                                 PhD in Haemostasis & Vascular Biology (1997-2000). Supervisor Dr Nuala A Booth. Funded by ACTR.

University of Aberdeen, Aberdeen, UK.                                                                                     BSc (Hons) (1993-1997) in Molecular and Cellular Biology.

Employment

2016: Senior Lecturer, University of Aberdeen, School of Medicine, Medical Sciences and Nutrition.  Insitute of Medical Sciences, (IMS).

2011-2016: British Heart Foundation Fellow, Senior Research Fellow, School of Medicine and Dentistry, IMS.

2010-2011: Research Fellow funded by British Heart Foundation, School of Medicine and Dentistry, IMS.

2007-2010: Tenure-track Independent Research Fellow in Cardiovascular Medicine, Department of BIological Sciences, University of Leeds, Leeds, UK.

2004-2006: Postdoctoral research associate, University of Illinois at Urbana-Champaign, Department of Medicine, Champaign, Illinois, USA.

2001-2003: Postdoctoral research fellow, Department of Molecular and Cellular Biology, University of Aberdeen, UK.             

 

Qualifications

  • BSc hons Molecular Biology 
    1997 - University of Aberdeen 
  • PhD Thrombosis & Vascular Biology 
    2001 - University of Aberdeen 

Latest Publications

View My Publications

Research

Research Areas

Accepting PhDs

I am currently accepting PhDs in Biomedical Sciences.


Please get in touch if you would like to discuss your research ideas further.

Email Me

Biomedical Sciences

Supervising
Accepting PhDs

Research Specialisms

  • Biological Sciences
  • Human Biology
  • Cardiology
  • Cell Biology
  • Immunology

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Current Research

POST-DOC

Dr Claire Whyte

BHF funded post-doc (Dec 2015-May 2019).  Claire has been in the lab since January 2011 and is on her second BHF-funded project grant.  Claire is currently working on the role of platelet-derived plasmiongen in driving local fibrinolysis.  

CURRENT PhD STUDENTS

Mohammad Jalal: Start date 01/12/2012; Funded by the Saudi Arabian Government. 4 year PhD.

Paraskevi Untiveros: Start date 01/09/2014; Funded by the Chief Scientist Office. Clinical Fellow 3 year PhD.

Gael Morrow: Start date 12/01/2015; Funded by the British Society of Haemostasis and Thrombosis, British Society of Haematology and Lifeblood.  3 Year PhD.

Maria-Louise Williams: Start date 01/10/16; Funded by the Institute of Medical Sciences, University of Aberdeen. 3 year PhD.

LAB ALLUMNI

Mrs Ausra Lionikiene. Ausra was employed a research technician on my BHF-funded fellowship and studying the biological significance of factor XII.  Ausra was an integral member of the team organising the lab, finances and all the personnel.  

Funding and Grants

CURRENT GRANTS

1. British Heart Foundation Project Grant PI: NJ Mutch (Dec 2015-Dec 2018) 'Platelet plasminogen as a driver of local fibrinolysis'

2. British Society of Haematology / Lifeblood / British Society of Thrombosis & Haemostasis PhD Studentship PI: NJ Mutch; Co-I CS Whyte (Jan 2015-Jan 2018) 'The impact of thrombus composition on regulation of fibrinolysis under flow'

4. Friends of Anchor PI: Dr Paraskevi UntiverosCo-I Dr Nicola J Mutch, Dr Henry Watson (Aug 2016-Aug 2017) The role of ABO blood group in thrombosis

5. Chief Scientist Office, Scottish Government Fellow: P Untiveros; Supervisors: NJ Mutch, H Watson ''Influence of Anaemia on Clot Structure'

6. Friends of Anchor PI: NJ Mutch (Apr 2015-Nov 2016) 'A functional role of platelet FXIII-A in clot retraction'

RECENT GRANTS

1. British Heart Foundation Basic Science Fellowship Fellow: NJ Mutch (Mar 2011-Mar 2016 Includes two maternity leaves) 'Characterising the physiological role of factor XII and the contact system'

2. British Heart Foundation Project Grant PI: NJ Mutch; Co-I: RAS Ariëns (Jan 2012-Dec 2015) 'Changes in fibrin clot structure and susceptibility to lysis induced by polyphosphate'

3. Aberdeen Development Trust PhD Studentship PI: NJ Mutch (Oct 2012-Apr 2016) 'The antifibrinolytic function of factor XIII'

4. Chest, Heart and Stroke Scotland PI Isobel Ford Co-I NJ Mutch, MJ McLeod. () Responsiveness to thrombolytic therapy of for Ischaemic stroke

5. British Heart Foundation Project Grant (PG/07/122/23480). PI: NJ Mutch (Jun 2008-Oct 2012) 'Polyphosphate as a physiological surface for contact activation
'

Teaching

Teaching Responsibilities

Course coordinator for BM5003 Cardiovascular Health and Disease

Publications

Page 7 of 8 Results 61 to 70 of 78

  • Impact of fibrin structure on fibrinolysis by different plasminogen activators: studies using fluorescent confocal microscopy

    Whyte, C. S., Mutch, N. J.
    Journal of Thrombosis and Haemostasis, vol. 10, no. 6, pp. E24
    Contributions to Journals: Reviews of Books, Films and Articles
  • Platelet factor XIII stabilises thrombi against premature fibrin degradation

    Mutch, N. J., Fraser, S. R., Booth, N. A.
    Journal of Thrombosis and Haemostasis, vol. 10, no. 6, pp. E15
    Contributions to Journals: Reviews of Books, Films and Articles
  • Polyphosphate scores a hat trick in regulating host defense mechanisms

    Mutch, N. J.
    Journal of Thrombosis and Haemostasis, vol. 10, no. 6, pp. 1142-1144
    Contributions to Journals: Editorials
  • Polyphosphate stabilises factor XIIa and acts as a cofactor in factor XIIa-mediated plasminogen activation

    Brain, C., Mutch, N. J.
    Journal of Thrombosis and Haemostasis, vol. 10, no. 6, pp. E13
    Contributions to Journals: Reviews of Books, Films and Articles
  • The antifibrinolytic function of factor XIII is exclusively expressed through a2-antiplasmin cross-linking. Blood. 2011;117(23):6371-6374.

    Fraser, S. R., Booth, N. A., Mutch, N. J.
    Blood, vol. 118, no. 26, pp. 6993
    Contributions to Journals: Articles
  • Factor XIIa regulates the structure of the fibrin clot independently of thrombin generation through direct interaction with fibrin

    Konings, J., Govers-Riemslag, J. W. P., Philippou, H., Mutch, N. J., Borissoff, J. I., Allan, P., Mohan, S., Tans, G., Ten Cate, H., Ariëns, R. A. S.
    Blood, vol. 118, no. 14, pp. 3942-3951
    Contributions to Journals: Articles
  • Emerging roles for factor XII in vivo

    Mutch, N. J.
    Journal of Thrombosis and Haemostasis, vol. 9, no. 7, pp. 1355-1358
    Contributions to Journals: Editorials
  • The antifibrinolytic function of factor XIII is exclusively expressed through α2-antiplasmin cross-linking

    Fraser, S. R., Booth, N. A., Mutch, N. J.
    Blood, vol. 117, no. 23, pp. 6371-6374
    Contributions to Journals: Articles
  • Platelet polyphosphate is a proinflammatory and procoagulant mediator in vivo

    Mueller, F., Mutch, N. J., Schenk, W. A., Smith, S. A., Esterl, L., Spronk, H. M., Schmidbauer, S., Gahl, W. A., Morrissey, J. H., Renne, T.
    Arteriosclerosis Thrombosis and Vascular Biology, vol. 30, no. 11, pp. E192
    Contributions to Journals: Abstracts
  • Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis

    Mutch, N. J., Koikkalainen, J. S., Fraser, S. R., Duthie, K. M., Griffin, M., Mitchell, J., Watson, H. G., Booth, N. A.
    Journal of Thrombosis and Haemostasis, vol. 8, no. 9, pp. 2017-2024
    Contributions to Journals: Articles
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