The Microscopy and Histology Core Facility has a wealth of knowledge and expertise to assist you with your research. We are available to work with researchers within the University of Aberdeen and also with external laboratories and commercial companies. 

Services

  • Direct instrument use - we offer access to our equipment following training with facility staff. 
  • Training – we can organise training on our equipment one to one or in small groups. We also run regular microscopy courses covering all the important information regarding the systems we have within our facility. 
  • Consultancy and advice services – we can be contracted for consulting services to provide interpretation and analysis of data.
  • Research projects - we are able to carry out research for you. We can prepare samples, take images and produce data as required. 

Contact us at microscopy@abdn.ac.uk for more information and a quote for any of the above services.
 

Equipment

Optical Microscopy
Image of EvosXL

EVOS XL light microscope

  • An all in one microscope with phase and colour brightfield imaging capabilities
  • Samples can be viewed on slides or tissue culture plates
Image of EVOS M5000 fluorescence microscope

EVOS M5000 fluorescence microscope

  • 3 colour fluorescence, transmitted light and colour imaging
  • Autofocus, z stack and time lapse imaging and single click multi channel capture
  • Software for fast acquisition and analysis
Image of Zeiss AxioScan Z1 slide scanner

Zeiss AxioScan Z1 slide scanner

  • An entire sample on a slide can be imaged, both brightfield and 4 colour fluorescence
  • Up to 100 slides can be scanned in one batch
Image of Zeiss Imager M2 upright microscope (Nessie)

Zeiss Imager M2 upright microscope (Nessie) 

  • A fully motorised filter turret and z focus
  • Hamamatsu Flash 4 LT camera
  • Fluorescence and phase contrast imaging
Image of Olympus upright microscope (Kelpie)

Olympus upright microscope (Kelpie)

  • Brightfield imaging
  • Zeiss MRc colour camera
Image of Zeiss stereo zoom microscope

Zeiss stereo zoom microscope

  • Dissecting microscope with Leica MC170 HD camera
Image of HoloMonitor

HoloMonitor

  • Incubator tolerant phase imaging microscope
  • Label free cell culture analysis
Image of Zeiss Axio Observer Z1 invert microscope (Haggis)

Zeiss Axio Observer Z1 invert microscope (Haggis)

  • Incubator for live cell work
  • DIC and fluorescence imaging
  • Motorised filters and Flash 4 camera
  • Oil objectives for higher resolution imaging
Image of Zeiss Axio Observer Z1 invert microscope (Tatties)

Zeiss Axio Observer Z1 invert microscope (Tatties)

  • Fluorescence and phase contrast imaging
  • Motorised filters and Zeiss 503 camera
  • Long distance x20 and x40 objectives
Confocal Microscopy
Image of Zeiss LSM700 confocal microscope​

Zeiss LSM700 confocal microscope​

  • Upright confocal microscope
  • Motorised stage and a wide range of laser lines
  • Can also be used as a widefield fluorescence microscope
Image of  Zeiss LSM880 confocal microscope + Airyscan Fast

Zeiss LSM880 confocal microscope + Airyscan Fast

  • Incubator for live cell work and motorised stage 
  • Airyscan Fast gives an instant 4-8x improvement of signal to noise compared to normal confocal
  • Enhanced resolution in x, y and z with high acquisition speed
Image of Zeiss LSM710 confocal microscope

Zeiss LSM710 confocal microscope

  • Inverted confocal microscope
  • Motorised stage and a wide range of laser lines
Image of Ultraview VoX spinning disk confocal microscope

Ultraview VoX spinning disk confocal microscope

  • Acquisition of images at a very high frame rate
  • Minimum illumination of samples for gentle imaging
  • Faster than point scanning confocal so good for live cell imaging
Electron Microscopy
Image of Leica UC6 and UC7T ultramicrotomes

Leica UC6 and UC7T ultramicrotomes

  • Ultrathin sectioning for TEM
  • Sectioning onto grids, coverslips and wafers
  • Cryoultramicrotomy available
Image of Ted Pella Biowave microwave tissue processor

Ted Pella Biowave microwave tissue processor

  • Rapid sample processing
  • Microwave and vacuum function to enhance sample preparation 
Image of Leica Empact 2/RTS high pressure freezer

Leica Empact 2/RTS high pressure freezer

  • Cryo-fixation of samples for TEM
  • Enhanced preservation of sample morphology
Image of Leica AFS2/FSP automated freeze substitution system

Leica AFS2/FSP automated freeze substitution system

  • Low temperature processing of TEM samples
  • Preservation of epitopes for immuno TEM preparation
Image of Bal-Tec Critical Point Dryer


Bal-Tec Critical Point Dryer

  • For drying SEM samples
Image of sputter coater

Quorum Q150T ES Sputter Coater

  • Capable of sputtering and carbon coating
Image of JEOL 1400 plus TEM

JEOL 1400 plus TEM

  • AMT UltraVUE camera
  • Advanced, user friendly TEM to allow visualisation of samples at high magnification
  • Tomography allowing 3D visualisation of samples
Image of Zeiss EVO MA10 SEM

Zeiss EVO MA10 SEM

  • Oxford INCA x-ray microanalysis
  • An easy to use SEM with a magnification range of x20 – x50,000
  • Resolution is ~5nm in biological samples

Field Emission SEM available in the Meston Building, more info can be found on the ACEMAC website.

Histology

Image of wax microtome

Image of resin microtome

Leica RM2165 and RM2125RT microtomes

  • Sectioning of histological samples embedded in paraffin or resin
  • Multiple blade holders allowing sectioning of wide range of sample types
Image of Ted Pella Biowave microwave tissue processor

Ted Pella Biowave microwave tissue processor

  • Microwave and vacuum function for sample processing, staining, IHC
Image of Leica 1850 UV and 1850 cryostats 

Leica 1850 UV and 1850 cryostats 

  • Sectioning of samples that have been snap frozen
  • Disposable and Tungsten Carbide blade holders for variety of sample types

Image of Thermo Shandon Citadel

Image of  Leica EMTP tissue processors

Thermo Shandon Citadel and Leica EMTP tissue processors

  • Automated processing of samples
  • Process to acrylic, lowicryl and epoxy resins
Image of Leica embedding centre

Leica embedding centre

  • With heated forceps for paraffin embedding
Image of depariffinisation and staining station

Deparaffinization and Staining station

  • Deparaffinization, dehydration for pre-staining
  • Multiple histological stains available (H&E set up)
  • Rehydration, clearing and coverslipping
Micro CT
Image of Skyscan CT

Skyscan 1072

  • Sample size up to 1.5cm x 3cm
  • Resolution of up to 4µm
  • Magnification between x15 and x120
Image of Nikon XT H 225ST

Nikon XT H 225ST

  • Can be used to scan a wide variety of samples
  • Resolution 5 - 125µm voxel size
  • Maximum sample diameter of 25cm (weight 30kg)