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The School of Natural and Computing Sciences

Dr Thomas Baddeley

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Dr Thomas Baddeley
Dr Thomas Baddeley
Dr Thomas Baddeley

PhD, BSc Hons

Senior Research Fellow

About
Telephone Number
+44 (0)1224 274238
School/Department
School of Natural and Computing Sciences
Linkedin
Google Scholar
Pure

North East Analytical Research (NEAR) Symposium

Link to the NEAR Symposium Website

NEAR Symposium

Qualifications

  • PhD Chemistry 
    2002 - University of Aberdeen 
  • BSc Hons Chemistry 
    1998 - University of Aberdeen 

External Memberships

  • Head of DMPK / Analytical Chemistry for TauRx Therapeutics
  • Cofounder of the North East Analytical Research (NEAR) Symposium

Latest Publications

View My Publications

Research

Research Overview

My focus is on the analytical pathways involved in pharmaceutical drug development.

  • This starts early during R and D looking at physical chemical testing of novel compounds and early analytical development to determine material purity and its impurities.
  • As the candidates progress further, bioanalytical methods, initial metabolism and material characterisation are developed.
  • Once into non clinical and clinical development validation according to ICH Q3 is required for material assays and ICH M7 for bioanalytical methods

 

 

Current Research

The development and use of new analytical methods in the study of small organic molecules undergoing clinical evaluation.

The development and use of bioanalytical methods used in clinical and non clinical studies

DMPK studies supporting novel pharmaceutical development

Past Research

The synthesis and study of novel organic compounds for use as potential drug candidates and excipients.

The study of the physical properties of novel oligosaccharides

Knowledge Exchange

Speaker at NEAR Symposium 2024 in Aberdeen

Speaker at REID bioanalytical Forum 2019, Cambridge

Speaker at INFORM 2018 in Copenhagen

 

Publications

Page 2 of 4 Results 11 to 20 of 35

  • A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy

    Schwab, K., Frahm, S., Horsley, D., Rickard, J. E., Melis, V., Goatman, E. A., Magbagbeolu, M., Douglas, M., Leith, M. G., Baddeley, T. C., Storey, J. M. D., Riedel, G., Wischik, C. M., Harrington, C. R., Theuring, F.
    Frontiers in Molecular Neuroscience, vol. 10, 447
    Contributions to Journals: Articles

  • Structural studies of (E)-2-(benzylidene)-1- tetralone derivatives: Crystal structures and Hirshfeld surface analysis

    Baddeley, T. C., Gomes, L. R., Low, J. N., Turner, A. B., Wardell, J. L., Watson, G. J.
    Zeitschrift fur Kristallographie - Crystalline Materials, vol. 232, no. 10, pp. 697-718
    Contributions to Journals: Articles

  • In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development

    Steven, J., Müller, M. R., Carvalho, M. F., Ubah, O. C., Kovaleva, M., Donohoe, G., Baddeley, T., Cornock, D., Saunders, K., Porter, A. J., Barelle, C. J.
    Frontiers in Immunology, vol. 8, 1361
    Contributions to Journals: Articles

  • Crystal structures of four 1-(aryl)-[1,2,4]triazolo[4,3-a]quinoxaline derivatives

    Nogueira, T. C. M., Pinheiro, A. C., de Souza, M. V. N., Baddeley, T. C., Wardell, J. L., Wardell, S. M. S. V.
    Journal of Molecular Structure, vol. 1128, pp. 579-589
    Contributions to Journals: Articles

  • Complex Disposition of Methylthioninium Redox Forms Determines Efficacy in Tau Aggregation Inhibitor Therapy for Alzheimer's Disease

    Baddeley, T. C., McCaffrey, J., Storey, J. M. D., Cheung, J. K. S., Melis, V., Horsley, D., Harrington, C. R., Wischik, C. M.
    Journal of Pharmacology and Experimental Therapeutics, vol. 352, no. 1, pp. 110-118
    Contributions to Journals: Articles

  • Tautomers and polymorphs of pyrazolinone derivatives, generated from reactions of arylhydrazines, ArNHNH2, with 1,3-dicarbonyl compounds

    Baddeley, T. C., Howie, R. A., De Lima, G. M., Wardell, J. L., Wardell, S. M.
    Zeitschrift fur Kristallographie, vol. 228, no. 2, pp. 77-91
    Contributions to Journals: Articles

  • New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes

    Baddeley, T., Clunas, S., Harrington, C. R., Horsley, D., Ishaq, A., Khan, K., Loh, Y. S., Marshall, C., Rickard, J. E., Simpson, M., Sinclair, J. P., Storey, J. M. D., Williamson, C., Wischik, C. M., Wood, B. A.
    Patents: Patents

  • Variation in supramolecular arrangements of hydrazones, o-H2NC6H4CMe=NNHC6H4X (X = H, o-, m- and p-NO2), derived from o-aminoacetophenone and phenylhydrazines

    Howie, R. A., Baddeley, T. C., Wardell, J. L., Wardell, S. M. S. V.
    Journal of Molecular Structure, vol. 1020, pp. 16-22
    Contributions to Journals: Articles

  • 1,3-Diphenyl-4,5-dihydro-1H-pyrazol-5-one

    Baddeley, T., Wardell, S. M. S., Tiekink, E., Wardell, J.
    Acta Crystallographica Section E: Structure Reports Online, vol. E68, pp. o1016-o1017
    Contributions to Journals: Articles

  • 3,7-diamino-10H-phenothiazine salts and their use: WO2007110627

    Wischik, C. M., Rickard, J. E., Harrington, C. R., Horsley, D., Storey, J. M. D., Marshall, C., Sinclair, J. P., Baddeley, T.
    Patents: Patents
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