Advanced Research Fellow
- About
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- Email Address
- fiona.campbell@abdn.ac.uk
- Telephone Number
- +44 (0)1224 438617
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I am a principal investigator based at the Rowett Institute and coordinator of the PGT Human Nutrition MSc programme. My research focuses on advanced glycation end-products (AGEs) in the diet. During food processing AGEs are formed as the result of the Maillard reaction and are absorbed by the body during digestion. To investigate how dietary AGEs, contribute to diet induced conditions such as type 2 diabetes and dementia we are using human intervention studies to test the effects of highly processed foods high in AGEs on sensitive measures of metabolic health and cognition. I am also researching the role of processing methods in improving food quality and the potential for phytochemicals incorporated into processed foods to ameliorate negative health outcomes.
External Memberships
Member of the Nutrition Society,
Member of Biochemical Society,
Member of British Society for Proteome Resarch (BSPR).
Latest Publications
Selenium Supplementation in Pregnancy-Maternal and Newborn Outcomes
Journal of Nutrition and Metabolism, vol. 2022, 4715965Contributions to Journals: ArticlesThe Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction
Molecular Nutrition & Food Research, vol. 65, no. 1, 1900934Contributions to Journals: Review articlesAnthocyanin-enriched bilberry extract attenuates glycaemic response in overweight volunteers without changes in insulin
Journal of Functional Foods, vol. 64, 103597Contributions to Journals: ArticlesCinnamon Shows Antidiabetic Properties that Are Species-Specific: Effects on Enzyme Activity Inhibition and Starch Digestion
Plant Foods for Human Nutrition, vol. 74, no. 4, pp. 544-552Contributions to Journals: ArticlesEarly and reversible changes to the hippocampal proteome in mice on a high-fat diet
Nutrition and Metabolism, vol. 16, no. 1, 57Contributions to Journals: Articles- [ONLINE] https://rdcu.be/bPqy4
- [ONLINE] DOI: https://doi.org/10.1186/s12986-019-0387-y
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12782/1/McLean2019_Article_EarlyAndReversibleChangesToThe_VoR.pdf
- [ONLINE] http://www.ncbi.nlm.nih.gov/pubmed/31462902 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC6708244
- [ONLINE] View publication in Mendeley
- Research
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Research Overview
A high-fat/sugar diet leads to the formation of Advanced Glycation End products (AGEs) in body tissues. AGEs cause damage and inflammation and are also absorbed from the diet particularly from processed foods. We are interested in how dietary AGEs contribute to diet induced conditions such as type 2 diabetes and cognitive decline.
Current Research
Current research in my laboratory is focused on investigating damaged proteins/advanced glycation end-products (AGEs) in the diet.
During food processing AGEs are formed as the result of the Maillard reaction and are absorbed by the body in the course of digestion. AGEs are associated with the metabolic syndrome and dementia. We aim to identify foods high in AGEs and test the effects of these foods on sensitive measures of metabolic health and cognition in human intervention studies.
In addition we are investigating the role of processing methods in improving food quality e.g. avoiding prolonged heat treatment of dairy products known to increase AGE formation. We are also determining the potential of phytochemicals incorporated into processed foods to ameliorate these negative metabolic outcomes.
This research could lead to the development of new functional foods and improvements to existing food products. It will also provide health professionals and the public with better information on how changes in diet can be beneficial.
This research is part of Scottish Government Strategic Research Programme funded through the Rural and Environment Science and Analytical Services (RESAS) division to advance the evidence base in the development of rural affairs, food and environment policies.
- Teaching
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Teaching Responsibilities
Programme coordinator for MSc Human Nutrition
Course Coordinator for RN5001 Fundamentals of human nutrition and metabolism and RN5003 Foundations of Nutrition.
- Publications
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Rapid and widely disseminated acute phase protein response after experimental bacterial infection of pigs
Veterinary Research, vol. 40, no. 3, 23Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1051/vetres/2009006
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/745/1/v09006%255B1%255D.pdf
SERRS immunoassay for quantitative human CRP analysis
Analyst, vol. 133, no. 10, pp. 1355-1357Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1039/b808087a
The association between plasma levels of acute phase proteins, haptoglobin, alpha-1 acid glycoprotein (AGP), Pig-MAP, transthyretin and serum amyloid A (SAA) in Large White and Meishan pigs
Veterinary Immunology and Immunopathology, vol. 119, no. 3-4, pp. 303-309Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.vetimm.2007.05.008
Effects of sub-clinical post-weaning colibacillosis and dietary protein on acute phase proteins in weaner pigs
Livestock Science , vol. 108, no. 1-3, pp. 182-185Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.livsci.2007.01.048
A time-resolved immunofluorometric assay for porcine C-reactive protein quantification in whole blood
Luminescence, vol. 22, no. 3, pp. 171-176Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/bio.945
Characterisation of the pig acute phase protein response to road transport
Veterinary Journal, vol. 173, no. 3, pp. 669-674Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.tvjl.2006.02.006
Pig acute-phase protein levels after stress induced by changes in the pattern of food administration
Animal , vol. 1, no. 1, pp. 133-139Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1017/S1751731107283909
The porcine acute phase protein response to acute clinical and subclinical experimental infection with Streptococcus suis
Veterinary Immunology and Immunopathology, vol. 113, no. 1-2, pp. 157-168Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.vetimm.2006.04.008
The welfare of finishing pigs in two contrasting housing systems: Fully-slatted versus straw-bedded accommodation
Livestock Production Science, vol. 103, no. 1-2, pp. 104-115Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.livsci.2006.01.008
The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig
Veterinary Research, vol. 36, no. 4, pp. 657-664Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1051/vetres:2005017
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/746/1/v4069.pdf
Relative importance of malonyl CoA and carnitine in maturation of fatty acid oxidation in newborn rabbit heart
American Journal of Physiology, Heart and Circulatory Physiology, vol. 284, no. 1, pp. H283-H289Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1152/ajpheart.00461.2002
45. Acute phase proteins: Biomarkers for use in animal health & welfare and in food quality & safety
Research in Veterinary Science, vol. 74, no. Supplement 1Contributions to Journals: AbstractsMonitoring the innate immune response with acute phase protein
SPVS Bulletin, pp. 39-41Contributions to Journals: Literature ReviewsArachidonic acid stimulates internalisation of leptin by human placental choriocarcinoma (BeWo) cells
Biochemical and Biophysical Research Communications, vol. 299, no. 3, pp. 432-437Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0006-291X(02)02647-5
A role for peroxisome proliferator-activated receptor alpha (PPAR alpha) in the control of cardiac malonyl-CoA levels: REDUCED FATTY ACID OXIDATION RATES AND INCREASED GLUCOSE OXIDATION RATES IN THE HEARTS OF MICE LACKING PPARa ARE ASSOCIATED WITH HIGHER CONCENTRATIONS OF MALONYL-CoA AND REDUCED EXPRESSION OF MALONYL-CoA DECARBOXYLASEREDUCED FATTY ACID OXIDATION RATES AND INCREASED GLUCOSE OXIDATION RATES IN THE HEARTS OF MICE LACKING PPARa ARE ASSOCIATED WITH HIGHER CONCENTRATIONS OF MALONYL-CoA AND REDUCED EXPRESSION OF MALONYL-CoA DECARBOXYLASE
The Journal of Biological Chemistry, vol. 277, no. 6, pp. 4098-4103Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1074/jbc.M106054200
Low fatty acid oxidation rates in isolated working hearts from PPAR alpha null mice does not impair functional recovery following ischemia
Diabetes, vol. 50, no. Suppl. 2, pp. A308-A309Contributions to Journals: ArticlesPPAR alpha regulates cardiac energy metabolism by controlling malonyl CoA concentrations in the heart
Journal of Molecular and Cellular Cardiology, vol. 33, no. 6, pp. A164Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0022-2828(01)90627-3
Preferential distribution of long chain polyunsaturated fatty acids in phospatidyl ethanolamine fraction of Guinea pig alveolar apical membranes
Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 62, no. 6, pp. 341-348Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1054/plef.2000.0164
Immunological manipulation of lactation
Chapters in Books, Reports and Conference Proceedings: Conference ProceedingsDifferential distribution and metabolism of arachidonic acid and docosahexaenoic acid by human placental choriocarcinoma (BeWo) cells
Molecular & Cellular Biochemistry, vol. 185, no. 1-2, pp. 191-198Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1023/A:1006852230337
Detection and cellular localization of plasma membrane-associated and cytoplasmic fatty acid-binding proteins in human placenta
Placenta, vol. 19, no. 5-6, pp. 409-415Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0143-4004(98)90081-9
Interaction of free fatty acids with human leptin
Biochemical and Biophysical Research Communications, vol. 247, no. 3, pp. 654-658Contributions to Journals: ArticlesPlacental membrane fatty acid-binding protein preferentially binds arachidonic and docosahexaenoic acids
Life Sciences, vol. 63, no. 4, pp. 235-240Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0024-3205(98)00267-7
Preferential uptake of long-chain polyunsaturated fatty acids by human placental cells
Chapters in Books, Reports and Conference Proceedings: Conference ProceedingsUptake of long chain fatty acids by human placental choriocarcinoma (BeWo) cells
Journal of Lipid Research, vol. 38, no. 12, pp. 2558-2568Contributions to Journals: Articles