Dr Seonaidh Cotton
Dr Seonaidh Cotton

Dr Seonaidh Cotton

BSc (Hons), MLitt, PhD

Senior Trial Manager

About

Health Services Research Unit Health Sciences Building (Third Floor) Foresterhill Aberdeen AB25 2ZD

Biography

I joined HSRU in 2007 as a trial manager.  I graduated from the University of Aberdeen with a BSc in Health Sciences in 1993, an MLitt in 1995, and a PhD in 2007.  Prior to joining the Unit, I worked in the Department of Public Health at the University of Aberdeen.

I am the Senior Trial Manager within CHaRT supporting the portfolio of trials.   I also currently work on the BICS trial - a multicentre trial investigating the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease.    

Previously I was the Deputy Senior Trial Manager and supported a number of studies including RAACENOEMPOWER and ELECTRIC (all now completed).  I also worked as trial manager on a number of CHaRT trials, including TWICSCLASSNIAMIFOCCUSREFLUX and the Cysteamine in CF study.  

I am interested in methodological research that can be carried out alongside existing trials, including the provision of information to potential participants and strategies to increase response rates.

 

Qualifications

  • BSc Health Sciences 
    1993 - University of Aberdeen 
  • MLitt by research 
    1994 - University of Aberdeen 
  • PhD Public Health 
    2008 - University of Aberdeen 
Research

Research Overview

Trial methodology & trial management

Research Areas

Applied Health Sciences

Nutrition and Health

Current Research

I am the Senior Trial Manager within CHaRT supporting the portfolio of trials.   I also currently work on the BICS trial - a multicentre trial investigating the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease.    

I am interested in methodological research that can be carried out alongside existing trials, including the provision of information to potential participants and strategies to increase response rates.

Past Research

Since joining the Unit I have worked on a number of trials that have now been completed. 

TWICS  - a multicentre trial investigating the effectiveness of low dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease.

CLASS - a multicentre trial comparing foam sclerotherapy and endovenous laser ablation with conventional surgery in patients with varicose veins;

NIAMI - a phase II multicentre trial investigating whether an intravenous injection of sodium nitrite given immediately before the infarct related artery is opened reduces ischaemia reperfusion injury in patients with myocardial infarction;

FOCCUS - a pragmatic multi-centred randomised controlled trial of surgical HDU care versus HDU care delivered in an ICU and pre-operative fluid loading in high-risk patients undergoing major elective surgery

REFLUX - a multi-centre randomised trial comparing a policy of relatively early laparoscopic surgery with a continued best medical management policy for people with more severe gastro-oesophageal reflux disease.

The Cysteamine in CF study - a single-centre, single group open label study of oral cysteamine in patients with Cystic Fibrosis.

I also supported RAACENOEMPOWER and ELECTRIC (all now completed) as senior trial manager.

Teaching

Teaching Responsibilities

I have supervised a number of undergraduate and Masters level research projects, including topics such as provision of information to potential participants, strategies to increase response rates, and outcome measures.

 

 

Non-course Teaching Responsibilities

Outwith the University, I am a faculty member on the Edinburgh Clinical Trial Management Course (ECTMC).

 

Publications

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  • Trial Forge Guidance 3: Randomised trials and how to recruit and retain individuals from ethnic minority groups– practical guidance to support better practice

    Dawson, S., Banister, K., Biggs, K., Cotton, S., Devane, D., Gardner, H., Gillies, K., Gopalakrishnan, G., Isaacs, T., Khunti, K., Nichol, A., Parker, A., Russell, A. M., Shepherd, V., Shiely, F., Shorter, G. W., Starling, B., Williams, H., Willis, A., Witham, M. D., Treweek, S.
    Trials, vol. 23, 672
    Contributions to Journals: Articles
  • Randomised controlled trial comparing the clinical and cost-effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long-term catheters: study protocol for the CATHETER II study

    Abdel-fattah, M., Johnson, D., Constable, L., Thomas, R., Cotton, S., Tripathee, S., Cooper, D., Boran, S., Dimitropoulos, K., Evans, S., Granitsiotis, P., Hashim, H., Kilonzo, M., Larcombe, J., Little, P., MacLennan, S., Murchie, P., Myint, P., N’Dow, J., Norrie, J., Omar, M. I., Paterson, C., Scotland, G., Thiruchelvam, N., MacLennan, G.
    Trials, vol. 23, no. 1, 630
    Contributions to Journals: Articles
  • Effectiveness and cost-effectiveness of text messages with or without endowment incentives for weight management in men with obesity (Game of Stones): study protocol for a randomised controlled trial

    Macaulay, L., O’Dolan, C., Avenell, A., Carroll, P., Cotton, S., Dombrowski, S., Elders, A., Goulao, B., Gray, C., Harris, F. M., Hunt, K., Kee, F., MacLennan, G., McDonald, M. D., McKinley, M., Skinner, R., Torrens, C., Tod, M., Turner, K., van der Pol, M., Hoddinott, P.
    Trials, vol. 23, no. 1, 582
    Contributions to Journals: Articles
  • Reducing asthma attacks in children using exhaled nitric oxide (RAACENO) as a biomarker to inform treatment strategy: a multicentre, parallel, randomised, controlled, phase 3 trial

    Turner, S., Cotton, S., Wood, J., Bell, V., Raja, E. A., Scott, N., Morgan, H., Lawrie, L., Emele, D., Kennedy, C., Scotland, G., Fielding, S., MacLennan, G., Norrie, J., Forrest, M., Gaillard, E. A., de Jongste, J. C., Pijnenburg, M. W., Thomas, M., Price, D.
    The Lancet. Respiratory medicine, vol. 10, no. 6, pp. 584-592
    Contributions to Journals: Articles
  • Treatment guided by fractional exhaled nitric oxide in addition to standard care in 6- to 15-year-olds with asthma: the RAACENO RCT

    Turner, S., Cotton, S., Wood, J., Bell, V., Raja, E. A., Scott, N., Morgan, H., Lawrie, L., Emele, D., Kennedy, C., Scotland, G., Fielding, S., MacLennan, G., Norrie, J., Forrest, M., Gaillard, E. A., de Jongeste, J., Pijnenburg, M. W., Thomas, M., Price, D.
    Efficacy and Mechanism Evaluation, vol. 9, no. 4
    Contributions to Journals: Articles
  • ScotCap - A large observational cohort study

    MacLeod, C., Hudson, J., Brogan, M., Cotton, S., Treweek, S., MacLennan, G., Watson, A. J. M.
    Colorectal Disease, vol. 24, no. 4, pp. 411-421
    Contributions to Journals: Articles
  • Use of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial. (BICS)

    Cotton, S., Devereux, G., Abbas, H., Briggs, A. H., Campbell, K., Chaudhuri, R., Choudhury, G., Dawson, D., De Soyza, A., Fielding, S., Gompertz, S., Haughney, J., Lang, C. C., Lee, A., MacLennan, G., MacNee, W., McCormack, K., McMeekin, N., Mills, N. L., Morice, A., Norrie, J., Petrie, L., Price, D., Short, P., Vestbo, J., Walker, P., Wedzicha, J. A., Wilson, A., Lipworth, B. J.
    Trials, vol. 23, no. 1, 307
    Contributions to Journals: Articles
  • The relative importance of information items and preferred mode of delivery when disseminating results from trials to participants: a mixed methods study

    Wood, J., Cotton, S., Gillies, K.
    Health Expectations, vol. 25, no. 1, pp. 419-429
    Contributions to Journals: Articles
  • The ALLEGRO trial: a placebo controlled randomised trial of intravenous lidocaine in accelerating gastrointestinal recovery after colorectal surgery

    Paterson, H., Cotton, S., Norrie, J., Nimmo, S., Foo, I., Balfour, A., Speake, D., MacLennan, G., Stoddart, A., Innes, K., Cameron, S., Aucott, L., McCormack, K.
    Trials, vol. 23, no. 1, 84
    Contributions to Journals: Articles
  • A multicentre open label randomised clinical trial using exhaled nitric oxide in addition to standard care to reduce asthma attacks in children

    Turner, S., Cotton, S., Wood, J., Bell, V., Raja, E. A., Scott, N., Morgan, H., Lawrie, L., Emele, D., Kennedy, C., Scotland, G., Fielding, S., MacLennan, G., Norrie, J., Forrest, M., Gaillard, E. A., Gaillard, E. A., de Jongeste, J., Pijnenburg, M. W., Thomas, M., Price, D.
    Efficacy and Mechanism Evaluation
    Contributions to Journals: Articles
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