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Professor Mark Vickers

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Professor Mark Vickers
Professor Mark Vickers
Professor Mark Vickers

MBChB MRCP DM FRCPath

Chair in Applied Medicine (Clin)

About
Email Address
m.a.vickers@abdn.ac.uk
Telephone Number
+44 (0)1224 272401
Office Address

1. Room 3:25, Institute of Medical Sciences

2. Blood Transfusion Centre, Foresterhill Road, Aberdeen AB25 2ZW

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

I graduated from Oxford Medical School in 1983, having completed a Biochemistry Part II at Cambridge. After general medical jobs in London, I worked with Doug Higgs on genes surrounding the alpha-globin gene cluster. I then trained in clinical Haematology at the Hammersmith, Reading and John Radcliffe Hospitals (1990–1996). I moved to Aberdeen in 1996 and was promoted to Professor in the section of Applied Medicine in 2008. I took over directorship of the Academic Transfusion Medicine Unit in 2010.

External Memberships

Member of Royal College of Physicians

Fellow of Royal College of Pathologists

British Society for Haematology

 

Research

Research Overview

My main current interest is in how cells are recognised as being damaged by phagocytes, using red blood cells as the main model system. Our work has implicated unusual glycosylation motifs as being key to the process and are of particular relevance to the mechanism of haemolysis in sickle cell disease and malaria. The mechanism gives insight into splenic function, notably susceptibility to pneumococcal infection. I have interests in cellular immunotherapy, including the use of blood donor derived cytotoxic lymphocytes to treat post-transplant lympoproliferative disease and COVID-19. I am supervising PhD students developing innate immunotherapeutic reagents to treat cancers. I am also involved in collection and use of convalescent plasma for COVID-19.My main current interest is in how cells are recognised as being damaged by phagocytes, using red blood cells as the main model system. Our work has implicated unusual glycosylation motifs as being key to the process and are of particular relevance to the mechanism of haemolysis in sickle cell disease and malaria.  The mechanism gives insight into splenic function, notably susceptibility to pneumococcal infection.  I have interests in cellular immunotherapy, including the use of blood donor derived cytotoxic lymphocytes to treat post-transplant lympoproliferative disease and COVID-19.  I am supervising PhD students developing innate immunotherapeutic reagents to treat cancers.  I am also involved in collection and use of convalescent plasma for COVID-19.

 

Knowledge Exchange

I have given talks about the use of convalescent plasma and T cells to treat COVID-19.

Collaborations

Prof. Alex Rowe, Edinburgh University.

Prof. Stuart Haslam, Imperial College London.

Prof. David Rees, King's College London.

Supervision

Shiva Nickaria, Raquel Ferro, Ellen Main - all working on immunotherapies.

Teaching

Teaching Responsibilities

I organise, and deliver much of, the haematology training in the medical school.  I remain an enthusiastic bedside teacher.  I co-ordinated the third year medical degree 1997-2010.

Publications

Page 1 of 2 Results 1 to 50 of 92

  • Development of a novel test of splenic function for use in a clinical diagnostic laboratory

    Khan, A. A., Laas, C. E., Brewin, J. N., Potter, V., Cao, H., Vickers, M. A., Clark, B., Rees, D. C.
    British Journal of Haematology, vol. 206, no. 1, pp. 320-330
    Contributions to Journals: Articles

  • EBV T-cell immunotherapy generated by peptide selection has enhanced effector functionality compared to LCL stimulation

    Cooper, R. S., Sutherland, C., Smith, L. M., Cowan, G., Barnett, M., Mitchell, D., McLean, C., Imlach, S., Hayes, A., Zahra, S., Manchanayake, C., Vickers, M., Graham, G., McGowan, N., Turner, M. L., Campbell, J. D. M., Fraser, A. R.
    Frontiers in Immunology, vol. 15
    Contributions to Journals: Articles

  • Measurement of erythrocyte membrane mannoses to assess splenic function

    Cao, H., Mathur, A., Robertson, C., Antonopoulos, A., Henderson, S., Girard, L., Wong, J. H., Davie, A., Wright, S., Brewin, J. N., Rees, D. C., Dell, A., Haslam, S. M., Vickers, M.
    British Journal of Haematology, vol. 198, no. 1, pp. 155-164
    Contributions to Journals: Articles

  • Hyposplenism and gastrointestinal diseases: significance and mechanisms

    Mathur, A., McLean, M. H., Cao, H., Vickers, M. A.
    Digestive Diseases, vol. 40, pp. 290–298
    Contributions to Journals: Review articles

  • Oxidative stress, malaria, sickle cell disease, and innate immunity

    Cao, H., Vickers, M.
    Trends in Immunology, vol. 42, no. 10, pp. 849-851
    Contributions to Journals: Articles

  • Cytometric analysis of T cell phenotype using cytokine profiling for improved manufacturing of an EBV-specific T cell therapy

    Cooper, R., Kowalczuk, A., Wilkie, G., Vickers, M., Turner, M., Campbell, J., Fraser, A.
    Clinical and Experimental Immunology, vol. 206, no. 1, 68-81
    Contributions to Journals: Articles

  • The Red Blood Cell as a Novel Regulator of Human B-cell Activation

    Lennon, C. S., Cao, H., Hall, A. M., Vickers, M. A., Barker, R. N.
    Immunology, vol. 163, no. 4
    Contributions to Journals: Articles

  • Low-Dose Vitamin D3 Supplementation Does Not Affect Natural Regulatory T Cell Population but Attenuates Seasonal Changes in T Cell-Produced IFN-γ: results from the D-SIRe2 randomised controlled trial

    Maboshe, W. F., MacDonald, H. M., Wassall, H., Fraser, W. D., Tang, J. C. Y., Fielding, S., Barker, R. N., Vickers, M. A., Ormerod, A., Thies, F.
    Frontiers in Immunology, vol. 12, 623087
    Contributions to Journals: Articles

  • Sialic acid‐binding immunoglobulin‐like lectin (Siglec)‐15 is a rapidly internalised cell‐surface antigen expressed by acute myeloid leukaemia cells

    Cao, H., Neerincx, A., de Bono, B., Lakner, U., Huntington, C., Elvin, J., Gudgin, E., Pridans, C., Vickers, M., Huntly, B., Trowsdale, J., Barrow, A.
    British Journal of Haematology, vol. 193, no. 5, pp. 946-950
    Contributions to Journals: Articles

  • Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance

    Cao, H., Antonopoulos, A., Henderson, S., Wassall, H. J., Brewin, J., Masson, A., Shepherd, J., Konieczny, G., Patel, B., Williams, M., Davie, A., Forrester, M. A., Hall, L. S., Minter, B., Tampakis, D., Moss, M., Lennon, C., Pickford, W., Erwig, L., Robertson, B., Dell, A., Brown, G., Wilson, H., Rees, D. C., Haslam, S. M., Rowe, J. A., Barker, R., Vickers, M.
    Nature Communications, vol. 12, no. 1, 1792
    Contributions to Journals: Articles

  • Human erythrocyte surface fucose expression increases with age and hyperglycemia: [version 1; peer review: awaiting peer review]

    Cao, H., Bagchi, A., Tampakis, D., Laidvee, I., Williams, M., Minter, B., Wright, S., Antonopoulos, A., Haslam, S. M., Barker, R. N., Vickers, M.
    Wellcome open research, vol. 6, 28
    Contributions to Journals: Articles

  • High mannose N-glycans on red blood cells as phagocytic ligands, mediating both sickle cell anaemia and resistance to malaria

    Cao, H., Antonopoulos, A., Henderson, S., Wassall, H. J., Brewin, J., Masson, A., Shepherd, J., Konieczny, G., Patel, B., Williams, M., Davie, A., Forrester, M. A., Hall, L., Minter, B., Tampakis, D., Moss, M., Lennon, C., Pickford, W., Erwig, L., Robertson, B., Dell, A., Brown, G. D., Wilson, H., Rees, D. C., Haslam, S. M., Rowe, J. A., Barker, R., Vickers, M.
    bioRxiv
    Contributions to Journals: Articles

  • Paraprotein associated syndrome treated successfully with chemotherapy

    Gurung, R., Robertson, C., Vickers, M. A.
    BMJ Case Reports, vol. 13, no. 9, e232866
    Contributions to Journals: Articles

  • Long-Term Follow Up After Third Party Viral-Specific Cytotoxic Lymphocytes For Immunosuppression- And Epstein-Barr Virus-Associated Lymphoproliferative Disease

    Kazi, S., Mathur, A., Wilkie, G., Cheal, K., Battle, R., McGowan, N., Fraser, N., Hargreaves, E., Turner, D., Campbell, J. D. M., Turner, M., Vickers, M. A.
    Haematologica, vol. 104, no. 8, pp. e356-e359
    Contributions to Journals: Articles

  • Investigating thrombocytosis

    Mathur, A., Samaranayake, S., Storrar, N. P., Vickers, M. A.
    BMJ (Online), vol. 366, l4183
    Contributions to Journals: Articles

  • Combination peptide immunotherapy suppresses antibody and helper T cell responses to the major human platelet autoantigen GPIIb/IIIa in HLA-transgenic mice

    Hall, L. S., Lennon, C. S., Hall, A. M., Urbaniak, S. J., Vickers, M. A., Barker, R. N.
    Haematologica, vol. 104, no. 5, pp. 1074-1082
    Contributions to Journals: Articles

  • Adoptive T Cell Therapy Strategies for Viral Infections in Patients Receiving Haematopoietic Stem Cell Transplantation

    Ottaviano, G., Chiesa, R., Feuchtinger, T., Vickers, M. A., Dickinson, A., Gennery, A. R., Veys, P., Todryk, S.
    Cells, vol. 8, no. 1, 47
    Contributions to Journals: Review articles

  • Similarities and differences in surface receptor expression by THP-1 monocytes and differentiated macrophages polarized using seven different conditioning regimens

    Forrester, M. A., Wassall, H. J., Hall, L. S., Cao, H., Wilson, H. M., Barker, R. N., Vickers, M. A.
    Cellular Immunology, vol. 332, pp. 58-76
    Contributions to Journals: Articles

  • Combined linkage and association analysis of classical Hodgkin lymphoma

    Lawrie, A., Han, S., Sud, A., Hosking, F., Cezard, T., Turner, D., Clark, C., Murray, G. I., Culligan, D. J., Houlston, R. S., Vickers, M. A.
    Oncotarget, vol. 9, no. 29, pp. 20377-20385
    Contributions to Journals: Articles

  • Cytotoxic T-lymphocyte therapy for post-transplant lymphoproliferative disorder after solid organ transplantation in children

    Chiou, F. K., Beath, S. V., Wilkie, G. M., Vickers, M. A., Gupte, G. L.
    Pediatric Transplantation, vol. 22, no. 2, 13133
    Contributions to Journals: Articles

  • Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia

    Le Sommer, S., Morrice, N., Pesaresi, M., Thompson, D., Vickers, M. A., Murray, G. I., Mody, N., Neel, B. G., Bence, K. K., Wilson, H. M., Delibegovic, M.
    Cancer Research, vol. 78, no. 1, pp. 75-87
    Contributions to Journals: Articles

  • Exteriorisation of Mannoses on Human Erythrocyte Membrane Skeleton Provides 'Eat Me' Signals for Oxidatively Damaged Cells to be Cleared By Macrophages: A Pathway Mediating Hemolysis in Sickle Cell Disease

    Vickers, M. A., Barker, R. N., Cao, H., Wassall, H. J., Forrester, M. A., Hall, L. S., Moss, M., Henderson, S., Konieczny, G., Beverly, M., Shepherd, J., Haslam, S. M., Rees, D. C., Wilson, H. M., Tampakis, D., Williams, M. L.
    Blood, vol. 130, no. 1, pp. 919
    Contributions to Journals: Articles

  • Season of infectious mononucleosis as a risk factor for multiple sclerosis: a UK primary care case-control study

    Downham, C., Visser, E., Vickers, M., Counsell, C.
    Multiple Sclerosis and Related Disorders, vol. 17, pp. 103-106
    Contributions to Journals: Articles

  • Effective antigen presentation to helper T cells by human eosinophils

    Farhan, R. K., Vickers, M. A., Ghaemmagham, A. M., Hall, A. M., Barker, R. N., Walsh, G. M.
    Immunology, vol. 149, no. 4, pp. 413-422
    Contributions to Journals: Articles

  • Leukocyte Ig-Like receptor B1 restrains dendritic cell function through increased expression of the NF-κB regulator ABIN1/TNIP1

    Khanolkar, R. C., Kalogeropoulos, M., Lawrie, A., Roghanian, A., Vickers, M. A., Young, N. T.
    Journal of Leukocyte Biology, vol. 100, no. 4, pp. 737-746
    Contributions to Journals: Articles

  • Adoptive immunotherapy for primary immunodeficiency disorders with virus-specific T lymphocytes

    Naik, S., Nicholas, S. K., Martinez, C. A., Leen, A. M., Hanley, P. J., Gottschalk, S. M., Rooney, C. M., Hanson, I. C., Krance, R. A., Shpall, E. J., Cruz, C. R., Amrolia, P., Lucchini, G., Bunin, N., Heimall, J., Klein, O. R., Gennery, A. R., Slatter, M. A., Vickers, M. A., Orange, J. S., Heslop, H. E., Bollard, C. M., Keller, M. D.
    Journal of Allergy and Clinical Immunology, vol. 137, no. 5, pp. 1498-1505
    Contributions to Journals: Articles

  • Intraoperative salvage does not affect expression of markers for erythrophagocytosis

    Chakravarty, P. D., Porter, C., Cao, H., Cairns, L., Moss, M., Duthie, R., Ashcroft, P., Jeffrey, R., Gibson, G., Buchan, K., Erwig, L., Barker, R. N., Vickers, M. A.
    Transfusion Medicine, vol. 26, no. 2, pp. 147-149
    Contributions to Journals: Letters

  • Systematic review and meta-analysis of the sero-epidemiological association between Epstein-Barr virus and rheumatoid arthritis

    Ball, R. J., Avenell, A., Aucott, L., Hanlon, P., Vickers, M. A.
    Arthritis Research & Therapy, vol. 17, pp. 274
    Contributions to Journals: Articles

  • Intraoperative cell salvage may damage erythrocytes as indicated by macrophage uptake

    Chakravarty, P. D., Porter, C., Cao, H., Cairns, L., Barker, R. N., Moss, M., Duthie, R., Jeffrey, R. P., Ashcroft, G. P., Gibson, G., Buchan, K., Erwig, L., Vickers, M. A.
    Annual Meeting of the Society-of-Academic-and-Research-Surgery (SARS(, pp. 31-31
    Contributions to Journals: Abstracts

  • How do immune responses differ against senescent and damaged erythrocytes: profiling sugar and protein changes on the cell surface

    Cao, H., Tampakis, D., Moss, M., Pickford, W. J., Hall, L. S., Crocker, P. R., Erwig, L. P., Vickers, M. A., Barker, R. N.
    Immunology, vol. 143, no. s2, pp. 118-119
    Contributions to Journals: Abstracts

  • Establishment and operation of a Good Manufacturing Practice-compliant allogeneic Epstein-Barr virus (EBV)-specific cytotoxic cell bank for the treatment of EBV-associated lymphoproliferative disease

    Vickers, M. A., Wilkie, G. M., Robinson, N., Rivera, N., Haque, T., Crawford, D. H., Barry, J., Fraser, N., Turner, D. M., Robertson, V., Dyer, P., Flanagan, P., Newlands, H. R., Campbell, J., Turner, M.
    British Journal of Haematology, vol. 167, no. 3, pp. 402-410
    Contributions to Journals: Articles

  • Human interleukin-27: wide individual variation in plasma levels and complex inter-relationships with interleukin-17A

    Forrester, M. A., Robertson, L., Bayoumi, N., Keavney, B. D., Barker, R. N., Vickers, M. A.
    Clinical and Experimental Immunology, vol. 178, no. 2, pp. 373-383
    Contributions to Journals: Articles

  • Combination peptide immunotherapy suppresses antibody and helper T cell responses to the RhD protein in HLA-transgenic mice

    Vickers, M. A., Hall, L. S., Hall, A. M., Pickford, W. J., Urbaniak, S. J., Barker, R. N.
    54th Annual Scientific Meeting of the British-Society-for-Haematology, pp. 12-12
    Contributions to Journals: Abstracts

  • Expansion of Foxp3+ T-cell populations by Candida albicans enhances both Th17-cell responses and fungal dissemination after intravenous challenge

    Whibley, N., Maccallum, D. M., Vickers, M. A., Zafreen, S., Waldmann, H., Hori, S., Gaffen, S. L., Gow, N. A. R., Barker, R. N., Hall, A. M.
    European Journal of Immunology, vol. 44, no. 4, pp. 1069-1083
    Contributions to Journals: Articles

  • The epidemiology of infectious mononucleosis in Northern Scotland: a decreasing incidence and winter peak

    Visser, E., Milne, D., Collacott, I., McLernon, D., Counsell, C., Vickers, M.
    BMC Infectious Diseases, vol. 14, 151
    Contributions to Journals: Articles

  • Combination peptide immunotherapy suppresses antibody and helper T cell responses to the RhD protein in HLA-transgenic mice

    Hall, L. S., Hall, A. M., Pickford, W., Vickers, M. A., Urbaniak, S. J., Barker, R. N.
    Haematologica, vol. 99, no. 3, pp. 588-596
    Contributions to Journals: Articles

  • Systematic review and meta-analysis of the sero-epidemiological association between Epstein-Barr virus and systemic lupus erythematosus

    Hanlon, P., Avenell, A., Aucott, L., Vickers, M. A.
    Arthritis Research & Therapy, vol. 16, no. 1, R3
    Contributions to Journals: Articles

  • Quantitative variation in plasma angiotensin-i converting enzyme activity shows allelic heterogeneity in the ABO blood group locus

    Terao, C., Bayoumi, N., McKenzie, C. A., Zelenika, D., Muro, S., Mishima, M., Connell, J. M. C., Vickers, M. A., Mark Lathrop, G., Farrall, M., Matsuda, F., Keavney, B. D., The Nagahama Cohort Research Group
    Annals of Human Genetics, vol. 77, no. 6, pp. 465-471
    Contributions to Journals: Articles

  • The soluble isoform of CTLA-4 as a regulator of T-cell responses

    Ward, F. J., Dahal, L. N., Wijisekera, S. K., Abdul-Jawad, S. K., Kaewarpai, T., Xu, H., Vickers, M. A., Barker, R. N.
    European Journal of Immunology, vol. 43, no. 5, pp. 1274-1285
    Contributions to Journals: Articles

  • Systematic review and meta-analysis of the sero-epidemiological association between Epstein Barr virus and multiple sclerosis

    Almohmeed, Y. H., Avenell, A., Aucott, L., Vickers, M. A.
    PloS ONE, vol. 8, no. 4, e61110
    Contributions to Journals: Articles

  • Acute myeloid leukemia presenting in a mother and daughter pair with the identical acquired karyotypic abnormality consisting of inversion 3q21q26 and monosomy 7: a review of possible mechanisms

    Lawrie, A., Stevenson, D. A. J., Doig, T., Vickers, M., Culligan, D. J.
    Cancer Genetics and Cytogenetics, vol. 205, no. 11, pp. 599-602
    Contributions to Journals: Articles

  • Production of the effector cytokine interleukin-17, rather than interferon-γ, is more strongly associated with autoimmune hemolytic anemia

    Hall, A. M., Zamzami, O. M., Whibley, N., Hampsey, D. P., Haggart, A. M., Vickers, M. A., Barker, R. N.
    Haematologica, vol. 97, no. 10, pp. 1494-1500
    Contributions to Journals: Articles

  • Candida albicans evades protective immunity by promoting the expansion of induced CD4(+) CD25(+) FoxP3(+) Helioslo regulatory T cells that enhance Th17 responses

    Whibley, N. W., MacCallum, D. M., Vickers, M. A., Waldmann, H., Hori, S., Gow, N. A. R., Barker, R. N., Hall, A. M.
    European Congress of Immunology, pp. 206-206
    Contributions to Journals: Abstracts

  • Identification, immunomodulatory activity, and immunogenicity of the major helper T-cell epitope on the K blood group antigen

    Stephen, J., Cairns, L. S., Pickford, W. J., Vickers, M. A., Urbaniak, S. J., Barker, R. N.
    Blood, vol. 119, no. 23, pp. 5563-5574
    Contributions to Journals: Articles

  • Effects of ultraviolet light on human serum 25-hydroxyvitamin D and systemic immune function

    Milliken, S. V. I., Wassall, H., Lewis, B. J., Logie, J., Barker, R. N., Macdonald, H., Vickers, M. A., Ormerod, A. D.
    Journal of Allergy and Clinical Immunology, vol. 129, no. 6, pp. 1554-1561
    Contributions to Journals: Articles

  • Candida albicans promotes the differentiation of induced CD4(+) CD25(+) Foxp3(+) regulatory T cells

    Whibley, N., MacCallum, D. M., Vickers, M. A., Gow, N. A., Barker, R. N., Hall, A. M.
    Immunology, vol. 135, no. Suppl. 1, pp. 161
    Contributions to Journals: Abstracts

  • Evidence-based focused review of the treatment of idiopathic warm immune hemolytic anemia in adults

    Crowther, M., Chan, Y. T., Garbett, I. K., Lim, W., Vickers, M. A., Crowther, M. A.
    Blood, vol. 118, no. 15, pp. 4036-4040
    Contributions to Journals: Articles

  • Foundation Years Journal

    Vickers, M.
    Other Contributions: Other Contributions

  • The doctor's dilemma: stimulating T cells

    Vickers, M.
    Blood, vol. 114, no. 16, pp. 3361-3362
    Contributions to Journals: Comments and Debates

  • Helper T cells point the way to specific immunotherapy for autoimmune disease

    Hall, A. M., Vickers, M. A., Barker, R. N., Erwig, L. P.
    Cardiovascular & Hematological Disorders - Drug Targets, vol. 9, no. 3, pp. 159-166
    Contributions to Journals: Articles
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