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Dr Andrew Angel

Dr Andrew Angel
Dr Andrew Angel
Dr Andrew Angel

Senior Lecturer

Accepting PhDs

About
Email Address
andrew.angel@abdn.ac.uk
Office Address
339 Meston Building
Old Aberdeen Campus
Meston Walk
AB24 3UE

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School/Department
School of Natural and Computing Sciences

Latest Publications

  • Spt4 facilitates the movement of RNA polymerase II through the +2 nucleosomal barrier

    Uzun, U., Brown, T., Fishcl, H., Angel, A., Mellor, J.
    Cell Reports, vol. 36, no. 13, pp. 4064-4075
    Contributions to Journals: Articles

  • FACT is recruited to the +1 nucleosome of transcribed genes and spreads in a Chd1-dependent manner

    Jeronimo, C., Angel, A., Nguyen, V. Q., Kim, J. M., Poitras, C., Lambert, E., Collin, P., Mellor, J., Wu, C., Robert, F.
    Molecular Cell, vol. 81, no. 17, pp. 3542-3559.e11
    Contributions to Journals: Articles

  • Global and Gene-specific Transcriptional Responses to Acute Stress

    Fishcl, H., Brown, T., Angel, A., Mellor, J.
    Working Papers: Preprint Papers

  • Mapping Human Transient Transcriptomes Using Single Nucleotide Resolution 4sU Sequencing (SNU-Seq)

    Lorenz, P., Lamstaes, A., Fishcl, H., Xi, S., Saukko-Paavola, A., Murray, S. C., Brown, T., George, C., Furger, A., Angel, A., Mellor, J.
    Working Papers: Preprint Papers

  • Transcriptional changes are regulated by metabolic pathway dynamics but decoupled from protein levels

    Feltham, J., Xi, S., Murray, S. C., Wouters, M., Urdiain-Arraiza, J., Heilig, R., George, C., Townley, A. F., Kessler, B. M., Liberatori, S., Charles, P. D., Angel, A., Fischer, R., Mellor, J.
    Working Papers: Preprint Papers

View My Publications

Research

Research Overview

I am a mathematical modeller of complex biological systems. I apply techniques from statistical physics, mathematics and computer science in order to elucidate the mechanisms that underpin the basic building blocks of life.

Often applying stochastic modelling to systems of interacting biological components, I currently focus on transcription and related areas including chromatin, nucleosome chaperoning and metabolic cycling.

Research Areas

Accepting PhDs

I am currently accepting PhDs in Physics.

Please get in touch if you would like to discuss your research ideas further.

Email Me

Physics

Accepting PhDs
View Research Area

Research Specialisms

  • Molecular Biology
  • Mathematical Modelling
  • Applied Physics

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Current Research

Gene Expression and Transcription in the Yeast Metabolic Cycle

Modelling the Complex Dynamics of Polymerase II Transcription

Modelling the Chaperoning of Nucleosomes During Transcription

Improving the Quantitative Analysis of ChIP-seq Data

Past Research

Modelling Antisense Transcription

Modelling the Epigenetics of Vernalization

Collaborations

Professor Jane Mellor, University of Oxford

Transcription, Chromatin and the Yeast Metabolic Cycle

 

Professor Francois Robert, IRCM Montreal

Transcription through nucleosomes

 

Dr Michael Tellier, University of Leicester

Analysis of ChIP-seq data

Publications

Page 1 of 2 Results 1 to 10 of 19

  • Spt4 facilitates the movement of RNA polymerase II through the +2 nucleosomal barrier

    Uzun, U., Brown, T., Fishcl, H., Angel, A., Mellor, J.
    Cell Reports, vol. 36, no. 13, pp. 4064-4075
    Contributions to Journals: Articles

  • FACT is recruited to the +1 nucleosome of transcribed genes and spreads in a Chd1-dependent manner

    Jeronimo, C., Angel, A., Nguyen, V. Q., Kim, J. M., Poitras, C., Lambert, E., Collin, P., Mellor, J., Wu, C., Robert, F.
    Molecular Cell, vol. 81, no. 17, pp. 3542-3559.e11
    Contributions to Journals: Articles

  • Global and Gene-specific Transcriptional Responses to Acute Stress

    Fishcl, H., Brown, T., Angel, A., Mellor, J.
    Working Papers: Preprint Papers

  • Mapping Human Transient Transcriptomes Using Single Nucleotide Resolution 4sU Sequencing (SNU-Seq)

    Lorenz, P., Lamstaes, A., Fishcl, H., Xi, S., Saukko-Paavola, A., Murray, S. C., Brown, T., George, C., Furger, A., Angel, A., Mellor, J.
    Working Papers: Preprint Papers

  • Transcriptional changes are regulated by metabolic pathway dynamics but decoupled from protein levels

    Feltham, J., Xi, S., Murray, S. C., Wouters, M., Urdiain-Arraiza, J., Heilig, R., George, C., Townley, A. F., Kessler, B. M., Liberatori, S., Charles, P. D., Angel, A., Fischer, R., Mellor, J.
    Working Papers: Preprint Papers

  • H3K4me3 is neither instructive for, nor informed by, transcription

    Murray, S. C., Lorenz, P., Howe, F. S., Wouters, M., Brown, T., Xi, S., Fischl, H., Khushaim, W., Rayappu, J. R., Angel, A., Mellor, J.
    Working Papers: Preprint Papers

  • A Dynamic Model of Resource Allocation in Response to the Presence of a Synthetic Construct

    Nyström, A., Papachristodoulou, A., Angel, A.
    ACS Synthetic Biology, vol. 7, no. 5, pp. 1201-1210
    Contributions to Journals: Articles

  • Antisense transcription-dependent chromatin signature modulates sense transcript dynamics

    Brown, T., Howe, F. S., Murray, S. C., Wouters, M., Lorenz, P., Seward, E., Rata, S., Angel, A., Mellor, J.
    Molecular Systems Biology, vol. 14, no. 2, e8007
    Contributions to Journals: Articles

  • Vernalizing cold is registered digitally at FLC

    Angel, A., Song, J., Yang, H., Questa, J. I., Dean, C., Howard, M.
    Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 13, pp. 4146-4151
    Contributions to Journals: Articles

  • Vernalization - a cold-induced epigenetic switch

    Song, J., Angel, A., Howard, M., Dean, C.
    Journal of Cell Science, vol. 125, no. 16, pp. 3723-3731
    Contributions to Journals: Articles
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