Publications | The Institute of Medical Sciences

Fundamental limits on symmetry breaking by Turing-like activator-inhibitor mechanisms

2026 - Accepted/In press

Hiscock, T., Muzatko, D., Daga, B.

Development

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1242/dev.205067

Baseline characteristics of patients recruited to the mannitol for cerebral oedema after acute intracerebral haemorrhage (MACE-ICH) trial

2026

Krishnan, K., Grace, E., Woodhouse, L., Roffe, C., Dawson, J., England, T. J., Hewson, D. W., Dineen, R. A., Law, Z. K., Pszczolkowski, S., Wells, K., Buck, A., Craig, J., Havard, D., Macleod, M. J., Werring, D. J., Doubal, F. N., Sprigg, N., Bath, P. M.

Clinical Neurology and Neurosurgery, vol. 264, 109342

Contributions to Journals: Articles

Online: https://www.sciencedirect.com/science/article/pii/S030384672600034X
Digital Object Identifier: https://doi.org/10.1016/j.clineuro.2026.109342

Profound cell wall remodeling in Candida parapsilosis during systemic infection confers simultaneous tolerance to echinocandins and host immunity

2026 - E-pub ahead of print

Daneshnia, F., Cai, L., Gunasekaran, D., Gautam, I., Perry, A., Ghahfarokhy, P. M., Ebadati, A., Munoz, J., Padilla, D., Hilmioglu-Polat, S., Mei, S., Floyd, D. J., Schikora-Tamarit, M. �., Funtes, D., Artigués-Lleixà, M., Walker, L., Gonçalves, S. M., Salehi, M., Carvalho, A., Desai, J. V., Perlin, D. S., Munro, C., Hopke, A., Wang, T., Gabaldón, T., Fang, W., Nobile, C. J., Mansour, M. K., Arastehfar, A.

Microbiology spectrum

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1128/spectrum.03043-25

Timing matters: early administration of a high-affinity antibody targeting the tau repeat domain prevents aggregation in a mouse tauopathy model

2026 - Accepted/In press

Porter, A.

Alzheimer's Research & Therapy

Contributions to Journals: Articles

Effects of hydromethylthionine mesylate and rivastigmine in a pharmacological mouse model of Alzheimer's disease

2026

Robinson, L., Bray, J., Melis, V., Harrington, C. R., Wischik, C. M., Riedel, G.

Behavioural Pharmacology, pp. 64-69

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1097/FBP.0000000000000865

Clinical, imaging and blood biomarker outcomes in a Phase 3 clinical trial of tau aggregation inhibitor hydromethylthionine mesylate in mild cognitive impairment and mild to moderate dementia due to Alzheimer’s disease

2026

Wischik, C. M., Stefanacci, R., Bentham, P., Gauthier, S., Zetterberg, H., Wilcock, G. K., Froelich, L., Burns, A., MacSweeney, E., Ballard, C., Yu, J., Choon, T. S., Asvatourian, V., Muehlemann, N., Priel, J., Kook, K., Sullivan, T., Downie, D., Miller, S., Pringle, C., Storey, J. M. D., Baddeley, T., Harrington, C. R., Penny, L. K., Arastoo, M., Staff, R., Sandu, A., Shiells, H., Lo, S., Nazlee, N., Evans, E., Hull, C., Schelter, B. O.

The Journal of Prevention of Alzheimer's Disease, vol. 13, no. 3, 100480

Contributions to Journals: Articles

Online: https://www.sciencedirect.com/science/article/pii/S227458072600004X
Digital Object Identifier: https://doi.org/10.1016/j.tjpad.2026.100480
Open Access: http://aura.abdn.ac.uk/bitstreams/75aac545-e8a2-4266-92e5-bf2b51de39fc/download

The structural basis for the selective antagonism of soluble TNF-alpha by variable new antigen receptors

2026

Ubah, O., Lake, E. W., Ott, K., Priyanka, S., Celeda, S., Gunaratne, G. S., West, J., Shi, K., Moeller, N. H., Porter, A., Aihara, H., Kosoff, D., LeBeau, A. M., Barelle, C.

Nature Communications, vol. 17, 256

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1038/s41467-025-66967-3
Open Access: http://aura.abdn.ac.uk/bitstreams/57c7ae6d-fc4e-4c8f-aeb1-0b6cf5d97be5/download

Inhibiting disulphide bonding in truncated tau297-391 results in enhanced self-assembly of tau into seed-competent assemblies

2026

Oakley, S. S., Marshall, K. E., Meisl, G., Copsey, A., Maina, M. B., Milton, R., Vorley, T., Storey, J., Harrington, C., Wischik, C., Xue, W., Serpell, L. C.

ACS Chemical Neuroscience, vol. 17, no. 1, pp. 124-138

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1021/acschemneuro.5c00639
Open Access: http://aura.abdn.ac.uk/bitstreams/9a4ac37d-645d-4169-8d5b-f4f01f76ce49/download

Systematic gait analysis in alpha-synuclein transgenic line 62 mice using the CatWalk

2026

Schwab, K., Robinson, L., Bray, J., Anschuetz, A., Mondesir, M., Magri', M., Harrington, C., Riedel, G.

Behavioural Brain Research, vol. 496, 115819

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1016/j.bbr.2025.115819
Open Access: http://aura.abdn.ac.uk/bitstreams/7c7b8eee-d670-4e6e-9d18-97a78483d184/download

Association of neighbourhood deprivation with secondary prevention prescribing and all-cause mortality among stroke patients in Scotland: a population-based study

2026

Sterling, K., Turner, M., Langhorne, P., Macleod, M.

Cerebrovascular Diseases, vol. 55, no. 1, pp. 63-71

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1159/000546261
Open Access: http://aura.abdn.ac.uk/bitstreams/3d0b7aba-4f38-4a03-a45a-986a2ba03c86/download
Additional Links: View publication in Scopus

Comparison of steroidogenic disruption in adrenal H295R and ovarian KGN and COV434 cell models and the implications to assess female reproductive toxicity

2026

Vazakidou, P., Koopmans, C., Nijmeijer, S., Lecante, L. L., Liu, P., Mazaud Guittot, S., Fowler, P. A. F., Leonards, P. E., van Duursen, M. B.

Reproductive Toxicology, vol. 139, pp. 109088

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1016/j.reprotox.2025.109088
Open Access: http://aura.abdn.ac.uk/bitstreams/3d396091-3127-40d9-a956-6615758203e9/download

Investigation into ligand selectivity and bias at the formyl peptide receptor family

2026

Jack, C. E., Thomson, C. M., Dall’Angelo, S., Thompson, D., Hislop, J. N.

Journal of Pharmacology and Experimental Therapeutics, vol. 393, no. 1, 103764

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1016/j.jpet.2025.103764
Open Access: http://aura.abdn.ac.uk/bitstreams/99b140b9-fc97-45f5-928b-83c065c6adc5/download

A2A Adenosine Receptor Agonists With Last-Step Enzymatic 18F-Labelling Potential (Fluorinase) for Positron Emission Tomography (PET)

2025 - E-pub ahead of print

Charalambous, N., Schleidt, C., Liu, R., Heitman, L. H., Dall’Angelo, S., O’Hagan, D., Lowe, P. T.

European Journal of Organic Chemistry, e202501125

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1002/ejoc.202501125

Effect of the Icelandic Mutation APP^A673T in the Murine APP Gene on Phenotype of Line 66 Tau Mice

2025

Anschuetz, A., Robinson, L., Mondesir, M., Melis, V., Platt, B., Harrington, C. R., Riedel, G., Schwab, K.

Biomolecules, vol. 16, no. 1, 28

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.3390/biom16010028
Additional Links: View publication in Scopus

Characterising interleukin-27 (IL-27) responses in human blood derived macrophage cells

2026

Helps, T., Baker, C., Wilson, H. M., Arthur, S., Murray, G. I., McLean, M. H.

Cytokine, vol. 198, 157097

Contributions to Journals: Articles

Online: https://www.sciencedirect.com/science/article/pii/S1043466625002443
Digital Object Identifier: https://doi.org/10.1016/j.cyto.2025.157097
Open Access: http://aura.abdn.ac.uk/bitstreams/3e7fe931-d2d8-4471-9b22-612503b2102a/download

Fast zero-shot deep learning-based denoising method for low-field MR images

2025 - E-pub ahead of print

Ayde, R., Zihlmann, G., Salameh, N., Sarracanie, M.

Magnetic Resonance Materials in Physics, Biology and Medicine

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1007/s10334-025-01311-w
Open Access: http://aura.abdn.ac.uk/bitstreams/4c9541fb-5108-42f8-a502-523af1f96d7d/download
Additional Links: View publication in Scopus

Hyphal growth determines spatial organization and coexistence in a pathogenic polymicrobial community in a spatially structured environment

2025

Mancini, L., Saliekh, L., Claydon, R., Kotar, J., Benyei, E. B., Munro, C. A., Shendruk, T. N., Brown, A., Welch, M., Cicuta, P.

The ISME Journal, vol. 19, no. 1, pp. wraf279

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1093/ismejo/wraf279
Open Access: http://aura.abdn.ac.uk/bitstreams/5a520a70-90d9-4170-a8ba-5fc5c6ab3d5a/download

A scoping review of randomised controlled trials of vaccines that recruited care home residents: lessons for future trials

2025

Subbarayan, S., Smith-Dodd, I., Nicolson, G., Burton, J. K., Vasan, S. S., Shenkin, S. D., Soiza, R., The WATCH Consortium, Treweek, S., Stewart, C., Macleod, M.

Age and Ageing, vol. 54, no. 12, afaf355

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1093/ageing/afaf355
Open Access: http://aura.abdn.ac.uk/bitstreams/042377b1-a7c0-4f28-b2be-141e5228d177/download

Physical Exercise or Cognitive Behavioral Therapy for Takotsubo Cardiomyopathy: A Randomized Controlled Trial

2025 - E-pub ahead of print

Gamble, D. T., Ross, J., Khan, H., Cheyne, L., Rudd, A., Srinivasan, J., Horgan, G., Hogg, D., Myint, P. K., Newby, D. E., Williams, C., Gray, S., Dawson, D.

Circulation. Heart Failure

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1161/CIRCHEARTFAILURE.125.013229

A comparison of T1ρ with native T1 and T2 mapping for detecting oedema in Takotsubo cardiomyopathy

2025

Balode, L., Kelly, R., Higgins, D. M., Gamble, D., Dawson, D., Ross, P. J.

Journal of Cardiovascular Magnetic Resonance, vol. 27, no. 2, 101965

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1016/j.jocmr.2025.101965
Open Access: http://aura.abdn.ac.uk/bitstreams/8662aa31-2b20-41af-b517-a4bd49e782d3/download

Exploring the roles of conserved context-dependent cis-regulatory elements (ccdCREs) in multicellularity, human health and disease

2025

McEwan, A. R., Rattray, A., Hutchings, G., Hay, E. A., Murgatroyd, C., MacKenzie, A.

FEBS Journal, vol. 292, no. 23, pp. 6163-6181

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1111/febs.70174
Open Access: http://aura.abdn.ac.uk/bitstreams/2c996e73-a60d-4020-a024-0fe503ad3ce7/download

Factors influencing time spent in hospital for unscheduled readmissions after stroke discharge

2025

Turner, M., McLernon, D., Murchie, P., Langhorne, P., Macleod, M.

International Journal of Stroke, vol. 20, no. 10, pp. 1290 - 1300

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1177/17474930251355864
Open Access: http://aura.abdn.ac.uk/bitstreams/f9d66105-841c-4590-9fd8-e49727648046/download

Generation of a Ym1 Deficient Mouse utilising CRISPR-Cas9 in CB6 Embryos

2025

Parkinson, J. E., Baldwin, G. E., Papotto, P. H., Humphreys, N. E., Day, A. J., Adamson, A. D., Allen, J. E., Sutherland, T.

Transgenic Research, vol. 34, 44

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1007/s11248-025-00455-8
Open Access: http://aura.abdn.ac.uk/bitstreams/37246ce9-2c1d-4057-baf6-147a283e5f0f/download

How many people have a Huntington's Disease expansion: A population-based prevalence study in Northern Scotland

2025

Cruickshank, H., Miedzybrodzka, Z.

Neuroepidemiology, vol. 59, no. 6, pp. 633–640

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1159/000542739
Open Access: http://aura.abdn.ac.uk/bitstreams/721bd4a1-3c4f-4c63-8ab7-5efedaa20752/download
Additional Links: View publication in Scopus

In vitro evolution of caspofungin resistance in Candidozyma auris via FKS1 hotspot I mutations results in moderate fitness trade-offs but no reduction in virulence

2025

Ross, Z. K., Alsayegh, S., Zhao, Y., McPherson, S., Munro, C. A., Lorenz, A.

Microbiological Research, vol. 301, 128322

Contributions to Journals: Articles

Digital Object Identifier: https://doi.org/10.1016/j.micres.2025.128322
Open Access: http://aura.abdn.ac.uk/bitstreams/f8d4ecd9-392c-46b5-8bb1-72a2940e5a3b/download

Fundamental limits on symmetry breaking by Turing-like activator-inhibitor mechanisms

Baseline characteristics of patients recruited to the mannitol for cerebral oedema after acute intracerebral haemorrhage (MACE-ICH) trial

Profound cell wall remodeling in Candida parapsilosis during systemic infection confers simultaneous tolerance to echinocandins and host immunity

Timing matters: early administration of a high-affinity antibody targeting the tau repeat domain prevents aggregation in a mouse tauopathy model

Effects of hydromethylthionine mesylate and rivastigmine in a pharmacological mouse model of Alzheimer's disease

Clinical, imaging and blood biomarker outcomes in a Phase 3 clinical trial of tau aggregation inhibitor hydromethylthionine mesylate in mild cognitive impairment and mild to moderate dementia due to Alzheimer’s disease

The structural basis for the selective antagonism of soluble TNF-alpha by variable new antigen receptors

Inhibiting disulphide bonding in truncated tau297-391 results in enhanced self-assembly of tau into seed-competent assemblies

Systematic gait analysis in alpha-synuclein transgenic line 62 mice using the CatWalk

Association of neighbourhood deprivation with secondary prevention prescribing and all-cause mortality among stroke patients in Scotland: a population-based study

Comparison of steroidogenic disruption in adrenal H295R and ovarian KGN and COV434 cell models and the implications to assess female reproductive toxicity

Investigation into ligand selectivity and bias at the formyl peptide receptor family

A2A Adenosine Receptor Agonists With Last-Step Enzymatic 18F-Labelling Potential (Fluorinase) for Positron Emission Tomography (PET)

Effect of the Icelandic Mutation APPA673T in the Murine APP Gene on Phenotype of Line 66 Tau Mice

Characterising interleukin-27 (IL-27) responses in human blood derived macrophage cells

Fast zero-shot deep learning-based denoising method for low-field MR images

Hyphal growth determines spatial organization and coexistence in a pathogenic polymicrobial community in a spatially structured environment

A scoping review of randomised controlled trials of vaccines that recruited care home residents: lessons for future trials

Physical Exercise or Cognitive Behavioral Therapy for Takotsubo Cardiomyopathy: A Randomized Controlled Trial

A comparison of T1ρ with native T1 and T2 mapping for detecting oedema in Takotsubo cardiomyopathy

Exploring the roles of conserved context-dependent cis-regulatory elements (ccdCREs) in multicellularity, human health and disease

Factors influencing time spent in hospital for unscheduled readmissions after stroke discharge

Generation of a Ym1 Deficient Mouse utilising CRISPR-Cas9 in CB6 Embryos

How many people have a Huntington's Disease expansion: A population-based prevalence study in Northern Scotland

In vitro evolution of caspofungin resistance in Candidozyma auris via FKS1 hotspot I mutations results in moderate fitness trade-offs but no reduction in virulence

Effect of the Icelandic Mutation APP^A673T in the Murine APP Gene on Phenotype of Line 66 Tau Mice