BSc (Hons) (Glasgow, 1977); PhD (Glasgow, 1980)
Senior Research Fellow
- About
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- Email Address
- c.harrington@abdn.ac.uk
- Telephone Number
- +44 (0)1224 438563
- Office Address
Liberty Building, Institute of Medical Sciences, Foresterhill Road, Aberdeen AB25 2ZP United Kingdom
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Charlie Harrington graduated in Microbiology from Glasgow University where he developed an interest in chemical microbiology and the study of microbial cell walls. He completed his PhD working with Dr Julia Douglas on cell wall synthesis in yeast and followed with a one-year NIH-funded Fellowship with Dr Wilf Arnold in Kansas City, Missouri studying enzymes within the yeast cell envelope. After this, Charlie joined Professor Sir James Baddiley in the Department of Biochemistry at the University of Cambridge as a Research Fellow, where he spent four years investigating the synthesis of bacterial cell wall polymers. Dr Harrington then spent over two years at Murex Medical Research Ltd., Cambridge, developing diagnostic tests for microbial diseases, including methicillin-resistant Staphylococcus aureus and sexually transmitted diseases. This combined monoclonal antibody technology with his knowledge of the microbial cell surface.
In 1988, he joined Claude Wischik working at the Medical Research Council’s Laboratory of Molecular Biology. Working in the Cambridge Brain Bank Laboratory over a period of 10 years. During this time, Wischik, Harrington and colleagues developed an assay for screening agents having the potential to prevent the tau pathology that is the hallmark of Alzheimer’s disease. Charlie moved with Professor Wischik, in 1998, to the University of Aberdeen, where he was appointed as a Senior Research Fellow.
The Alzheimer's research was translated to the clinic, through a spin-out company, TauRx Therapeutics, who are conducting phase 3 trials of hydromethylthionine. Dr Harrington is Chief Scientific Officer for TauRx Therapeutics Ltd responsible for the non-clinical activities of the company.
Qualifications
- BSc (Hons) Microbiology1977 - University of Glasgow
- PhD Microbiology1980 - University of Glasgow
Latest Publications
LETC inhibits α-Syn aggregation and ameliorates motor deficiencies in the L62 mouse model of synucleinopathy
European Journal of Pharmacology, 176505Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.ejphar.2024.176505
Apathy-like behaviour in tau mouse models of Alzheimer’s disease and frontotemporal dementia
Behavioural Brain Research, vol. 456, 114707Contributions to Journals: ArticlesA Meta-Analysis on Presynaptic Changes in Alzheimer's Disease
Journal of Alzheimer's Disease, vol. 97, no. 1, pp. 145-162Contributions to Journals: ArticlesSolubility of α-synuclein species in the L62 mouse model of synucleinopathy
Scientific Reports, vol. 14, no. 6239Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/s41598-024-56735-6
Exploring the Anti-Hypoxaemia Effect of Hydromethylthionine: A Prospective Study of Phase 3 Clinical Trial Participants
International Journal of Molecular Sciences, vol. 24, no. 18, 13747Contributions to Journals: Articles
- Research
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Research Overview
Dr Harrington has research interests in the neurodegenerative diseases and, in particular, Alzheimer’s disease. His main focus has been on the biology of tau protein in aging and in Alzheimer’s disease. Dr Harrington’s research is aimed at diseases that are characterised by protein aggregation and methods by which these processes might be prevented.
- Publications
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Page 8 of 10 Results 71 to 80 of 93
Thiazin red as a neuropathological tool for the rapid diagnosis of Alzheimer's disease in tissue imprints
Acta Neuropathologica, vol. 116, no. 5, pp. 507-515Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s00401-008-0431-x
Inhibitors of protein aggregation: WO2007110629
Patents: PatentsCharacteristics of neuronal lipofuscin in the superior temporal gyrus in Alzheimers disease do not differ from non-diseased controls: a comparison with disease-related changes in the superior frontal gyrus
Acta Neuropathologica, vol. 109, no. 5, pp. 490-496Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s00401-005-0993-9
Inhibition of tau-tau-association
Patents: PatentsAlzheimer's disease
The Oxford Companion to The Mind. Gregory, R. (ed.). 2 edition. Oxford University Press, pp. 24-27, 4 pagesChapters in Books, Reports and Conference Proceedings: ChaptersNaphthoquinone-type inhibitors of protein aggregation
Patents: PatentsMaterials and methods relating to protein aggregation in neurodegenerative disease: WO2002059150
Patents: PatentsLoss of synaptic but not cytoskeletal proteins in the cerebellum of chronic schizophrenics
Neuroscience Letters, vol. 317, no. 3, pp. 161-165Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0304-3940(01)02458-2
Inhibition of tau-tau-association
Patents: PatentsMaterials and methods relating to protein aggregation in neurodegenerative disease: WO2002055720
Patents: Patents