Academic Lead Postgraduate Research (IMS)
Deputy Lead IMS Health and Safety Co-ordinator
I am currently a senior lecturer in the Institute of Medical Sciences. I am a biochemist and molecular biologist working with bacteria in the Microbiology Programme of SMMSN. My research focusses on bacterial ion channels and transporters. These specialised membrane proteins help bacteria survive their environment. I investigate the molecular mechanisms of these proteins and how to use this knowledge to inhibit bacterial cell growth.
I am currently accepting PhDs in Biomedical Sciences.
Please get in touch if you would like to discuss your research ideas further.
Prof. I. R. Booth (Aberdeen), Dr T.Rasmussen (Aberdeen), Dr A. Moura (Aberdeen), Prof. J. Naismith (St. Andrews), Prof. S. Conway (Oxford), Prof. B. Poolman (Groningen), Prof. Z. Ignatova (Pottsdam), Prof. C. Grebogi (Aberdeen), Prof. J. Banga (CSIC), Dr J. Yates (AstraZeneca), Dr. A. Valleriani (MPIKG), Prof. R. Bovenberg (DSM)
Funding and Grants
Marie Curie Initial Training Networks (ITN) Call: FP7-PEOPLE-2011-ITN (awarded 2011) ‘NICHE’ Network for Integrated Cellular Homeostasis. This grant brings together 8 partners from 6 academic institutions across Europe and 3 industrial partners to create a training network that will fund 11 PhD students and 2 Postdoctoral workers. My position on this proposal is Assistant Coordinator, also with responsibility for the training programme.
Medical Research Scotland Vacation Scholarship (awarded 03/2011) for Mr Vojtech Prazak (1st year undergraduate University of Aberdeen), funding for 8 weeks summer project 2011. Structure-Function studies of critical gating residues in mechanosensitive channels
Wellcome Trust Programme Grant Renewal (awarded 07/2010). Principal Applicant Prof. Ian Booth. Coapplicant (1) Prof. J.H. Naismith, (St. Andrews), Coapplicant (2) Dr S. Conway (Oxford), Coapplicant (3) Dr S. Miller, Coapplicant (4) Dr T. Rasmussen, Coapplicant (5) Dr M.D. Edwards.Molecular mechanisms of gating ion channels and transporters in bacterial homeostasis. 01.01.11-31.12.16
BBSRC Research Grant (awarded 06/10) Principal Investigator 01.07.10-30.06.15 Conformational states of membrane proteins: Technology development for bioscience
SFC (SULSA pool) Summer Studentship (with Morgiane Richard and A. Moura) for Aljosa Sarcevic from 31/05/10 for a 10 week project ‘Model of a Toxic metabolic Switch: Production of Methylglyoxal by Gram-Negative Bacteria’
BBSRC (SysMo Initiative). Awarded March 2007. Principal Investigator Professor I.R. Booth, Co-Investigators; Dr S.Miller, Professor C. Grebogi and Dr A. Moura (University of Aberdeen): 01.06.07-01.06.10 Ion and Solute Homeostasis in Enteric Bacteria (Kosmobac)
Wellcome Trust Programme Grant Renewal (awarded 2005). Principal Applicant Professor I.R. Booth, Coapplicant (1) Dr S. Miller, Coapplicant (2) Dr M.D. Edwards January 2006-December 2011. Gating of bacterial transporters and ion channels in cellular homeostasis
Royal society Conference Award 2005
MRC New Investigator Award (awarded 2004) July 2005-2008 Biogenesis and Structure-Function analysis of the MscS Mechanosensitive Channel in Escherichia coli.
Course Co-ordinator MC3504 Molecular Microbiology
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Interaction of the Mechanosensitive Channel, MscS, with the Membrane Bilayer through Lipid Intercalation into Grooves and PocketsJournal of Molecular Biology, vol. 431, no. 17, pp. 3339-3352Contributions to Journals: Articles
Widening access to students from remote and rural backgrounds8th National Scottish Medical Education ConferenceContributions to Conferences: Posters
Adenosine Monophosphate Binding Stabilizes the KTN Domain of the Shewanella denitrificans Kef Potassium Efflux SystemBiochemistry, vol. 56, no. 32, pp. 4219-4234Contributions to Journals: Articles
On the mobility, membrane location and functionality of mechanosensitive channels in Escherichia coliScientific Reports, vol. 6, 32709Contributions to Journals: Articles
The photochemical thiol-ene reaction as a versatile method for the synthesis of glutathione S-conjugates targeting the bacterial potassium efflux system KefOrganic chemistry frontiers : an international journal of organic chemistry / Royal Society of Chemistry, vol. 3, no. 4, pp. 439-446Contributions to Journals: Articles
The role of lipids in mechanosensationNature Structural & Molecular Biology, vol. 22, pp. 991-998Contributions to Journals: Articles
Properties of the mechanosensitive channel MscS pore revealed by tryptophan scanning mutagenesisBiochemistry, vol. 54, no. 29, pp. 4519-4530Contributions to Journals: Articles
The evolution of bacterial mechanosensitive channelsCell Calcium, vol. 57, no. 3, pp. 140-150Contributions to Journals: Literature Reviews
Understanding the structural requirements for activators of the Kef bacterial potassium efflux systemBiochemistry, vol. 53, no. 12, pp. 1982-1992Contributions to Journals: Articles
Probing the structure of the mechanosensitive channel of small conductance in lipid bilayers with pulsed electron-electron double resonanceBiophysical Journal, vol. 106, no. 4, pp. 834-842Contributions to Journals: Articles