Professor Pieter Van West
MSc (Wageningen, The Netherlands, 1993) PhD (Wageningen, The Netherlands, 2000)
Chair in Mycology
Office 2:33, Lab 2:39
Aberdeen Oomycete Laboratory
College of Life Sciences and Medicine
Institute of Medical Sciences
Prof. Dr. Ir. Pieter van West is a past Royal Society University Research Fellow. He is Director of the International Centre for Aquaculture Research and Development (ICARD) at the University of Aberdeen, Board member of the Sustainable Aquaculture Innovation Centre (SAIC), Fellow of the Royal Society of Edinburgh and he was President of the British Mycological Society 2017-2018) .
His current research programme focuses on oomycete biology. Several economically and environmentally important oomycetes, or watermoulds, are studied at most disciplinary levels (taxonomy, ecology, epidemiology, biochemistry and cellular and molecular biology and especially host-microbe interactions). He is particularly interested in developing novel methods to control oomycete pathogens.
The animal pathogenic oomycetes under investigation are Saprolegnia parasitica, Saprolegnia australis, Saprolegnia diclina, Aphanomyces spp. and Halioticida spp.
The plant pathogenic species include mainly Phytophthora infestans and several Pythium spp. and the algal pathogenic species include Eurychasma dicksonii, Olpidiopsis spp., Anisolpidium spp. and Maulinia spp.
Memberships and Affiliations
- Internal Memberships
Director of the International Centre for Aquaculture Research and Development (ICARD)
- External Memberships
Fellow of the Royal Society of Edinburgh
Board member of the Sustainable Aquaculture Innovation Centre (SAIC)
Past President of the British Mycological Society
Editorial Board member of Fungal Biology
Editorial Board member of Fungal Biology Reviews
Fundamental molecular processes in Oomycete pathogens
The group of oomycete pathogens cause destructive diseases of thousands of (commercially important) plant species and fish. These so-called watermoulds have many fungus-like characteristics, but are not true-fungi. In fact, they are closely related to kelp and diatoms.
One particular oomycete, Phytophthora infestans, the causal agent of potato late blight, generates global yield losses estimated to exceed over £3 billion annually, making it one of the most important biotic constraints to global food production. It is probably the most destructive plant pathogen in human history, as it caused tremendous human suffering in the mid 1840's due to failed potato crops in Ireland and the UK.
One of the most destructive oomycete pathogens on fish is Saprolegnia parasitica. It is endemic to all fresh water habitats around the world and is partly responsible for the decline of natural populations of salmonids and other fresh water fish. Today, losses in the salmon aquaculture business in Scotland alone are estimated at several millions of pounds annually.
Despite their economic importance, little is known about the molecular mechanisms accounting for the success of Oomycetes as plant or fish pathogens, or the fundamental molecular processes underlying their development. My research program aspires to identify molecular characteristics that are essential for the development and pathogenesis of Phytophthora, Pythium and Saprolegnia species.
Work mainly focuses on the isolation and functional characterisation of genes encoding recognition molecules and stage-specific proteins to enable
- understanding and unravelling fundamental molecular processes in Oomycetes
- the detection of molecular targets for novel control strategies, possibly directed against a variety of Oomycete pathogens.
1 Identification and functional characterisation of zoospore specific proteins from oomycetes via genomic, transcriptomic and proteomics approaches (Figure 1).
Figure 1. Zoospores are released from a sporangium of Saprolegnia parasitica (taken from van West, 2006)
2 Identification and functional characterisation of proteins from Saprolegnia parastica, a fish pathogen of salmonids and other fresh water fish (Figure 2), that are essential for development and pathogenicity.
Figure 2. Saprolegnia infection on pre-smolt salmon.
3 Investigating the mechanism of Phytophthora and Saprolegnia protein translocation into the host cells (Figure 3).
Figure 3 Oomycete effector translocation (Image taken from Wawra et al., 2012 Current Opinion in Microbiology doi:10.1016/j.mib.2012.10.008).
4 Research into oomycete-insect interactions
Figure 4 Saprolegnia infections of waterborne insects (Image taken from Sarowar et al. 2013 Fungal Biology 117: 752-763).
5 Research into oomycete-algae interactions.
Figure 5 Eurychasma infections in Ectocarpus (Image taken from Strittmatter et al., 2015, Plant Cell & Environment doi: 10.1111/pce.12533).
6 Discovering and describing novel oomycete species
Figure 6 Oospores of Pythium polare, a pathogen of moss from the arctic and antarctic regions (Image taken from Tojo et al. 2012, Fungal Biology doi:10.1016/j.funbio.2012.04.005).
Eukaryotic Microbiology lectures in course BI25M5 (Microbes, Infection & Immunity)
Molecular Plant Pathology lectures in course AG3816 (Biology and Ecology of Plant Disease)
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Can Ulcerative Dermal Necrosis (UDN) in Atlantic salmon be attributed to ultraviolet radiation and secondary Saprolegnia parasitica infections?Fungal Biology Reviews, vol. 40, pp. 70-75Contributions to Journals: Review articles
Transformation systems, gene silencing and gene editing technologies in oomycetesFungal Biology ReviewsContributions to Journals: Review articles
Current practices and emerging possibilities for reducing the spread of oomycete pathogens in terrestrial and aquatic production systems in the European UnionFungal Biology ReviewsContributions to Journals: Articles
Phylogenetic and Functional Diversity of Saprolegniales and Fungi Isolated from Temperate Lakes in Northeast GermanyJournal of Fungi, vol. 7, no. 11, 968Contributions to Journals: Articles
Evaluation of potential transfer of the pathogen Saprolegnia parasitica between farmed salmonids and wild fishPathogens, vol. 10, no. 8, 926Contributions to Journals: Articles
Pathogenicity and Host Range of Pythium kashmirense: a soil-borne oomycete recently discovered in the UKJournal of Fungi, vol. 7, no. 6, 479Contributions to Journals: Articles
Development of a 3D spheroid cell culture system from fish cell lines for in vitro infection studies: Evaluation with Saprolegnia parasiticaJournal of Fish Diseases, vol. 44, no. 6, pp. 701-710Contributions to Journals: Articles
Transcriptome analysis reveals immune pathways underlying resistance in the common carp Cyprinus carpio against the oomycete Aphanomyces invadansGenomics, vol. 113, no. 1P2, pp. 944-956Contributions to Journals: Articles
The chaperone Lhs1 contributes to the virulence of the fish-pathogenic oomycete Aphanomyces invadansFungal Biology, vol. 124, no. 12, pp. 1024-1031Contributions to Journals: Articles
Molecular insights into the mechanisms of susceptibility of Labeo rohita against oomycete Aphanomyces invadansScientific Reports, vol. 10, 19531Contributions to Journals: Articles