Dr Hai Deng
08/2018 - Reader, University of Aberdeen, UK
08/2014- 07/2018 Senior Lecturer, University of Aberdeen, UK
10/2008-07/2014 Lecturer, University of Aberdeen, UK
06/2002-09/2008 Postdoctoral fellow, University of St Andrews, UK
1999-2002 Ph.D. University of Wales Swansea, UK
Memberships and Affiliations
- Internal Memberships
CM2514 course coordinator
- External Memberships
External reviewer for a series of peer-reviewed journals within my area of interest, including Chem. Sci., Chem Comm., ACS Chem. Biol., ChemBioChem, Marine Biotechnology, Org & Biomol. Chem, FEMS Microbiology Ecology, Chemistry today, Marine Drugs, Fish and Shellfish Immunology, and Virulence.
A reviewer of research councils, BBSRC (UK) and FCT (Fundação para a Ciência e a Tecnologia in the field of Chemistry and Biochemistry, 2010-2011), Fonds de recherche du Québec - Nature et technologies, Québec, Canada (2015-2016) and charities, Leverhulme Trust (UK).
The projects in my group mainly lie on the interface of chemistry and biology. I have expertise in bioinformatics/biochemistry/genetics/organic chemistry. As such I am interested in identifying novel enzymes in secondary metabolism and exploring novel enzymatic mechanisms (J. Biol. Chem. 2013; ChemBioChem 2014; Chem. Sci. 2015; Chem. Biol. 2015; Angew Chemie Int. Ed. 2015, Org. Biomol. Chem. 2016 and 2017), tracing biosynthesis pathways using bioinformatics and genetic manipulations (Org. Biomol. Chem. 2014; Chem. Biol. 2015; Angew Chemie Int. Ed. 2015), characterizing novel natural product scaffold (Tetrahedron, 2013 and Org. Biomol. Chem., 2015, 2016 and 2017). These interests inevitably take us towards designing novel substrates for enzymes (industrial biotechnology/ biotransformation/synthetic biology), inhibiting enzymes (medicinal chemistry), applying these biocatalysts to industrial biotechnology and synthetic biology. The expertise established in my laboratory is:
- Using chemical tools for enzymology studies;
- Synthetic biology enabling industrial biological application;
- Chemical synthesis of small molecules;
- Biotransformation of novel enzymes for lead compound discovery.
- Genome mining of biosynthetic genes from microbial genomes for natural product discovery;
- Genetic manipulation of microbial biosynthetic genes;
- Microbiology, especially cultivation and fermentation of marine-derived and terrestrial actinobacteria for analysis of secondary metabolite profiles.
- Molecular taxonomy of new actinobacteria.
Biological and Environmental Sciences
Funding and Grants
We gratefully thank the funding bodies below for financial supports of our research
MRC, BBSRC, Leverhulm Trust, EU FP7, Tenuvas.
CM4518 Biological origin of natural products
CM1020 Chemistry for Biosciences 1
CM1512 Chemistry for Biosciences 2
CM3534 Organic and Biological Chemistry
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A ribosomally synthesised and post-translationally modified peptide containing a β-enamino acid and a macrocyclic motifNature Communications, vol. 13, no. 1, 5044Contributions to Journals: Articles
A Second Near-Infrared Ru(II) Polypyridyl Complex for Synergistic Chemo-Photothermal TherapyJournal of Medicinal Chemistry, vol. 65, no. 3, pp. 2225-2237Contributions to Journals: Articles
Organic NIR-II dyes with ultralong circulation persistence for image-guided delivery and therapyJournal of Controlled Release, vol. 342, pp. 157-169Contributions to Journals: Articles
Aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetaseNature Communications, vol. 13, no. 1, 62Contributions to Journals: Articles
Characterization of a class II ketol-acid reductoisomerase from Mycobacterium tuberculosisRSC Advances, vol. 12, no. 17, pp. 10540-10544Contributions to Journals: Articles
The chemical profile of activated secondary metabolites by overexpressing LaeA in Aspergillus nigerMicrobiological Research, vol. 248, 126735Contributions to Journals: Articles
Peculiarities of promiscuous l-threonine transaldolases for enantioselective synthesis of β-hydroxy-α-amino acidsApplied Microbiology and Biotechnology, vol. 105, pp. 3507–3520Contributions to Journals: Articles
Bacterial Pathogens: Threat or Treat? (a review on bioactive natural products from bacterial pathogens)Natural Product Reports, vol. 38, no. 4, pp. 782-821Contributions to Journals: Review articles
Genomic scanning enabling discovery of a new antibacterial bicyclic carbamate-containing alkaloidSynthetic and Systems Biotechnology, vol. 6, no. 1, pp. 12-19Contributions to Journals: Articles
Discovery and biosynthetic investigation of a new antibacterial dehydrated non‐ribosomal tripeptideAngewandte Chemie International Edition, vol. 60, no. 6, pp. 3229-3237Contributions to Journals: Articles