I completed my MSc in Medical Biology at the University of Groningen in the Netherlands in 2003 cum laude (with first class honours). I then moved to the University of Oxford where I obtained my DPhil in 2007. After a number of post-doctoral research posts at the University of Aberdeen, I was appointed Lecturer in Skeletal Regenerative Medicine in 2012.
The goal of my research has been to achieve a greater understanding of the pharmacology of anti-resorptive bisphosphonate drugs and related compounds. Using fluorescently-labelled bisphosphonates, I studied their skeletal distribution and targetting of cells in vivo, and how this is influenced by bone mineral affinity of the bisphosphonate. I also investigated the mechanisms of their immunomodulatory effects and their in vitro and in vivo anti-tumour activity.
My current research interests are centered around skeletal biology, with a particular focus on mesenchymal stromal cells (MSCs). Ongoing work is aimed at elucidating the developmental origins of MSCs using genetic lineage tracing, and the role of yes-associated protein (Yap) and the Hippo pathway in the regulation of MSC proliferation and differentiation. Increasing our understanding of the biology of MSCs will enable the development of novel treatments that target endogenous MSCs to promote skeletal health.