Honorary Senior Lecturer
- About
-
- Email Address
- felix.grassmann@abdn.ac.uk
- Office Address
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I received my PhD in the field of human genetics from the University of Regensburg, Germany. I spent several years as a postdoctoral researcher at the Karolinska Institute in Stockholm, Sweden and was appointed as Senior Lecturer of Bioinformatics and Biostatistics at the Institute of Medical Sciences. Currently, I am a Professor of Epidemiology and the Health and Medical University in Potsdam, Germany as well as a Honorary Senior Lecturer at the IMS in Aberdeen.
Prizes and Awards
2018 Leopoldina Postdoc Fellowship
2016 Travel Grant “RD Meeting Travel Grant” 2016 (Kyoto, Japan)
2016 Pro Retina “Makula-Forschungspreis” (Excellence in Visual Science Award)
2015 Distinguished PhD-Thesis Award (University of Regensburg)
2015 Travel Grant “ARVO Travel Grant“ 2015 (Denver, Colorado, USA)
2012 ProRetina Travel Award (RD Meeting 2012)
2009 Alumni Award University of Regensburg
2009 ProRetina Poster Award
- Research
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Research Overview
The main focus of my research is to understand the inherited and acquired genetics in complex diseases. To this end, I am working with public datasets as well as consortia to generate the largest datasets for each disease of interest. I am particularly interested in diseases with a significant individual and societal burden in aging populations such as age-related macular degeneration, breast cancer and cardiometabolic diseases. My group uses the full spectrum of high-throughput omics tools available to understand the underlying biology behind those diseases with the potential to uncover novel ways to treat of prevent them.
Research Areas
Research Specialisms
- Bioinformatics
- Biomedical Sciences
- Epidemiology
- Human Genetics
- Statistics
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
- Publications
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Page 1 of 1 Results 1 to 60 of 60
Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation
Cell MetabolismContributions to Journals: ArticlesAn ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans
Molecular PsychiatryContributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/s41380-023-02359-7
A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry
Breast Cancer Research, vol. 25, no. 1, pp. 93Contributions to Journals: ArticlesLow leukocyte mitochondrial DNA abundance drives atherosclerotic cardiovascular diseases: a cohort and Mendelian randomization study
Cardiovascular Research, vol. 119, no. 4, pp. 998-1007Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/cvr/cvac182
The association between mitochondrial DNA abundance and stroke: A combination of multivariable-adjusted survival and Mendelian randomization analyses
Atherosclerosis, vol. 354, pp. 1-7Contributions to Journals: ArticlesSeed sequence polymorphism rs2168518 and allele-specific target gene regulation of hsa-miR-4513
Human Molecular Genetics, vol. 31, no. 6, pp. 875-887Contributions to Journals: ArticlesCYP2D6 genotype predicts tamoxifen discontinuation and drug response: a secondary analysis of the KARISMA trial
Annals of Oncology, vol. 32, no. 10, pp. 1286-1293Contributions to Journals: ArticlesLymph node metastases in breast cancer: investigating associations with tumor characteristics, molecular subtypes, and polygenic risk score using a continuous growth model
International Journal of Cancer, vol. 149, no. 6, pp. 1348-1357Contributions to Journals: ArticlesMammographic features are associated with cardiometabolic disease risk and mortality
European Heart Journal, vol. 42, no. 34, pp. 3361–3370Contributions to Journals: ArticlesDeciphering the genetic and epidemiological landscape of mitochondrial DNA abundance
Human Genetics, vol. 140, pp. 849-861Contributions to Journals: ArticlesAssociation between breast cancer risk and disease aggressiveness: Characterizing underlying gene expression patterns
International Journal of Cancer, vol. 148, no. 4, pp. 884-894Contributions to Journals: ArticlesPleiotropic Locus 15q24.1 Reveals a Gender-Specific Association with Neovascular but Not Atrophic Age-Related Macular Degeneration (AMD)
Cells, vol. 9, no. 10, 2257Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/cells9102257
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/15353/1/Kiel_PlleiotropicLens_VOR.pdf
- [ONLINE] View publication in Scopus
The association of single nucleotide polymorphisms (SNPs) with breast density and breast cancer survival: the Malmö Diet and Cancer Study
Acta radiologica (Stockholm, Sweden : 1987), vol. 61, no. 10, pp. 1326-1334Contributions to Journals: ArticlesA mega-analysis of expression quantitative trait loci in retinal tissue
PLoS Genetics, vol. 16, no. 9, pp. e1008934Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1371/journal.pgen.1008934
- [ONLINE] View publication in Scopus
Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease
BMC Medical Genomics, vol. 13, 120Contributions to Journals: ArticlesA Circulating MicroRNA Profile in a Laser-Induced Mouse Model of Choroidal Neovascularization
International Journal of Molecular Sciences, vol. 21, no. 8, 2689Contributions to Journals: ArticlesInsights into the loss of the Y chromosome with age in control individuals and in patients with age-related macular degeneration using genotyping microarray data
Human Genetics, vol. 139, pp. 401-407Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s00439-019-02029-1
- [ONLINE] View publication in Scopus
CYP2D6 Genotype Predicts Tamoxifen Discontinuation and Prognosis in Patients With Breast Cancer
Journal of Clinical Oncology, vol. 38, no. 6, pp. 548-557Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1200/JCO.19.01535
- [ONLINE] View publication in Scopus
Complement C3 Inhibitor Pegcetacoplan for Geographic Atrophy Secondary to Age-Related Macular Degeneration: A Randomized Phase 2 Trial
Ophthalmology, vol. 127, no. 2, pp. 186-195Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.ophtha.2019.07.011
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/14537/1/Liao_AAO_Complement_VOR.pdf
- [ONLINE] View publication in Scopus
A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration
Scientific Reports, vol. 10, 1584Contributions to Journals: ArticlesInterval breast cancer is associated with other types of tumors
Nature Communications, vol. 10, 4648Contributions to Journals: ArticlesCost-effective molecular inversion probe-based ABCA4 sequencing reveals deep-intronic variants in Stargardt disease
Human Mutation, vol. 40, no. 10, pp. 1749-1759Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/humu.23787
- [ONLINE] View publication in Scopus
Deep-intronic ABCA4 variants explain missing heritability in Stargardt disease and allow correction of splice defects by antisense oligonucleotides
Genetics in Medicine, vol. 21, no. 8, pp. 1751-1760Contributions to Journals: ArticlesThe agonistic TSPO ligand XBD173 attenuates the glial response thereby protecting inner retinal neurons in a murine model of retinal ischemia
Journal of Neuroinflammation, vol. 16, 43Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s12974-019-1424-5
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/14979/1/Mages_etal_JN_Agonistic_VOR.pdf
- [ONLINE] View publication in Scopus
Conduct and Quality Control of Differential Gene Expression Analysis Using High-Throughput Transcriptome Sequencing (RNASeq)
Methods in Molecular Biology. HUMANA PRESS INC, pp. 29-43, 15 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1007/978-1-4939-8669-9_2
- [ONLINE] View publication in Scopus
Y chromosome mosaicism is associated with age-related macular degeneration
European Journal of Human Genetics, vol. 27, pp. 36-41Contributions to Journals: ArticlesAssessment of Novel Genome-Wide Significant Gene Loci and Lesion Growth in Geographic Atrophy Secondary to Age-Related Macular Degeneration
JAMA Ophthalmology, vol. 137, no. 8, pp. 867-876Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1001/jamaophthalmol.2019.1318
- [ONLINE] View publication in Scopus
Spectral domain optical coherence tomography allows the unification of clinical decision making for the evaluation of choroidal neovascularization activity
Ophthalmologica, vol. 241, no. 1, pp. 32-37Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1159/000489344
- [ONLINE] View publication in Scopus
Evaluation of serum sphingolipids and the influence of genetic risk factors in age-related macular degeneration
PloS ONE, vol. 13, no. 8, e0200739Contributions to Journals: ArticlesRecurrent structural variation, clustered sites of selection, and disease risk for the complement factor H (CFH) gene family
Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 19, pp. E4433-E4442Contributions to Journals: ArticlesPleiotropic effects of risk factors in age-related macular degeneration and seemingly unrelated complex diseases
Retinal Degenerative Diseases. Ash, J. D., Anderson, R. E., LaVail, M. M., Rickman, C. B., Hollyfield, J. G. (eds.). Springer New York LLC, pp. 247-255, 9 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1007/978-3-319-75402-4_30
- [ONLINE] View publication in Scopus
A mega-analysis of expression quantitative trait loci (eQTL) provides insight into the regulatory architecture of gene expression variation in liver
Scientific Reports, vol. 8, 5865Contributions to Journals: ArticlesA Deep Learning Algorithm for Prediction of Age-Related Eye Disease Study Severity Scale for Age-Related Macular Degeneration from Color Fundus Photography
Ophthalmology, vol. 125, no. 9, pp. 1410-1420Contributions to Journals: ArticlesInvestigating the modulation of genetic effects on late AMD by age and sex: Lessons learned and two additional loci
PloS ONE, vol. 13, no. 3, e0194321Contributions to Journals: ArticlesGenetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits
Genome Medicine, vol. 9, 29Contributions to Journals: ArticlesRecombinant Haplotypes Narrow the ARMS2/HTRA1 Association Signal for Age-Related Macular Degeneration
Genetics, vol. 205, no. 2, pp. 919-924Contributions to Journals: ArticlesAge-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator
Journal of Neuroinflammation, vol. 14, 4Contributions to Journals: ArticlesMutation spectrum of the ABCA4 gene in 335 stargardt disease patients from a multicenter German cohort—impact of selected deep intronic variants and common SNPs
Investigative Ophthalmology and Visual Science, vol. 58, no. 1, pp. 394-403Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1167/iovs.16-19936
- [ONLINE] View publication in Scopus
An Eye on Age-Related Macular Degeneration: The Role of MicroRNAs in Disease Pathology
Molecular Diagnosis and Therapy, vol. 21, no. 1, pp. 31-43Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1007/s40291-016-0234-z
- [ONLINE] View publication in Scopus
Genetische Risiken und Therapieentwicklung bei Netzhautdegenerationen
Medizinische Genetik, vol. 29, no. 2, pp. 195-201Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1007/s11825-017-0134-6
- [ONLINE] View publication in Scopus
Features of age-related macular degeneration in the general adults and their dependency on age, sex, and smoking: Results from the German KORA study
PloS ONE, vol. 11, no. 11, e0167181Contributions to Journals: ArticlesDistinct genetic risk profile of the rapidly progressing diffuse-trickling subtype of geographic atrophy in age-related macular degeneration (AMD)
Investigative Ophthalmology and Visual Science, vol. 57, no. 6, pp. 2463-2471Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1167/iovs.15-18593
- [ONLINE] View publication in Scopus
Multiallelic copy number variation in the complement component 4A (C4A) gene is associated with late-stage age-related macular degeneration (AMD)
Journal of Neuroinflammation, vol. 13, 81Contributions to Journals: ArticlesA large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants
Nature Genetics, vol. 48, pp. 134-143Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/ng.3448
- [ONLINE] View publication in Scopus
Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-βsignaling
Human Molecular Genetics, vol. 24, no. 22, pp. 6361-6373Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/hmg/ddv346
- [ONLINE] View publication in Scopus
Genetisches Risiko bei der altersabhängigen Makuladegeneration
BioSpektrum, vol. 21, no. 7, pp. 703-705Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s12268-015-0633-4
- [ONLINE] View publication in Scopus
What Does Genetics Tell Us About Age-Related Macular Degeneration?
Annual review of vision science, vol. 1, pp. 73-96Contributions to Journals: ArticlesThe genetics of age-related macular degeneration (AMD) - Novel targets for designing treatment options?
European Journal of Pharmaceutics and Biopharmaceutics, vol. 95, no. Part B, pp. 194-202Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.ejpb.2015.04.039
- [ONLINE] View publication in Scopus
A Candidate Gene Association Study Identifies DAPL1 as a Female-Specific Susceptibility Locus for Age-Related Macular Degeneration (AMD)
NeuroMolecular Medicine, vol. 17, no. 2, pp. 111-120Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s12017-015-8342-1
- [ONLINE] View publication in Scopus
Clinical and genetic factors associated with progression of geographic atrophy lesions in age-related macular degeneration
PloS ONE, vol. 10, no. 5, e0126636Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1371/journal.pone.0126636
- [ONLINE] View publication in Scopus
Common synonymous variants in ABCA4 are protective for chloroquine induced maculopathy (toxic maculopathy) Neuro-ophthalmology
BMC Ophthalmology, vol. 15, 18Contributions to Journals: ArticlesRare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration
Human Molecular Genetics, vol. 23, no. 21, pp. 5827-5837Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/hmg/ddu276
- [ONLINE] View publication in Scopus
A circulating MicroRNA profile is associated with late- stage neovascular age-related macular degeneration
PloS ONE, vol. 9, no. 9, e0107461Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1371/journal.pone.0107461
- [ONLINE] View publication in Scopus
In-depth characterisation of retinal pigment epithelium (RPE) cells derived from human induced pluripotent stem cells (hiPSC)
NeuroMolecular Medicine, vol. 16, no. 3, pp. 551-564Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s12017-014-8308-8
- [ONLINE] View publication in Scopus
Bedeutung des komplementsystems für die altersabhängige makuladegeneration
Deutsches Arzteblatt International, vol. 111, no. 8, pp. 133-138Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3238/arztebl.2014.0133
- [ONLINE] View publication in Scopus
Genetic risk models in age-related macular degeneration
Advances in Experimental Medicine and Biology, vol. 801, pp. 291-300Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/978-1-4614-3209-8_37
- [ONLINE] View publication in Scopus
Identification of a rare coding variant in complement 3 associated with age-related macular degeneration
Nature Genetics, vol. 45, no. 11, pp. 1375-1379Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1038/ng.2758
- [ONLINE] View publication in Scopus
The retinitis pigmentosa 28 protein FAM161A is a novel ciliary protein involved in intermolecular protein interaction and microtubule association
Human Molecular Genetics, vol. 21, no. 21, pp. 4573-4586Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/hmg/dds268
- [ONLINE] View publication in Scopus
Modelling the genetic risk in age-related macular degeneration
PloS ONE, vol. 7, no. 5, e37979Contributions to Journals: ArticlesWie groß sind die kleinen genetischen Risiken?
Medizinische Genetik, vol. 23, no. 3, pp. 377-384Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s11825-011-0295-7
- [ONLINE] View publication in Scopus