Professor Pieter Van West

Professor Pieter Van West
Professor Pieter Van West

Professor Pieter Van West

MSc (Wageningen, The Netherlands, 1993) PhD (Wageningen, The Netherlands, 2000)

Chair in Mycology

About

Office 2:33, Lab 2:39
Aberdeen Oomycete Laboratory
College of Life Sciences and Medicine
Institute of Medical Sciences
Foresterhill
Aberdeen
AB25 2ZD

Biography

Prof. Dr. Ir. Pieter van West is a past Royal Society University Research Fellow. He is Director of the International Centre for Aquaculture Research and Development (ICARD) at the University of Aberdeen, Board member of the Sustainable Aquaculture Innovation Centre (SAIC), Fellow of the Royal Society of Edinburgh and he was President of the British Mycological Society 2017-2018) . 

His current research programme focuses on oomycete biology. Several economically and environmentally important oomycetes, or watermoulds, are studied at most disciplinary levels (taxonomy, ecology, epidemiology, biochemistry and cellular and molecular biology and especially host-microbe interactions). He is particularly interested in developing novel methods to control oomycete pathogens.

The animal pathogenic oomycetes under investigation are Saprolegnia parasitica, Saprolegnia australis, Saprolegnia diclinaAphanomyces spp. and Halioticida spp.

The plant pathogenic species include mainly Phytophthora infestans and several Pythium spp. and the algal pathogenic species include Eurychasma dicksonii, Olpidiopsis spp., Anisolpidium spp. and Maulinia spp.

 

 



Memberships and Affiliations

Internal Memberships

Director of the International Centre for Aquaculture Research and Development (ICARD)

External Memberships

Fellow of the Royal Society of Edinburgh 

Board member of the Sustainable Aquaculture Innovation Centre (SAIC)

Past President of the British Mycological Society

Editorial Board member of Fungal Biology

Editorial Board member of Fungal Biology Reviews

 

Research

Research Overview

Fundamental molecular processes in Oomycete pathogens

The group of oomycete pathogens cause destructive diseases of thousands of (commercially important) plant species and fish. These so-called watermoulds have many fungus-like characteristics, but are not true-fungi. In fact, they are closely related to kelp and diatoms.

One particular oomycete, Phytophthora infestans, the causal agent of potato late blight, generates global yield losses estimated to exceed over £3 billion annually, making it one of the most important biotic constraints to global food production. It is probably the most destructive plant pathogen in human history, as it caused tremendous human suffering in the mid 1840's due to failed potato crops in Ireland and the UK.

One of the most destructive oomycete pathogens on fish is Saprolegnia parasitica. It is endemic to all fresh water habitats around the world and is partly responsible for the decline of natural populations of salmonids and other fresh water fish. Today, losses in the salmon aquaculture business in Scotland alone are estimated at several millions of pounds annually.

Despite their economic importance, little is known about the molecular mechanisms accounting for the success of Oomycetes as plant or fish pathogens, or the fundamental molecular processes underlying their development. My research program aspires to identify molecular characteristics that are essential for the development and pathogenesis of Phytophthora, Pythium and Saprolegnia species.

Work mainly focuses on the isolation and functional characterisation of genes encoding recognition molecules and stage-specific proteins to enable

  1. understanding and unravelling fundamental molecular processes in Oomycetes
  2. the detection of molecular targets for novel control strategies, possibly directed against a variety of Oomycete pathogens.

Current Research

1 Identification and functional characterisation of zoospore specific proteins from oomycetes via genomic, transcriptomic and proteomics approaches (Figure 1).

Figure 1. Zoospores are released from a sporangium of Saprolegnia parasitica (taken from van West, 2006)

 

2 Identification and functional characterisation of proteins from Saprolegnia parastica, a fish pathogen of salmonids and other fresh water fish (Figure 2), that are essential for development and pathogenicity.

Figure 2. Saprolegnia infection on pre-smolt salmon.

 

3 Investigating the mechanism of Phytophthora and Saprolegnia protein translocation into the host cells (Figure 3).

 

 

Figure 3 Oomycete effector translocation (Image taken from Wawra et al., 2012 Current Opinion in Microbiology doi:10.1016/j.mib.2012.10.008).

 

 4 Research into oomycete-insect interactions

 

Figure 4 Saprolegnia infections of waterborne insects (Image taken from Sarowar et al. 2013 Fungal Biology 117: 752-763).

 

5 Research into oomycete-algae interactions. 

Figure 5 Eurychasma infections in Ectocarpus (Image taken from Strittmatter et al., 2015, Plant Cell & Environment doi: 10.1111/pce.12533).

 

6 Discovering and describing novel oomycete species 

Figure 6 Oospores of Pythium polare, a pathogen of moss from the arctic and antarctic regions (Image taken from Tojo et al. 2012, Fungal Biology doi:10.1016/j.funbio.2012.04.005).

Teaching

Teaching Responsibilities

Eukaryotic Microbiology lectures in course BI25M5 (Microbes, Infection & Immunity)

Molecular Plant Pathology lectures in course AG3816 (Biology and Ecology of Plant Disease)

Publications

Page 5 of 11 Results 41 to 50 of 110

  • Role of Pathogen-Derived Cell Wall Carbohydrates and Prostaglandin E2 in Immune Response and Suppression of Fish Immunity by the Oomycete Saprolegnia parasitica

    Belmonte, R., Wang, T., Duncan, G. J., Skaar, I., Mélida, H., Bulone, V., van West, P., Secombes, C. J.
    Infection and Immunity, vol. 82, no. 11, pp. 4518-4529
    Contributions to Journals: Articles
  • Seaweed biodiversity in the south-western Antarctic Peninsula: surveying macroalgal community composition in the Adelaide Island/Marguerite Bay region over a 35-year time span

    Mystikou, A., Peters, A. F., Asensi, A. O., Fletcher, K. I., Brickle, P., van West, P., Convey, P., Kuepper, F. C.
    Polar Biology, vol. 37, no. 11, pp. 1607-1619
    Contributions to Journals: Articles
  • Deciphering microbial landscapes of fish eggs to mitigate emerging diseases

    Liu, Y., de Bruijn, I., Jack, A. L., Drynan, K., van den Berg, A. H., Thoen, E., Sandoval-Sierra, V., Skaar, I., van West, P., Diéguez-Uribeondo, J., van der Voort, M., Mendes, R., Mazzola, M., Raaijmakers, J. M.
    The ISME Journal, vol. 8, no. 10, pp. 2002-2014
    Contributions to Journals: Articles
  • Infection strategies of pathogenic oomycetes in fish

    Sarowar, M. N., Saraiva, M., Jessop, C. N., Lilje, O., Gleason, F. H., West, P. v.
    Freshwater Fungi. Jones, E. B. G., Hyde, K. D., Pang, K. (eds.). Walter de Gruyter, pp. 217-244, 28 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
  • A putative serine protease, SpSsp1, from Saprolegnia parasitica is recognised by sera of rainbow trout, Oncorhynchus mykiss

    Minor, K. L., Anderson, V. L., Davis, K. S., Van Den Berg, A. H., Christie, J. S., Loebach, L., Faruk, A. R., Wawra, S., Secombes, C. J., Van West, P.
    Fungal Biology, vol. 118, no. 7, pp. 630-639
    Contributions to Journals: Articles
  • Animal pathogenic Oomycetes

    van West, P., Beakes, G. W.
    Fungal Biology, vol. 118, no. 7, pp. 525-526
    Contributions to Journals: Articles
  • Reprint of: Saprolegnia strains isolated from river insects and amphipods are broad spectrum pathogens

    Sarowar, M. N., van den Berg, A. H., McLaggan, D., Young, M. R., van West, P.
    Fungal Biology, vol. 118, no. 7, pp. 579-590
    Contributions to Journals: Articles
  • Auto-aggregation in zoospores of Phytophthora infestans: the cooperative roles of bioconvection and chemotaxis

    Savory, A. I. M., Grenville-Briggs, L. J., Wawra, S., van West, P., Davidson, F. A.
    Journal of the Royal Society Interface, vol. 11, no. 94, 20140017
    Contributions to Journals: Articles
  • Global distribution of two fungal pathogens threatening endangered sea turtles

    Sarmiento-Ramirez, J. M., Abella-Perez, E., Phillott, A. D., Sim, J., van West, P., Martin, M. P., Marco, A., Dieguez-Uribeondo, J.
    PloS ONE, vol. 9, no. 1, e85853
    Contributions to Journals: Articles
  • Parental transfer of the antimicrobial protein LBP/BPI protects Biomphalaria glabrata eggs against oomycete infections

    Baron, O. L., van West, P., Industri, B., Ponchet, M., Dubreuil, G., Gourbal, B., Reichhart, J., Coustau, C.
    PLoS Pathogens, vol. 9, no. 12, e1003792
    Contributions to Journals: Articles

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