Professor Mirela Delibegovic

Professor Mirela Delibegovic
Professor Mirela Delibegovic

Professor Mirela Delibegovic

PhD

Dean for Industrial Engagement in Research & Knowledge Transfer, Personal Chair

Accepting PhDs

About

University of Aberdeen

School of Medicine, Medical Sciences and Nutrition

Institute of Medical Sciences (IMS)

Aberdeen, AB25 2ZD, UK

Biography

EDUCATION

2003-2007: American Heart Association Fellowship, Harvard Medical School, Boston, USA

1999- 2003: University of Dundee: PhD in Biochemistry, MRC Protein Phosphorylation Unit, Dundee, UK.     Supervisor Professor Dame Patricia T.W. Cohen

1995–1999: University of Edinburgh Medical School: BSc Honours in Pharmacology, Edinburgh, UK.

1994–1995: George Heriot’s School, Edinburgh, UK.

1991–1994: Mesa Selimovic Grammar School, Tuzla, Bosnia & Hercegovina 

RESEARCH AND PROFESSIONAL EXPERIENCE

2019-: Dean for Industrial Engagement in Research and Knowledge Exchange

2018-: Director (Diabetes), Aberdeen Cardiovascular and Diabetes Centre, University of Aberdeen

2018-: Systems Physiology Programme Lead, Institute of Medical Sciences

2015-: Professor (Personal Chair), University of Aberdeen

2014-2015: Reader; University of Aberdeen, School of Medical Sciences

2012-2014: Senior Research Fellow, University of Aberdeen, School of medical sciences

2010-2012: Promotion to UoA Grade 7 (Lecturer), University of Aberdeen, School of Biological Sciences

2007-2012: Research Councils UK (RCUK) 5-year tenure-track Fellowship,. University of Aberdeen, School of Biological Sciences.

2003–2007: Harvard Medical School and BIDMC, Department of Medicine.  American Heart Association (AHA) Postdoctoral Personal Fellowship. Mentor: Prof. Benjamin Neel.

Qualifications

  • PhD Biochemistry 
    2003 - University of Dundee 
  • BSc Hons Pharmacology 
    1999 - University of Edinburgh 

Memberships and Affiliations

Internal Memberships

Director, Aberdeen Cardiovascular and Diabetes Centre

https://www.abdn.ac.uk/acdc/people/index.php

 Systems Physiology Programme Lead, Institute of Medical Sciences

https://www.abdn.ac.uk/ims/research/systems-physiology-1594.php

External Memberships

2021-: Vice-Chair: British Heart Foundation Project Grants Committee

2021-: Diabetes Research & Wellness Foundation, Research Advisory Board

2019-2022: British Heart Foundation Project Grants Committee

2015-2021: Diabetes UK Main Research Grants Committee

2018–: University of Aberdeen Lead on the Scottish Universities Life Sciences Alliance (SULSA)

2015-: Carnegie Trust Assessor

2011 (Inaugural elected member): The Royal Society of Edinburgh (RSE) Young Academy of Scotland

Prizes and Awards

· Royal Society of Edinburgh (RSE) Young Academy of Scotland Fellow (Inaugural Elected Fellow) (2011)

  Winner of the 2018 Wellcome Prize for Outstanding Achievement in Public Engagement in the Biomedical Sciences, University of Aberdeen

· Joint winner: Public prize, Principal’s Prize for Public Engagement with Research 2018, University of Aberdeen

· “Super Zena” (“Super Woman”) 2018 award at the First International Women’s conference, Bosnia and Hercegovina

Research

Research Overview

 WE CURRENTLY HAVE A POSITION FOR A POSTDOCTORAL FELLOW (2021-2024) TO WORK ON A BHF-FUNDED PROJECT IN DIABETIC RETINOPATHY.

The aim of our laboratory is to understand how ageing and poor nutrition lead to development of diseases such as diabetes, cardiovascuar disease, cancer and other age-associated comorbidities. 

Recently one of our publications in which we compared two nutritional interventions, achievable in humans, on metabolic health was selected as the Editor's Choice: highlight in Ageing research by Scientific Reports (nature online journal).

Lab News

Congratulations to Mr Oliver Helk for successfully defending his PhD thesis on "Investigating the role of PTP1B in human health: a translational approach" in Dec 2020. Oliver is now the clinical associate professor at the Medical University of Vienna, Austria. Special thanks to his examiners Prof Faisal Kahn (University of Dundee) and Dr Antonio Gonzalez Sanchez (Rowett Institute). 

Congratulations to Ms Fabiana Baganha Carreiras for successfully defending her dual degree MoGlyNet Program Marie-Curie PhD thesis in Leiden and in Aberdeen (May 2020); 2 viva voce, 1 week apart. Online celebrations still managed to be fun!

Congratulations to Ms Sarah Kamli-Salino for successfully defending her Masters by Research (MRes) thesis (Feb 2020) and being awarded the Distinction! Hard work pays off; Sarah is now doing her PhD in the lab funded by MRS/AstraZeneca PhD studentship. Thanks to Sarah's examiners: Dr Paul Meakin (University of Leeds) and Dr Justin Rochford (Rowett Institute).

I recently run the Royal Parks Half Marathon (Oct 2019) raising funds for Diabetes UK; I managed to raise an amazing £1,521 for this great charity and the funds will go towards funding of new research into causes, treatment and care of diabetes! Thanks to all the supporters!!!!

 

Research Areas

Accepting PhDs

I am currently accepting PhDs in Biomedical Sciences, Nutrition and Health.


Please get in touch if you would like to discuss your research ideas further.

Email Me

Biomedical Sciences

Supervising
Accepting PhDs

Nutrition and Health

Supervising
Accepting PhDs

Research Specialisms

  • Nutrition
  • Biochemistry
  • Molecular Biology
  • Immunology
  • Diabetes

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Current Research

 Research Fellows 

Ruta Dekeryte (2014-2018) was awarded the competitive IMS PhD studentship  to work on the project investigating dietary and pharmacological approaches in combating cognitive dysfunction in models of Alzheimer's disease. Ruta is now working as Research Fellow in the lab on the Cohen Global Pharmaceuticals drug discovery project (2018-2022).

 Dr Andrew Mcewan (2019- 2022) is research fellow in the lab working on the Cohen Global Pharmaceuticals project. Andy obtained his PhD in chemistry from the University of St Andrews. 

Dr Azita Kouchmeshky (2021- ) is a research fellow in the lab working on the Cohen Global Pharmaceuticals project. Azita obtained her PhD in neuroscience from the University of Aberdeen and is working as the in vivo biologist. 

Meghan Hamer (2021-) is a research fellow in the lab working on the Cohen Global Pharmaceuticals project. Meghan is a peptide chemist working alongside Dr Sergio Dall'Angelo. Meghan did her PhD at the University of Strathclyde. 

 WE CURRENTLY HAVE A POSITION FOR A POSTDOCTORAL FELLOW (2021-2024) TO WORK ON A BHF-FUNDED PROJECT IN DIABETIC RETINOPATHY. 



Current PhD students

  Fiona Clegg is a SCREDS Clinical Lecturer in Gastroenterology, working towards her PhD in my lab. Fiona's research interests are in Gastroenterology and Hepatology, and particularly in liver fibrosis, hepatocarcinogenesis and non-alcoholic fatty liver disease (NAFLD).

Ms Sarah Kamli-Salino did her final year Honours project in our laboratory and obtained her BSc Hons in Physiology at the University of Aberdeen in 2018. She then did her 1-year MRes project (2018-2019) in our laboratory, testing novel drugs for treatment of cardiovascular disease, funded by the Development Trust. She is now funded by Medical Research Scotland/ Astra Zeneca (2019-2023) for her PhD studies on synthetic cannabinoids in diabetic nephropathy. 

Miss Besa Emini is a joint, dual degree PhD student at the University of Antwerp and University of Aberdeen, as a part of the MoglyNet EU  Consortium. She is working on novel drugs for treatment of atherosclerosis. 

Ms Abrar Othman is a PhD student (2019-2022) funded by the Saudi Arabian Cultural Bureau working on the role of PTP1B in macrophage signalling and inflammation. She obtained her Bachelor of Applied Medical Sciences at King Abdul-Aziz University (Jeddah, Saudi Arabia) and her Masters (Honours) of Clinical Biochemistry from the University of Manchester in 2016. 

Ms Marina Souza Matos is a Brazilian PhD student in the lab (2019-2022) funded by two separate PhD studentships (Elphinstone Scholarship and the IMS studentship), co-supervised by Prof Bettina Platt, and working on the role of essential amino acid signalling in cognitive function. She obtained her undergraduate in Pharmacy from the Federal University of Rio de Janeiro in 2016. She did her undergraduate internship at Beth Israel Deaconess Medical Centre, Harvard medical school, in the laboratory of Prof Hollenberg in 2015. In 2019, she obtained her Masters in Physiology from the Federal University of Rio de Janeiro. 

Lab technician

Ms Michela Donarumma joined our laboratory as the core lab technician in December 2020; prior to her joining the University of Aberdeen in 2010, Michela worked as a reseach assistant at Brigham and Women's Hospital in Boston, USA. 

Knowledge Exchange

Public Engagement in Research Awards

 To listen to our podcast on the panel dicussion organised for International Women's Day 2021 "Different Day Same Problem: Covid-19, Leadership and Inequality" follow this link: https://share.transistor.fm/s/05c80a76 

For the BHF Alumni organised panel discussion in which I took part on "The Future of the Lab after Covid-19" register here: https://alumni.bhf.org.uk/events/45004 

• Winner of the 2018 Wellcome Prize for Outstanding Achievement in Public Engagement in the Biomedical Sciences

• Joint winner: Public prize, Principal’s Prize for Public Engagement with Research 2018

• “Super Zena” (“Super Woman”) 2018 award at the First International Women’s conference, Bosnia and Hercegovina

•  Vitae (global leader in supporting the professional development of researchers) “Talking heads: PIs on mentoring research staff” project; invited speaker to help new PIs achieve most from their research staff; series of short online videos

• National Coordinating Centre for Public Outreach – recognized as 1 out of 20 top UK scientists in 2010 for their outreach activities.

 

Funding and Grants

Research Grants (active)

  • British Heart Foundation Project Grant (2021-2024):  Targetting PTP1B to prevent diabetic retinopathy; Principal Investigator (co-PI: Prof John Forrester, Dr Lucia Kuffova)
  • Chief Scientist Office (2020-2021): Rapid Research in Covid-19 programe (RARC-19 programme) (2020): Development of sensitive, rapid and high-throughput antibody assays for COVID-19; Principal Investigator (co-PI: Vertebrate Antibodies Ltd, NHS Grampian; UoA: Dr Nimesh Mody, Prof Graeme Murray)
  • British Heart Foundation Non-clinical PhD studentship (2021-2024): "Targeting myeloid PTP1B to prevent obesity related retinal microvascular disease" PI (co-PIs: Prof John Forrester, Dr Lucia Kuffova)
  • British Heart Foundation Project Grant  (2020-2023); The FPR2 ligand W-peptide: A new therapeutic approach to treat atherosclerosis. Co-PI (PI: Dr Dawn Thompson)
  • Medical Research Scotland PhD studentship (2019-2023): Principal Investigator (with Dr Heather Wilson as co-PI and Dr Denis Feliers, AstraZeneca industrial partnership).
  • Cohen Global Pharmaceuticals LLP: Commercial  Project (2018-2022): Principal Investigator; Commercial drug development project
  • Diabetes UK Project Grant (2018-2021) “Inhibition of macrophage PTP1B as a novel therapy for improved wound healing in diabetes" Principal Investigator (co-PI: Carvalho E., Wilson, H. M., Rajnicek, A. M.)
  • Tenovus Scotland (2018-2021): Characterising the role of FGF21 in hepatocarcinogenesis in humans; Co-PI (PI: Fiona Clegg; co-PIs: Graeme Murray, Mairi McLean)
  • Alzheimer’s Research UK Major Project Grant (2017-2022) “Neruronal hBACE1: the link between Alzheimer's disease and diabetes" Co-applicant (PI: Platt, B., co-PI: Riedel, G.)
  • British Heart Foundation Project Grant (2017-2021): "Synthetic derivatives of Fenretinide: a novel approach to prevent lipotoxicity, insulin resistance and vascular endothelial dysfunction" Co-applicant (PI: Dr Nimesh Mody; co-PI: Prof Matteo Zanda). 

Research Grants (completed)

       British Heart Foundation PhD studentship (2016-2019): “The regulation of phosphoprotein     enriched in astrocytes-15 in vascular smooth muscle cells”. Co-applicant (PI: Prof Graeme Nixon)

 

Teaching
Publications

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  • Hepatic protein tyrosine phosphatase 1B (PTP1B) deficiency protects against obesity-induced endothelial dysfunction

    Agouni, A., Tual-Chalot, S., Chalopin, M., Duluc, L., Mody, N., Martinez, M. C., Andriantsitohaina, R., Delibegovic, M.
    Biochemical Pharmacology, vol. 92, no. 4, pp. 607-617
    Contributions to Journals: Articles
  • Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21

    Lees, E. K., Krol, E., Grant, L., Shearer, K., Wyse, C., Moncur, E., Bykowska, A. S., Mody, N., Gettys, T., Delibegovic, M.
    Aging Cell, vol. 13, no. 5, pp. 817-827
    Contributions to Journals: Articles
  • Myeloid-Cell Protein Tyrosine Phosphatase-1B Deficiency in Mice Protects Against High-Fat Diet and Lipopolysaccharide-Induced Inflammation, Hyperinsulinemia, and Endotoxemia Through an IL-10 STAT3-Dependent Mechanism

    Grant, L., Shearer, K. D., Czopek, A., Lees, E. K., Owen, C., Agouni, A., Workman, J., Martin-Granados, C., Forrester, J. V., Wilson, H. M., Mody, N., Delibegovic, M.
    Diabetes, vol. 63, no. 2, pp. 456-470
    Contributions to Journals: Articles
  • Evidence for a role of executive functions in learning biology

    Rhodes, S. M., Booth, J. N., Campbell, L. E., Blythe, R. A., Wheate, N. J., Delibegovic, M.
    Infant and Child Development, vol. 23, no. 1, pp. 67-83
    Contributions to Journals: Articles
  • Inducible Liver-Specific Knockdown of Protein Tyrosine Phosphatase 1B Improves Glucose and Lipid Homeostasis in Adult Mice

    Owen, C., Lees, E. K., Grant, L., Zimmer, D. J., Mody, N., Bence, K. K., Delibegovic, M.
    Diabetologia, vol. 56, no. 10, pp. 2286-2296
    Contributions to Journals: Articles
  • High fat diet-induced deterioration of cognitive deficits in hBACE1 knock-in mouse model of Alzheimer’s disease, reversal by anti-obesity, anti-diabetes compound MN101

    Plucinska, K., Delibegovic, M., Mody, N., Shearer, K. D., McIlroy, G. D., Riedel, G., Platt, B.
    British Neuroscience Association Festival
    Contributions to Conferences: Posters
  • BACE1: The missing link between Alzheimer’s disease, diabetes and obesity?

    Plucinska, K., Delibegovic, M., Mody, N., Shearer, K. D., McIlroy, G. D., Riedel, G., Platt, B.
    Alzheimer Research UK
    Contributions to Conferences: Posters
  • BACE1: the missing link between Alzheimer's disease, diabetes and obesity?

    Plucinska, K., Delibegovic, M., Mody, N., Shearer, K. D., Riedel, G., Platt, B.
    Alzheimer Research UK
    Contributions to Conferences: Posters
  • Fenretinide Treatment Prevents Diet-Induced Obesity in Association With Major Alterations in Retinoid Homeostatic Gene Expression in Adipose, Liver and Hypothalamus

    McIlroy, G. D., Delibegovic, M., Owen, C., Stoney, P. N., Shearer, K. D., McCaffery, P. J., Mody, N.
    Diabetes, vol. 62, no. 3, pp. 825-836
    Contributions to Journals: Articles
  • PTP1B in the periphery: regulating insulin sensitivity and ER stress

    Delibegovic, M., Mody, N.
    Protein tyrosine phosphatase control of metabolism. Bence, K. K. (ed.). Springer, pp. 91-105, 15 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

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