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The Institute of Medical Sciences

Dr Charles Harrington

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Dr Charles Harrington
Dr Charles Harrington
Dr Charles Harrington

BSc (Hons) (Glasgow, 1977); PhD (Glasgow, 1980)

Senior Research Fellow

About
Email Address
c.harrington@abdn.ac.uk
Telephone Number
+44 (0)1224 438563
Office Address

Liberty Building, Institute of Medical Sciences, Foresterhill Road, Aberdeen AB25 2ZP United Kingdom

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

Charlie Harrington graduated in Microbiology from Glasgow University where he developed an interest in chemical microbiology and the study of microbial cell walls. He completed his PhD working with Dr Julia Douglas on cell wall synthesis in yeast and followed with a one-year NIH-funded Fellowship with Dr Wilf Arnold in Kansas City, Missouri studying enzymes within the yeast cell envelope. After this, Charlie joined Professor Sir James Baddiley in the Department of Biochemistry at the University of Cambridge as a Research Fellow, where he spent four years investigating the synthesis of bacterial cell wall polymers. Dr Harrington then spent over two years at Murex Medical Research Ltd., Cambridge, developing diagnostic tests for microbial diseases, including methicillin-resistant Staphylococcus aureus and sexually transmitted diseases. This combined monoclonal antibody technology with his knowledge of the microbial cell surface.

In 1988, he joined Claude Wischik working at the Medical Research Council’s Laboratory of Molecular Biology. Working in the Cambridge Brain Bank Laboratory over a period of 10 years. During this time, Wischik, Harrington and colleagues developed an assay for screening agents having the potential to prevent the tau pathology that is the hallmark of Alzheimer’s disease. Charlie moved with Professor Wischik, in 1998, to the University of Aberdeen, where he was appointed as a Senior Research Fellow.

The Alzheimer's research was translated to the clinic, through a spin-out company, TauRx Therapeutics, who are conducting phase 3 trials of hydromethylthionine.  Dr Harrington is Chief Scientific Officer for TauRx Therapeutics Ltd responsible for the non-clinical activities of the company.

Qualifications

  • BSc (Hons) Microbiology 
    1977 - University of Glasgow 
  • PhD Microbiology 
    1980 - University of Glasgow 

Latest Publications

View My Publications

Research

Research Overview

Dr Harrington has research interests in the neurodegenerative diseases and, in particular, Alzheimer’s disease. His main focus has been on the biology of tau protein in aging and in Alzheimer’s disease. Dr Harrington’s research is aimed at diseases that are characterised by protein aggregation and methods by which these processes might be prevented.

Publications

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  • Stripline resonator and preamplifier for preclinical magnetic resonance imaging at 4.7 T

    Lavdas, I., Seton, H., Harrington, C. R., Wischik, C. M.
    Magnetic Resonance Materials in Physics, Biology and Medicine, vol. 24, no. 6, pp. 331-337
    Contributions to Journals: Articles

  • 3,6-Disubstituted xanthylium salts

    Clunas, S., Storey, J. M. D., Horsley, D., Rickard, J. E., Harrington, C. R., Wischik, C. M.
    Patents: Patents

  • Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC): methods of treatment of a tauopathy condition comprising the use of thioninium compounds

    Wischik, C. M., Rickard, J. E., Harrington, C. R., Horsley, D., Storey, J. M. D., Marshall, C., Sinclair, J. P.
    Patents: Patents

  • Ligands for aggregated tau molecules: WO2010034982

    Kemp, S. J., Storey, J. M. D., Rickard, J. E., Harrington, C. R., Horsley, D., Wischik, C. M., Clunas, S., Heinrich, T.
    Patents: Patents

  • Rationale for tau aggregation inhibitor therapy in Alzheimer's disease and other tauopathies

    Wischik, C. M., Wischik, D. J., Storey, J. M. D., Harrington, C. R.
    Emerging drugs and targets for Alzheimer's disease: Volume 1: Beta-Amyloid, Tau Protein and Glucose Metabolism. Martinez, A. (ed.), pp. 210-232, 23 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Lewy body variant of Alzheimer's disease: selective neocortical loss of t-SNARE proteins and loss of MAP2 and alpha-synuclein in medial temporal lobe

    Mukaetova-Ladinska, E. B., Xuereb, J. H., Garcia-Sierra, F., Hurt, J., Gertz, H. J., Hills, R., Brayne, C., Huppert, F. A., Paykel, E. S., McGee, M. A., Jakes, R., Honer, W. G., Harrington, C. R., Wischik, C. M., CC75C Collaboration Group
    The Scientific World Journal, vol. 9, pp. 1463-1475
    Contributions to Journals: Articles

  • What is the molecular pathology that underlies hippocampal memory decline?

    Harrington, C. R.
    Journal of Neurology, Neurosurgery & Psychiatry, vol. 80, no. 7, pp. 703
    Contributions to Journals: Editorials

  • Therapeutic Use of Diaminophenothiazines: WO2009044127

    Wischik, C. M., Damon J., W., Storey, J. M. D., Harrington, C. R.
    Patents: Patents

  • Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine

    Deiana, S., Harrington, C. R., Wischik, C. M., Riedel, G.
    Psychopharmacology, vol. 202, no. 1-3, pp. 53-65
    Contributions to Journals: Articles

  • Thiazin red as a neuropathological tool for the rapid diagnosis of Alzheimer's disease in tissue imprints

    Luna-Munoz, J., Peralta-Ramirez, J., Chavez-Macias, L., Harrington, C. R., Wischik, C. M., Mena, R.
    Acta Neuropathologica, vol. 116, no. 5, pp. 507-515
    Contributions to Journals: Articles

  • Inhibitors of protein aggregation: WO2007110629

    Wischik, C. M., Rickard, J. E., Horsley, D., Harrington, C. R.
    Patents: Patents

  • Characteristics of neuronal lipofuscin in the superior temporal gyrus in Alzheimers disease do not differ from non-diseased controls: a comparison with disease-related changes in the superior frontal gyrus

    Mountjoy, C., Dowson, J. H., Harrington, C. R., Cairns, M. R., Wilton-Cox, H.
    Acta Neuropathologica, vol. 109, no. 5, pp. 490-496
    Contributions to Journals: Articles

  • Inhibition of tau-tau-association

    Wischik, C. M., Edwards, P. C., Harrington, C. R., Roth, M., Klug, A.
    Patents: Patents

  • Alzheimer's disease

    Wischik, C. M., Harrington, C. R., Roth, M.
    The Oxford Companion to The Mind. Gregory, R. (ed.). 2 edition. Oxford University Press, pp. 24-27, 4 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Naphthoquinone-type inhibitors of protein aggregation

    Wischik, C. M., Horsley, D., Rickard, J. E., Harrington, C. R.
    Patents: Patents

  • Materials and methods relating to protein aggregation in neurodegenerative disease: WO2002059150

    Wischik, C. M., Rickard, J. E., Horsley, D., Harrington, C. R.
    Patents: Patents

  • Loss of synaptic but not cytoskeletal proteins in the cerebellum of chronic schizophrenics

    Mukaetova-Ladinska, E. B., Hurt, J., Honer, W. G., Harrington, C. R., Wischik, C. M.
    Neuroscience Letters, vol. 317, no. 3, pp. 161-165
    Contributions to Journals: Articles

  • Inhibition of tau-tau-association

    Wischik, C. M., Edwards, P. C., Harrington, C. R., Roth, M., Klug, A.
    Patents: Patents

  • Materials and methods relating to protein aggregation in neurodegenerative disease: WO2002055720

    Wischik, C. M., Horsley, D., Rickard, J. E., Harrington, C. R.
    Patents: Patents

  • Neurofibrillary labels

    Wischik, C. M., Harrington, C. R., Rickard, J. E., Horsley, D.
    Patents: Patents

  • Accumulation of C-terminally truncated tau protein associated with vulnerability of the perforant pathway in early stages of neurofibrillary pathology in Alzheimer’s disease

    Garcia-Sierra, F., Wischik, C. M., Harrington, C. R., Luna-Munoz, J., Mena, R.
    Journal of Chemical Neuroanatomy, vol. 22, no. 1-2, pp. 65-77
    Contributions to Journals: Articles

  • Loss of synaptic, but not cytoskeletal proteins in the cerebellum of people with chronic schizophrenia

    Mukaetova-Ladinska, E. B., Hurt, J., Honer, W. G., Harrington, C. R., Wischik, C. M.
    Schizophrenia Research, vol. 49, no. Suppl. 1, pp. 55
    Contributions to Journals: Abstracts

  • The molecular basis of tau protein pathology in Alzheimer's Disease and related neurodegenerative dementias

    Wischik, C. M., Theuring, F., Harrington, C. R.
    Neurobiology of Alzheimer’s Disease. Dawbarn, D., Allen, S. (eds.). 2 edition. Oxford University Press
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Dementia with Lewy bodies

    Harrington, C. R.
    The Encyclopedia of Aging. A Comprehensive Resource in Gerontology and Geriatrics, 3rd Edition. G.L. Maddox, et al., Editors. Springer Publishing Company, New York, pp. 280-282, 2 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Prion diseases

    Harrington, C. R.
    The Encyclopedia of Aging: A Comprehensive Resource in Gerontology and Geriatrics. Maddox, G. (ed.). 3 edition. Springer, pp. 817-819, 3 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
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