Professor Mark Vickers

Professor Mark Vickers
MBChB MRCP DM FRCPath

Chair in Applied Medicine (Clin)

Overview

Contact Details

Telephone
work +44 (0)1224 272401
Email
Address
The University of Aberdeen 1. Room 3:25, Institute of Medical Sciences
2. Blood Transfusion Centre, Foresterhill Road, Aberdeen AB25 2ZW

Biography

I graduated from Oxford Medical School in 1983, having completed a Biochemistry Part II at Cambridge. After general medical jobs in London, I worked with Doug Higgs on genes surrounding the alpha-globin gene cluster. I then trained in clinical Haematology at the Hammersmith, Reading and John Radcliffe Hospitals (1990–1996). I moved to Aberdeen in 1996 and was promoted to Professor in the section of Applied Medicine in 2008. I took over directorship of the Academic Transfusion Medicine Unit in 2010.


External Memberships and Affiliations

Member of Royal College of Physicians

Fellow of Royal College of Pathologists

British Society for Haematology

 

Research

Research Overview

My main current interest is in how cells are recognised as being damaged by phagocytes, using red blood cells as the main model system. Our work has implicated unusual glycosylation motifs as being key to the process and are of particular relevance to the mechanism of haemolysis in sickle cell disease and malaria. The mechanism gives insight into splenic function, notably susceptibility to pneumococcal infection. I have interests in cellular immunotherapy, including the use of blood donor derived cytotoxic lymphocytes to treat post-transplant lympoproliferative disease and COVID-19. I am supervising PhD students developing innate immunotherapeutic reagents to treat cancers. I am also involved in collection and use of convalescent plasma for COVID-19.My main current interest is in how cells are recognised as being damaged by phagocytes, using red blood cells as the main model system. Our work has implicated unusual glycosylation motifs as being key to the process and are of particular relevance to the mechanism of haemolysis in sickle cell disease and malaria.  The mechanism gives insight into splenic function, notably susceptibility to pneumococcal infection.  I have interests in cellular immunotherapy, including the use of blood donor derived cytotoxic lymphocytes to treat post-transplant lympoproliferative disease and COVID-19.  I am supervising PhD students developing innate immunotherapeutic reagents to treat cancers.  I am also involved in collection and use of convalescent plasma for COVID-19.

 

Knowledge Exchange and Public Engagement

I have given talks about the use of convalescent plasma and T cells to treat COVID-19.

Collaborations

Prof. Alex Rowe, Edinburgh University.

Prof. Stuart Haslam, Imperial College London.

Prof. David Rees, King's College London.

Supervision

Shiva Nickaria, Raquel Ferro, Ellen Main - all working on immunotherapies.

Teaching

Teaching Responsibilities

I organise, and deliver much of, the haematology training in the medical school.  I remain an enthusiastic bedside teacher.  I co-ordinated the third year medical degree 1997-2010.

Publications

Publications 

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  • Oxidative stress, malaria, sickle cell disease, and innate immunity

    Cao, H., Vickers, M.

    Trends in Immunology

    Contributions to Journals: Articles

  • Low-Dose Vitamin D3 Supplementation Does Not Affect Natural Regulatory T Cell Population but Attenuates Seasonal Changes in T Cell-Produced IFN-γ: results from the D-SIRe2 randomised controlled trial

    Maboshe, W. F., MacDonald, H. M., Wassall, H., Fraser, W. D., Tang, J. C. Y., Fielding, S., Barker, R. N., Vickers, M. A., Ormerod, A., Thies, F.

    Frontiers in Immunology, vol. 12, 623087

    Contributions to Journals: Articles

  • Sialic acid‐binding immunoglobulin‐like lectin (Siglec)‐15 is a rapidly internalised cell‐surface antigen expressed by acute myeloid leukaemia cells

    Cao, H., Neerincx, A., de Bono, B., Lakner, U., Huntington, C., Elvin, J., Gudgin, E., Pridans, C., Vickers, M., Huntly, B., Trowsdale, J., Barrow, A.

    British Journal of Haematology, vol. 193, no. 5, pp. 946-950

    Contributions to Journals: Articles

  • Cytometric analysis of T cell phenotype using cytokine profiling for improved manufacturing of an EBV-specific T cell therapy

    Cooper, R., Kowalczuk, A., Wilkie, G., Vickers, M., Campbell, J., Turner, M., Fraser, A.

    Clinical and Experimental Immunology

    Contributions to Journals: Articles

  • Hyposplenism and gastrointestinal diseases: significance and mechanisms

    Mathur, A., McLean, M. H., Cao, H., Vickers, M. A.

    Digestive Diseases

    Contributions to Journals: Review articles

  • Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance

    Cao, H., Antonopoulos, A., Henderson, S., Wassall, H. J., Brewin, J., Masson, A., Shepherd, J., Konieczny, G., Patel, B., Williams, M., Davie, A., Forrester, M. A., Hall, L. S., Minter, B., Tampakis, D., Moss, M., Lennon, C., Pickford, W., Erwig, L., Robertson, B., Dell, A., Brown, G., Wilson, H., Rees, D. C., Haslam, S. M., Rowe, J. A., Barker, R., Vickers, M.

    Nature Communications, vol. 12, no. 1, 1792

    Contributions to Journals: Articles

  • Human erythrocyte surface fucose expression increases with age and hyperglycemia: [version 1; peer review: awaiting peer review]

    Cao, H., Bagchi, A., Tampakis, D., Laidvee, I., Williams, M., Minter, B., Wright, S., Antonopoulos, A., Haslam, S. M., Barker, R. N., Vickers, M.

    Wellcome open research, vol. 6, 28

    Contributions to Journals: Articles

  • High mannose N-glycans on red blood cells as phagocytic ligands, mediating both sickle cell anaemia and resistance to malaria

    Cao, H., Antonopoulos, A., Henderson, S., Wassall, H. J., Brewin, J., Masson, A., Shepherd, J., Konieczny, G., Patel, B., Williams, M., Davie, A., Forrester, M. A., Hall, L., Minter, B., Tampakis, D., Moss, M., Lennon, C., Pickford, W., Erwig, L., Robertson, B., Dell, A., Brown, G. D., Wilson, H., Rees, D. C., Haslam, S. M., Rowe, J. A., Barker, R., Vickers, M.

    bioRxiv

    Contributions to Journals: Articles

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