Dr Derryck Shewan
BSc (Aberdeen, 1991), PhD (London, 1994). Recipient of the College of Life Sciences and Medicine award for Excellence in Teaching, 2009 and of the Aberdeen University Students Association award for Most Accessible Lecturer (Champion for Disabilities), 201
Derryck Shewan graduated in Physiology from the University of Aberdeen in 1991, having gained a particular interest in the mechanisms of axon guidance. He undertook a studentship with Prof Jim Cohen at Guy’s Hospital Medical School, under the co-supervision of Prof Martin Berry, in the Developmental Neurobiology department, which has since evolved to the MRC Unit for Developmental Neurobiology at Hunt’s House, Kings College London. He gained his PhD in Anatomy and Cell Biology in 1994 having studied mechanisms of axon growth and regeneration, building up an appreciation of the changing nature of neuronal behaviour during development. In 1994 Dr Shewan was appointed a Research Fellow in Dr Cohen’s laboratory, which involved some time working with Dr Geneviève Rougon and her colleagues at the CNRS Faculté des Sciences de Luminy in Marseille. In 1997 he moved to the Department of Anatomy at the University of Cambridge as a Research Associate in Prof Christine Holt’s laboratory. Having spent 3 years studying the development of the visual system, Dr Shewan moved on in 2000 to the Department of Physiology at the University of Cambridge as a Research Associate in Professor James Fawcett’s laboratory. In 2001 he moved with Professor Fawcett’s group to he Cambridge Centre for Brain Repair. Dr Shewan was appointed Lecturer in Biomedical Sciences at the University of Aberdeen in 2003, and promoted to Senior Lecturer in 2006. He now forms part of the Aberdeen University Spinal Injury Research Group. He was afforded the College of Life Sciences and Medicine Award for Excellence in Teaching in 2009, nominated again in 2010, nominated for the Students Association award for Supporting Students in 2011 and afforded the Students Association award for most Accessible Lecturer (Champion for Disabilities) in 2016.
Dr Shewan is interested in the changing intracellular signalling mechanisms that accompany neuronal maturation. In particular, he focuses on the growth and regenerative capacities of embryonic and adult neurons in order to find differences that may help to explain why neurons of the central nervous system become incapable of regenerating after injury. A more detailed synopsis of Dr Shewan's work can be found at the Cell and Developmental Biology Research Theme at the University of Aberdeen.
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I am the co-ordinator of Biomedical Sciences Honours year research projects (BM4501, DB 4501, PA4501, PY4501 and SR4501).
Also at Level 4 I deliver lectures on axon guidance andÂ contributeÂ to courseÂ assessmentsÂ on theÂ HonoursÂ yearÂ coreÂ courseÂ onÂ AdvancedÂ Molecules,Â MembranesÂ andÂ CellsÂ (BM4004), as well as lecture on Sensory Systems and participate in the assessment of student seminars on Brain Function and Malfunction (AN4002).
At level 2Â IÂ presentÂ andÂ demonstrate on Foundation Skills for Life Sciences (BI2005) and also tutor and act as Theme leader for 'Nervous System Diseases' on the Research Skills for Life Sciences course (BI2506). I deliver lectures on Sensory Systems on Physiology of Human Cells (BI20B2).
I co-ordinate the DevelopMental Theme for the Phase 1 MBChB Student Selected Module 1.
IÂ participate in University Open,Â ApplicantÂ and Induction days, and host School visits for secondary school pupils.
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The therapeutic potential of targeting exchange protein directly activated by cyclic adenosine 3′,5′-monophosphate (Epac) for central nervous system traumaNeural Regeneration Research, vol. 16, no. 3, pp. 460-469Contributions to Journals: Review articles
Epac2 Elevation Reverses Inhibition by Chondroitin Sulfate Proteoglycans In Vitro and Transforms Postlesion Inhibitory Environment to Promote Axonal Outgrowth in an Ex Vivo Model of Spinal Cord InjuryJournal of Neuroscience, vol. 39, no. 42, pp. 8330-8346Contributions to Journals: Articles
The cAMP-producing agonist beraprost inhibits human vascular smooth muscle cell migration via exchange protein directly activated by cAMPCardiovascular Research, vol. 107, no. 4, pp. 546-555Contributions to Journals: Articles
Inception of an online skills resource for medical science undergraduates: The School of Medical Science Skills Support CentreContributions to Conferences: Posters
Development of interactive online resources to support and enhance numerical skills among Medical Science studentsUniversity of Aberdeen 6th Annual Teaching and Learning Symposium.Chapters in Books, Reports and Conference Proceedings: Conference Proceedings
Mammalian growth cone turning assays identify distinct cell signalling mechanisms that underlie axon growth, guidance and regenerationMethods in Molecular Biology. Humana Press pp. 167-178, 12 pages.Chapters in Books, Reports and Conference Proceedings: Conference Proceedings
VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasmNeuron, vol. 70, no. 5, pp. 951-965Contributions to Journals: Articles
New perspectives in cyclic AMP-mediated axon growth and guidance: the emerging epoch of EpacBrain Research Bulletin, vol. 84, no. 4-5, pp. 280-288Contributions to Journals: Special Issues
cAMP-Dependent Axon Guidance is Distinctly Regulated by Epac and Protein Kinase AJournal of Neuroscience, vol. 29, no. 49, pp. 15434-15444Contributions to Journals: Articles
cGMP promotes neurite outgrowth and growth cone turning and improves axon regeneration on spinal cord tissue in combination with cAMPBrain Research, vol. 1294, pp. 12-21Contributions to Journals: Articles