Professor Stefan Hoppler

Professor Stefan Hoppler
Professor Stefan Hoppler
Professor Stefan Hoppler

University Diploma (equiv. to MSc) in Zoology and Molecular Biology, Univ. of Zürich, Switzerland. Dr. phil. II (equiv. to Ph.D.) in Zoology, Univ. of Zürich, Switzerland

Personal Chair

Email Address
Telephone Number
+44 (0)1224 437383
Office Address


Institute of Medical Sciences (6.22)

School of Medicine, Medical Sciences & Nutrition

Foresterhill Health Campus

ABERDEEN, AB25 2ZD, Scotland, UK

School of Medicine, Medical Sciences and Nutrition


Born and brought up in Winterthur, Switzerland. Undergraduate studies in Zoology and Molecular Biology at the University of Zürich, Switzerland.  Postgraduate studies in Zürich and at the M.R.C. Laboratory of Molecular Biology in Cambridge, UK with Dr. Mariann Bienz on the function of homeotic genes and wingless signalling in Drosophila midgut development. 

Postdoc with Prof. Randall Moon at the University of Washington in Seattle, U.S.A. studying Wnt signalling in early amphibian development (Publications). Postdoct. Research Assistant with Dr. Enrique Amaya, Univ. of Cambridge, U.K.. Principal Investigator at Wellcome Trust Biocentre, University of Dundee.

With the University of Aberdeen since summer 2003. Promotion to Reader (~Associate Professor) in 2006. Promotion to full Professor in 2012.

Memberships and Affiliations

Internal Memberships

Aberdeen Developmental Biology Group

Aberdeen Cardiovascular and Diabetes Centre

External Memberships

Genetics Society (committee member since 2017), Scientific Meetings Secretary (from 2021)
British Society for Developmental Biology (Committee Member 2005-2010, and Meeting Organiser 2005 and 2011)
Society for Developmental Biology (North America)
International Society for Developmental Biologists
International Society of Differentiation
Biochemical Society (UK)
Anatomical Society of Great Britain and Ireland


Panel Member UKRI-BBSRC Collaborative Training Collaborative Training Partnerships (CTP2) Programme Assessment Panel (2021)
BBSRC Committee C, appointed core member 2016 - 2020


Editorial Board of Genes (MDPI publishers) (from 2020)
Editorial Board of the journal Developmental Dynamics (2009 - 2015)
Editorial Board of the journal Hereditas (since 2015)


Latest Publications

View My Publications

Prizes and Awards

·      Royal Society/Leverhulme Senior Research Fellowship, 2020.

·      William Evans Visiting Fellowship, University of Otago, New Zealand (2011)

·      Royal Society of Edinburgh, International Exchange Fellowship (2011)

·      Wellcome Trust Research Career Development Fellowship (1997)

·      EMBO Fellowship Award (1994)

·      Max Perutz Prize for Graduate Studies (1993)



Research Overview

The tissues and organs of developing embryos are organised by cell-to-cell signalling. These interactions are mediated by a relatively small number of signalling molecules. These signals are repeatedly used at different stages of development and in different tissues of the embryo. Wnts are one important class of such signalling molecules. They are secreted glycoproteins which function as cell-to-cell signals in develomental processes in all multicellular animals examined. Abnormally activated Wnt signalling is also involved in certain types of tumours such as breast and colon cancer.

We want to understand the normal role of Wnt signalling in patterning the developing vertebrate embryo. Where and when are Wnts used during embryogenesis and what is their function in different organs and at different stages? We have recently analysed the molecular mechanisms of tissue-specific Wnt signalling and are currently studying Wnt function in heart and brain development. We use Xenopus as our model system and apply modern techniques, such as transgenesis and antisense oligos. We also using human Embryonic Stem Cells to model the functional role of Wnt signalling in heart muscle differentiation.

Funding and Grants

 Current Grant Funding:

British Heart Foundation non-clinical studentship “Wnt Signalling Response to Myocardial Infarction”, £123,883, Aug 2020 – July 2023

BBSRC Project Grant “Diversification of Vertebrate Tcf Structure and Function”, £503,452, July 2020 – July 2023

British Heart Foundation Project Grant, Applicants: Adam Lynch and S. Hoppler, “Characterisation of a Novel Selectable Cell-Surface Regulator of Cardiovascular Progenitors for Stem Cell-Mediated Regeneration”, £196,608 Oct 2019 – Dec 2021

British Heart Foundation Programme Grant, Applicant: S. Hoppler (7.4hrs/week), "How does Wnt control gene-regulatory networks to coordinate cardiomyocyte differentiation", £1,006,869, Principal Investigator, Aug. 2018 – Jul. 2023



Page 3 of 5 Results 21 to 30 of 43

  • Wnt Signaling in Heart Organogenesis

    Hoppler, S., Mazzotta, S., Kühl, M.
    Wnt Signaling in Development and Disease: Molecular Mechanisms and Biological Functions. John Wiley & Sons Ltd., pp. 293-301, 9 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
  • sfrp1 promotes cardiomyocyte differentiation in Xenopus via negative-feedback regulation of Wnt signalling

    Gibb, N., Lavery, D. L., Hoppler, S.
    Development, vol. 140, no. 7, pp. 1537-1549
    Contributions to Journals: Articles
  • The Wnt signaling mediator tcf1 is required for expression of foxd3 during Xenopus gastrulation

    Janssens, S., van den Broekm, O., Davenport, I. R., Akkers, R. C., Liu, F., Veenstr, G. J. C., Hoppler, S., Vleminckx, K., Destree, O.
    International Journal of Developmental Biology, vol. 57, no. 1, pp. 49-54
    Contributions to Journals: Articles
  • Different requirements for GATA factors in cardiogenesis are mediated by non-canonical Wnt signaling

    Afouda, B. A., Hoppler, S.
    Developmental Dynamics, vol. 240, no. 3, pp. 649-662
    Contributions to Journals: Articles
  • Cardiac MHCα expression in Xenopus

    Hoppler, S., Afouda, B. A.
    Development, vol. 137, pp. 3-4
    Contributions to Journals: Comments and Debates
  • Crosstalk between Wnt and bone morphogenic protein signaling: A turbulent relationship

    Itasaki, N., Hoppler, S.
    Developmental Dynamics, vol. 239, no. 1, pp. 16-33
    Contributions to Journals: Literature Reviews
  • Role of an aquaporin in the sheep tick Ixodes ricinus: assessment as a potential control target

    Campbell, E. M., Burdin, M., Hoppler, S., Bowman, A. S.
    International Journal for Parasitology, vol. 40, no. 1, pp. 15-23
    Contributions to Journals: Articles
  • Wnt/β-catenin signalling regulates cardiomyogenesis via GATA transcription factors

    Martin, J., Afouda, B. A., Hoppler, S.
    Journal of Anatomy, vol. 216, no. 1, pp. 92-107
    Contributions to Journals: Articles
  • Xenopus explants as an experimental model system for studying heart development

    Afouda, B. A., Hoppler, S.
    Trends in Cardiovascular Medicine, vol. 19, no. 7, pp. 220-226
    Contributions to Journals: Literature Reviews
  • 13-P107 GATA transcription factors integrate Wnt signaling during heart development

    Afouda, B. A., Patient, R. K., Hoppler, S.
    Mechanisms of Development, vol. 126, no. Supplement, pp. S227
    Contributions to Journals: Abstracts
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Books and Reports

Chapters in Books, Reports and Conference Proceedings

Contributions to Journals