Dr Arimantas Lionikas

Dr Arimantas Lionikas
Dr Arimantas Lionikas
Dr Arimantas Lionikas

Senior Lecturer

About
Email Address
a.lionikas@abdn.ac.uk
Telephone Number
+44 (0)1224 438025
Office Address

School of Medicine, Medical Sciences and Nutrition

IMS Building, Room 2:21

University of Aberdeen Foresterhill Aberdeen AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

I am senior lecturer at the school of Medicine, Medical Sciences and Nutrition, teaching topics related to physiology, genetics, and sports science. I also conduct research aiming to understand the mechanisms underlying the morphology and function of skeletal muscle, with a particular focus on the role of genetic factors. Skeletal muscle is responsible for vital functions such as locomotion, respiration, and maintenance of glucose homeostasis and its decline due to disease or aging presents an increasing healthcare concern. As the results of the work in my lab, we know now that there are hundreds of genes affecting skeletal muscle and the work to identify their role and mechanisms is ongoing.

My career has been significantly influenced by interests in sports and exercise. I graduated from the Lithuanian Sports University as a PE teacher in 1992, received a Masters degree in 1994 and was awarded a PhD from the same institution in 1999 for the work on acute muscle adaptation to exercise. From 1999 to 2000, I was a Guest Researcher at the Department of Physiology and Pharmacology at the Karolinska Institute (advisor prof Jan Henriksson) in Sweden working on the effects of exercise on muscle signalling. From 2001 to 2003, I did postdoctoral work in muscle biology at the Pennsylvania State University (USA) and Uppsala University (Sweden; advisor prof Lars Larsson). After my second postdoctoral position in quantitative genetics at Pennsylvania State University (advisors Dr David A. Blizard and Dr George P. Vogler; from 2003 to 2007) I continued to work there as a Research Associate until 2009. In March of 2009, I took my current post in Aberdeen.

Outside of work I spend a significant amount of time in the gym. Greco wrestling is my favourite and I have been lucky to find a place and group people in every country I have been to, to continue practicing it in some form and shape. The gym had to be replaced by jogging and cycling during COVID-19.

Research

Research Overview

Skeletal muscle is responsible for many vital functions, including locomotion, respiration, maintenance of glucose homeostasis, thermoregulation, protection of bones and internal organs, and it also serves as a source of amino acids in time of starvation. The average appendicular muscle mass in healthy middle age females and males is 20 kg and 30 kg, respectively. However, individual differences are substantial; same sex, similar age and height people can differ 2-fold in muscle mass. The proportion of the fast-to-slow twitch fibres in the muscle can also differ from 20/80% to 80/20%. These differences impact on strength, power, and endurance of muscle contractions and are also associated with the risk of diseases which rely on muscle function. In adolescence and young adults, differences in muscle properties can influence success in sports, but it becomes increasingly important later in life. Low muscle mass and function increase the risk of type 2 diabetes and, compounded by aging-related decline, leads to frailty and admissions of the elderly to long-term care facilities. These differences in muscle properties result from the effects of developmental and postnatal environment, and from the genetic influences that can affect both pre- and post-natal phases. My research focus is to understand the physiological and genetic mechanisms underlying individual differences in skeletal muscle. This can lead to better prevention and discovery of new targets for pharmacological interventions to reverse the loss of muscle mass and function.

Research Areas

Biomedical Sciences

Supervising

Research Specialisms

  • Genetics
  • Physiology
  • Biomedical Sciences

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Current Research

My research aims to identify the genetic causes underlying the differences in muscle mass. We have carried out and integrated genome-wide association analyses in humans, using the UK Biobank resource, and in the laboratory mouse and rat models. The main outcome of these analyses were 182 genomic loci associated with differences in appendicular muscle mass in middle age, healthy individuals (Figure 1).

 Appendicular muscle mass  Manhattan plot

Figure 1. Map of Genome Associations with the Appendicular Muscle Mass in Humans. Significance level is presented on the vertical axis, while the chromosomal position of each genetic marker is shown on the horizontal axis. The red line across the plot represents the genome-wide threshold of significance (p < 5 x 10-8). This plot shows the association of variants with minor allele frequency >0.001 (Hernandez Cordero et al. 2019).

Furthermore, we found that inheriting large number of the “reducing” variants across these loci leads to lower muscle mass in the elderly population (Figure 2), indicating a sustained influence of those genetic variants across the lifespan. We also discovered that around a dozen of these loci overlap the syntenic regions of mouse and rat genomes. Syntenic regions refer to blocks of homologous genes arranged in the same order in the genome of different species. This convergence on the syntenic regions implicate a common cause and mechanism of function across mammalian species. 

 Genetic lean mass score

Figure 2. Genetic Lean Mass Score Affects the Appendicular Lean Mass (ALM) in Elderly Humans. The plot shows the ALM (kg) of the elderly cohort on the vertical axis. The elderly cohort was ranked by “genetic lean mass score” (calculated as a sum across 182 loci of the products of locus effect size and genotype dosage) and clustered in five quantiles (Q1–Q5) (horizontal axis). The average genetic lean mass score (±standard error) of each quantile is shown in parentheses below the horizontal axis. The overall quantile effect of the genetic lean mass score on ALM was tested with the Kruskal-Wallis test, and the resulting p-value is presented on the horizontal line above the bars. The ALM median differences between the groups were tested using a Wilcoxon test; the significance level of each comparison is presented above the horizontal lines with a Holm adjusted p-value (Hernandez Cordero et al. 2019).

The ultimate goal of genome-wide association studies is to identify the causative genes and understand mechanism of their effects. Achieving this is challenging because the confidence interval of each identified locus contains more than one, and often dozens, of genes. Furthermore, an interesting finding of these studies was that very few identified loci harbour genes known to affect myogenesis or growth and maintenance of muscle tissue. This means two things: 1) novel genes affecting skeletal muscle will be identified, and 2) additional studies are needed in order to prioritise and validate causative genes. We are currently working on validation and understanding the role of STC2 and POU3F4 encoding genes.

In a recent study we found that STC2 acts as a supressor of muscle growth (Lionikas et al. 2023). Mice lacking the Stc2 gene had up to 10% larger muscles than their wildtype littermates (Figure 3). This increase was mediated by larger cross-sectional area of muscle fibres. The STC2 induces this effect by supressing the insulin-like growth factor signalling which promotes protein accrual in skeletal muscle tissue.

Stc2 effect on muscle Picture1.png

Figure 3. Stc2 effects on muscle weight. The knockout mice (KO) have larger tibialis anterior (TA), externsor digitorum longus (EDL), plantaris (Plant) and soleus muscles. Sex-adjusted weight shown. Red symbols - female, black - male. The horizontal line represents the mean value, the error bars represent standard deviation (modified from Lionikas et al. 2023).

 

Past Research

Muscle mass can differ for two main morphological reasons: the number of muscle fibres comprising the muscle and the size of the fibres. The fibre number in mammals is determined prenatally and very shortly after birth and appears to be stable until some fibres are lost due to aging. The fibre size, i.e. cross-sectional area, is very pliable and depends on environmental factors such level and type of physical activity, constitutive factors such as sex and age, and genetic factors. Assessing the contribution between the fibre number and fibre size is important because they are influenced at different phases of the lifespan, and therefore likely to be determined by different genetic and molecular mechanisms. However, assessment of the role between the number and size of muscle fibres is not practical in humans due to an invasive nature of the biopsy procedure. We therefore conducted studies in laboratory mice. We studied transverse sections of mouse soleus muscle because a) all the fibres present in the muscle can be captured in one 10-µm thick slice; and b) unlike most rodent muscles, the soleus is similar to human muscles with respect to the expressed fibre types, i.e. type I and type IIA, and their proportions. Similarly to humans, muscle mass can differ more than 2-fold between inbred mouse strains (Figure 3). A difference between inbred strains housed under the same environmental conditions is an outcome of inheritance of the variants of genes influencing skeletal muscle. These studies revealed a number of strains differing in muscle mass. Importantly, in some of the strains, e.g. BEL and BEH, this difference is due to both the number and size of muscle fibres (Figure 3), but others, e.g. LG/J and SM/J, differ in the size but not the number of fibres (Lionikas et al. 2010, Carroll et al. 2011). These findings indicate that: 1) BEH and BEL strains captured variants of the genes involved both in the developmental processes and the postnatal growth and maintenance of the muscle, and 2) the LG/J and SM/J strains captured genetic variants involved only in muscle growth and maintenance. We later conducted a genome-wide association analysis on muscle weight of mice derived from a LG/J and SM/J intercross and found several genomic regions contributing to the difference in fibre size between these two strains (Gonzales et al. 2018).

 

Cross-section of soleus muscle from BEL (top) and BEH (bottom) mouse strains

Figure 3. Cross-sections of soleus muscle from BEL (top image) and BEH (bottom image) strains. Samples were taken from male mice of the same age, subjected to ATPase staining following acid preincubation and imaged with 5X objective. Dark fibres are type I, pale fibres IIA. There are over 2-times more fibres and the fibres are over 2-times lager in the BEH strain soleus compared to BEL.

Knowledge Exchange

Skeletal muscle is a source of our strength, power, and stamina. Muscles enable us to move and breathe, protect our bones and internal organs, help to maintain healthy level of blood sugar, and generate heat to regulate body temperature. However, we become weaker as we age. What happens to our muscles? This animation, entitled "Ageing muscle: use it or lose it", explains the workings of the muscles, how muscles change as we age, and what can be done to maintain them throughout our lifespan.

Collaborations

Dr David Blizard, The Pennsylvania State University

Dr Abraham Palmer, University of California San Diego

Dr Veronique Blanquet, University of Limoges

Dr Thomas Coate, Georgetown University

Dr Claus Oxvig, Aarhus University

Funding and Grants

2007 – 2009 Dissection of Muscle Weight QTL via Congenic Strains (R03 AR052879); National Institute of Arthritis Musculoskeletal and Skin Diseases ($145,000 total cost); Role: PI

2009 - 2014 Genetic Variation of Muscle Mass (R01 AR056280); National Institute of Arthritis Musculoskeletal and Skin Diseases ($1,326,999 total cost); Role: Co-I

2009-2013 Genetic Mechanisms of Muscle Fibre Variation; European Commision – Marie Curie International Reintegration Grant (€87,500 total cost); Role: PI

Publications

Page 1 of 1 Results 1 to 50 of 50

  • Validation of positional candidates Rps6ka6 and Pou3f4 for a locus associated with skeletal muscle mass variability

    Lionikas, A.
    G3: Genes, Genomes, Genetics Mission
    Contributions to Journals: Articles
  • Stanniocalcin-2 inhibits skeletal muscle growth and is upregulated in functional overload-induced hypertrophy

    Lionikas, A., Hernandez Cordero, A. I., Kilikevicius, A., Carroll, A. M., Bewick, G., Bünger, L., Ratkevicius, A., Heisler, L., Harboe, M., Oxvig, C.
    Physiological reports, vol. 11, no. 15, e15793
    Contributions to Journals: Articles
  • Analysis of independent cohorts of outbred CFW mice reveals novel loci for behavioral and physiological traits and identifies factors determining reproducibility

    Zou, J., Gopalakrishnan, S., Parker, C. C., Nicod, J., Mott, R., Cai, N., Lionikas, A., Davies, R. W., Palmer, A., Flint, J.
    G3: Genes, Genomes, Genetics Mission, vol. 12, no. 1, jkab394
    Contributions to Journals: Articles
  • Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2

    Hernandez Cordero, A. I., Gonzales, N. M., Parker, C. C., Sokoloff, G., Vandenbergh, D. J., Cheng, R., Abney, M., Sko, A., Douglas, A., Palmer, A. A., Gregory, J. S., Lionikas, A.
    American Journal of Human Genetics, vol. 105, no. 6, pp. 1222-1236
    Contributions to Journals: Articles
  • Myostatin dysfunction is associated with lower physical activity and reduced improvements in glucose tolerance in response to caloric restriction in Berlin high mice

    Kvedaras, M., Minderis, P., Krusnauskas, R., Lionikas, A., Ratkevicius, A.
    Experimental Gerontology, vol. 128, 110751
    Contributions to Journals: Articles
  • Myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice

    Fokin, A., Minderis, P., Venckunas, T., Lionikas, A., Kvedaras, M., Ratkevicius, A.
    Journal of musculoskeletal & neuronal interactions, vol. 19, no. 3, pp. 342-353
    Contributions to Journals: Articles
  • Low Citrate Synthase Activity Is Associated with Glucose Intolerance and Lipotoxicity

    Alhindi, Y., Vaanholt, L. M., Al-Tarrah, M., Gray, S. R., Speakman, J. R., Hambly, C., Alanazi, B. S., Gabriel, B. M., Lionikas, A., Ratkevicius, A.
    Journal of Nutrition and Metabolism, vol. 2019, 8594825
    Contributions to Journals: Articles
  • Genome wide association analysis in a mouse advanced intercross line

    Gonzales, N. M., Seo, J., Hernandez Cordero, A., St. Pierre, C., Gregory, J., Distler, M., Abney, M., Canzar, S., Lionikas, A., Palmer, A.
    Nature Communications, vol. 9, 5162
    Contributions to Journals: Articles
  • Replication and discovery of musculoskeletal QTLs in LG/J and SM/J advanced intercross lines

    Hernandez Cordero, A. I., Carbonetto, P., Verri, G. R., Gregory, J. S., Vandenbergh, D. J., Gyekis, J. P., Blizard, D. A., Lionikas, A.
    Physiological reports, vol. 6, no. 4, 13561
    Contributions to Journals: Articles
  • H55N polymorphism is associated with low citrate synthase activity which regulates lipid metabolism in mouse muscle cells

    Gabriel, B. M., Al-Tarrah, M., Alhindi, Y. Z. Y., Kilikevicius, A., Venckunas, T., Gray, S. R., Lionikas, A., Ratkevicius, A.
    PloS ONE, vol. 12, no. 11, pp. 1-20
    Contributions to Journals: Articles
  • Fine mapping of genes determining extrafusal fiber properties in murine soleus muscle

    Carroll, A., Cheng, R., Collie-Duguid, E., Meharg, C., Scholz, M., Fiering, S., Fields, J., Palmer, A., Lionikas, A.
    Physiological Genomics, vol. 49, no. 3, pp. 141-150
    Contributions to Journals: Articles
  • Forced Running Endurance Is Influenced by Gene(s) on Mouse Chromosome 10

    Kvedaras, M., Minderis, P., Fokin, A., Ratkevicius, A., Venckunas, T., Lionikas, A.
    Frontiers in Physiology, vol. 8, 9
    Contributions to Journals: Articles
  • Baseline Muscle Mass Is a Poor Predictor of Functional Overload-Induced Gain in the Mouse Model

    Kilikevicius, A., Bunger, L., Lionikas, A.
    Frontiers in Physiology, 534
    Contributions to Journals: Articles
  • Genome-wide association of multiple complex traits in outbred mice by ultra low-coverage sequencing

    Nicod, J., Davies, R. W., Cai, N., Hassett, C., Goodstadt, L., Cosgrove, C., Yee, B. K., Lionikaite, V., McIntyre, R. E., Remme, C. A., Lodder, E. M., Gregory, J. S., Hough, T., Joynson, R., Phelps, H., Nell, B., Rowe, C., Wood, J., Walling, A., Bopp, N., Bhomra, A., Hernandez-Pliego, P., Callebert, J., Aspden, R. M., Talbot, N. P., Robbins, P. A., Harrison, M., Fray, M., Launay, J., Pinto, Y. M., Blizard, D. A., Bezzina, C. R., Adams, D. J., Franken, P., Weaver, T., Wells, S., Brown, S. D. M., Potter, P. K., Klenerman, P., Lionikas, A., Mott, R., Flint, J.
    Nature Genetics, vol. 48, no. 8, pp. 912-918
    Contributions to Journals: Articles
  • Genome-wide association study of behavioral, physiological and gene expression traits in outbred CFW mice

    Parker, C. C., Gopalakrishnan, S., Carbonetto, P., Gonzales, N. M., Leung, E., Park, Y. J., Aryee, E., Davis, J., Blizard, D. A., Ackert-Bicknell, C. L., Lionikas, A., Pritchard, J. K., Palmer, A. A.
    Nature Genetics, vol. 48, no. 8, pp. 919-926
    Contributions to Journals: Articles
  • Myostatin dysfunction is associated with reduction in overload induced hypertrophy of soleus muscle in mice

    Minderis, P., Kilikevicius, A., Baltusnikas, J., Alhindi, Y., Venckunas, T., Bunger, L., Lionikas, A., Ratkevicius, A.
    Scandinavian Journal of Medicine & Science in Sports, vol. 26, no. 8, pp. 894-901
    Contributions to Journals: Articles
  • Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration

    Joyce, P. I., Fratta, P., Landman, A. S., Mcgoldrick, P., Wackerhage, H., Groves, M., Busam, B. S., Galino, J., Corrochano, S., Beskina, O. A., Esapa, C., Ryder, E., Carter, S., Stewart, M., Codner, G., Hilton, H., Teboul, L., Tucker, J., Lionikas, A., Estabel, J., Ramirez-Solis, R., White, J. K., Brandner, S., Plagnol, V., Bennet, D. L. H., Abramov, A. Y., Greensmith, L., Fisher, E. M. C., Acevedo-Arozena, A.
    Human Molecular Genetics, vol. 25, no. 2, pp. 291-307
    Contributions to Journals: Articles
  • Myostatin dysfunction impairs force generation in extensor digitorum longus muscle and increases exercise-induced protein efflux from extensor digitorum longus and soleus muscles

    Baltusnikas, J., Kilikevicius, A., Venckunas, T., Fokin, A., Bunger, L., Lionikas, A., Ratkevicius, A.
    Applied Physiology Nutrition and Metabolism / Physiologie Appliquée, Nutrition et Métabolisme, vol. 40, no. 8, pp. 817-821
    Contributions to Journals: Articles
  • Regenerated soleus muscle shows reduced creatine kinase efflux after contractile activity in vitro

    Baltusnikas, J., Kilikevicius, A., Venckunas, T., Fokin, A., Lionikas, A., Ratkevicius, A.
    Applied Physiology Nutrition and Metabolism / Physiologie Appliquée, Nutrition et Métabolisme, vol. 40, no. 2, pp. 129-133
    Contributions to Journals: Articles
  • Novel mutations in human and mouse SCN4A implicate AMPK in myotonia and periodic paralysis

    Corrochano, S., Männikkö, R., Joyce, P. I., McGoldrick, P., Wettstein, J., Lassi, G., Raja Rayan, D. L., Blanco, G., Quinn, C., Liavas, A., Lionikas, A., Amior, N., Dick, J., Healy, E. G., Stewart, M., Carter, S., Hutchinson, M., Bentley, L., Fratta, P., Cortese, A., Cox, R., Brown, S. D. M., Tucci, V., Wackerhage, H., Amato, A. A., Greensmith, L., Koltzenburg, M., Hanna, M. G., Acevedo-Arozena, A.
    Brain, vol. 137, no. 12, pp. 3171-3185
    Contributions to Journals: Articles
  • Discovery and refinement of muscle weight QTLs in B6 x D2 advanced intercross mice

    Carbonetto, P., Cheng, R., Gyekis, J. P., Parker, C. C., Blizard, D. A., Palmer, A. A., Lionikas, A.
    Physiological Genomics, vol. 46, no. 16, pp. 571-582
    Contributions to Journals: Articles
  • Genetics, muscle mass and strength

    Lionikas, A., Wackerhage, H.
    Molecular Exercise Physiology: An Introduction. Taylor and Francis Inc., pp. 156-173, 18 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
  • Genetic and genomic analyses of musculoskeletal differences between BEH and BEL strains

    Lionikas, A., Kilikevicius, A., Bünger, L., Meharg, C., Carroll, A. M., Ratkevicius, A., Venckunas, T., Blizard, D. A.
    Physiological Genomics, vol. 45, no. 20, pp. 940-947
    Contributions to Journals: Articles
  • Divergent physiological characteristics and responses to endurance training among inbred mouse strains

    Kilikevicius, A., Venckunas, T., Zelniene, R., Carroll, A. M., Lionikaite, S., Ratkevicius, A., Lionikas, A.
    Scandinavian Journal of Medicine & Science in Sports, vol. 23, no. 5, pp. 657-668
    Contributions to Journals: Articles
  • Analyses of muscle spindles in the soleus of six inbred mouse strains: Spind.les in soleus muscle

    Lionikas, A., Smith, C. J., Smith, T. L., Bunger, L., Banks, R. W., Bewick, G. S.
    Journal of Anatomy, vol. 223, no. 3, pp. 289-296
    Contributions to Journals: Articles
  • Constitutive expression of Yes-associated protein (Yap) in adult skeletal muscle fibres induces muscle atrophy and myopathy

    Judson, R. N., Gray, S. R., Walker, C., Carroll, A. M., Itzstein, C., Lionikas, A., Zammit, P. S., De Bari, C., Wackerhage, H.
    PloS ONE, vol. 8, no. 3, e59622
    Contributions to Journals: Articles
  • Resolving candidate genes of mouse skeletal muscle QTL via RNA-Seq and expression network analyses

    Lionikas, A., Meharg, C., Derry, J. M. J., Ratkevicius, A., Carroll, A. M., Vandenbergh, D. J., Blizard, D. A.
    BMC Genomics, vol. 13, 592
    Contributions to Journals: Articles
  • QTL analysis of type I and type IIA fibers in soleus muscle in a cross between LG/J and SM/J mouse strains

    Carroll, A. M., Palmer, A., Lionikas, A.
    Frontiers in Genetics, vol. 2, 99
    Contributions to Journals: Articles
  • B6-MSM consomic mouse strains reveal multiple loci for genetic variation in sucrose octaacetate aversion

    Ishii, A., Koide, T., Takahashi, A., Shiroishi, T., Hettinger, T., Frank, M., Savoy, L., Formaker, B., Yertutanol, S., Lionikas, A., Blizard, D.
    Behavior Genetics, vol. 41, no. 5, pp. 716-723
    Contributions to Journals: Articles
  • H55N polymorphism as a likely cause of variation in citrate synthase activity of mouse skeletal muscle

    Ratkevicius, A., Carroll, A. M., Kilikevicius, A., Venckunas, T., McDermott, K. T., Gray, S. R., Wackerhage, H., Lionikas, A.
    Physiological Genomics, vol. 42A, no. 2, pp. 96-102
    Contributions to Journals: Articles
  • Fine-mapping of muscle weight QTL in LG/J and SM/J intercrosses

    Lionikas, A., Cheng, R., Lim, J., Palmer, A., Blizard, D.
    Physiological Genomics, vol. 42A, no. 1, pp. 33-38
    Contributions to Journals: Articles
  • Genomic analysis of variation in hindlimb musculature of mice from the C57BL/6J and DBA/2J lineage

    Lionikas, A., Carlborg, ?., Lu, L., Peirce, J. L., Williams, R. W., Yu, F., Vogler, G. P., McClearn, G. E., Blizard, D. A.
    Journal of Heredity, vol. 101, no. 3, pp. 360-367
    Contributions to Journals: Articles
  • Genetic architecture for hole-board behaviors across substantial time intervals in young, middle-aged and old mice

    Foreman, J. E., Lionikas, A., Lang, D. H., Gyekis, J. P., Krishnan, M., Sharkey, N. A., Gerhard, G. S., Grant, M., Vogler, G. P., Mack, H., Stout, J. T., Griffith, J., Lakoski, J. M., Hofer, S. M., McClearn, G. E., Vandenbergh, D. J., Blizard, D. A.
    Genes, Brain, and Behavior, vol. 8, no. 7, pp. 714-727
    Contributions to Journals: Articles
  • Bone, muscle, and physical activity: structural equation modeling of relationships and genetic influence with age

    Lang, D. H., Conroy, D. E., Lionikas, A., Mack, H. A., Larsson, L., Vogler, G. P., Vandenbergh, D. J., Blizard, D. A., McClearn, G. E., Sharkey, N. A.
    Journal of Bone and Mineral Research, vol. 24, no. 9, pp. 1608-1617
    Contributions to Journals: Articles
  • QTL analyses of temporal and intensity components of home-cage activity in KJR and C57BL/6J strains

    Umemori, J., Nishi, A., Lionikas, A., Sakaguchi, T., Kuriki, S., Blizard, D. A., Koide, T.
    BMC Genetics, vol. 10, 40
    Contributions to Journals: Articles
  • Blood pressure and heart rate QTL in mice of the B6/D2 lineage: sex differences and environmental influences

    Blizard, D. A., Lionikas, A., Vandenbergh, D. J., Vasilopoulos, T., Gerhard, G. S., Griffith, J. W., Klein, L. C., Stout, J. T., Mack, H. A., Lakoski, J. M., Larsson, L., Spicer, J. M., Vogler, G. P., McClearn, G. E.
    Physiological Genomics, vol. 36, no. 3, pp. 158-166
    Contributions to Journals: Articles
  • Learning in the 2-bottle alcohol preference test

    Blizard, D. A., Vandenbergh, D. J., Lionikas, A., McClearn, G. E.
    Alcoholism: Clinical and Experimental Research, vol. 32, no. 12, pp. 2041-2046
    Contributions to Journals: Articles
  • Diverse effects of stanozolol in C57BL/6J and A/J mouse strains

    Lionikas, A., Blizard, D. A.
    European Journal of Applied Physiology, vol. 103, no. 3, pp. 333-341
    Contributions to Journals: Articles
  • Echocardiographic parameters in athletes of different sports

    Venckunas, T., Lionikas, A., Marcinkeviciene, J. E., Raugaliene, R., Alekrinskis, A., Stasiulis, A.
    Journal of Sports Science and Medicine, vol. 7, no. 1, pp. 151-156
    Contributions to Journals: Articles
  • Muscle cell and motor protein function in patients with a IIa myosin missense mutation (Glu-706 to Lys)

    Li, M., Lionikas, A., Yu, F., Tajsharghi, H., Oldfors, A., Larsson, L.
    Neuromuscular Disorders, vol. 16, no. 11, pp. 782-791
    Contributions to Journals: Articles
  • Anomaly of anatomical origin of soleus muscle

    Lionikas, A., Glover, M. G., Yu, F., Larsson, L., Vogler, G. P., McClearn, G. E., Blizard, D. A.
    Anatomical Science International, vol. 81, no. 1, pp. 47-49
    Contributions to Journals: Articles
  • Human skeletal muscle myosin function at physiological and non-physiological temperatures

    Lionikas, A., Li, M., Larsson, L.
    Acta Physiologica, vol. 186, no. 2, pp. 151-158
    Contributions to Journals: Articles
  • Genetic determinants of weight of fast- and slow-twitch skeletal muscles in old mice

    Lionikas, A., Blizard, D. A., Vandenbergh, D. J., Stout, J. T., Vogler, G. P., McClearn, G. E., Larsson, L.
    Mammalian Genome, vol. 17, no. 6, pp. 615-628
    Contributions to Journals: Articles
  • QTL influencing baseline hematocrit in the C57BL/6J and DBA/2J lineage: age-related effects

    Johannes, F., Blizard, D. A., Lionikas, A., Lang, D. H., Vandenbergh, D. J., Stout, J. T., Strauss, J. A., McClearn, G. E., Vogler, G. P.
    Mammalian Genome, vol. 17, no. 6, pp. 689-699
    Contributions to Journals: Articles
  • Adjusting data to body size: a comparison of methods as applied to quantitative trait loci analysis of musculoskeletal phenotypes

    Lang, D. H., Sharkey, N. A., Lionikas, A., Mack, H. A., Larsson, L., Vogler, G. P., Vandenbergh, D. J., Blizard, D. A., Stout, J. T., Stitt, J. P., McClearn, G. E.
    Journal of Bone and Mineral Research, vol. 20, no. 5, pp. 748-757
    Contributions to Journals: Articles
  • Genetic determinants of weight of fast- and slow-twitch skeletal muscle in 500-day-old mice of the C57BL/6J and DBA/2J lineage

    Lionikas, A., Blizard, D. A., Gerhard, G. S., Vandenbergh, D. J., Stout, J. T., Vogler, G. P., McClearn, G. E., Larsson, L.
    Physiological Genomics, vol. 21, no. 2, pp. 184-192
    Contributions to Journals: Articles
  • Genetic architecture of fast- and slow-twitch skeletal muscle weight in 200-day-old mice of the C57BL/6J and DBA/2J lineage

    Lionikas, A., Blizard, D. A., Vandenbergh, D. J., Glover, M. G., Stout, J. T., Vogler, G. P., McClearn, G. E., Larsson, L.
    Physiological Genomics, vol. 16, no. 1, pp. 141-152
    Contributions to Journals: Articles
  • Effects of concentric and eccentric contractions on phosphorylation of MAPK(erk1/2) and MAPK(p38) in isolated rat skeletal muscle

    Wretman, C., Lionikas, A., Widegren, U., Lännergren, J., Westerblad, H., Henriksson, J.
    The Journal of Physiology, vol. 535, no. Pt 1, pp. 155-164
    Contributions to Journals: Articles
  • Influence of exercise intensity on ERK/MAP kinase signalling in human skeletal muscle

    Widegren, U., Wretman, C., Lionikas, A., Hedin, G., Henriksson, J.
    Pflugers Archiv : European Journal of Physiology, vol. 441, no. 2-3, pp. 317-22
    Contributions to Journals: Articles
  • Differential activation of mitogen-activated protein kinase signalling pathways by isometric contractions in isolated slow- and fast-twitch rat skeletal muscle

    Wretman, C., Widegren, U., Lionikas, A., Westerblad, H., Henriksson, J.
    Acta Physiologica Scandinavica, vol. 170, no. 1, pp. 45-49
    Contributions to Journals: Articles

Refine

Chapters in Books, Reports and Conference Proceedings

Contributions to Journals