Professor Paul Haggarty

Professor Paul Haggarty
Professor Paul Haggarty

Professor Paul Haggarty

BSc PhD

Personal Chair

About

Lifelong Health Division

Rowett Institute of Nutrition and Health

University of Aberdeen

Greenburn Road

Aberdeen

AB21 9SB, UK.

Biography

I have over 30 years research experience in the field of human health. In the course of my career I have worked with research groups in the UK and internationally (India, Mexico, Malaysia, Norway), including as a Fulbright Senior Research Scholar in the USA at Cornell University. Most of my research has focused on human nutrition, epigenetics and genetics. My overall aim is to provide new knowledge leading to practical applications with a beneficial effect on health, quality of life, society and the economy. My work is published in journals such as Lancet, Nature, American Journal of Clinical Nutrition, and Annual Review of Nutrition. My research is acknowledged as internationally important, it is cited in national reports and policy statements, and it is used directly by policy makers. I have served on various scientific advisory committees including; the UK Scientific Advisory Committee on Nutrition; Swedish Medical Research Council international Evaluation Panel on Ageing and Health; the Scientific Advisory Board of Breast Cancer Campaign; the Advisory Committee on Novel Foods and Processes; and I recently joined the BBSRC Bioscience for Health Strategy Advisory Panel.

Memberships and Affiliations

Internal Memberships

Head of Lifelong Health Division: This division consists of 30 staff (17 principal investigators and a variable compliment of visiting workers and students) working in the area of Diet and Lifelong health.  http://www.abdn.ac.uk/rowett/research/lifelong-health.php

Head of the Public Health Nutrition Group: This research group consists of 13 research staff and associated assistants, students and visiting workers. The group was constituted to apply knowledge of nutrition science and expertise in epidemiology and social sciences to address nutrition issues of wider public health importance. It has a number of international research students and overseas links and the work is designed to be of national and international relevance. https://www.abdn.ac.uk/rowett/research/public-health-nutrition-688.php

Member of Institute Executive Committee and Senior Management Group: These groups have responsibility for the development of institute strategy and its implementation, the organization and running of the institute, and its integration with the wider university, strategic appointments and recruitment, oversight of the institute budget, decisions on resource allocation, staffing, strategic planning, management of research, health and safety, knowledge exchange, and external links.

Manager of research programme on Diet and Health: I currently manage one of two work-packages led by Rowet Institute and commissioned by Scottish Government. This is worth around £12m over 5 years and involves input from 37 principle investigators across 4 independent research providers (Rowett Institute, James Hutton Institute, Moredun Institute, Biostatistics Service Scotland).

External Memberships
  • Member of the Biotechnology and Biological Sciences Research Council (BBSRC) Bioscience for Health Strategy Advisory Panel (2016-2018).
  • Chair of UK Scientific Advisory Committee on Nutrition (SACN) working group on UK saturated fat recommendations (from 2015).
  • Member of UK Scientific Advisory Committee on Nutrition (SACN) (2006-present).
  • Member of UK Advisory Committee on Novel Foods and Processes (ACNFP) (2008-2012).
  • Member of EU Joint Programming Initiative Evaluation Panel: A Healthy Diet for a Healthy Life; Transnational Research on Nutrition and Cognitive Function (2015).
  • Chair of “Food and Obesity” topic at the Royal College of Physicians of Edinburgh Symposium on Obesity; a 21st Century Epidemic (2015).
  • Member of the UK Department of Health Commissioning Panel for Iodine and Health, Department of Health, London (2014).
  • Member of the Advisory Group for the University of Aberdeen Centre for Genome-Enabled Biology and Medicine.
  • Assesor on the Swedish Research Council Ageing and Health Panel (2013).
  • Member of the Scientific Advisory Board of Breast Cancer Campaign (2012- 2013).
  • Member of SACN Working Group on Approaches to the Nutritional Assessment of Novel Foods (ANANF) (2008-present).
  • Member of North of Scotland NHS Research Ethics Committee (2004-2011).
  • Member of British Nutrition Foundation Task Force on Nutrition and development: long and short term consequences for health (2009-2011).
  • Member of SACN working group on Folate and Disease Prevention (2006-2008).
  • Member of SACN working group on Folate and Cancer (2008-2009).
  • Member of Scottish Government short life working group on vitamin D (2008-2009).
Research

Research Overview

Life expectancy is increasing across the globe and there is a need to ensure that physical and mental health is maintained as long as possible into old age. Some individuals are genetically predisposed to health and longevity but there is a growing awareness of the importance of early life events in programming lifelong health and the role of diet in particular. Health and life expectancy are also strongly related to socioeconomic status but the links with diet and behaviour are poorly understood.

My research is concerned with these issues and specifically the way in which diet at different life-stages interacts directly with the human genome to influence health and disease risk throughout life, and the mechanism by which it does this. It deals with early life factors and reproduction. It seeks to determine the nature of the links between early life and later health and to identify critical modifiable factors in the early environment. It also seeks to identify the evolutionary links between health, fertility, and reproduction that cannot be modified. This work involves the study of epigenetics in reproduction, cognition, and cancer, in a range of study designs; from in vitro studies in isolated cells and tissues through to large cohort and case-control studies involving thousands of individuals.

Reproduction: I have a long standing research interest in nutrition in pregnancy and the importance of this to lifelong health, with a particular emphasis on the maternal and fetal requirement for polyunsaturated fatty acids, and the roles of the B vitamins and vitamin D. This includes work on maternal diet and status, maternal adaptations in fat metabolism, the role of the placenta and early embryo. and vitamin D status an season in mothers and babies. I have also investigated the complex interaction between diet and social circumstances in determining birth outcomes and the modulating role of factors such as smoking and alcohol consumption. I have worked on placental function and fetal growth and have worked with colleagues to develop innovative ways of using MRI to investigate oxygen supply to the fetus in utero.

 

Collaborations

In the course of my career I have worked with many research groups in the UK and internationally (India, Mexico, Malaysia, Norway), including as a Fulbright Senior Research Scholar in the USA at Cornell University.

Current external collaborations include:

  • University of Oxford (Professor Leanne Hodgson); Epigenetic response to diet.
  • University of Cambridge (Professor Anne Ferguson-Smith); Imprinting methylation; early life influences and later cognition and mood
  • University College London (Professor Marcus Richards); Imprinting methylation; early life influences and later cognition and mood

Funding and Grants

  • Imprinting methylation; early life influences and later cognition and mood (Haggarty, Murray, Phillips, Staff, Hocking, Ferguson-Smith, Richards). BBSRC & ESRC. (£447,000; Nov 2015 to Oct 2018).
  • Genetic determinants of breast cancer susceptibility (Haggarty, Heys). The Gates Trust (£52,000; Oct 2008 to Oct 2016).
  • A pilot study of epigenetic imprinting and breast cancer using Next Generation Sequencing (Haggarty, Heys, Husain). Friends of Anchor (£9,000; July 2015 to July 2016).
  • Nutrition, Epigenetics and Health. Scottish Government (approximately £500,000 over 5 years; April 2011 to April 2016).
Teaching

Teaching Responsibilities

I have over 20 years experience teaching undergraduate and postgraduate courses in the life sciences and nutrition and currently teach on the following courses within University of Aberdeen:

  • Public Health Nutrition MSc (PU5504)
  • Human Nutrition MSc (MT5401)
  • Genes and evolution BSc (BI2002)
  • Reproductive Biology BSc (DB3502)
  • Advanced Molecular and Functional Genomics MSc (MB5016)
  • Molecular Nutrition MSc (MT5511)
  • Genetics - Complex Disease MSc (MB5515)
  • University of Aberdeen Annual International Summer School Advanced Course in Dietary Assessment Methods (http://www.abdn.ac.uk/acdam/).
  • Nutrition and Wellbeing Massive Open Online Course (MOOC) (https://www.futurelearn.com/courses/nutrition-wellbeing)

I have supervised over 35 MSc, PhD, BSc Med Sci, BSc and MD students.

 

 

 

Publications

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  • Blood pressure in relation to birth weight in twins and singleton controls matched for gestational age

    McNeill, G., Tuya, C., Campbell, D. M., Haggarty, P., Smith, W. C. S., Masson, L. F., Cumming, A. M., Broom, I., Haites, N. E.
    American Journal of Epidemiology, vol. 158, no. 2, pp. 150-155
    Contributions to Journals: Articles
  • Validation of energy intake estimated from a food frequency questionnaire: a doubly labelled water study

    Andersen, L. F., Tomten, H., Haggarty, P., Lovo, A., Hustvedt, B. E.
    European Journal of Clinical Nutrition, vol. 57, no. 2, pp. 279-284
    Contributions to Journals: Articles
  • Placental regulation of fatty acid delivery and its effect on fetal growth - A review

    Haggarty, P.
    Placenta, vol. 23
    Contributions to Journals: Articles
  • The effect of maternal smoking and ethanol on fatty acid transport by the human placenta

    Haggarty, P., Abramovich, D. R., Page, K.
    British Journal of Nutrition, vol. 87, no. 3, pp. 247-252
    Contributions to Journals: Articles
  • High omega-3:omega-6 fatty acid ratios in culture medium reduce endometrial-cell survival in combined endometrial gland and stromal cell cultures from women with and without endometriosis

    Gazvani, M. R., Smith, L. M., Haggarty, P., Fowler, P. A. F., Templeton, A. A.
    Fertility and Sterility, vol. 76, no. 4, pp. 717-722
    Contributions to Journals: Articles
  • Leptin expression in placental and fetal tissues: does leptin have a functional role?

    Hoggard, N., Haggarty, P., Thomas, L., Lea, R.
    Biochemical Society Transactions, vol. 29, pp. 57-63
    Contributions to Journals: Articles
  • Leptin secretion to both the maternal and fetal circulation in the ex vivo perfused human term placenta

    Hoggard, N., Crabtree, J., Allstaff, S., Abramovich, D. R., Haggarty, P.
    Placenta, vol. 22, no. 4, pp. 347-352
    Contributions to Journals: Articles
  • The measurement of fetal liver T(*)(2) in utero before and after maternal oxygen breathing: progress towards a non-invasive measurement of fetal oxygenation and placental function

    Semple, S. I., Wallis, F., Haggarty, P., Abramovich, D., Ross, J. A., Redpath, T. W., Gilbert, F. J.
    Magnetic Resonance Imaging, vol. 19, no. 7, pp. 921-8
    Contributions to Journals: Articles
  • The effect of maternal smoking and the presence of ethanol on fatty acid transport by the human placenta

    Haggarty, P., Ashton, J., Joynson, M., Abramovich, D. R., Page, K. R.
    The Journal of Physiology, vol. 528P, no. Special Issue S1, pp. 38P-39P
    Contributions to Journals: Articles
  • Free and esterified fatty acid and cholesterol synthesis in adult males and its effect on the doubly-labelled water method

    Haggarty, P., Shetty, P., Thangam, S., Kumar, S., Kurpad, A., Ashton, J., Milne, E., Earl, C.
    British Journal of Nutrition, vol. 83, no. 3, pp. 227-234
    Contributions to Journals: Articles

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Books and Reports

Chapters in Books, Reports and Conference Proceedings

Contributions to Journals