Dr Fiona Campbell

Dr Fiona Campbell
Dr Fiona Campbell
Dr Fiona Campbell

Advanced Research Fellow

About

Biography

I am a principal investigator based at the Rowett Institute and coordinator of the PGT Human Nutrition MSc programme. My research focuses on advanced glycation end-products (AGEs) in the diet. During food processing AGEs are formed as the result of the Maillard reaction and are absorbed by the body during digestion. To investigate how dietary AGEs, contribute to diet induced conditions such as type 2 diabetes and dementia we are using human intervention studies to test the effects of highly processed foods high in AGEs on sensitive measures of metabolic health and cognition. I am also researching the role of processing methods in improving food quality and the potential for phytochemicals incorporated into processed foods to ameliorate negative health outcomes.

 

External Memberships

Member of the Nutrition Society,

Member of Biochemical Society,

Member of British Society for Proteome Resarch (BSPR).

Latest Publications

View My Publications

Research

Research Overview

A high-fat/sugar diet leads to the formation of Advanced Glycation End products (AGEs) in body tissues. AGEs cause damage and inflammation and are also absorbed from the diet particularly from processed foods. We are interested in how dietary AGEs contribute to diet induced conditions such as type 2 diabetes and cognitive decline.

Current Research

Current research in my laboratory is focused on  investigating damaged proteins/advanced glycation end-products (AGEs) in the diet.

During food processing AGEs are formed as the result of the Maillard reaction and are absorbed by the body in the course of digestion. AGEs are associated with the metabolic syndrome and dementia.  We aim to identify foods high in AGEs and test the effects of these foods on sensitive measures of metabolic health and cognition in human intervention studies.

In addition we are investigating the role of processing methods in improving food quality e.g. avoiding prolonged heat treatment of dairy products known to increase AGE formation. We are also determining the potential of phytochemicals incorporated into processed foods to ameliorate these negative metabolic outcomes.

This research could lead to the development of new functional foods and improvements to existing food products. It will also provide health professionals and the public with better information on how changes in diet can be beneficial.

This research is part of Scottish Government Strategic Research Programme funded through the Rural and Environment Science and Analytical Services (RESAS) division to advance the evidence base in the development of rural affairs, food and environment policies. 

Teaching

Teaching Responsibilities

Programme coordinator for MSc Human Nutrition

Course Coordinator for RN5001 Fundamentals of human nutrition and metabolism and RN5003 Foundations of Nutrition.

Publications

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  • Low fatty acid oxidation rates in isolated working hearts from PPAR alpha null mice does not impair functional recovery following ischemia

    Campbell, F. M., Kozak, R., Weinheimer, C. J., Courjois, M. R., Kelly, D. P., Lopaschuk, G. D.
    Diabetes, vol. 50, no. Suppl. 2, pp. A308-A309
    Contributions to Journals: Articles
  • PPAR alpha regulates cardiac energy metabolism by controlling malonyl CoA concentrations in the heart

    Campbell, F. M., Kozak, R., Wagner, A., Altarejos, J. Y., Dyck, J. R. B., Belke, D. D., Severson, D. L., Weinheimer, C. J., Courtois, M. R., Kelly, D. P., Lopaschuk, G. D.
    Journal of Molecular and Cellular Cardiology, vol. 33, no. 6, pp. A164
    Contributions to Journals: Articles
  • Preferential distribution of long chain polyunsaturated fatty acids in phospatidyl ethanolamine fraction of Guinea pig alveolar apical membranes

    Mukhopadhyay, S., Muimo, R., Campbell, F. M., Gordon, M. J., Monaghan, A. S., Dutta-Roy, A. K.
    Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 62, no. 6, pp. 341-348
    Contributions to Journals: Articles
  • Immunological manipulation of lactation

    Wilde, C. J., Addey, C. V. P., Campbell, F. M., Peaker, M.
    Chapters in Books, Reports and Conference Proceedings: Conference Proceedings
  • Differential distribution and metabolism of arachidonic acid and docosahexaenoic acid by human placental choriocarcinoma (BeWo) cells

    Crabtree, J. T., Gordon, M. J., Campbell, F. M., Dutta-Roy, A. K.
    Molecular & Cellular Biochemistry, vol. 185, no. 1-2, pp. 191-198
    Contributions to Journals: Articles
  • Detection and cellular localization of plasma membrane-associated and cytoplasmic fatty acid-binding proteins in human placenta

    Campbell, F. M., Bush, P. G., Veerkamp, J. H., Dutta-Roy, A. K.
    Placenta, vol. 19, no. 5-6, pp. 409-415
    Contributions to Journals: Articles
  • Interaction of free fatty acids with human leptin

    Campbell, F. M., Gordon, M. J., Hoggard, N., Dutta-Roy, A. K.
    Biochemical and Biophysical Research Communications, vol. 247, no. 3, pp. 654-658
    Contributions to Journals: Articles
  • Placental membrane fatty acid-binding protein preferentially binds arachidonic and docosahexaenoic acids

    Campbell, F. M., Gordon, M. J., Dutta-Roy, A. K.
    Life Sciences, vol. 63, no. 4, pp. 235-240
    Contributions to Journals: Articles
  • Preferential uptake of long-chain polyunsaturated fatty acids by human placental cells

    Campbell, F. M., Clohessy, A. M., Gordon, M. J., Dutta-Roy, A. K.
    Chapters in Books, Reports and Conference Proceedings: Conference Proceedings
  • Uptake of long chain fatty acids by human placental choriocarcinoma (BeWo) cells

    Campbell, F. M., Clohessy, A. M., Gordon, M. J., Page, K. R., Dutta-Roy, A. K.
    Journal of Lipid Research, vol. 38, no. 12, pp. 2558-2568
    Contributions to Journals: Articles
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