BSc (Hons), Molecular and Cellular Biology; PhD, Thrombosis & Haemostasis
Personal Chair
- About
-
- Email Address
- n.j.mutch@abdn.ac.uk
- Telephone Number
- +44 (0)1224 437492
- Office Address
Lab 1.33 01224 437417
Office 5.16 01224 437492
School of Medicine, Medical Sciences and Nutrition,
Institute of Medical Sciences
University of Aberdeen
Foresterhill
Aberdeen
AB25 2ZD
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Education
2001 PhD, Thrombosis & Vascular Biology; University of Aberdeen
1997 BSc (Hons) Molecular Biology; University of Aberdeen
Employment
2022- Cardiometabolic Disease Theme Lead, University of Aberdeen
2021- Personal Chair, University of Aberdeen
2017-2021 Reader, University of Aberdeen
2016- 2017 Senior Lecturer, University of Aberdeen
2011– 2016 British Heart Foundation Fellow, Senior Research Fellow, University of Aberdeen
2010-2011 British Heart Foundation Fellow, Lecturer, University of Aberdeen
2007-2010 Independent Research Fellow in cardiovascular medicine, University of Leeds, UK
2004-2006 Postdoctoral research associate, University of Illinois at Urbana-Champaign, USA
Qualifications
- BSc hons Molecular Biology1997 - University of Aberdeen
- PhD Thrombosis & Vascular Biology2001 - University of Aberdeen
External Memberships
2024-2030: Council Member of the International Society for Thrombosis and Haemostasis (ISTH)
2024-2026: Vice-Chair of the Education Committee of the ISTH
2024-2028: European Haematology Association (EHA) Fellowships & Grants Committee
2021-2024: Past President of the British Society of Haemostasis and Thrombosis (BSHT)
2022-2024: Basic Science Chair of the Annual Congress Planning Committee of the ISTH
2023 onwards: Steering Committee of UK Thrombosis Research Network
2024: Faculty Member of the CAS-AM course on anticoagulation management
Latest Publications
Endothelial cell source dictates the expression and release of fibrinolytic markers in a proinflammatory environment
Research and Practice in Thrombosis and Haemostasis, vol. 9, no. 5, 102929Contributions to Journals: ArticlesAcute obstetric coagulopathy is associated with excess plasmin generation and proteolysis of fibrinogen and factor V
Blood Advances, vol. 9, no. 11, pp. 2751-2762Contributions to Journals: ArticlesActivated platelets retain and protect most of their factor XIII-A cargo from proteolytic activation and degradation
Blood Advances, vol. 8, no. 19, pp. 5072–5085.Contributions to Journals: ArticlesStandardization of definition and management for bleeding disorder of unknown cause: communication from the SSC of the ISTH
Journal of Thrombosis and Haemostasis, vol. 22, no. 7, pp. 2059-2070Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jtha.2024.03.005
- [ONLINE] View publication in Scopus
A novel method to quantify fibrin–fibrin and fibrin–α2-antiplasmin cross-links in thrombi formed from human trauma patient plasma
Journal of Thrombosis and Haemostasis, vol. 22, no. 6, pp. 1758-1771Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jtha.2024.03.001
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/5cb7441a-bc85-4e41-8f20-2688b11f3c70/download
- [ONLINE] View publication in Scopus
Prizes and Awards
2024: ISTH Esteemed Career Award
2012: Desiree Collen Young Investigator Award, International Society of Fibrinolysis & Proteolysis
- Research
-
Research Areas
Accepting PhDs
I am currently accepting PhDs in Biomedical Sciences.
Please get in touch if you would like to discuss your research ideas further.
Research Specialisms
- Biological Sciences
- Human Biology
- Cardiology
- Cell Biology
- Immunology
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
Current Research
POST-DOC
Dr Claire Whyte
BHF funded post-doc (Dec 2015-May 2019). Claire has been in the lab since January 2011 and is on her second BHF-funded project grant. Claire is currently working on the role of platelet-derived plasmiongen in driving local fibrinolysis.
CURRENT PhD STUDENTS
Mohammad Jalal: Start date 01/12/2012; Funded by the Saudi Arabian Government. 4 year PhD.
Paraskevi Untiveros: Start date 01/09/2014; Funded by the Chief Scientist Office. Clinical Fellow 3 year PhD.
Gael Morrow: Start date 12/01/2015; Funded by the British Society of Haemostasis and Thrombosis, British Society of Haematology and Lifeblood. 3 Year PhD.
Maria-Louise Williams: Start date 01/10/16; Funded by the Institute of Medical Sciences, University of Aberdeen. 3 year PhD.
LAB ALLUMNI
Mrs Ausra Lionikiene. Ausra was employed a research technician on my BHF-funded fellowship and studying the biological significance of factor XII. Ausra was an integral member of the team organising the lab, finances and all the personnel.
Funding and Grants
CURRENT GRANTS
1. British Heart Foundation Project Grant PI: NJ Mutch (Dec 2015-Dec 2018) 'Platelet plasminogen as a driver of local fibrinolysis'
2. British Society of Haematology / Lifeblood / British Society of Thrombosis & Haemostasis PhD Studentship PI: NJ Mutch; Co-I CS Whyte (Jan 2015-Jan 2018) 'The impact of thrombus composition on regulation of fibrinolysis under flow'
4. Friends of Anchor PI: Dr Paraskevi Untiveros, Co-I Dr Nicola J Mutch, Dr Henry Watson (Aug 2016-Aug 2017) The role of ABO blood group in thrombosis
5. Chief Scientist Office, Scottish Government Fellow: P Untiveros; Supervisors: NJ Mutch, H Watson ''Influence of Anaemia on Clot Structure'
6. Friends of Anchor PI: NJ Mutch (Apr 2015-Nov 2016) 'A functional role of platelet FXIII-A in clot retraction'
RECENT GRANTS
1. British Heart Foundation Basic Science Fellowship Fellow: NJ Mutch (Mar 2011-Mar 2016 Includes two maternity leaves) 'Characterising the physiological role of factor XII and the contact system'
2. British Heart Foundation Project Grant PI: NJ Mutch; Co-I: RAS Ariëns (Jan 2012-Dec 2015) 'Changes in fibrin clot structure and susceptibility to lysis induced by polyphosphate'
3. Aberdeen Development Trust PhD Studentship PI: NJ Mutch (Oct 2012-Apr 2016) 'The antifibrinolytic function of factor XIII'
4. Chest, Heart and Stroke Scotland PI Isobel Ford Co-I NJ Mutch, MJ McLeod. () Responsiveness to thrombolytic therapy of for Ischaemic stroke
5. British Heart Foundation Project Grant (PG/07/122/23480). PI: NJ Mutch (Jun 2008-Oct 2012) 'Polyphosphate as a physiological surface for contact activation
' - Teaching
-
Courses
- MT5524/MT5024 - Molecular Pharmacology
- BDS - Cardiovascular System
- BDS - Endocrinology
Teaching Responsibilities
Course coordinator for BM5003 Cardiovascular Health and Disease
- Publications
-
Page 9 of 9 Results 81 to 85 of 85
Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo
Cell, vol. 139, no. 6, pp. 1143-1156Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.cell.2009.11.001
TAFIa, PAI-1 and α2-antiplasmin: complementary roles in regulating lysis of thrombi and plasma clots
Journal of Thrombosis and Haemostasis, vol. 5, no. 4, pp. 812-817Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/J.1538-7836.2007.02430.X
Polyphosphate modulates blood coagulation and fibrinolysis
PNAS, vol. 103, no. 4, pp. 903-908Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1073/pnas.0507195103
Thrombus lysis by uPA, scuPA and tPA is regulated by plasma TAFI
Journal of Thrombosis and Haemostasis, vol. 1, no. 9, pp. 2000-2007Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1046/J.1538-7836.2003.00383.X
Localization and identification of thrombin and plasminogen activator activities in model human thrombi by in situ zymography
Thrombosis and Haemostasis, vol. 88, no. 6, pp. 996-1003Contributions to Journals: Articles
