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Aberdeen Centre for Women's Health Research

Dr Seonaidh Cotton

Dr Seonaidh Cotton
Dr Seonaidh Cotton
Dr Seonaidh Cotton

BSc (Hons), MLitt, PhD

Senior Trial Manager

About
Email Address
s.c.cotton@abdn.ac.uk
Telephone Number
+44 (0)1224 438178
Office Address

Health Services Research Unit Health Sciences Building (Third Floor) Foresterhill Aberdeen AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

I joined HSRU in 2007 as a trial manager.  I graduated from the University of Aberdeen with a BSc in Health Sciences in 1993, an MLitt in 1995, and a PhD in 2007.  Prior to joining the Unit, I worked in the Department of Public Health at the University of Aberdeen.

I am the Senior Trial Manager within CHaRT supporting the portfolio of trials.   I also currently work on the BICS trial - a multicentre trial investigating the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease.    

Previously I was the Deputy Senior Trial Manager and supported a number of studies including RAACENO, EMPOWER and ELECTRIC (all now completed).  I also worked as trial manager on a number of CHaRT trials, including TWICS, CLASS, NIAMI, FOCCUS, REFLUX and the Cysteamine in CF study.  

I am interested in methodological research that can be carried out alongside existing trials, including the provision of information to potential participants and strategies to increase response rates.

 

Qualifications

  • BSc Health Sciences 
    1993 - University of Aberdeen 
  • MLitt by research 
    1994 - University of Aberdeen 
  • PhD Public Health 
    2008 - University of Aberdeen 
Research

Research Overview

Trial methodology & trial management

Research Areas

Applied Health Sciences

View Research Area

Nutrition and Health

View Research Area

Current Research

I am the Senior Trial Manager within CHaRT supporting the portfolio of trials.   I also currently work on the BICS trial - a multicentre trial investigating the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease.    

I am interested in methodological research that can be carried out alongside existing trials, including the provision of information to potential participants and strategies to increase response rates.

Past Research

Since joining the Unit I have worked on a number of trials that have now been completed. 

TWICS  - a multicentre trial investigating the effectiveness of low dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease.

CLASS - a multicentre trial comparing foam sclerotherapy and endovenous laser ablation with conventional surgery in patients with varicose veins;

NIAMI - a phase II multicentre trial investigating whether an intravenous injection of sodium nitrite given immediately before the infarct related artery is opened reduces ischaemia reperfusion injury in patients with myocardial infarction;

FOCCUS - a pragmatic multi-centred randomised controlled trial of surgical HDU care versus HDU care delivered in an ICU and pre-operative fluid loading in high-risk patients undergoing major elective surgery

REFLUX - a multi-centre randomised trial comparing a policy of relatively early laparoscopic surgery with a continued best medical management policy for people with more severe gastro-oesophageal reflux disease.

The Cysteamine in CF study - a single-centre, single group open label study of oral cysteamine in patients with Cystic Fibrosis.

I also supported RAACENO, EMPOWER and ELECTRIC (all now completed) as senior trial manager.

Teaching

Courses

Teaching Responsibilities

I have supervised a number of undergraduate and Masters level research projects, including topics such as provision of information to potential participants, strategies to increase response rates, and outcome measures.

 

 

Non-course Teaching Responsibilities

Outwith the University, I am a faculty member on the Edinburgh Clinical Trial Management Course (ECTMC).

 

Publications

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  • Exploring Opinions and Concerns about the Human Papillomavirus Vaccine on a United Kingdom Online Discussion Forum

    Klejnotowska, A., Skea, Z., Cotton, S., Cruickshank, M.
    Journal of Colposcopy and Lower Genital Tract Pathology, vol. 1, no. 3, pp. 117-123
    Contributions to Journals: Articles

  • Effectiveness of conservative management versus laparoscopic cholecystectomy in the prevention of recurrent symptoms and complications in adults with uncomplicated symptomatic gallstone disease (C-GALL trial): pragmatic, multicentre randomised controlled trial

    Ahmed, I., Hudson, J., Innes, K., Hernández, R., Gillies, K., Bruce, R., Bell, V., Avenell, A., Blazeby, J., Brazzelli, M., Cotton, S., Croal, B., Forrest, M., MacLennan, G., Murchie, P., Wileman, S., Ramsay, C.
    BMJ, vol. 383, e075383
    Contributions to Journals: Articles

  • Emergency Department Resuscitative Endovascular Balloon Occlusion of the Aorta in Trauma Patients With Exsanguinating Hemorrhage: The UK-REBOA Randomized Clinical Trial

    Jansen, J. O., Hudson, J., Cochran, C., MacLennan, G., Lendrum, R., Sadek, S., Gillies, K., Cotton, S., Kennedy, C., Boyers, D., Ferry, G., Lawrie, L., Nath, M., Wileman, S., Forrest, M., Brohi, K., Harris, T., Lecky, F., Moran, C., Morrison, J. J., Norrie, J., Paterson, A., Tai, N., Welch, N., Campbell, M. K., Aylwin, C., Bew, D., Brooks, A., Chinery, J., Cowlam, T., Frith, D., George, A., Hudson, A., Johnstone, P., Mahmood, A., Novak, A., O'Meara, M., Reid, S., Sattout, A., Smith, C., Stansfield, T., Thompson, J., UK-REBOA Study Group
    JAMA, vol. 330, no. 19, pp. 1862-1871
    Contributions to Journals: Articles

  • Laparoscopic cholecystectomy versus conservative management for adults with uncomplicated symptomatic gallstones: the C-GALL RCT

    Innes, K., Ahmed, I., Hudson, J., Hernández, R. A., Gillies, K., Bruce, R., Bell, V., Avenell, A., Blazeby, J. M., Brazzelli, M., Cotton, S., Croal, B., Forrest, M., MacLennan, G., Murchie, P., Wileman, S., Ramsay, C.
    Health and Social Care Delivery Research
    Contributions to Journals: Articles

  • A qualitative process evaluation within a clinical trial that used healthcare technologies for children with asthma: insights and implications

    Lawrie, L., Turner, S., Cotton, S., Wood, J., Morgan, H.
    PloS ONE, vol. 18, no. 1, 0280086
    Contributions to Journals: Articles

  • An interview study within a clinical trial that used healthcare technologies for children with asthma – insights and implications

    Lawrie, L., Turner, S., Cotton, S., Wood, J., Morgan, H.
    ICTMC 2022, pp. 370
    Contributions to Conferences: Abstracts

  • Trial Forge Guidance 3: Randomised trials and how to recruit and retain individuals from ethnic minority groups– practical guidance to support better practice

    Dawson, S., Banister, K., Biggs, K., Cotton, S., Devane, D., Gardner, H., Gillies, K., Gopalakrishnan, G., Isaacs, T., Khunti, K., Nichol, A., Parker, A., Russell, A. M., Shepherd, V., Shiely, F., Shorter, G. W., Starling, B., Williams, H., Willis, A., Witham, M. D., Treweek, S.
    Trials, vol. 23, no. 1, 672
    Contributions to Journals: Articles

  • Randomised controlled trial comparing the clinical and cost-effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long-term catheters: study protocol for the CATHETER II study

    Abdel-fattah, M., Johnson, D., Constable, L., Thomas, R., Cotton, S., Tripathee, S., Cooper, D., Boran, S., Dimitropoulos, K., Evans, S., Granitsiotis, P., Hashim, H., Kilonzo, M., Larcombe, J., Little, P., MacLennan, S., Murchie, P., Myint, P., N’Dow, J., Norrie, J., Omar, M. I., Paterson, C., Scotland, G., Thiruchelvam, N., MacLennan, G.
    Trials, vol. 23, no. 1, 630
    Contributions to Journals: Articles

  • Effectiveness and cost-effectiveness of text messages with or without endowment incentives for weight management in men with obesity (Game of Stones): study protocol for a randomised controlled trial

    Macaulay, L., O’Dolan, C., Avenell, A., Carroll, P., Cotton, S., Dombrowski, S., Elders, A., Goulao, B., Gray, C., Harris, F. M., Hunt, K., Kee, F., MacLennan, G., McDonald, M. D., McKinley, M., Skinner, R., Torrens, C., Tod, M., Turner, K., van der Pol, M., Hoddinott, P.
    Trials, vol. 23, no. 1, 582
    Contributions to Journals: Articles

  • Reducing asthma attacks in children using exhaled nitric oxide (RAACENO) as a biomarker to inform treatment strategy: a multicentre, parallel, randomised, controlled, phase 3 trial

    Turner, S., Cotton, S., Wood, J., Bell, V., Raja, E. A., Scott, N., Morgan, H., Lawrie, L., Emele, D., Kennedy, C., Scotland, G., Fielding, S., MacLennan, G., Norrie, J., Forrest, M., Gaillard, E. A., de Jongste, J. C., Pijnenburg, M. W., Thomas, M., Price, D.
    The Lancet. Respiratory medicine, vol. 10, no. 6, pp. 584-592
    Contributions to Journals: Articles

  • Treatment guided by fractional exhaled nitric oxide in addition to standard care in 6- to 15-year-olds with asthma: the RAACENO RCT

    Turner, S., Cotton, S., Wood, J., Bell, V., Raja, E. A., Scott, N., Morgan, H., Lawrie, L., Emele, D., Kennedy, C., Scotland, G., Fielding, S., MacLennan, G., Norrie, J., Forrest, M., Gaillard, E. A., de Jongeste, J., Pijnenburg, M. W., Thomas, M., Price, D.
    Efficacy and Mechanism Evaluation, vol. 9, no. 4, pp. 1-153
    Contributions to Journals: Articles

  • ScotCap - A large observational cohort study

    MacLeod, C., Hudson, J., Brogan, M., Cotton, S., Treweek, S., MacLennan, G., Watson, A. J. M.
    Colorectal Disease, vol. 24, no. 4, pp. 411-421
    Contributions to Journals: Articles

  • Use of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial. (BICS)

    Cotton, S., Devereux, G., Abbas, H., Briggs, A. H., Campbell, K., Chaudhuri, R., Choudhury, G., Dawson, D., De Soyza, A., Fielding, S., Gompertz, S., Haughney, J., Lang, C. C., Lee, A., MacLennan, G., MacNee, W., McCormack, K., McMeekin, N., Mills, N. L., Morice, A., Norrie, J., Petrie, L., Price, D., Short, P., Vestbo, J., Walker, P., Wedzicha, J. A., Wilson, A., Lipworth, B. J.
    Trials, vol. 23, no. 1, 307
    Contributions to Journals: Articles

  • The relative importance of information items and preferred mode of delivery when disseminating results from trials to participants: a mixed methods study

    Wood, J., Cotton, S., Gillies, K.
    Health Expectations, vol. 25, no. 1, pp. 419-429
    Contributions to Journals: Articles

  • The ALLEGRO trial: a placebo controlled randomised trial of intravenous lidocaine in accelerating gastrointestinal recovery after colorectal surgery

    Paterson, H., Cotton, S., Norrie, J., Nimmo, S., Foo, I., Balfour, A., Speake, D., MacLennan, G., Stoddart, A., Innes, K., Cameron, S., Aucott, L., McCormack, K.
    Trials, vol. 23, no. 1, 84
    Contributions to Journals: Articles

  • A multicentre open label randomised clinical trial using exhaled nitric oxide in addition to standard care to reduce asthma attacks in children

    Turner, S., Cotton, S., Wood, J., Bell, V., Raja, E. A., Scott, N., Morgan, H., Lawrie, L., Emele, D., Kennedy, C., Scotland, G., Fielding, S., MacLennan, G., Norrie, J., Forrest, M., Gaillard, E. A., Gaillard, E. A., de Jongeste, J., Pijnenburg, M. W., Thomas, M., Price, D.
    Efficacy and Mechanism Evaluation
    Contributions to Journals: Articles

  • Has the human papillomavirus (HPV) immunization programme improved obstetric outcomes in spontaneous delivery?: An ecological study

    Xu, X., Woolner, A., Bhattacharya, S., Cotton, S., Zhao, F., Cruickshank, M.
    European Journal of Obstetrics & Gynecology and Reproductive Biology, vol. 262, pp. 221-227
    Contributions to Journals: Articles

  • Tibial nerve stimulation compared with sham to reduce incontinence in care home residents: ELECTRIC RCT

    Booth, J., Aucott, L., Cotton, S., Davis, B., Fenocchi, L., Goodman, C., Hagen, S., Harari, D., Lawrence, M., Lowndes, A., Macaulay, L., MacLennan, G., Mason, H., McClurg, D., Norrie, J., Norton, C., O'Dolan, C., Skelton, D., Surr, C., Treweek, S.
    Health technology assessment (Winchester, England), vol. 25, no. 41, pp. 1-109
    Contributions to Journals: Articles

  • Providing trial results to participants in Phase III pragmatic effectiveness RCTs: a scoping review

    Bruhn, H., Cowan, E., Campbell, M., Constable, L., Cotton, S., Entwistle, V., Humphreys, R., Innes, K., Jayacodi, S., Jayacodi, S., Knapp, P., South, A., Gillies, K.
    Trials, vol. 22, 361
    Contributions to Journals: Articles

  • Developing the INCLUDE Ethnicity Framework: a tool to help trialists design trials that better reflect the communities they serve

    Treweek, S., Banister, K., Bower, P., Cotton, S., Devane, D., Gardner, H., Isaacs, T., Nestor, G., Oshisanya, A., Parker, A., Rochester, L., Soulsby, I., Williams, H. C., Witham, M. D.
    Trials, vol. 22, 337
    Contributions to Journals: Articles

  • It is unprecedented: trial management during the COVID-19 pandemic and beyond

    Mitchell, E. J., Ahmed, K., Breeman, S., Cotton, S., Constable, L., Ferry, G., Goodman, K., Hickey, H., Meakin, G., Mironov, K., Quann, N., Wakefield, N., McDonald, A.
    Trials, vol. 21, pp. 784
    Contributions to Journals: Articles

  • How to Deal with a Temporary Suspension and Restarting Your Trial: Our Experiences and lessons Learnt

    Constable, L., Davidson, T., Breeman, S., Cotton, S., McDonald, A., Wileman, S., Norrie, J.
    Trials, vol. 21, no. 1, pp. 765
    Contributions to Journals: Articles

  • Using systematic data categorisation to quantify the types of data collected in clinical trials: the DataCat project

    Crowley, E., Treweek, S., Banister, K., Breeman, S., Constable, L., Cotton, S., Duncan, A., El Feky, A., Gardner, H., Goodman, K., Lanz, D., McDonald, A., Ogburn, E., Starr, K., Stevens, N., Valente, M., Fernie, G.
    Trials, vol. 21, no. 1, pp. 535
    Contributions to Journals: Articles

  • Verifying participant-reported clinical outcomes: challenges and implications

    Breeman, S., Constable, L., Duncan, A., Starr, K., McDonald, A., Wileman, S., Cotton, S.
    Trials, vol. 21, no. 1, pp. 241
    Contributions to Journals: Articles

  • Trial Forge Guidance 2: how to decide if a further Study Within A Trial (SWAT) is needed

    Treweek, S., Bevan, S., Bower, P., Briel, M., Campbell, M., Christie, J., Collett, C., Cotton, S., Devane, D., El Feky, A., Galvin, S., Gardner, H., Gillies, K., Hood, K., Jansen, J., Littleford, R., Parker, A., Ramsay, C., Restrup, L., Sullivan, F., Torgerson, D., Tremain, L., von Elm, E., Westmore, M., Williams, H., Williamson, P. R., Clarke, M.
    Trials, vol. 21, 33
    Contributions to Journals: Articles

  • Women’s Preferences for Communication with the Cervical Screening Programme: A Qualitative Study

    Ravindran, R., Cotton, S., Cruickshank, M.
    Cytopathology, vol. 31, no. 1, pp. 47-52
    Contributions to Journals: Articles

  • ELECtric Tibial nerve stimulation to Reduce Incontinence in Care homes: protocol for the ELECTRIC randomised trial

    Booth, J., Aucott, L., Cotton, S., Goodman, C., Hagen, S., Harari, D., Lawrence, M., Lowndes, A., Macaulay, L., MacLennan, G., Mason, H., McClurg, D., Norrie, J., Norton, C., O'Dolan, C., Skelton, D. A., Surr, C., Treweek, S.
    Trials, vol. 20, 723
    Contributions to Journals: Articles

  • Five-Year Outcomes of a Randomized Trial of Treatments for Varicose Veins

    Brittenden, J., Cooper, D., Dimitrova, M., Scotland, G., Cotton, S. C., Elders, A., MacLennan, G., Ramsay, C. R., Norrie, J., Burr, J. M., Campbell, B., Bachoo, P., Chetter, I., Gough, M., Earnshaw, J., Lees, T., Scott, J., Baker, S. A., Tassie, E., Francis, J., Campbell, M. K.
    The New England Journal of Medicine, vol. 381, no. 10, pp. 912-922
    Contributions to Journals: Articles

  • Low-dose oral theophylline combined with inhaled corticosteroids for people with chronic obstructive pulmonary disease and high risk of exacerbations: a RCT

    Devereux, G., Cotton, S., Fielding, S., McMeekin, N., Barnes, P. J., Briggs, A., Burns, G., Chaudhuri, R., Chrystyn, H., Davies, L., Soyza, A. D., Gompertz, S., Haughney, J., Innes, K., Kaniewska, J., Lee, A., Morice, A., Norrie, J., Sullivan, A., Wilson, A., Price, D.
    Health technology assessment (Winchester, England), vol. 23, no. 37, pp. 1-146
    Contributions to Journals: Articles

  • Estimating Site Performance (ESP): can trial managers predict recruitment success at trial sites? An exploratory study

    Bruhn, H., Treweek, S., Duncan, A., Shearer, K., Cameron, S., Campbell, K., Innes, K., McRae, D., Cotton, S. C.
    Trials, vol. 20, 192
    Contributions to Journals: Articles

  • Reducing Asthma Attacks in Children using Exhaled Nitric Oxide as a biomarker to inform treatment strategy: a randomised trial (RAACENO)

    Turner, S., Cotton, S. C., Emele, C. D., Thomas, R. E., Fielding, S. A., Gaillard, E. A., de Jongste, J. C., Morgan, H. M., Nielson, A. R., Norrie, J., Pijnenburg, M. W., Price, D. B., Thomas, M.
    Trials, vol. 20, 573
    Contributions to Journals: Articles

  • Information needs of young women vaccinated against HPV attending colposcopy: a qualitative study

    Young, A., Cotton, S., Cruickshank, M. E.
    BMC Women's Health, vol. 18, no. 1, 200
    Contributions to Journals: Articles

  • Effect of Theophylline as Adjunct to Inhaled Corticosteroids on Exacerbations in Patients With COPD: A Randomized Clinical Trial

    Devereux, G., Cotton, S., Fielding, S., McMeekin, N., Barnes, P. J., Briggs, A., Burns, G., Chaudhuri, R., Chrystyn, H., Davies, L., De Soyza, A., Gompertz, S., Haughney, J., Innes, K., Kaniewska, J., Lee, A., Morice, A., Norrie, J., Sullivan, A., Wilson, A., Price, D.
    JAMA, vol. 320, no. 15, pp. 1548-1559
    Contributions to Journals: Articles

  • Relative importance of informational items in Participant Information Leaflets for trials: a Q-Methodology approach

    Innes, K. A., Cotton, S., Campbell, M. K., Elliott, J., Gillies, K.
    BMJ Open, vol. 8, no. 9, e023303
    Contributions to Journals: Articles

  • Patient reported measures of informed consent for clinical trials: A systematic review

    Gillies, K., Duthie, A., Cotton, S., Campbell, M. K.
    PloS ONE, vol. 13, no. 6, e0199775
    Contributions to Journals: Articles

  • Use of 'Low-Dose' Theophylline to Reduce Exacerbations of COPD: A Pragmatic Multicentre Randomised Placebo Controlled Trial

    Price, D. B., Cotton, S., Fielding, S., McMeekin, N., Barnes, P., Briggs, A., Burns, G., Chaudhuri, R., Chrystyn, H., Davies, L., De Soyza, A., Gompertz, S., Haughney, J., Lee, A., Morice, A., Norrie, J., Sullivan, A., Wilson, A., Devereux, G.
    American Thoracic Society 2018 International Conference, A7709
    Contributions to Journals: Abstracts

  • Trial Forge Guidance 1: What is a Study Within A Trial (SWAT)

    Treweek, S., Bevan, S., Bower, P., Campbell, M., Christie, J., Clarke, M., Collett, C., Cotton, S. C., Devane, D., El Feky, A., Flemyng, E., Galvin, S., Gardner, H. R., Gillies, K., Jansen, J., Littleford, R., Parker, A., Ramsay, C., Restrup, L., Sullivan, F., Torgerson, D., Tremain, L., Westmore, M., Williamson, P. R.
    Trials, vol. 19, 139
    Contributions to Journals: Letters

  • The influence of early research experience in medical school on the decision to intercalate and future career in clinical academia: A questionnaire study

    Boyle, S. E., Cotton, S. C., Myint, P. K., Hold, G. L.
    BMC Medical Education, vol. 17, 245
    Contributions to Journals: Articles

  • Reduction in colposcopy workload and associated clinical activity following HPV catch-up vaccination programme in Scotland: an ecological study

    Cruickshank, M. E., Pan, J., Cotton, S. C., Kavanagh, K., Robertson, C., Cuschieri, K., Cubie, H., Palmer, T., Pollock, K. G.
    BJOG-An International Journal of Obstetrics and Gynaecology, vol. 124, no. 9, pp. 1386-1393
    Contributions to Journals: Articles

  • The impact of HPV type on colposcopy performance in women offered HPV immunisation in a catch-up vaccine programme: a two centre observational study

    Munro, A., Gillespie, C., Cotton, S., Busby-Earle, C., Kavanagh, K., Cuschieri, K., Cubie, H., Robertson, C., Smart, L., Pollock, K., Moore, C., Palmer, T., Cruickshank, M. E.
    BJOG-An International Journal of Obstetrics and Gynaecology, vol. 124, no. 9, pp. 1394-1401
    Contributions to Journals: Articles

  • Psychosocial morbidity in women with abnormal cervical cytology managed by cytological surveillance or initial colposcopy: longitudinal analysis from the TOMBOLA randomised trial

    Fielding, S., Rothnie, K., Gray, N. M., Little, J., Cruickshank, M., Neal, K., Walker, L., Whynes, D., Cotton, S., Sharp, L.
    Psycho-Oncology, vol. 26, no. 4, pp. 476–483
    Contributions to Journals: Articles

  • An Open-Label Investigation of the Pharmacokinetics and Tolerability of Oral Cysteamine in Adults with Cystic Fibrosis

    Devereux, G., Steele, S., Griffiths, K., Devlin, E., Fraser-Pitt, D., Cotton, S., Norrie, J., Chrystyn, H., O'Neil, D.
    Clinical Drug Investigation, vol. 36, no. 8, pp. 605-612
    Contributions to Journals: Articles

  • HPV immunisation and cervical screening - confirmation of changed performance of cytology as a screening test in immunised women: a retrospective population based cohort study

    Palmer, T. J., McFadden, M., Pollock, K. G. J., Kavanagh, K., Cuschieri, K., Cruickshank, M., Cotton, S., Nicoll, S., Robertson, C.
    British Journal of Cancer, vol. 114, no. 5, pp. 582-589
    Contributions to Journals: Articles

  • Behavioural recovery after treatment for varicose veins

    Cotton, S. C., MacLennan, G., Brittenden, J., Prior, M., Francis, J.
    British Journal of Surgery, vol. 103, no. 4, pp. 374-381
    Contributions to Journals: Articles

  • Impact of post-colposcopy management on women's long-term worries: results from the UK population-based TOMBOLA trial

    Sharp, L., Cotton, S., Cruickshank, M., Gray, N., Smart, L., Whynes, D., Little, J., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    Journal of Family Planning and Reproductive Health Care, vol. 42, no. 1, pp. 43-51
    Contributions to Journals: Articles

  • Decision aids for people considering taking part in clinical trials

    Gillies, K., Cotton, S. C., Brehaut, J. C., Politi, M. C., Skea, Z.
    Cochrane Database of Systematic Reviews, no. 11, CD009736
    Contributions to Journals: Articles

  • Long-term Worries after Colposcopy: Which Women Are at Increased Risk?

    Sharp, L., Cotton, S. C., Cruickshank, M. E., Gray, N. M., Neal, K., Rothnie, K., Thornton, A. J., Walker, L. G., Little, J., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    Women's Health Issues, vol. 25, no. 5, pp. 517-527
    Contributions to Journals: Articles

  • SMS text pre-notification and delivery of reminder e-mails to increase response rates to postal questionnaires in the SUSPEND trial: a factorial design, randomised controlled trial

    Starr, K., McPherson, G., Forrest, M., Cotton, S. C.
    Trials, vol. 16, 295
    Contributions to Journals: Articles

  • Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: study protocol for a randomised controlled trial

    Devereux, G., Cotton, S., Barnes, P., Briggs, A., Burns, G., Chaudhuri, R., Chrystyn, H., Davies, L., De Soyza, A., Fielding, S., Gompertz, S., Haughney, J. A. F., Lee, A. J., McCormack, K., McPherson, G., Morice, A., Norrie, J., Sullivan, A., Wilson, A., Price, D.
    Trials, vol. 16, 267
    Contributions to Journals: Articles

  • Making randomised trials more efficient: report of the first meeting to discuss the Trial Forge platform

    Treweek, S., Altman, D. G., Bower, P., Campbell, M., Chalmers, I., Cotton, S., Craig, P., Crosby, D., Davidson, P., Devane, D., Duley, L., Dunn, J., Elbourne, D., Farrell, B., Gamble, C., Gillies, K., Hood, K., Lang, T., Littleford, R., Loudon, K., McDonald, A., McPherson, G., Nelson, A., Norrie, J., Ramsay, C., Sandercock, P., Shanahan, D. R., Summerskill, W., Sydes, M., Williamson, P., Clarke, M.
    Trials, vol. 16, 261
    Contributions to Journals: Articles

  • A normal colposcopy examination fails to provide psychological reassurance for women who have had low-grade abnormal cervical cytology

    Cotton, S. C., Sharp, L., Little, J., Gray, N. M., Walker, L. G., Whynes, D. K., Cruickshank, M. E., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    Cytopathology, vol. 26, no. 3, pp. 178-187
    Contributions to Journals: Articles

  • Clinical effectiveness and cost-effectiveness of foam sclerotherapy, endovenous laser ablation and surgery for varicose veins: results from the Comparison of LAser, Surgery and foam Sclerotherapy (CLASS) randomised controlled trial

    Brittenden, J., Cotton, S. C., Elders, A., Tassie, E., Scotland, G., Ramsay, C. R., Norrie, J., Burr, J., Francis, J., Wileman, S., Campbell, B., Bachoo, P., Chetter, I., Gough, M., Earnshaw, J., Lees, T., Scott, J., Baker, S. A., MacLennan, G., Prior, M., Bolsover, D., Campbell, M. K.
    Health Technology Assessment, vol. 19, no. 27, pp. 1-342
    Contributions to Journals: Articles

  • Management of women with low grade cytology: how reassuring is a normal colposcopy examination?

    Cruickshank, M. E., Cotton, S. C., Sharp, L., Smart, L., Walker, L. G., Little, J., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    BJOG-An International Journal of Obstetrics and Gynaecology, vol. 122, no. 3, pp. 380-386
    Contributions to Journals: Articles

  • Normative data for the Hospital Anxiety and Depression Scale

    Breeman, S., Cotton, S., Fielding, S., Jones, G. T.
    Quality of Life Research, vol. 24, no. 2, pp. 391-398
    Contributions to Journals: Articles

  • Measuring the psychosocial burden in women with low-grade abnormal cervical cytology in the TOMBOLA trial: psychometric properties of the Process and Outcome Specific Measure (POSM)

    Rothnie, K., Cotton, S. C., Fielding, S., Gray, N. M., Little, J., Cruickshank, M. E., Walker, L. G., Avis, M., Sharp, L.
    Health and Quality of Life Outcomes, vol. 12, 154
    Contributions to Journals: Articles

  • Cost-effectiveness of ultrasound-guided foam sclerotherapy, endovenous laser ablation or surgery as treatment for primary varicose veins from the randomized CLASS trial

    Tassie, E., Scotland, G., Brittenden, J., Cotton, S. C., Elders, A., Campbell, M. K., Campbell, B., Gough, M., Burr, J. M., Ramsay, C. R., CLASS Study Team
    British Journal of Surgery, vol. 101, no. 12, pp. 1532-1540
    Contributions to Journals: Articles

  • A randomized trial comparing treatments for varicose veins

    Brittenden, J., Cotton, S. C., Elders, A., Ramsay, C. R., Norrie, J., Burr, J., Campbell, B., Bachoo, P., Chetter, I., Gough, M., Earnshaw, J., Lees, T., Scott, J., Baker, S. A., Francis, J., Tassie, E., Scotland, G., Wileman, S., Campbell, M. K.
    The New England Journal of Medicine, vol. 371, no. 13, pp. 1218-1227
    Contributions to Journals: Articles

  • Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)

    Siddiqi, N., Neil, C., Bruce, M., Maclennan, G., Cotton, S. C., Papadopoulou, S., Feelisch, M., Bunce, N., Lim, P. O., Hildick-Smith, D., Horowitz, J., Madhani, M., Boon, N., Dawson, D., Kaski, J. C., Frenneaux, M., NIAMI investigators
    European Heart Journal, vol. 35, no. 19, pp. 1255-1262
    Contributions to Journals: Articles

  • The unintended consequences of cervical screening: distress in women undergoing cytologic surveillance

    Sharp, L., Cotton, S., Cruickshank, M., Gray, N. M., Harrild, K., Smart, L., Walker, L. G., Little, J., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    Journal of Lower Genital Tract Disease, vol. 18, no. 2, pp. 142-150
    Contributions to Journals: Articles

  • Patient information leaflets (PILs) for UK randomised controlled trials: a feasibility study exploring whether they contain information to support decision making about trial participation

    Gillies, K., Huang, W., Skea, Z., Brehaut, J., Cotton, S.
    Trials, vol. 15, 62
    Contributions to Journals: Articles

  • Nitrites in Acute Myocardial Infarction

    Siddiqi, N., Bruce, M., Neil, C. J., MacLennan, G., Cotton, S., Papadopoulou, S. A., Jagpal, B., Brown, S., Gonzalez, F. P., Singh, S., Schwarz, K., Feelisch, M., Bunce, N., Lim, P. O., Hildick-Smith, D., Horowitz, J., Madhani, M., Boon, N., Dawson, D., Kaski, J., Frenneaux, M. P.
    Circulation, vol. 128, no. 24, pp. 2705
    Contributions to Journals: Abstracts

  • Impact of alternative management policies on health-related quality of life in women with low-grade abnormal cervical cytology referred for colposcopy

    Whynes, D. K., Sharp, L., Cotton, S. C., Cruickshank, M., Gray, N. M., Little, J., Waugh, N.
    European Journal of Obstetrics & Gynecology and Reproductive Biology, vol. 169, no. 1, pp. 88-92
    Contributions to Journals: Articles

  • Clinical and economic evaluation of laparoscopic surgery compared with medical management for gastro-oesophageal reflux disease: 5-year follow-up of multicentre randomised trial (the REFLUX trial)

    Grant, A. M., Boachie, C., Cotton, S. C., Faria, R., Bojke, L., Epstein, D. M., Ramsay, C. R., Corbacho, B., Sculpher, M., Krukowski, Z. H., Heading, R. C., Campbell, M. K.
    Health Technology Assessment, vol. 17, no. 22, pp. 1-166
    Contributions to Journals: Articles

  • Protocol: does sodium nitrite administration reduce ischaemia-reperfusion injury in patients presenting with acute ST segment elevation myocardial infarction? Nitrites in acute myocardial infarction (NIAMI)

    Siddiqi, N., Bruce, M., Neil, C. J., Jagpal, B., MacLennan, G. S., Cotton, S. C., Papadopoulo, S. A., Bunce, N., Lim, P., Schwarz, K., Singh, S., Hildick-Smith, D., Horowitz, J. D., Madhani, M., Boon, N., Kaski, J., Dawson, D., Frenneaux, M. P.
    Journal of translational medicine, vol. 11, 116
    Contributions to Journals: Articles

  • Minimal access surgery compared with medical management for gastro-oesophageal reflux disease: five year follow-up of a randomised controlled trial (REFLUX)

    Grant, A. M., Cotton, S. C., Boachie, C., Ramsay, C. R., Krukowski, Z. H., Heading, R. C., Campbell, M. K., REFLUX Trial Group
    BMJ, vol. 346, f1908
    Contributions to Journals: Articles

  • Which women default from follow-up cervical cytology tests? A cohort study within the TOMBOLA trial

    Sharp, L., Cotton, S., Thornton, A., Gray, N., Whynes, D., Smart, L., Waugh, N., Duncan, I., Cruickshank, M., Little, J., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    Cytopathology, vol. 23, no. 3, pp. 150-160
    Contributions to Journals: Articles

  • A pragmatic multi-centre randomised controlled trial of fluid loading in high-risk surgical patients undergoing major elective surgery: the FOCCUS study

    Cuthbertson, B. H., Campbell, M. K., Stott, S. A., Elders, A., Hernández, R., Boyers, D., Norrie, J., Kinsella, J., Brittenden, J., Cook, J., Rae, D., Cotton, S. C., Alcorn, D., Addison, J., Grant, A., The FOCCUS study group
    Critical Care, vol. 15, no. 6, R296
    Contributions to Journals: Articles

  • Analysis of patient information leaflets (PILs), used in clinical trials using the Informed Consent Evaluation instrument (ICEi)

    Gillies, K., Skea, Z. C., Huang, W., Cotton, S. C.
    Trials, vol. 12, no. Suppl 1, pp. A121
    Contributions to Journals: Articles

  • Human papillomavirus infection and anxiety: analyses in women with low-grade cervical cytological abnormalities unaware of their infection status

    Johnson, C. Y., Sharp, L., Cotton, S. C., Harris, C. A., Gray, N. M., Little, J., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    PloS ONE, vol. 6, no. 6, e21046
    Contributions to Journals: Articles

  • Long-term psychosocial impact of alternative management policies in women with low-grade abnormal cervical cytology referred for colposcopy: a randomised controlled trial

    Sharp, L., Cotton, S., Gray, N., Avis, M., Russell, I., Walker, L., Waugh, N., Whynes, D., Woolley, C., Thornton, A. J., Smart, L., Cruickshank, M., Little, J., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    British Journal of Cancer, vol. 104, no. 2, pp. 255-264
    Contributions to Journals: Articles

  • The role of human papillomavirus testing in the management of women with low-grade abnormalities: multicentre randomised controlled trial

    Cotton, S., Sharp, L., Little, J., Cruickshank, M., Seth, R., Smart, L., Duncan, I., Harrild, K., Neal, K., Waugh, N., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    BJOG-An International Journal of Obstetrics and Gynaecology, vol. 117, no. 6, pp. 645-659
    Contributions to Journals: Articles

  • Pragmatic multi-centre randomised trial of (1) routine postoperative ICU care and/or (2) pre-operative fluid loading in high-risk surgical patients undergoing major elective and urgent surgery

    Cuthbertson, B., Campbell, M. K., Stott, S., Vale, L. D., Norrie, J. D. T., Kinsella, J., Cook, J. A., Brittenden, J., Grant, A. M., Alcorn, D., Serpell, M., McColl, S., Rae, D., Shepherd, K., Addison, J., McPherson, G. C., McDonald, A. M., Cotton, S. C., Elders, A. S., MacLennan, G. S., Boyers, D., Hernández, R. A.
    Edinburgh, United Kingdom: Chief Scientist Office. 7 pages
    Books and Reports: Commissioned Reports

  • After-effects reported by women following colposcopy, cervical biopsies and LLETZ: results from the TOMBOLA trial

    Sharp, L., Cotton, S. C., Cochran, C., Gray, N. M., Little, J., Neal, K., Cruickshank, M. E., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    BJOG-An International Journal of Obstetrics and Gynaecology, vol. 116, no. 11, pp. 1506-1514
    Contributions to Journals: Articles

  • Comprehensive cancer control-research & development: Knowing what we do and doing what we know

    Kerner, J. F., Cazap, E., Yach, D., Pierotti, M. A., Daidone, M. G., De Blasio, P., Geary, P., Schacter, B., Sant, M., Habbema, J. D. F., Sankaranarayanan, R., Sutcliffe, C., Sutcliffe, S., Kaijage, J. K., Scanlan, P. A., Gibson, S., Mes-Masson, A. M., Sawyer, M., Shepherd, L., Watson, P., Zanke, B., Small, I. A., Olmedo, D. B., Breitenbach, M. D., Santini, L. A., Maltoni, L. A., Ramalho, D., Ferreira, C. G., Sharp, L., Cruickshank, M., Smart, L., Harrild, K., Waugh, N., Little, J., Seth, R., Neal, K., Duncan, I., Ioka, A., Ito, Y., Sato, N., Tsukuma, H., Li, J., Zhang, B. N., Fan, J. H., Qiao, Y. L., Zhong, H. Y., Curado, M. P., Pontes, T. J., Peacock, S., Van Der Hoek, K., Hoch, J., Musa, Z., Weir, H. K., Friedman, C., German, R., Ceilleachair, A. O., Comber, H., Cotton, S., Tilson, L., Walsh, C., Usher, C., Barry, M., Chilcott, J., Tappenden, P., Whyte, S., Staines, A., Greenberg, A., Fairclough, L., Roberts, W., Masterson Tavares Pereira Ferrera, D., Fonseca, E. R., Casado, L., McBride, M. L., Goddard, K., Lorenzi, M., Spinelli, J. J., Broemeling, A. M., Glickman, V., Pritchard, S., Siegel, L., Rogers, P. C., Sheps, S., Annunziata, M. A., Giovannini, L., Bianchet, K., Muzzatti, B., Berretta, M., Lleshi, A., Tirelli, U., Sisimayi, C. N., Sarwal, K., Torrance, H., Baili, P., Amati, C., Di Salvo, F., Frazzingaro, C., Sanz, N., Micheli, A.
    Tumori, vol. 95, no. 5, pp. 610-622
    Contributions to Journals: Articles

  • Biopsy and selective recall compared with immediate large loop excision in management of women with low grade abnormal cervical cytology referred for colposcopy: multicentre randomised controlled trial

    Sharp, L., Cruickshank, M., Little, J., Cotton, S., Harrild, K., Cochran, C., Duncan, I., Gray, N., Hammond, R., Smart, L., Thornton, A., Waugh, N., Woolley, C., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    British Medical Journal, vol. 339, b2548
    Contributions to Journals: Articles

  • Cytological surveillance compared with immediate referral for colposcopy in management of women with low grade cervical abnormalities: multicentre randomised controlled trial

    Little, J., Sharp, L., Cotton, S., Cruickshank, M., Duncan, I., Harrild, K., Jenkins, D., Smart, L., Waugh, N., Cochran, C., Gray, N., Hammond, R., Neal, K., Thornton, A. J., Woolley, C., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    British Medical Journal, vol. 339, b2546
    Contributions to Journals: Articles

  • Options for managing low grade cervical abnormalities detected at screening: cost effectiveness study

    Whynes, D., Philips, Z., Woolley, C., Cotton, S., Cruickshank, M., Harrild, K., Little, J., Neal, K., Sharp, L., Waugh, N., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    British Medical Journal, vol. 339, no. -, b2549
    Contributions to Journals: Articles

  • Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake

    Sharp, L., Little, J., Brockton, N. T., Cotton, S. C., Masson, L. F., Haites, N. E., Cassidy, J.
    British Journal of Nutrition, vol. 99, no. 2, pp. 379-389
    Contributions to Journals: Articles

  • Lifestyle and sociodemographic factors associated with high-risk HPV infection in UK women

    Cotton, S. C., Sharp, L., Seth, R., Masson, L. F., Little, J., Cruickshank, M. E., Neal, K., Waugh, N. R., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    British Journal of Cancer, vol. 97, no. 1, pp. 133-139
    Contributions to Journals: Articles

  • Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1

    Little, J., Sharp, L., Masson, L. F., Brockton, N. T., Cotton, S. C., Haites, N. E., Cassidy, J.
    International Journal of Cancer, vol. 119, no. 9, pp. 2155-2164
    Contributions to Journals: Articles

  • Reasons for participation and non-participation in a randomized controlled trial: postal questionnaire surveys of women eligible for TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears)

    Sharp, L., Cotton, S. C., Alexander, L., Williams, E., Gray, N. M., Reid, J. M., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    Clinical Trials, vol. 3, pp. 431-442
    Contributions to Journals: Articles

  • Trial of management of borderline and other low grade abnormal smears (TOMBOLA): Trial design

    Cotton, S. C., Sharp, L., Little, J., Cruickshank, M. E., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    Contemporary Clinical Trials, vol. 27, no. 5, pp. 449-471
    Contributions to Journals: Articles

  • Enclosing a pen with a postal questionnaire can significantly increase the response rate

    Sharp, L., Cochran, C., Cotton, S. C., Gray, N. M., Gallagher, M. E., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    Journal of Clinical Epidemiology, vol. 59, no. 7, pp. 747-754
    Contributions to Journals: Articles

  • Psychological effects of a low-grade abnormal cervical smear test result:anxiety and associated factors

    Gray, N. M., sharp, L., Cotton, S. C., Masson, L. F., little, J., Walker, L. G., Avis, M., Philips, Z., Russell, I., Whynes, D. K., Cruickshank, M. E., Woolley, C. M., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    British Journal of Cancer, vol. 94, pp. 1253-1262
    Contributions to Journals: Articles

  • Refining the management of low-grade cervical abnormailities in the UK National Health Service and defining the potential for human papillomavirus testing: A commentary on emerging evidence

    Bentley, E., Cotton, S. C., Cruickshank, M. E., Duncan, I., Gray, N. M., Jenkins, D., little, J., Neal, K., Philips, Z., Russell, I., Seth, R., sharp, L., Waugh, N. R.
    Journal of Lower Genital Tract Disease, vol. 10, no. 1, pp. 26-38
    Contributions to Journals: Articles

  • Developing a questionnaire to measure the psychosocial impact of an abnormal cervical smear result and its subsequent management: the TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) trial.

    Gray, N. M., Sharp, L., Cotton, S. C., Avis, M., Philips, Z., Russell, I., Walker, L. G., Whynes, D. K., Little, J.
    Quality of Life Research, vol. 14, no. 6, pp. 1553-1562
    Contributions to Journals: Articles

  • Cytochrome P-450 1A1 Gene Polymorphisms and Risk of Breast Cancer: A HuGE Review

    Masson, L. F., Sharp, L., Cotton, S. C., Little, J.
    American Journal of Epidemiology, vol. 161, no. 10, pp. 901-915
    Contributions to Journals: Articles

  • CYP17 gene polymorphisms: prevalence and associations with hormone levels and related factors. A HuGE Review

    Sharp, L., Cardy, A. H., Cotton, S. C., Little, J.
    American Journal of Epidemiology, vol. 160, no. 8, pp. 729-740
    Contributions to Journals: Articles

  • Are lifestyle factors associated with infection with high risk human papilloma virus? results from TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears)

    Cotton, S. C., Sharp, L., Seth, R.
    Journal of Epidemiology and Community Health, vol. 58, no. Supplement II
    Contributions to Journals: Articles

  • Dietary intake of folate and related micronutrients, genetic polymorphisms in MTHFR and colorectal cancer: a population based case-control study in Scotland

    Sharp, L., Little, J., Brockton, N. T., Cotton, S. C., Haites, N. E., Cassidy, J.
    The Journal of Nutrition, vol. 132 Supplement 11
    Contributions to Journals: Articles

  • Women’s experiences of having an abnormal smear result: qualitative analyses from TOMBOLA

    Gray, N. M., Sharp, L., Cotton, S. C., Little, J., Avis, M., Philips, Z., Walker, L. G., Duncan, I.
    Journal of Obstetrics and Gynaecology, vol. 22, pp. 107-111
    Contributions to Journals: Articles

  • Genetic polymorphisms in folate metabolism, dietary folate intake and colorectal cancer: a population-based case-control study

    Sharp, L., Little, J., Brockton, N. T., Cotton, S. C., Haites, N. E., Cassidy, J.
    Journal of Epidemiology and Community Health, vol. 55, no. Supplement 1
    Contributions to Journals: Articles

  • Glutathione S-transferase polymorphisms and colorectal cancer: A HuGE review

    Cotton, S. C., Sharp, L., Little, J., Brockton, N.
    American Journal of Epidemiology, vol. 151, pp. 732
    Contributions to Journals: Literature Reviews

  • N-Acetyltransferase polymorphisms and colorectal cancer: A HuGE review

    Brockton, N., Little, J., Sharp, L., Cotton, S. C.
    American Journal of Epidemiology, vol. 151, pp. 846-861
    Contributions to Journals: Literature Reviews

  • SEARCH international case-control study of childhood brain tumours: Role of index pregnancy and birth, and mother's reproductive history

    McCredie, M., Little, J., Cotton, S., Mueller, B., Peris-Bonet, R., Choi, N. W., Cordier, S., Filippini, G., Holly, E. A., Modan, B., Arslan, A., Preston-Martin, S.
    Paediatric and Perinatal Epidemiology, vol. 13, no. 3, pp. 325-341
    Contributions to Journals: Articles

  • Partnerships in purchasing: Development of consortium-based purchasing among GP fundholders

    Laing, A., Cotton, S.
    Health Services Management Research, vol. 10, no. 4, pp. 245-254
    Contributions to Journals: Review articles

  • Patterns of inter-organizational purchasing: Evolution of consortia-based purchasing amongst GP fundholders

    Laing, A., Cotton, S.
    European Journal of Purchasing and Supply Management, vol. 3, no. 2, pp. 83-91
    Contributions to Journals: Articles

  • The Adenoma-Carcinoma Sequence and Prospects for the Prevention of Colorectal Neoplasia

    Cotton, S., Sharp, L., Little, J.
    Critical Reviews in Oncogenesis, vol. 7, no. 5-6, pp. 293-342
    Contributions to Journals: Articles

  • Purchasing health care services: Information sources and decisional criteria

    Laing, A. W., Cotton, S.
    Journal of Marketing Management, vol. 12, no. 8, pp. 719-734
    Contributions to Journals: Articles

  • Towards an understanding of health care purchasing: The purchasing behaviour of general practice fundholders

    Laing, A., Cotton, S.
    Journal of Marketing Management, vol. 11, no. 6, pp. 583-600
    Contributions to Journals: Articles

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