Professor Bettina Platt

Professor Bettina Platt
Professor Bettina Platt

Professor Bettina Platt

PhD (Dr rer. nat.), Dipl. Biol., FRSB

Chair in Translational Neuroscience

Accepting PhDs

About

Room 6.28; School of Medicine, Medical Sciences & Nutrition University of Aberdeen Institute of Medical Sciences Foresterhill ABERDEEN AB25 2ZD Scotland, UK

Biography

Bettina Platt graduated with distinction from the University of Mainz, Germany and received her PhD from the University of Düsseldorf, Germany. After completing a prestigious personal European Fellowship at the University of Leeds, Prof Platt joined the University of Aberdeen in 1997, initially within the Department of Biomedical Sciences. Since 2009, Prof Platt holds the Chair in Translational Neuroscience within the School of Medical Sciences. She heads a multi-disciplinary research team that investigates aspects of brain function and malfunction from the single molecule to the systems level. Prof Platt has acted as Research Director for a number of large research initiatives, some of which were co-funded by the pharmaceutical industry and the Scottish government. Her national and international collaborations have brought together novel research strategies, technologies and disciplines such as imaging, drug discovery, electronics, and computer science. Prof Platt is a Fellow of the Society of Biology and a founding member of the Scottish Dementia Research Consortium (SDRC). Additionally, Prof Platt was a member of the SDRC executive board until 2016 and previously sat on the Alzheimer’s Society funding board. She currently is a member of the Scottish Alzheimer Research UK (ARUK) network board, and the ARUK Scientific Advisory Board.

 

External Memberships

Executive Board member, Scottish Dementia Research Consortium

North-East of Scotland Alzheimer Research UK (ARUK) network coordinator (preclinical)

Member of the ARUK Scientific Advisory Board

Alzheimer’s Society Grant Advisory Board.

Editorial Advisory Board, Recent Patents on CNS Drug Discovery

Latest Publications

View My Publications

Research

Research Overview

Research interests: Alzheimer's disease and other dementias, mechanisms of neuronal plasticity, neurodegeneration and neuroprotection.

The amazing ability of the nervous system to learn and adapt to changing conditions forms the basis of our cognitive and intellectual abilities as humans, and how crucially we depend on this is demonstrated in patients suffering from neurodegenerative diseases such as Alzheimer's disease (AD).

We are currently combining various procedures, from standard histology and immunocytochemistry, to cell death essays and more functional techniques based on electrophysiological and imaging techniques, as well as behavioural studies. Latest developments include the use of EEG recordings, and PET/CT applications. Together, we cover aspects from the systems to the single cell level, and even to single receptors / channels, for disease target identification, drug development and testing within the sector of CNS diseases.

The main projects currently under investigation can be summarised as follows:

1)      Alzheimer’s disease and neurodegeneration: causes, biomarkers and treatments.

2)      Mechanisms of neuronal plasticity.

3)      Therapeutics in CNS disorders.

4)      Translational technologies.

 

Research Areas

Accepting PhDs

I am currently accepting PhDs in Biomedical Sciences.


Please get in touch if you would like to discuss your research ideas further.

Email Me

Biomedical Sciences

Supervising
Accepting PhDs

Research Specialisms

  • Biomedical Sciences
  • Neuroscience
  • Animal Physiology
  • Dementia Studies

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Current Research

Alzheimer's disease, FTD, dementia, cognition, neurodegeneration, neurotoxicity, neuroprotection, neuronal plasticity, EEG, imaging, Ca signalling, plasticity.

Techniques and Skills:

  • Models of dementia: transgenic, pharmacological & viral models in vivo and in vitro (beta amyloid, tau, PS1, BACE; single / double & triple combinations; siRNA).
  • Drug discovery
  • Translational Technologies
  • In vitro electrophysiological recording techniques in brain slices, neuronal cultures, and isolated neurones (patch-clamping and field recordings).
  • In vivo electrophysiological recordings (evoked potentials and EEG recordings (wireless).
  • In vivo imaging (PET/CT & MRI)
  • Behavioural assessments (Cognition & Phenotyper).
  • Immunocytochemical and histological techniques, ELISAs, Western Blots.
  • Confocal  / fluorescent microscopy.
  • Time-lapse imaging
  • Cell culture, brain slice, cell lines
  • Assays for cell death / neuroprotection  / viability

Collaborations

1)      Within Aberdeen University:

Prof Gernot Riedel (animal models / behaviour); Prof Roger Pertwee (cannabinoids); Prof Matteo Zanda (novel PET ligands); Dr Rod Scott  & Prof Marcel Jaspars (natural toxins and cell transfection); Dr Derryck Shewan (neurite outgrowth / time lapse); Prof Andy Welch (PET/CT); Dr Hugh Seton (MRI); Dr Thiel, Dr Schelter & Prof Grebogi (Computer Science & Modelling); Dr Delibegovic & Dr Mody (phosphatases; diabetes and AD)

2)      External Collaborators:

Prof Peer Wulff (viral strategies); Prof Jim Austin (University of York): EEG and image analyses, data sharing; Prof. Thanos Salifoglou (University of Crete, Greece): Aluminium speciation and toxicity; Prof. J. Micheau (Univ. Bordeaux II): CREB and hippocampal function, cell transfection, siRNA; Dr. Grazina Niewadomska (Univ. Warsaw, Poland): Tau pathology; Dr K. Bruce (U Penn., USA) and Dr Neel (U Ontario): Phosphatase knock-out mice.

3)      Industry-based collaborators

Dr Karsten Wicke (Abbott / AbbVie), B Cruts (BrainMarker, The Netherlands), Dr Hong Wan (Pfizer), J McAvoy (Cybula) and Prof Hugh Marston (Lilly).

Teaching

Teaching Responsibilities

Course co-ordinator for AN4002/AN4003 (Brain function & malfunction)

Publications

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  • Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline

    Koss, D. J., Jones, G., Cranston, A., Gardner, H., Kanaan, N. M., Platt, B.
    Acta Neuropathologica, vol. 132, no. 6, pp. 875–895
    Contributions to Journals: Articles
  • Mutant Tau knock-in mice display frontotemporal dementia relevant behaviour and histopathology

    Koss, D. J., Robinson, L., Drever, B. D., Plucinska, K., Stoppelkamp, S., Veselcic, P., Riedel, G., Platt, B.
    Neurobiology of Disease, vol. 91, pp. 105-123
    Contributions to Journals: Articles
  • Neuronal human BACE1 knock-in induces systemic diabetes in mice

    Plucinska, K., Dekeryte, R., Koss, D., Shearer, K., Mody, N., Whitfield, P. D., Doherty, M. K., Mingarelli, M., Welch, A., Riedel, G., Delibegovic, M., Platt, B.
    Diabetologia, vol. 59, no. 7, pp. 1513-1523
    Contributions to Journals: Articles
  • Time-variant estimation of connectivity and Kalman's filter

    Sommerlade, L., Thiel, M., Platt, B., Plano, A., Riedel, G., Grebogi, C., Mader, W., Mader, M., Timmer, J., Schelter, B.
    Methods in Brain Connectivity Inference through Multivariate Time Series Analysis. Sameshima, K., Baccala, L. A. (eds.). CRC Press, pp. 161-177, 17 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
  • Investigation of a Type 2 diabetes-like phenotype in a mouse model of Alzheimer's disease

    Dekeryte, R., Plucinska, K., Koss, D., Shearer, K., Mody, N., Riedel, G., Platt, B., Delibegovic, M.
    Diabetic Medicine, vol. 33, no. Suppl. 1, pp. 82
    Contributions to Journals: Abstracts
  • Polymeric alkylpyridinium salts permit intracellular delivery of human Tau in rat hippocampal neurons: requirement of Tau phosphorylation for functional deficits

    Koss, D. J., Robinson, L., Mietelska-Porowska, A., Gasiorowska, A., Sepcic, K., Turk, T., Jaspars, M., Niewiadomska, G., Scott, R. H., Platt, B., Riedel, G.
    Cellular and Molecular Life Sciences, vol. 72, no. 23, pp. 4613-4632
    Contributions to Journals: Articles
  • Progressive age-related changes in sleep and EEG profiles in the PLB1(Triple) mouse model of Alzheimer's disease

    Jyoti, A., Plano, A., Riedel, G., Platt, B.
    Neurobiology of Aging, vol. 36, no. 10, pp. 2768-2784
    Contributions to Journals: Articles
  • On the identification of sleep stages in mouse electroencephalography time-series

    Lampert, T., Plano, A., Austin, J., Platt, B.
    Journal of Neuroscience Methods, vol. 246, pp. 52-64
    Contributions to Journals: Articles
  • Modulation of food consumption and sleep-wake cycle in mice by the neutral CB1 antagonist ABD459

    Goonawardena, A. V., Plano, A., Robinson, L., Ross, R., Greig, I., Pertwee, R. G., Hampson, R. E., Platt, B., Riedel, G.
    Behavioural Pharmacology, vol. 26, no. 3, pp. 289-303
    Contributions to Journals: Articles
  • Assessing the strength of directed influences among neural signals: An approach to noisy data

    Sommerlade, L., Thiel, M., Mader, M., Mader, W., Timmer, J., Platt, B., Schelter, B.
    Journal of Neuroscience Methods, vol. 239, pp. 47-64
    Contributions to Journals: Articles

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