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Professor Heather Wallace

Professor Heather Wallace
BSc (Glasgow) PhD (Aberdeen) FRCPath FBTS FRSC FRSB FBPhS European Registered Toxicologist (ERT)

Professor in Biochemical Pharmacology and Toxicology

Overview
Professor Heather Wallace
Professor Heather Wallace

Contact Details

Telephone
work +44 (0)1224 437956
work +44 (0)1224 437948
Email
Address
The University of Aberdeen School of Medicine, Medical Science and Nutrition, Institute of Medical Sciences, Room 6:21, Foresterhill Aberdeen AB25 2ZD

Biography

Heather is Professor of Biochemical Pharmacology and Toxicology in the School of Medicine, Medical Sciences and Nutrition.   She teaches undergraduate and postgraduate courses in Toxicology, Pharmacology, Clinical Pharmacology and Drug Discovery and Development.  Heather runs the Bio-Business programmes for PG and UG students encouraging and promoting connections between academia and the pharmaceutical and biotechnology industry through the Kosterlitz Centre for Industrial Engagement (KCIE). She runs a research laboratory with a focus on discovering novel targets for intervention in cancer.  Her aim is to inspire students and to promote scientific excellence and innovation in their future careers.

Heather believes in giving back to science and is a strong supporter of learned societies having served on several executive committees and councils.  She is currently President of EUROTOX and is championing the training of toxicologists across Europe in order to provide appropriately trained toxicologists required by academia, industry and the regulatory communities.

Heather sits on several governmental committees as a toxicologist: the Committee for Carcinogenicity of Chemicals in Food, Consumer Products and the Environment (COC), Herbal Medicine Advisory Committee (HMAC), Paediatric Medicines Expert Advisory Group (MHRA), Specialty Advisory Committee (Toxicology) and is the UK CPD Advisor for Toxicology for the Royal College of Pathologists.  She is Vice-Chair of the CONTAM Panel at the European Food Safety Authority (EFSA) which assesses the risk to human health of chemical contaminants in food and feed.

 Heather's research interests cover cancer chemotherapy, chemoprevention and selective drug delivery.  Her work is focused around the polyamine pathway as a target for intervention to develop new cancer treatments.  Her research interests include pathways of cell death and oxidative stress.

Heather is a keen golfer and tennis player and enjoys walking and cycling. 

Qualifications

FRCPath, Toxicology Royal College of Pathologists 2004
PhD, Biochemistry University of Aberdeen 1979
BSc, Biochemistry University of Glasgow 1976

Memberships and Affiliations

Internal

Head of Kosterlitz Centre for Industrial Engagement

Member of PGT Committee for School of Medicine, Medical Sciences and Nutrition

External Examiner at Univerity of Galway

External Examiner at Dublin City University

External

President of EUROTOX

Editor-in-Chief of Toxicology Research

Vice Chair of CONTAM Panel at European Food Safety Authority (EFSA)

Member of Expert Advisory Group for MHRA - Paediatric Medicines

Member of Herbal Medicines Advisory Committee at MHRA - Vice Chair

Member of the Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment (COC) 

Examiner in Toxicology for Royal College of Pathologists 

Member of Specialty Advisory Committee (Toxicology) for Royal College of Pathologists  

CPD Advisor for UK for Royal College of Pathologists 

Research

Research Overview

 Professsor Wallace's research interests are the role of polyamines in cell growth and apoptosis (cell death) particularly in relation to the possible regulatory role played by the polyamines in malignancy.  The polyamine pathway is a potential target for the development of anticancer strategies including chemotherapeutic, chemoprevention and drug delivery systems.  Recent interests include the understanding the mechanism of chemoprevention of human cancers by drugs such as the non steroidal anti-inflammatory drugs (NSAIDs) and natural products, the development of polyamine analogues as novel chemotherapeutic agents and using the polyamine transport system for selective delivery of drugs. Further details can be found on the Polyamine Research Group web pages.

Teaching

Teaching Responsibilities

Programme Co-ordinator for MSc Clinical Pharmacology, MSc Drug Discovery and Development, MSc Bio-Business and Medical Sciences,  MRes Drug Discovery and BSc degrees with Bio-Business

Course co-ordinator of:

Bio-Business courses (BT1502, BT3502, BT4506, BT5506, BT5012, BT5508)

Drug Metabolism and Toxcology (MT5003)

Molecular Pharmacology (MT5024)

Research Methods (MT5515)

Induction course level 5 (MT5010)

Mechanisms of Disease and Principles of Chemotherapy (PA3802)

Molecular Toxicology (PA4302)

Teaching includes:

Cancer biology, cancer chemotherapy, cancer chemoprevention, drug resistance, molecular carcinogenesis, mutagenesis, toxicity of pesticides, toxicity in vitro, mechanisms of toxicity, cell signalling systems, anti-inflammatory drugs, critial appraisal, in vitro model systems, designing a research project

Publications

Publications 

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  • Risk to human health related to the presence of perfluorooctane sulfonic acid and perfluorooctanoic acid in food

    Knutsen, H. K., Alexander, J., Barregård, L., Bignami, M., Brüschweiler, B., Ceccatelli, S., Cottrill, B., Dinovi, M., Edler, L., Grasl-Kraupp, B., Hogstrand, C., Hoogenboom, L. (., Nebbia, C. S., Oswald, I. P., Petersen, A., Rose, M., Roudot, A., Vleminckx, C., Vollmer, G., Wallace, H., Bodin, L., Cravedi, J., Halldorsson, T. I., Haug, L. S., Johansson, N., van Loveren, H., Gergelova, P., Mackay, K., Levorato, S., van Manen, M., Schwerdtle, T., EFSA Panel on Contaminants in the Food Chain (CONTAM)

    EFSA Journal, vol. 16, no. 12, e05194

    Contributions to Journals: Articles

    Digital Object Identifier
    https://doi.org/10.2903/j.efsa.2018.5194
    Open Access
    http://aura.abdn.ac.uk/bitstream/2164/11758/1/_CONTAM_et_al_2018_EFSA_Journal.pdf

  • Risk for animal and human health related to the presence of dioxins and dioxin-like PCBs in feed and food

    Knutsen, H. K., Alexander, J., Barregård, L., Bignami, M., Brüschweiler, B., Ceccatelli, S., Cottrill, B., Dinovi, M., Edler, L., Grasl-Kraupp, B., Hogstrand, C., Nebbia, C. S., Oswald, I. P., Petersen, A., Rose, M., Roudot, A., Schwerdtle, T., Vleminckx, C., Vollmer, G., Wallace, H., Fürst, P., Håkansson, H., Halldorsson, T., Lundebye, A., Pohjanvirta, R., Rylander, L., Smith, A., van Loveren, H., Waalkens-Berendsen, I., Zeilmaker, M., Binaglia, M., Gómez Ruiz, J. ., Horváth, Z., Christoph, E., Ciccolallo, L., Ramos Bordajandi, L., Steinkellner, H., Hoogenboom, L. (., EFSA Panel on Contaminants in the Food Chain (CONTAM)

    EFSA Journal, vol. 16, no. 11, e05333

    Contributions to Journals: Articles

    Digital Object Identifier
    https://doi.org/10.2903/j.efsa.2018.5333
    Open Access
    http://aura.abdn.ac.uk/bitstream/2164/11483/1/_28CONTAM_29_et_al_2018_EFSA_Journal.pdf

  • Two Years On: How the Core Curriculum has Shaped Pharmacology Courses at the University of Aberdeen

    Tucker, S., Fleming, I. N., Hislop, J. N., Murray, F., Scott, D. A., Wallace, H. M.

    Contributions to Specialist Publications: Featured Articles

  • Risk to human and animal health related to the presence of 4,15‐diacetoxyscirpenol in food and feed

    Knutsen, H. K., Alexander, J., Barregård, L., Bignami, M., Brüschweiler, B., Ceccatelli, S., Cottrill, B., Dinovi, M., Grasl-Kraupp, B., Hogstrand, C., Hoogenboom, L. (., Nebbia, C. S., Oswald, I. P., Petersen, A., Rose, M., Roudot, A., Schwerdtle, T., Vleminckx, C., Vollmer, G., Wallace, H., De Saeger, S., Eriksen, G. S., Farmer, P., Fremy, J., Gong, Y. Y., Meyer, K., Parent-Massin, D., van Egmond, H., Altieri, A., Colombo, P., Horvath, Z., Levorato, S., Edler, L., EFSA Panel on Contaminants in the Food Chain (CONTAM)

    EFSA Journal, vol. 16, no. 8, e05367

    Contributions to Journals: Articles

    Digital Object Identifier
    https://doi.org/10.2903/j.efsa.2018.5367
    Open Access
    http://aura.abdn.ac.uk/bitstream/2164/10992/1/_28CONTAM_29_et_al_2018_EFSA_Journal.pdf

  • Update: methodological principles and scientific methods to be taken into account when establishing Reference Points for Action (RPAs) for non‐allowed pharmacologically active substances present in food of animal origin

    Knutsen, H. K., Alexander, J., Barregård, L., Bignami, M., Brüschweiler, B., Ceccatelli, S., Cottrill, B., Dinovi, M., Edler, L., Grasl-Kraupp, B., Hogstrand, C., Nebbia, C. S., Oswald, I. P., Petersen, A., Rose, M., Roudot, A., Schwerdtle, T., Vollmer, G., Vleminckx, C., Wallace, H., Filipič, M., Fürst, P., O'Keeffe, M., Penninks, A., Van Leeuwen, R., Baert, K., Hoogenboom, L. (., EFSA Panel on Contaminants in the Food Chain (CONTAM)

    EFSA Journal, vol. 16, no. 7, e05332

    Contributions to Journals: Articles

    Digital Object Identifier
    https://doi.org/10.2903/j.efsa.2018.5332
    Open Access
    http://aura.abdn.ac.uk/bitstream/2164/10993/1/Panel_29_et_al_2018_EFSA_Journal.pdf

  • Risks for animal health related to the presence of fumonisins, their modified forms and hidden forms in feed

    Knutsen, H. K., Alexander, J., Barregård, L., Bignami, M., Brüschweiler, B., Ceccatelli, S., Cottrill, B., Dinovi, M., Edler, L., Grasl-Kraupp, B., Hogstrand, C., Hoogenboom, L. (., Nebbia, C. S., Petersen, A., Rose, M., Roudot, A., Schwerdtle, T., Vleminckx, C., Vollmer, G., Wallace, H., Dall'Asta, C., Eriksen, G. S., Taranu, I., Altieri, A., Roldán-Torres, R., Oswald, I. P., EFSA Panel on Contaminants in the Food Chain (CONTAM)

    EFSA Journal, vol. 16, no. 5, e05242

    Contributions to Journals: Articles

    Digital Object Identifier
    https://doi.org/10.2903/j.efsa.2018.5242
    Open Access
    http://aura.abdn.ac.uk/bitstream/2164/10994/1/_28CONTAM_29_et_al_2018_EFSA_Journal.pdf

  • Update of the Scientific Opinion on opium alkaloids in poppy seeds

    Knutsen, H. K., Alexander, J., Barregård, L., Bignami, M., Brüschweiler, B., Ceccatelli, S., Cottrill, B., Dinovi, M., Edler, L., Grasl-Kraupp, B., Hogstrand, C., Hoogenboom, L. (., Nebbia, C. S., Oswald, I. P., Petersen, A., Rose, M., Roudot, A., Schwerdtle, T., Vollmer, G., Wallace, H., Benford, D., Calò, G., Dahan, A., Dusemund, B., Mulder, P., Németh‐Zámboriné, ., Arcella, D., Baert, K., Cascio, C., Levorato, S., Schutte, M., Vleminckx, C., EFSA Panel on Contaminants in the Food Chain (CONTAM)

    EFSA Journal, vol. 16, no. 5, e05243

    Contributions to Journals: Articles

    Digital Object Identifier
    https://doi.org/10.2903/j.efsa.2018.5243
    Open Access
    http://aura.abdn.ac.uk/bitstream/2164/10995/1/_28CONTAM_29_et_al_2018_EFSA_Journal.pdf

  • Risks to human and animal health related to the presence of moniliformin in food and feed

    Knutsen, H. K., Alexander, J., Barregård, L., Bignami, M., Brüschweiler, B., Ceccatelli, S., Cottrill, B., Dinovi, M., Grasl-Kraupp, B., Hogstrand, C., Hoogenboom, L. (., Nebbia, C. S., Oswald, I. P., Petersen, A., Rose, M., Roudot, A., Schwerdtle, T., Vleminckx, C., Vollmer, G., Wallace, H., De Saeger, S., Eriksen, G. S., Farmer, P., Fremy, J., Gong, Y. Y., Meyer, K., Naegeli, H., Parent-Massin, D., van Egmond, H., Altieri, A., Colombo, P., Eskola, M., van Manen, M., Edler, L., EFSA Panel on Contaminants in the Food Chain (CONTAM)

    EFSA Journal, vol. 16, no. 3, e05082

    Contributions to Journals: Articles

    Digital Object Identifier
    https://doi.org/10.2903/j.efsa.2018.5082
    Open Access
    http://aura.abdn.ac.uk/bitstream/2164/10996/1/_28CONTAM_29_et_al_2018_EFSA_Journal.pdf
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