Professor Berndt Muller

Professor Berndt Muller
Professor Berndt Muller
Professor Berndt Muller

Personal Chair

Accepting PhDs

Email Address
Telephone Number
+44 (0)1224 437536
Office Address

Berndt Müller PhD

Institute of Medical Sciences (Room 4:35)

University of Aberdeen Foresterhill

Aberdeen AB25 2ZD Scotland, UK


School of Medicine, Medical Sciences and Nutrition


1978-1988:  Berndt graduated with a Diploma in Natural Sciences (Biology) from the Swiss Federal Institute of Technology, Zurich. He then joined the group of Professor Theodor Koller at the Institute for Cell Biology at the Swiss Federal Institute of Technology for postgraduate studies.  The degree of Dr. sc. nat. (PhD) was awarded for work on the DNA recombination protein RecA executed under the supervision of Professor Koller and Dr Andrzej Stasiak, and with Dr Elisabeth Di Capua.

1988-1993: Postdoctoral Researcher in the group of Dr Stephen West at the ICRF (now CRUK) Clare Hall Laboratories investigating DNA recombination enzymes. 

1993-1999: Junior group leader in the Laboratory for Developmental Biology at the Institute for Cell Biology of Bern University led by Professor Daniel Schümperli, investigating the control of animal histone gene expression brought about by RNA 3' end formation.  

since 1999:  Senior Lecturer, Reader and Professor at the University of Aberdeen leading work on RNA processing.  We have developed a strong research program that focuses on understanding the molecular machinery involved in mRNA 5' end formation by spliced leader trans-splicing.  Visit The Aberdeen Worm Laboratory site for more information.


  • Privatdozent Molecular Cell Biology 
    1999 - University of Bern 
  • PhD Cell Biology 
    1988 - Swiss Federal Institute of Technology, Zürich 
  • Diploma Natural Sciences 
    1983 - Swiss Federal Institute of Technology, Zürich 

External Memberships

Member of the Biochemical Society

Member of the Genetics Society

Member of the RNA Society


Research Overview

The lab has a long-standing interest in the control of gene expression at the level of mRNA.  This started in 1993, when Berndt joined the University of Bern where he worked with Prof Daniel Schümperli. 

Prior to that he did his PhD in the group of Prof Theo Koller at the Institute of Cell Biology of the ETH in Zürich, with Dr Andrzej Stasiak and Dr Elisabeth Di Capua, analysing the interaction of the recombination protein RecA protein with DNA.  He then spent 5 years in the lab of Dr Stephen West at ICRF (now Cancer Research UK) studying the Biochemistry of Genetic Recombination.

Subsequently, at Bern University, he identified factors that turn histone pre-mRNAs into mRNA by a unique 3' end formation process.  This work was continued at the University of Aberdeen and has led to insight into the molecular function of these factors.

At Aberdeen, he also linked the key translation factor eIF4E to autism, and explored how RNA stability is implicated in the aetiology of neurodevelopmental disorders.  

More recently he has focused on understanding the molecular mechanism of spliced leader trans-splicing in gene expression in nematodes. Have a look at for latest news.



Research Areas

Accepting PhDs

I am currently accepting PhDs in Biomedical Sciences.

Please get in touch if you would like to discuss your research ideas further.

Email Me

Biomedical Sciences

Accepting PhDs

Research Specialisms

  • Biochemistry
  • Molecular Biology
  • Cell Biology
  • Genetic Engineering

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Current Research

The current research focuses on understanding the mechanism of spliced leader trans-splicing in gene expression in nematodes. This is an unusual RNA splicing reaction, dependent on a set of specialised RNAs and proteins. The function of these molecules is being investigated  using genome engineering, RNAseq, proteomics and high resolution microscopy combined with biochemistry and molecular biology.

For more information visit The Aberdeen Worm Lab.



Teaching Responsibilities

Biochemistry Pogramme Coordinator

Course co-ordination of BC3503 (The Molecular Control of Cell Function) and BC4314 (Honours Biochemistry Option 2) 



Page 3 of 6 Results 21 to 30 of 53

  • Post-transcriptional control of animal histone gene expression: not so different after all...

    Nicholson, P., Muller, B. M.
    Molecular BioSystems, vol. 4, no. 7, pp. 721-725
    Contributions to Journals: Articles
  • Spliced leader trans-splicing in the nematode Trichinella spiralis uses highly polymorphic, noncanonical spliced leaders

    Pettitt, J., Muller, B. M., Stansfield, I., Connolly, B.
    RNA , vol. 14, no. 4, pp. 760-770
    Contributions to Journals: Articles
  • DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replication

    Muller, B. M., Blackburn, J., Feijoo, C., Zhao, X., Smythe, C.
    Journal of Cell Biology, vol. 179, no. 7, pp. 1385-1398
    Contributions to Journals: Articles
  • Histone gene expression and histone mRNA 3' end structure in Caenorhabditis elegans

    Keall, R., Whitelaw, S., Pettitt, J., Muller, B.
    BMC Molecular Biology, vol. 8, 51
    Contributions to Journals: Articles
  • Are multiple checkpoint mediators involved in a checkpoint linking histone gene expression with DNA replication?

    Muller, B., Blackburn, J., Feijoo, C., Zhao, X., Smythe, C.
    Biochemical Society Transactions, vol. 35, no. 5, pp. 1369-1371
    Contributions to Journals: Letters
  • The stem-loop binding protein stimulates histone translation at an early step in the initiation pathway

    Gorgoni, B., Andrews, S. C., Schaller, A., Schümperli, D., Gray, K., Muller, B. M.
    RNA , vol. 11, no. 7, pp. 1030-1042
    Contributions to Journals: Articles
  • The human histone gene expression regulator HBP/SLBP is required for histone and DNA synthesis, cell cycle progression and cell proliferation in mitotic cells

    Zhao, X., McKillop-Smith, S., Muller, B. M.
    Journal of Cell Science, vol. 117, no. 25, pp. 6043-6051
    Contributions to Journals: Articles
  • The Caenorhabditis elegans histone hairpin-binding protein is required for core histone gene expression and is essential for embryonic and postembryonic cell division

    Pettitt, J., Crombie, C., Schümperli, D., Muller, B. M.
    Journal of Cell Science, vol. 115, no. 4, pp. 857-866
    Contributions to Journals: Articles
  • Structure of the histone mRNA hairpin required for cell cycle regulation of histone gene expression

    Zanier, K., Crombie, C., Muller, B. M., Schümperli, D., Linge, J. P., Nilges, M., Sattler, M., Luyten, I.
    RNA , vol. 8, no. 1, pp. 29-46
    Contributions to Journals: Articles
  • Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein

    Pillai, R. S., Will, C. L., Lührmann, R., Schümperli, D., Muller, B. M.
    EMBO Journal, vol. 20, no. 19, pp. 5470-5479
    Contributions to Journals: Articles
Show 10 | 25 | 50 | 100 results per page


Chapters in Books, Reports and Conference Proceedings

Contributions to Journals