Dr Nigel Hoggard
Senior Research Fellow
Dr. Nigel Hoggard,
School of Medicine, Medical Sciences & Nutrition,
University of Aberdeen
AB25 2ZD UK.
Diet and metabolic health
The group’s research interests are in the mechanisms involved in the regulation of energy balance and body weight, and to determine how dysregulation leads to obesity and its associated pathologies. In particular we study the endocrine and physiological role of factors secreted by adipose tissue. A combination of in vivo and cell culture approaches is employed, integrating molecular and protein techniques into whole-organism physiology.
In particular we are interested in dietary strategies for alleviating the metabolic complications such as type 2 diabetes associated with obesity as alternatives to pharmaceutical interventions.
The genus Vaccinium (e.g. blueberry, blaeberry), has been used traditionally as a source of folk remedies for established diabetic symptoms. Berries from this family such as blueberries and blaeberries are enriched in polyphenolics recognized for their ability to provide cellular antioxidant protection, inhibit inflammatory genes, and consequently protect against oxidant-induced and inflammatory cell damage and cytotoxicity. The association of obesity with the expression of genes in the fat which cause a low level of inflammation in this tissue suggests that eating edible berries from this genus might provide a supplementary intervention to reduce this obesity- associated inflammation and the associated insulin resistance which this low level of inflammation may be causing.
I am investigating the idea that there are foods, or components of foods, which could be used as an alternative to drugs to prevent and treat type 2 diabetes (T2D) associated with obesity.
The research we are doing could help the food industry to make their products healthier and encourage people to eat a healthier diet.
Programme coordinator for the MSc in clinical nutrition:
Coordinator of the sixth century course SX3012 An Appetite for Food and Health
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Efficacy of Bilberry and Grape Seed Extract Supplement Interventions to Improve Glucose and Cholesterol Metabolism and Blood Pressure in Different Populations: A Systematic Review of the LiteratureNutrients, vol. 13, no. 5, 1692Contributions to Journals: Articles
Analysis of polyphenolic metabolites from in vitro gastrointestinal digested soft fruit extracts identify malvidin-3-glucoside as an inhibitor of PTP1BBiochemical Pharmacology, vol. 178, 114109Contributions to Journals: Articles
The anthocyanins in black currants regulate postprandial hyperglycaemia primarily by inhibiting α-glucosidase while other phenolics modulate salivary α-amylase, glucose uptake and sugar transportersThe Journal of Nutritional Biochemistry, vol. 78, 108325Contributions to Journals: Articles
Anthocyanin-enriched bilberry extract attenuates glycaemic response in overweight volunteers without changes in insulinJournal of Functional Foods, vol. 64, 103597Contributions to Journals: Articles
SerpinA3N is a novel hypothalamic gene upregulated by a high-fat diet and leptin in miceGenes & Nutrition, vol. 13, 28Contributions to Journals: Articles
A randomised, double-blind, cross-over trial to evaluate bread, in which gluten has been pre-digested by prolyl endoprotease treatment, in subjects self-reporting benefits of adopting a gluten-free or low-gluten dietBritish Journal of Nutrition, vol. 119, no. 5, pp. 496-506Contributions to Journals: Articles
Processing blueberries by homogenising increases postprandial glycaemia in response to an oral glucose tolerance test in healthy volunteers, compared with whole berriesScottish Section Meeting. Phytochemicals and health: new perspectives on plant based nutrition, pp. E52Contributions to Journals: Abstracts
The development of diet-induced obesity and glucose intolerance in C57BL/6 mice on a high-fat diet consists of distinct phasesPloS ONE, vol. 9, no. 8, e106159Contributions to Journals: Articles
The dietary flavonoids naringenin and quercetin acutely impair glucose metabolism in rodents possibly via inhibition of hypothalamic insulin signallingBritish Journal of Nutrition, vol. 109, no. 6, pp. 1040-1051Contributions to Journals: Articles
A comparative approach to understanding tissue-specific expression of uncoupling protein 1 expression in adipose tissueFrontiers in Genetics, vol. 3, 304Contributions to Journals: Articles