- Email Address
- Telephone Number
- +44 (0)1224 437536
- Office Address
Berndt Müller PhD
Institute of Medical Sciences (Room 4:35)
University of Aberdeen Foresterhill
Aberdeen AB25 2ZD Scotland, UK
- School of Medicine, Medical Sciences and Nutrition
1978-1988: Berndt graduated with a Diploma in Natural Sciences (Biology) from the Swiss Federal Institute of Technology, Zurich. He then joined the group of Professor Theodor Koller at the Institute for Cell Biology at the Swiss Federal Institute of Technology for postgraduate studies. The degree of Dr. sc. nat. (PhD) was awarded for work on the DNA recombination protein RecA executed under the supervision of Professor Koller and Dr Andrzej Stasiak, and with Dr Elisabeth Di Capua.
1988-1993: Postdoctoral Researcher in the group of Dr Stephen West at the ICRF (now CRUK) Clare Hall Laboratories investigating DNA recombination enzymes.
1993-1999: Junior group leader in the Laboratory for Developmental Biology at the Institute for Cell Biology of Bern University led by Professor Daniel Schümperli, investigating the control of animal histone gene expression brought about by RNA 3' end formation.
since 1999: Senior Lecturer, Reader and Professor at the University of Aberdeen leading work on RNA processing. We have developed a strong research program that focuses on understanding the molecular machinery involved in mRNA 5' end formation by spliced leader trans-splicing. Visit The Aberdeen Worm Laboratory site for more information.
- Privatdozent Molecular Cell Biology1999 - University of Bern
- PhD Cell Biology1988 - Swiss Federal Institute of Technology, Zürich
- Diploma Natural Sciences1983 - Swiss Federal Institute of Technology, Zürich
Member of the Biochemical Society
Member of the Genetics Society
Member of the RNA Society
The lab has a long-standing interest in the control of gene expression at the level of mRNA. This started in 1993, when Berndt joined the University of Bern where he worked with Prof Daniel Schümperli.
Prior to that he did his PhD in the group of Prof Theo Koller at the Institute of Cell Biology of the ETH in Zürich, with Dr Andrzej Stasiak and Dr Elisabeth Di Capua, analysing the interaction of the recombination protein RecA protein with DNA. He then spent 5 years in the lab of Dr Stephen West at ICRF (now Cancer Research UK) studying the Biochemistry of Genetic Recombination.
Subsequently, at Bern University, he identified factors that turn histone pre-mRNAs into mRNA by a unique 3' end formation process. This work was continued at the University of Aberdeen and has led to insight into the molecular function of these factors.
At Aberdeen, he also linked the key translation factor eIF4E to autism, and explored how RNA stability is implicated in the aetiology of neurodevelopmental disorders.
More recently he has focused on understanding the molecular mechanism of spliced leader trans-splicing in gene expression in nematodes. Have a look at https://www.aberdeenwormlab.org/ for latest news.
I am currently accepting PhDs in Biomedical Sciences.
Please get in touch if you would like to discuss your research ideas further.
The current research focuses on understanding the mechanism of spliced leader trans-splicing in gene expression in nematodes. This is an unusual RNA splicing reaction, dependent on a set of specialised RNAs and proteins. The function of these molecules is being investigated using genome engineering, RNAseq, proteomics and high resolution microscopy combined with biochemistry and molecular biology.
For more information visit The Aberdeen Worm Lab.
Biochemistry Pogramme Coordinator
Course co-ordination of BC3503 (The Molecular Control of Cell Function) and BC4314 (Honours Biochemistry Option 2)
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DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replicationJournal of Cell Biology, vol. 179, no. 7, pp. 1385-1398Contributions to Journals: Articles
Histone gene expression and histone mRNA 3' end structure in Caenorhabditis elegansBMC Molecular Biology, vol. 8, 51Contributions to Journals: Articles
Are multiple checkpoint mediators involved in a checkpoint linking histone gene expression with DNA replication?Biochemical Society Transactions, vol. 35, no. 5, pp. 1369-1371Contributions to Journals: Letters
The stem-loop binding protein stimulates histone translation at an early step in the initiation pathwayRNA , vol. 11, no. 7, pp. 1030-1042Contributions to Journals: Articles
The human histone gene expression regulator HBP/SLBP is required for histone and DNA synthesis, cell cycle progression and cell proliferation in mitotic cellsJournal of Cell Science, vol. 117, no. 25, pp. 6043-6051Contributions to Journals: Articles
The Caenorhabditis elegans histone hairpin-binding protein is required for core histone gene expression and is essential for embryonic and postembryonic cell divisionJournal of Cell Science, vol. 115, no. 4, pp. 857-866Contributions to Journals: Articles
Structure of the histone mRNA hairpin required for cell cycle regulation of histone gene expressionRNA , vol. 8, no. 1, pp. 29-46Contributions to Journals: Articles
Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like proteinEMBO Journal, vol. 20, no. 19, pp. 5470-5479Contributions to Journals: Articles
Assembly of U7 small nuclear ribonucleoprotein particle and histone RNA 3 ' processing in Xenopus egg extractsThe Journal of Biological Chemistry, vol. 275, no. 32, pp. 24284-24293Contributions to Journals: Articles
Positive and negative mutant selection in the human histone hairpin-binding protein using the yeast three-hybrid systemNucleic Acids Research, vol. 28, no. 7, pp. 1594-1603Contributions to Journals: Articles