Dr Sergiy Sylantyev
Rowett Institute, University of Aberdeen,
Ashgrove Rd. West, Aberdeen AB25 2ZD
I graduated with an MSc in animal and human physiology from the Odesa National University (Odesa, Ukraine) in 1998. After that I began my PhD research project on pharmacological profiles of the ligands of type A receptor of γ-aminobutyric acid (GABAAR) under supervision of Prof. Zinkovsky. This initiated my interest to ionotropic receptors' biophysics, molecular pharmacology and connected modulatory signalling. After gaining a PhD degree in Neuropharmacology in 2002 I worked as a postdoc in several institutions on various projects connected to cellular and molecular neuroscience, focusing on different types of ionotropic receptors. First, under supervision of Dr. Shyu Bai-Chuang (Institute of Biomedical Sciences, Taipei, Taiwan) I studied GABAAR signalling and its modulation in anterior cingulate cortex. Next, in the laboratory of Dr. John Clements (The John Curtin School of Medical Research, Australian National University, Canberra, Australia) I studied the effects of various mutations on signalling properties of the glycine receptor. After that I moved to the UK, where I obtained a Senior Postdoctoral Fellow position in the Queen Square Institute of Neurology (University College London). At this position working in a team led by Prof. Dmitri Rusakov, I was involved in a number of projects connected to fundamental neuroscience, which resulted in several high-profile publications. My first independent Chancellor's Fellow position was in the University of Edinburgh, where from 2014 to 2019 I studied molecular pharmacology and the functional role of spontaneously opening GABAARs in the brain. I joined the University of Aberdeen in 2020, aiming to investigate the role of GABAARs in modulation of appetite and feeding behaviour.
- PhD Pharmacology2002 - Odesa Medical University, Ukraine
- MSc Animal and Human Physiology1998 - Odesa National University, Ukraine
Prizes and Awards
Burgen Scholar Award of Academia Europaea, 2008
My current research interests are focused on the impact of GABAAR ligands on feeding behaviour and appetite, with a specific attention to underlying molecular mechanisms. One research direction is a role of GABAAR-mediated signalling in neurons of a specific type (AgRP cells), localized in hypothalamus, in regulation of feeding behaviour. Hypothalamic pool of AgRP cells seems to play a pivotal role in modulation of appetite, with GABAAR-mediated outgoing signalling as the main mechanism of fine tuning of feeding activity. This helps to understand neural mechanisms controlling development of obesity and related disorders (such as a Prader-Willi syndrome). Another focus is on the regulation of GABAAR function by pH fluctuations in the fish brain, and connected changes in feeding of fish species of industrial importance (rainbow trout, Atlantic salmon). The latter research direction, apart from clarification of understudied fundamental mechanisms of pH-mediated neural inhibitory signalling, in a long-term perspective should lead to optimization of fish feeding in aquaculture.
Biological and Environmental Sciences
Funding and Grants
Research grants in the University of Aberdeen
The Wellcome Trust ISSF Award, 2020: £20,000. GABAARs control over taste perception
BBSRC Research Grant, 2021 (co-investigator): £457,906. Regulation of feeding by brainstem GABA neurons.
Pump-Prime Interdisciplinary Research Grant, 2021: £10,000. The role of GABAARs in regulation of fish appetite.
Non-course Teaching Responsibilities
Invited lecturer: University of Edinburgh, course Pharmacology 3.
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The regulatory role of GABAA receptor in Actinia equina nervous system and the possible effect of global ocean acidificationPflugers Archiv : European Journal of PhysiologyContributions to Journals: Articles
Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidationCell Death and Differentiation, vol. 27, no. 10, pp. 2781-2796Contributions to Journals: Articles
Synaptic signalling in a network of dopamine neurons: what prevents proper inter cellular crosstalk?FEBS LETTERS, vol. 594, no. 20, pp. 3272-3292Contributions to Journals: Articles
Extracellular GABA waves regulate coincidence detection in excitatory circuitsThe Journal of Physiology, vol. 598, no. 18, pp. 4047-4062Contributions to Journals: Articles
First records of blue crab Callinectes sapidus (Rathbun 1869) on the north-western Black Sea shelfMarine Ecological Journal, vol. 2020, no. 1, pp. 67-69Contributions to Journals: Articles
Inorganic polyphosphate regulates AMPA and NMDA receptors and protects against glutamate excitotoxicity via activation of P2Y receptorsThe Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 39, no. 31, pp. 6038-6048Contributions to Journals: Articles
The role of tonic glycinergic conductance in cerebellar granule cells signalling and the effect of gain‐of‐function mutationThe Journal of Physiology, vol. 597, no. 9, pp. 2457-2481Contributions to Journals: Articles
The Functional Role of Spontaneously Opening GABAA Receptors in Neural TransmissionFrontiers in Molecular Neuroscience, vol. 12, no. 72, 72Contributions to Journals: Review articles
Hydrology and parasites: What divides the fish community of the lower Dniester and Dniester estuary into three?Estuarine, Coastal and Shelf Science, vol. 217, pp. 120-131Contributions to Journals: Articles
Glutamate Receptor Probing with Rapid Application and Solution Exchange (RASE)New York: Humana Press.Other Contributions: Other Contributions