Assessment of clinical and neuroimaging efficacy of treatment targeting tau pathology in mild cognitive impairment and mild to moderate Alzheimer’s disease with hydromethylthionine mesylate using external control data
Schelter, B. O., Shiells, H., Lo, S., Nazlee, N., Evans, E., Bentham, P., Gauthier, S., Zetterberg, H., Wilcock, G. K., Froelich, L., Burns, A., MacSweeney, E., Ballard, C., Yu, J., Choon, T. S., Asvatourian, V., Muehlemann, N., Priel, J., Kook, K., Sullivan, T., Downie, D., Miller, S., Pringle, C., Storey, J. M., Baddeley, T., Harrington, C. R., Staff, R., Sandu, A., Hull, C., Stefanacci, R., Wischik, C. M., Alzheimer's Disease Neuroimaging Initiative
The Journal of Prevention of Alzheimer's Disease, vol. 13, no. 6, 100560
Rapid detection of fibrinolytic activation in postpartum hemorrhage and acute obstetric coagulopathy using a novel assay
Ilich, A., Whyte, C. S., Moonla, C., Berkowitz, C., Pawlinski, I., Goraya, S., Lionikiene, A. S., Jenkins, P. V., de Lloyd, L., Bell, S. F., Collis, R. E., Collins, P. W., Mutch, N. J., Key, N. S.
Cap-adjacent 2′-O-ribose methylation of RNA in C. elegans is required for postembryonic growth and germline development in the presence of the decapping exonuclease EOL-1
Clemens, E., Brivio, S., Al-Khafaji, M. I., Eijlers, P., Kurukulasuriya, M. S., Haussmann, I. U., MacLeod, D., Wenzel, M., Muller, B., Soller, M., Pettitt, J.
A rationally designed novel bi-functional human TNF-α and Janus Kinase targeted soloMER® Drug Conjugate (SDC) with a neutrophil elastase cleavable linker delivering inflammation site-specific release of payload
Murray, E., Priyanka, S., Martinez Fraile, J., Grygorash, R., Idress, M. S., Brownbridge, L., Glavina, S., Camper, N., Boyd, R., Porter, A., Barelle, C., Ubah, O.
Journal of Medicinal Chemistry, vol. 69, no. 8, pp. 9664–9679
Genetic counselling implementation in dilated cardiomyopathy
Verdonschot, J. A. J., van Spaendonck-Zwarts, K. Y., Hellebrekers, D. M. E. I., Asselbergs, F. W., Behr, E. R., Charron, P., Dawson, D., Garcia-Pavia, P., Haugaa, K. H., Jurcut, R., Kuchynka, P., Lopes, L. R., Mazzanti, A., Metra, M., Monserrat, L., Kaski, J. P., Pantazis, A., Prasad, S. K., Rosano, G., Seferovic, P. M., Sheppard, M. N., Sinagra, G., Tome Esteban, M. T., Heymans, S. R. B., van Tintelen, J. P.
Novel cardiovascular metabolic risk factor mechanisms and therapeutic opportunities
Evans, P. C., Vilahur, G., Kleinbongard, P., Osto, E., Remme, C. A., Madonna, R., Aksentijevic, D., Sourij, H., Davidson, S. M., Santovito, D., Gindlhuber, J., Weber, C., Linke, W. A., Lutgens, E., Bertrand, L., Dawson, D., Bäck, M., Norata, G. D., Wojta, J., Perrino, C.
Clinical, imaging and blood biomarker outcomes in a Phase 3 clinical trial of tau aggregation inhibitor hydromethylthionine mesylate in mild cognitive impairment and mild to moderate dementia due to Alzheimer’s disease
Wischik, C. M., Stefanacci, R., Bentham, P., Gauthier, S., Zetterberg, H., Wilcock, G. K., Froelich, L., Burns, A., MacSweeney, E., Ballard, C., Yu, J., Choon, T. S., Asvatourian, V., Muehlemann, N., Priel, J., Kook, K., Sullivan, T., Downie, D., Miller, S., Pringle, C., Storey, J. M. D., Baddeley, T., Harrington, C. R., Penny, L. K., Arastoo, M., Staff, R., Sandu, A., Shiells, H., Lo, S., Nazlee, N., Evans, E., Hull, C., Schelter, B. O.
The Journal of Prevention of Alzheimer's Disease, vol. 13, no. 3, 100480
Baseline characteristics of patients recruited to the mannitol for cerebral oedema after acute intracerebral haemorrhage (MACE-ICH) trial
Krishnan, K., Grace, E., Woodhouse, L., Roffe, C., Dawson, J., England, T. J., Hewson, D. W., Dineen, R. A., Law, Z. K., Pszczolkowski, S., Wells, K., Buck, A., Craig, J., Havard, D., Macleod, M. J., Werring, D. J., Doubal, F. N., Sprigg, N., Bath, P. M.
Clinical Neurology and Neurosurgery, vol. 264, 109342
Timing matters: early administration of a high-affinity antibody targeting the tau repeat domain prevents aggregation in a mouse tauopathy model
Porter, A.
Alzheimer's Research & Therapy
Contributions to Journals: Articles
Long-read sequencing reveals increased isoform diversity in key transcription factor effectors of intercellular signalling at the invertebrate-vertebrate transition
Torres-Aguila, N. P., Salonna, M., Shimeld, S. M., Hoppler, S., Ferrier, D. E.
The Effect of SERM/CB2 Receptor Modulators on Repetitive Behaviours in Juvenile and Young Adult Mice May Have Implications for Tourette Syndrome Treatment
Gorberg, V., McCaffery, P., Anavi-Goffer, S.
International Journal of Molecular Sciences, vol. 27, no. 3, 1181
The structural basis for the selective antagonism of soluble TNF-alpha by variable new antigen receptors
Ubah, O., Lake, E. W., Ott, K., Priyanka, S., Celeda, S., Gunaratne, G. S., West, J., Shi, K., Moeller, N. H., Porter, A., Aihara, H., Kosoff, D., LeBeau, A. M., Barelle, C.
Inhibiting disulphide bonding in truncated tau297-391 results in enhanced self-assembly of tau into seed-competent assemblies
Oakley, S. S., Marshall, K. E., Meisl, G., Copsey, A., Maina, M. B., Milton, R., Vorley, T., Storey, J., Harrington, C., Wischik, C., Xue, W., Serpell, L. C.
ACS Chemical Neuroscience, vol. 17, no. 1, pp. 124-138