Professor Mark Vickers

Professor Mark Vickers
Professor Mark Vickers
Professor Mark Vickers

MBChB MRCP DM FRCPath

Chair in Applied Medicine (Clin)

About
Email Address
m.a.vickers@abdn.ac.uk
Telephone Number
+44 (0)1224 272401
Office Address

1. Room 3:25, Institute of Medical Sciences

2. Blood Transfusion Centre, Foresterhill Road, Aberdeen AB25 2ZW

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

I graduated from Oxford Medical School in 1983, having completed a Biochemistry Part II at Cambridge. After general medical jobs in London, I worked with Doug Higgs on genes surrounding the alpha-globin gene cluster. I then trained in clinical Haematology at the Hammersmith, Reading and John Radcliffe Hospitals (1990–1996). I moved to Aberdeen in 1996 and was promoted to Professor in the section of Applied Medicine in 2008. I took over directorship of the Academic Transfusion Medicine Unit in 2010.

External Memberships

Member of Royal College of Physicians

Fellow of Royal College of Pathologists

British Society for Haematology

 

Research

Research Overview

My main current interest is in how cells are recognised as being damaged by phagocytes, using red blood cells as the main model system. Our work has implicated unusual glycosylation motifs as being key to the process and are of particular relevance to the mechanism of haemolysis in sickle cell disease and malaria. The mechanism gives insight into splenic function, notably susceptibility to pneumococcal infection. I have interests in cellular immunotherapy, including the use of blood donor derived cytotoxic lymphocytes to treat post-transplant lympoproliferative disease and COVID-19. I am supervising PhD students developing innate immunotherapeutic reagents to treat cancers. I am also involved in collection and use of convalescent plasma for COVID-19.My main current interest is in how cells are recognised as being damaged by phagocytes, using red blood cells as the main model system. Our work has implicated unusual glycosylation motifs as being key to the process and are of particular relevance to the mechanism of haemolysis in sickle cell disease and malaria.  The mechanism gives insight into splenic function, notably susceptibility to pneumococcal infection.  I have interests in cellular immunotherapy, including the use of blood donor derived cytotoxic lymphocytes to treat post-transplant lympoproliferative disease and COVID-19.  I am supervising PhD students developing innate immunotherapeutic reagents to treat cancers.  I am also involved in collection and use of convalescent plasma for COVID-19.

 

Knowledge Exchange

I have given talks about the use of convalescent plasma and T cells to treat COVID-19.

Collaborations

Prof. Alex Rowe, Edinburgh University.

Prof. Stuart Haslam, Imperial College London.

Prof. David Rees, King's College London.

Supervision

Shiva Nickaria, Raquel Ferro, Ellen Main - all working on immunotherapies.

Teaching

Teaching Responsibilities

I organise, and deliver much of, the haematology training in the medical school.  I remain an enthusiastic bedside teacher.  I co-ordinated the third year medical degree 1997-2010.

Publications

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  • Combination peptide immunotherapy suppresses antibody and helper T cell responses to the RhD protein in HLA-transgenic mice

    Vickers, M. A., Hall, L. S., Hall, A. M., Pickford, W. J., Urbaniak, S. J., Barker, R. N.
    54th Annual Scientific Meeting of the British-Society-for-Haematology, pp. 12-12
    Contributions to Journals: Abstracts
  • Expansion of Foxp3+ T-cell populations by Candida albicans enhances both Th17-cell responses and fungal dissemination after intravenous challenge

    Whibley, N., Maccallum, D. M., Vickers, M. A., Zafreen, S., Waldmann, H., Hori, S., Gaffen, S. L., Gow, N. A. R., Barker, R. N., Hall, A. M.
    European Journal of Immunology, vol. 44, no. 4, pp. 1069-1083
    Contributions to Journals: Articles
  • The epidemiology of infectious mononucleosis in Northern Scotland: a decreasing incidence and winter peak

    Visser, E., Milne, D., Collacott, I., McLernon, D., Counsell, C., Vickers, M.
    BMC Infectious Diseases, vol. 14, 151
    Contributions to Journals: Articles
  • Combination peptide immunotherapy suppresses antibody and helper T cell responses to the RhD protein in HLA-transgenic mice

    Hall, L. S., Hall, A. M., Pickford, W., Vickers, M. A., Urbaniak, S. J., Barker, R. N.
    Haematologica, vol. 99, no. 3, pp. 588-596
    Contributions to Journals: Articles
  • Systematic review and meta-analysis of the sero-epidemiological association between Epstein-Barr virus and systemic lupus erythematosus

    Hanlon, P., Avenell, A., Aucott, L., Vickers, M. A.
    Arthritis Research & Therapy, vol. 16, no. 1, R3
    Contributions to Journals: Articles
  • Quantitative variation in plasma angiotensin-i converting enzyme activity shows allelic heterogeneity in the ABO blood group locus

    Terao, C., Bayoumi, N., McKenzie, C. A., Zelenika, D., Muro, S., Mishima, M., Connell, J. M. C., Vickers, M. A., Mark Lathrop, G., Farrall, M., Matsuda, F., Keavney, B. D., The Nagahama Cohort Research Group
    Annals of Human Genetics, vol. 77, no. 6, pp. 465-471
    Contributions to Journals: Articles
  • The soluble isoform of CTLA-4 as a regulator of T-cell responses

    Ward, F. J., Dahal, L. N., Wijisekera, S. K., Abdul-Jawad, S. K., Kaewarpai, T., Xu, H., Vickers, M. A., Barker, R. N.
    European Journal of Immunology, vol. 43, no. 5, pp. 1274-1285
    Contributions to Journals: Articles
  • Systematic review and meta-analysis of the sero-epidemiological association between Epstein Barr virus and multiple sclerosis

    Almohmeed, Y. H., Avenell, A., Aucott, L., Vickers, M. A.
    PloS ONE, vol. 8, no. 4, e61110
    Contributions to Journals: Articles
  • Acute myeloid leukemia presenting in a mother and daughter pair with the identical acquired karyotypic abnormality consisting of inversion 3q21q26 and monosomy 7: a review of possible mechanisms

    Lawrie, A., Stevenson, D. A. J., Doig, T., Vickers, M., Culligan, D. J.
    Cancer Genetics and Cytogenetics, vol. 205, no. 11, pp. 599-602
    Contributions to Journals: Articles
  • Production of the effector cytokine interleukin-17, rather than interferon-γ, is more strongly associated with autoimmune hemolytic anemia

    Hall, A. M., Zamzami, O. M., Whibley, N., Hampsey, D. P., Haggart, A. M., Vickers, M. A., Barker, R. N.
    Haematologica, vol. 97, no. 10, pp. 1494-1500
    Contributions to Journals: Articles
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