Dr Nigel Hoggard
PhD
Senior Research Fellow
- About
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Dr. Nigel Hoggard,
Rowett Institute,
School of Medicine, Medical Sciences & Nutrition,
University of Aberdeen
Foresterhill,
Aberdeen, Scotland,
AB25 2ZD UK.
- Research
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Research Overview
Diet and metabolic health
The group’s research interests are in the mechanisms involved in the regulation of energy balance and body weight, and to determine how dysregulation leads to obesity and its associated pathologies. In particular we study the endocrine and physiological role of factors secreted by adipose tissue. A combination of in vivo and cell culture approaches is employed, integrating molecular and protein techniques into whole-organism physiology.
In particular we are interested in dietary strategies for alleviating the metabolic complications such as type 2 diabetes associated with obesity as alternatives to pharmaceutical interventions.
The genus Vaccinium (e.g. blueberry, blaeberry), has been used traditionally as a source of folk remedies for established diabetic symptoms. Berries from this family such as blueberries and blaeberries are enriched in polyphenolics recognized for their ability to provide cellular antioxidant protection, inhibit inflammatory genes, and consequently protect against oxidant-induced and inflammatory cell damage and cytotoxicity. The association of obesity with the expression of genes in the fat which cause a low level of inflammation in this tissue suggests that eating edible berries from this genus might provide a supplementary intervention to reduce this obesity- associated inflammation and the associated insulin resistance which this low level of inflammation may be causing.
Current Research
I am investigating the idea that there are foods, or components of foods, which could be used as an alternative to drugs to prevent and treat type 2 diabetes (T2D) associated with obesity.
The research we are doing could help the food industry to make their products healthier and encourage people to eat a healthier diet.
- Teaching
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Teaching Responsibilities
Programme coordinator for the MSc in clinical nutrition:
https://www.abdn.ac.uk/study/postgraduate-taught/degree-programmes/1050/clinical-nutrition/
Coordinator of the sixth century course SX3012 An Appetite for Food and Health
- Publications
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Page 1 of 7 Results 1 to 10 of 67
Efficacy of Bilberry and Grape Seed Extract Supplement Interventions to Improve Glucose and Cholesterol Metabolism and Blood Pressure in Different Populations: A Systematic Review of the Literature
Nutrients, vol. 13, no. 5, 1692Contributions to Journals: ArticlesAnalysis of polyphenolic metabolites from in vitro gastrointestinal digested soft fruit extracts identify malvidin-3-glucoside as an inhibitor of PTP1B
Biochemical Pharmacology, vol. 178, 114109Contributions to Journals: ArticlesThe anthocyanins in black currants regulate postprandial hyperglycaemia primarily by inhibiting α-glucosidase while other phenolics modulate salivary α-amylase, glucose uptake and sugar transporters
The Journal of Nutritional Biochemistry, vol. 78, 108325Contributions to Journals: ArticlesAnthocyanin-enriched bilberry extract attenuates glycaemic response in overweight volunteers without changes in insulin
Journal of Functional Foods, vol. 64, 103597Contributions to Journals: ArticlesSerpinA3N is a novel hypothalamic gene upregulated by a high-fat diet and leptin in mice
Genes & Nutrition, vol. 13, 28Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s12263-018-0619-1
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11568/1/s12263_018_0619_1.pdf
A randomised, double-blind, cross-over trial to evaluate bread, in which gluten has been pre-digested by prolyl endoprotease treatment, in subjects self-reporting benefits of adopting a gluten-free or low-gluten diet
British Journal of Nutrition, vol. 119, no. 5, pp. 496-506Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1017/S0007114517003749
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9792/5/randomised_doubleblind_crossover_trial_to_evaluate_bread_in_which_gluten_has_been_predigested_by_prolyl_endoprotease_treatment_in_subjects_selfreporting_benefits_of_adopting_a_glutenfree_or_lowgluten_diet.pdf
Processing blueberries by homogenising increases postprandial glycaemia in response to an oral glucose tolerance test in healthy volunteers, compared with whole berries
Scottish Section Meeting. Phytochemicals and health: new perspectives on plant based nutrition, pp. E52Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1017/S0029665116000422
The development of diet-induced obesity and glucose intolerance in C57BL/6 mice on a high-fat diet consists of distinct phases
PloS ONE, vol. 9, no. 8, e106159Contributions to Journals: ArticlesThe dietary flavonoids naringenin and quercetin acutely impair glucose metabolism in rodents possibly via inhibition of hypothalamic insulin signalling
British Journal of Nutrition, vol. 109, no. 6, pp. 1040-1051Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1017/S0007114512003005
A comparative approach to understanding tissue-specific expression of uncoupling protein 1 expression in adipose tissue
Frontiers in Genetics, vol. 3, 304Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3389/fgene.2012.00304
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/5659/1/fgene_03_00304.pdf