Dr Roy Soiza

Dr Roy Soiza
Dr Roy Soiza

Dr Roy Soiza

MB ChB MRCP(UK)

Honorary Clinical Reader

About

c/o Ageing Clinical & Experimental Research, University of Aberdeen, Room 1:128, Polwarth Building, Aberdeen AB25 2ZD United Kingdom

Biography

I graduated from Edinburgh University in 2000 and became a Member of the Royal College of Physicians in 2003. Later that year, I joined the North of Scotland training programme as a Specialist Registrar in Geriatric Medicine and General Internal Medicine. In 2006, I joined the University of Aberdeen as Clinical Lecturer in Elderly Medicine.

I was a Consultant Geriatrician with NHS Grampian from 2008 to 2018, before joining the General Medicine Department at Aberdeen Royal Infirmary. I have held numerous roles in postgraduate medical training, including Training Programme Director for Core Medical Training and Geriatric Medicine and serving as Associate Postgraduate Dean from 2015-2017.  

I was awarded an NRS Career Research Fellowship in April 2012.

External Memberships

  • Consultant Physician, NHS Grampian
  • Associate Editor, Therapeutic Advances in Drug Safety 2010-, SAGE Open Medicine and SAGE Open Medical Reports 2012-, Age & Ageing 2020-
  • Editorial Board Member, American Journal of Cardiovascular Disease 2011-, BMC Health Services Research 2014-
  • Growing Older in Scotland Report, Reference Group Member
  • Reviewer, for numerous international medical journals and grant-awarding bodies including MRC, CSO, NIHR, Research Council of Norway, South African Medical Research Council and Italian Ministry of Education, Universities & Research

 

 

Other Recent Roles

 

  • Associate Postgraduate Dean (Medicine), NES, 1st Feb 2015 – 31st Aug 2017

  • NRS Career Research Fellow 2012-5

  • Treasurer, Scottish Society of Physicians, 2014-8

  • Executive Committee Member, Scottish Society of Physicians, 2012-8

  • Scottish Intercollegiate Guideline Network (SIGN), Delirium Guideline Development Group Member 2016-9

  • Chair, Organising Committee, RCPE Geriatric Medicine Symposium 2019

  • Faculty Member, Faculty Development Alliance (formerly SCOTS Supervisor Training Courses), 2010-7

  • Electives Adviser, University of Aberdeen Medical School, 2010-8

  • Training Programme Director, North of Scotland Deanery

    Core Medical Training                        2010-3

    Geriatric Medicine                              2011-5

  • Educational Supervisor, Foundation Programme, GP and Specialty Registrars, 2008-

  • Chair, Medical Specialties Training Committee, North of Scotland Deanery 2013-2015

  • Member, RCP/BGS Geriatric Medicine Specialty Certificate Exam (SCE) Question Writing Group, 2009-14

  • Advisory Board Member, Otsuka Pharmaceuticals (UK), 2010-12

  • External Examiner, MSc (Hons) research theses, Dundee University and Flinders University 2012-6

  • Clinical Supervisor, Physician Associate course, University of Aberdeen 2013-5

  • ‘Hospital to Home’ National Project Advisory Group Member, Institute for Research and Innovation in Social Services (IRISS), 2013-6

  • Expert panellist, for a number of Delphi expert panels, e.g. for the FORTA, OPERAM and PERFECTED clinical trials

Research

Research Overview

I am interested in all aspects of health and disease in old age. My chief interests are hyponatraemia in older people and clinical pharmacology in old age. More recently, I have been working on COVID-19 therapy trials, and leading on vaccine trials. I have also researched polypharmacy, whole body vibration exercise, vascular ageing and cognitive ageing. I run clinical trials in older people but have wide experience in epidmeiological and mechanistic studies, as well as systematic reviews.

 

 

Current Research

I am the Aberdeen Principal Investigator for the NOVAVAX, BiCARB, K-SWAY, LACE, RAINDROP and SENATOR randomised controlled trials.

I have an ongoing interest in hyponatraemia, most recently investigating the causes of hyponatraemia after head injury.

I also led Wave 4 of the Aberdeen 1936 Birth Cohort (ABC36) Study, a longitudinal cohort study of  cognitive ageing.

Funding and Grants

Current Grants

  • ‘An evidence synthesis suite to inform a a future randomised trial of reducing anticholinergic related harm in older adults’, PK Myint, RL Soiza et al (6 co-investigators), Dunhill Medical Trust Ref No RPGF180666, £99,165
  • ‘Oral iron, intravenous iron or discontinuation of therapy for older adults with treatment unresponsive iron deficiency anaemia- a pilot randomised controlled trial’, PK Myint, RL Soiza et al (7 co-investigators), CSO Grant Ref No HIPS/17/15, £283,555
  • ‘Development and clinical trials of a new Software ENgine for the Assessment & optimization of drug and non-drug Therapy in Older persons (SENATOR)’, EU FP7 Project Grant, D O’Mahony, RL Soiza et al (12 co-investigators), €5,938,947
  •  ‘Does oral sodium bicarbonate therapy improve function and quality of life in older patients with chronic kidney disease and low-grade acidosis? A multicentre randomized placebo controlled trial’ NIHR HTA Grant 10/71, MD Witham, RL Soiza et al (10 co-investigators), £1,471,735
  •  ‘Vitamin K supplementation to reduce falls in older people – a multicentre trial’ CSO Grant CZH/4/1100, MD Witham, M McMurdo, P Donnan, P Mc Namee, RL Soiza, V Cvoro, £213,493
  • ‘Assessment of association between slow muscle fibres of calf and postural integrity between elderly fallers and non fallers using MRI techniques – a proof of concept study’ NHS Grampian Endowment Fund Research Grant 14/19, PK Myint, SR Gray, J He, RL Soiza,£11,936

     

    Recent Grants
  • Vascular ageing and hyponatraemia, NRS Career Researcher Fellowship, £123,010
  •  ‘Association of White Matter Lesions with Endothelial Dysfunction and Postural Blood Pressure Instability (ENDOW Study)’ NHS Grampian Endowment Fund Research Grant, £16,000, GE Hoyle, RL Soiza, DJP Williams, DG Seymour, AD Murray
  • ‘Aberdeen 1936 Birth Cohort Study: Wave 4’ Development Trust Alzheimer’s Research Fund, £41,382, AD Murray, RL Soiza, LJ Whalley
  • 'Association of Postural Blood Pressure Instability with Arterial Stiffness and Endothelial Dysfunction' NHSG Endowments No. 08/26 £8,667, RL Soiza, S Saha, GE Hoyle, DJP Williams
  • ‘The role of serum urate in cognitive decline’ Tenovus Scotland Project Grant G09/20 £9,456, RL Soiza, AD Murray, L Phillips, RT Staff
  • ‘The association between plasma nitrite levels and degree of endothelial function measured by pulse wave analysis’ 50% NHSG Endowments No. 09/19 & 50% British Geriatrics Society SpR Start-up Grant - £13,704, RL Soiza, S Saha, DJP Williams, IJ Megson
  • ‘Arginine Methylation: the missing link between vascular risk and Alzheimer’s disease severity’. NHS Grampian Endowments Research Grant 11/08, £9,084 AA Mangoni, RL Soiza, D Mowat
  • ‘Can asymmetric dimethylarginine (ADMA) predict cognitive decline?’ NHS Grampian Endowments Research Grant No 11/07, £11,789, AA Mangoni, F Thies, RL Soiza, RT Staff

 

Publications

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  • Frailty is associated with increased waiting time for relevant process of care measures; findings from the Emergency Laparoscopic & Laparotomy Scottish Audit (ELLSA)

    Ramsay, E., Carter, B., Soiza, R., Duffy, S., Moug, S., Myint, P. K.
    British Journal of Surgery
    Contributions to Journals: Articles
  • Hyponatraemia in older people is usually multifactorial and commonly iatrogenic

    Soiza, R.
    Age and Ageing, vol. 50, no. 4, pp. 1071-1072
    Contributions to Journals: Editorials
  • Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

    RECOVERY Collaborative Group, Soiza, R.
    The Lancet, vol. 397, no. 10289, pp. 2049-2059
    Contributions to Journals: Articles
  • Should Kuwait Join Global Epidemiological Research for Older People?

    Serri, L. E., Myint, P. K., Poobalan, A., Soiza, R.
    Kuwait Medical Journal
    Contributions to Journals: Articles
  • Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

    RECOVERY Collaborative Group, Soiza, R.
    The Lancet, vol. 397, no. 10285, pp. 1637-1645
    Contributions to Journals: Articles
  • Anticholinergic burden (prognostic factor) for prediction of dementia or cognitive decline in older adults with no known cognitive syndrome (Review)

    Taylor-Rowan, M., Edwards, S., Noel-Storr, A. H., McCleery, J., Myint, P. K., Soiza, R., Stewart, C., Loke, Y. K., Quinn, T. J.
    Cochrane Database of Systematic Reviews, vol. 5, no. 4, CD013540
    Contributions to Journals: Articles
  • 503 Clinical Frailty Score (CFS) Vs Antibiotics, Time to Surgery and Time to Computerised Tomography (CT) Scan in An Emergency Surgical Population

    Palaniappan, S., Soiza, R., Moug, S., Myint, P.
    British Journal of Surgery, vol. 108, no. Supplement_2, znab134.193
    Contributions to Journals: Abstracts
  • An international consensus list of potentially clinically significant drug-drug interactions in older people

    Anrys, P., Petit, A., Thevelin, S., Sallevelt, B., Drenth, C., Soiza, R., Correa-Pérez, A., Dalleur, O., De Brauwer, I., Petrovic, M., Coleman, J., Dalton, K., O’Mahony, D., Löwe, J., Thürig, S., Gudmundsson, A., Cherubin, A., Panos, A., Mavridis, D., Rodondi, N., Spinewine, A.
    Journal of the American Medical Directors Association
    Contributions to Journals: Articles
  • Associations between Frailty, Physical Performance, and Renal Biomarkers in Older People with Advanced Chronic Kidney Disease

    Smith, G., Avenell, A., Band, M. M., Hampson, G., Lamb, E. J., Littleford, R. C., McNamee, P., Soiza, R., Sumukadas, D., Witham, M. D.
    European Geriatric Medicine
    Contributions to Journals: Articles
  • Development of a European consensus from dentists, dental hygienists and physicians on a standard for oral health care in care‐dependent older people: an e-Delphi study

    Charadram, N., Maniewicz, S., Maggi, S., Petrovic, M., Kossioni, A., Srinivasan, M., Schimmel, M., Mojon, P., Müller, F., e-Delphi working group, Soiza, R.
    Gerodontology, vol. 38, no. 1, pp. 41-56
    Contributions to Journals: Articles

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Books and Reports

Contributions to Journals

Other Contributions