I am interested in how a high-fat/sugar diet can cause obesity. In my lab we have shown changes in genes and proteins in the hypothalamus, the area of the brain which controls energy balance. These changes may lead to excess calorie consumption and obesity.
We have also identified protein changes in response to a high-fat/sugar diet in the the hippocampus using proteomics. The hippocampus is the area of the brain that controls memory formation, linking diet to rapid changes in cognition and memory
A high-fat/sugar diet leads to the formation of Advanced Glycation End products (AGEs) in body tissues. AGEs cause damage and inflammation and are also absorbed from the diet particularly from processed foods. We are interested in how dietary AGEs contribute to diet induced conditions such as type 2 diabetes and cognitive decline.