Publications | The Institute of Medical Sciences

A scoping review of randomised controlled trials of vaccines that recruited care home residents: lessons for future trials

2025

Subbarayan, S., Smith-Dodd, I., Nicolson, G., Burton, J. K., Vasan, S. S., Shenkin, S. D., Soiza, R., The WATCH Consortium, Treweek, S., Stewart, C., Macleod, M.

Age and Ageing, vol. 54, no. 12, afaf355

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1093/ageing/afaf355
Open Access: http://aura.abdn.ac.uk/bitstreams/042377b1-a7c0-4f28-b2be-141e5228d177/download

Exploring the roles of conserved context-dependent cis-regulatory elements (ccdCREs) in multicellularity, human health and disease

2025

McEwan, A. R., Rattray, A., Hutchings, G., Hay, E. A., Murgatroyd, C., MacKenzie, A.

FEBS Journal, vol. 292, no. 23, pp. 6163-6181

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1111/febs.70174
Open Access: http://aura.abdn.ac.uk/bitstreams/2c996e73-a60d-4020-a024-0fe503ad3ce7/download

How many people have a Huntington's Disease expansion: A population-based prevalence study in Northern Scotland

2025

Cruickshank, H., Miedzybrodzka, Z.

Neuroepidemiology, vol. 59, no. 6, pp. 633–640

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1159/000542739
Open Access: http://aura.abdn.ac.uk/bitstreams/721bd4a1-3c4f-4c63-8ab7-5efedaa20752/download
Additional Links: View publication in Scopus

In vitro evolution of caspofungin resistance in Candidozyma auris via FKS1 hotspot I mutations results in moderate fitness trade-offs but no reduction in virulence

2025

Ross, Z. K., Alsayegh, S., Zhao, Y., McPherson, S., Munro, C. A., Lorenz, A.

Microbiological Research, vol. 301, 128322

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1016/j.micres.2025.128322
Open Access: http://aura.abdn.ac.uk/bitstreams/f8d4ecd9-392c-46b5-8bb1-72a2940e5a3b/download

Inhibiting disulphide bonding in truncated tau297-391 results in enhanced self-assembly of tau into seed-competent assemblies

2025 - Accepted/In press

Oakley, S. S., Marshall, K. E., Meisl, G., Copsey, A., Maina, M. B., Milton, R., Vorley, T., Storey, J., Harrington, C., Wischik, C., Xue, W., Serpell, L. C.

ACS Chemical Neuroscience

Contributions to Journals: Articles

The structural basis for the selective antagonism of soluble TNF-alpha by variable new antigen receptors

2025 - Accepted/In press

LeBeau, A. M., Ubah, O., Lake, E. W., Ott, K., Priyanka, S., Celeda, S., West, J., Gunaratne, G. S., Shi, K., Moeller, N. H., Aihara, H., Kosoff, D., Porter, A., Barelle, C.

Nature Communications

Contributions to Journals: Articles

Discrimination of haematoma and peri-haematoma regions of sub-acute intracerebral haemorrhage using Field-Cycling Imaging at field strengths below 0.2 T

2025

Senn, N., Mallikourti, V., Ross, J., Levi, R., Oren, N., Broche, L., Waiter, G., Macleod, M.

Chapters in Books, Reports and Conference Proceedings: Conference Proceedings

Digital Object Identifier: https://doi.org/10.1177/17474930251379781

Stroke Diagnosis from Field-Cycling Imaging using Machine Learning

2025

Ali-Gombe, A., Senn, N., Broche, L., Mallikourti, V., Ross, J., Waiter, G., Macleod, M.

Chapters in Books, Reports and Conference Proceedings: Conference Proceedings

Digital Object Identifier: https://doi.org/10.1177/17474930251379781

Epigenetic and Structural Brain Aging and Their Associations With Major Depressive Disorder

2025

Xu, E. Y., Green, C., McCartney, D. L., Han, L. K., Evans, K. L., Walker, R. M., Gadd, D. A., Steele, D., Waiter, G., Campbell, A., Lawrie, S. M., Cole, J. H., McIntosh, A. M., Shen, X., Whalley, H. C.

Biological Psychiatry Global Open Science, vol. 5, no. 6, pp. 100577

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1016/j.bpsgos.2025.100577
Open Access: http://aura.abdn.ac.uk/bitstreams/5cf54a64-3fd3-4f73-8068-6206821ca431/download
Additional Links: View publication in Scopus

Identification of a regulatory sequence within the third intracellular loop that governs β-arrestin binding to the muscarinic M5 receptor

2025

Steinmüller, S., Thompson, K., Alenfelder, J., Drube, J., Hoffmann, C., Kostenis, E., Thompson, D., Hislop, J.

Cellular Signalling, vol. 135, 112004

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1016/j.cellsig.2025.112004
Open Access: http://aura.abdn.ac.uk/bitstreams/5ff1ddbd-0e5e-474f-8030-000c61ab9e08/download

Comparison of steroidogenic disruption in adrenal H295R and ovarian KGN and COV434 cell models and the implications to assess female reproductive toxicity

2025 - E-pub ahead of print

Vazakidou, P., Koopmans, C., Nijmeijer, S., Lecante, L. L., Liu, P., Mazaud Guittot, S., Fowler, P. A. F., Leonards, P. E., van Duursen, M. B.

Reproductive Toxicology

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1016/j.reprotox.2025.109088
Open Access: http://aura.abdn.ac.uk/bitstreams/3d396091-3127-40d9-a956-6615758203e9/download

Investigation into ligand selectivity and bias at the formyl peptide receptor family

2025 - E-pub ahead of print

Jack, C. E., Thomson, C. M., Dall’Angelo, S., Thompson, D., Hislop, J. N.

Journal of Pharmacology and Experimental Therapeutics

Contributions to Journals: Articles

Online: https://www.sciencedirect.com/science/article/pii/S0022356525402778
Digital Object Identifier: https://doi.org/10.1016/j.jpet.2025.103764

Quantification of plasma tau species containing the proline-rich region as a biomarker in Alzheimer’s disease

2025 - Accepted/In press

Porter, A.

Scientific Reports

Contributions to Journals: Articles

The protein-protein interaction between two spliced leader trans-splicing factors is mediated by two interlinked α-helical domains

2025

Eijlers, P., Pettitt, J., Müller, B.

microPublication Biology, 001705

Contributions to Journals: Articles

Online: https://www.micropublication.org/journals/biology/micropub-biology-001705
Digital Object Identifier: https://doi.org/10.17912/MICROPUB.BIOLOGY.001705

Randomised controlled trial of physical exercise or cognitive behavioural therapy for myocardial recovery after acute takotsubo cardiomyopathy

2025 - Accepted/In press

Gamble, D. T., Ross, J., Khan, M., Cheyne, L., Rudd, A., Srinivasan, J., Horgan, G., Hogg, D., Myint, P. K., Newby, D. E., Williams, C., Gray, S., Dawson, D.

Circulation. Heart Failure

Contributions to Journals: Articles

Takotsubo syndrome: cognitive behavioural therapy, physical training, and brain function recovery in the BREAKOUT trial

2025

Khan, H., Gamble, D., Rudd, A., Dospinescu, C., Creaney, C., Horgan, G., Holme, A. L., Wilson, H., Newby, D. E., Gray, S., Krishnadas, R., Williams, C., Waiter, G., Dawson, D.

European Heart Journal, vol. 46, no. 40, pp. 4127-4129

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1093/eurheartj/ehaf441
Open Access: http://aura.abdn.ac.uk/bitstreams/0886a4e1-0de4-43e3-9fbe-bbdedce5ab4e/download

Blood Biomarkers from Research Use to Clinical Practice: What Must Be Done? A Report from the EU/US CTAD Task Force

2025

Angioni, D., Delrieu, J., Hansson, O., Fillit, H., Aisen, P., Cummings, J., Sims, J. R., Braunstein, J. B., Sabbagh, M., Bittner, T., Pontecorvo, M., Bozeat, S., Dage, J. L., Largent, E., Mattke, S., Correa, O., Gutierrez Robledo, L. M., Baldivieso, V., Willis, D. R., Atri, A., Bateman, R. J., Ousset, P. J., Vellas, B., Weiner, M., EU/US/CTAD Task Force, Penny, L., Harrington, C.

Journal of Prevention of Alzheimer's Disease, vol. 9, no. 4, pp. 569-579

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.14283/jpad.2022.85
Open Access: http://aura.abdn.ac.uk/bitstreams/2bf41f9a-60f5-4b5b-b98f-671d243fb570/download
Additional Links: View publication in Scopus; https://abdn.elsevierpure.com/en/publications/46864cff-6f39-49e4-97f5-7b93c5ec7414

PTP1B deficiency in myeloid cells increases susceptibility to Candida albicans systemic infection by modulating antifungal immunity

2025

Allen, B., Dambuza, I. M., Berry, S., Reid, D. M., McVey, S. M., Mesiarikova, M., John, L., Davie, M., Baker, C. P., Arthur, J. S. C., Delibegovic, M., Brown, G. D., Wilson, H.

mBio, vol. 16, no. 10, e01516-25

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1128/mbio.01516-25
Open Access: http://aura.abdn.ac.uk/bitstreams/5e6687cb-f0ab-4820-8650-11a6d0348159/download
Additional Links: https://abdn.elsevierpure.com/en/publications/41d1cdee-8f38-47d4-a0c3-9d7c736c3e40

Feasibility of self-navigated motion resolved 3D lung MRI on a non-commercial 100 mT system

2025

Senn, N., Zihlmann, G., Sarracanie, M., Salameh, N.

Chapters in Books, Reports and Conference Proceedings: Conference Proceedings

Digital Object Identifier: https://doi.org/10.1007/s10334-025-01278-8

A comparison of T1ρ with native T1 and T2 mapping for detecting oedema in Takotsubo cardiomyopathy

2025 - E-pub ahead of print

Balode, L., Kelly, R., Higgins, D. M., Gamble, D., Dawson, D., Ross, P. J.

Journal of Cardiovascular Magnetic Resonance

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1016/j.jocmr.2025.101965

Generation of a Ym1 Deficient Mouse utilising CRISPR-Cas9 in CB6 Embryos

2025

Parkinson, J. E., Baldwin, G. E., Papotto, P. H., Humphreys, N. E., Day, A. J., Adamson, A. D., Allen, J. E., Sutherland, T.

Transgenic Research, vol. 34, 44

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1007/s11248-025-00455-8
Open Access: http://aura.abdn.ac.uk/bitstreams/37246ce9-2c1d-4057-baf6-147a283e5f0f/download

Retrospective use of the Pragmatic-Explanatory Continuum Indicator Summary-2 trial design tool to assess design choices in randomized controlled trials: an empirical review

2025

Willis, A., Shiely, F., Howie, A., Treweek, S., Taljaard, M., Loudon, K., Murphy, E., Bhakoo, A., Yazdani, Y., Ward, F., Janiaud, P., Haren, A., Yining Liang, A., Robinson, C., Deng, D., Hemkens, L., O'Sullivan Greene, E., Slattery, L., Zwarenstein, M.

Journal of Clinical Epidemiology, vol. 187, 111959

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1016/j.jclinepi.2025.111959
Open Access: http://aura.abdn.ac.uk/bitstreams/fbb883b9-9c9c-4075-a8f1-6995fa3f38e4/download

Divergent Morphologies and Common Signaling Features of Active and Inactive Oncogenic RHOA Mutants in Yeast

2025

Wang, C., Ohnuki, S., Savchenko, A., Aburatani, H., Yoshida, S., Hatakeyama, R., Ohya, Y.

Cells, vol. 14, no. 18, 1439

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.3390/cells14181439

Systematic gait analysis in alpha-synuclein transgenic line 62 mice using the CatWalk

2026

Schwab, K., Robinson, L., Bray, J., Anschuetz, A., Mondesir, M., Magri', M., Harrington, C., Riedel, G.

Behavioural Brain Research, vol. 496, 115819

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1016/j.bbr.2025.115819
Open Access: http://aura.abdn.ac.uk/bitstreams/7c7b8eee-d670-4e6e-9d18-97a78483d184/download

Gut microbiota-derived short-chain fatty acids and their role in human health and disease

2025

Mukhopadhya, I., Louis, P.

Nature Reviews Microbiology, vol. 23, pp. 635-651

Contributions to Journals: Review articles

Digital Object Identifier: https://doi.org/10.1038/s41579-025-01183-w
Open Access: http://aura.abdn.ac.uk/bitstreams/7383dd82-bf77-47ef-92e6-fb5bf2af4c9e/download