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The Rowett Institute

Dr Alexander Ross

Dr Alexander Ross
Dr Alexander Ross
Dr Alexander Ross

Advanced Research Fellow

About
Email Address
a.ross@abdn.ac.uk
Telephone Number
+44 (0)1224 438633
School/Department
School of Medicine, Medical Sciences and Nutrition
Research

Research Overview

In our research we are investigating how different foods and their constituents inform fullness and satiety to the brain. The objectives are to identify how cells of the gut and liver respond differently to different nutrients, and also how these nutrients may differentially affect metabolism to promote improved health. We are also interested in how diet-induced differences in the gut microbiome may alter host metabolism and health. The research results should provide evidence which, after validation in human trials, may be released as advice to the general public, or as product formulation advice to the food or drug industry aimed at healthy weight management. 

We use molecular biology and biochemical approaches including Next Generation Sequencing, Real-time PCR, in situ hybridization and Western blotting to identify target genes and exploit novel in vivo agonist/antagonist or antibody delivery in techniques aimed at addressing functional responses.

 

Research team

Prof Alexandra Johnstone

Claire Fyfe - Research Assistant

Gail Hepseed - Research assistant

 

 

Funding and Grants

Biotechnology and Biological Science Research Council (BBSRC) grant number BB/K001043/1 entitled: Inflammatory signals regulate neuroendocrine control of growth and energy balance through re-modelling of mammalian hypothalamus.

Publications

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  • Diurnal profiles of hypothalamic energy balance gene expression with photoperiod manipulation in the Siberian hamster, Phodopus sungorus

    Ellis, C., Moar, K., Logie, T., Ross, A., Morgan, P. J., Mercer, J.
    American Journal of Physiology-Regulatory Integrative and Comparative Physiology, vol. 294, no. 4, pp. R1148-R1153
    Contributions to Journals: Articles

  • Hypothalamic thyriod hormone in appetite and energy balance regulation

    Herwig, A., Ross, A., Nilaweera, K., Morgan, P. J., Barrett, P.
    Obesity Facts, vol. 1, no. 2, pp. 71-79
    Contributions to Journals: Articles

  • Hypothalamic Thyroid Hormone Catabolism Acts as a Gatekeeper for the Seasonal Control of Body Weight and Reproduction

    Barrett, P., Ebling, F. J. P., Schuhler, S., Wilson, D. L., Ross, A., Warner, A., Jethwa, P., Boelen, A., Visser, T. J., Ozanne, D. M., Archer, Z. A., Mercer, J., Morgan, P. J.
    Endocrinology, vol. 148, no. 8, pp. 3608-3617
    Contributions to Journals: Articles

  • Photoperiodic regulation of cellular retinoic acid-binding protein 1, GPR50 and nestin in tanycytes of the third ventricle ependymal layer of the Siberian hamster

    Barrett, P., Ivanova, E., Graham, E. S., Ross, A., Wilson, D. L., Ple, H., Mercer, J., Ebling, F. J., Schuhler, S., Dupre, S. M., Loudon, A., Morgan, P. J.
    Journal of Endocrinology, vol. 191, no. 3, pp. 687-698
    Contributions to Journals: Articles

  • Dynamic regulation of gene expression in the dmpARC and ependymal layer in the Siberian hamster during seasonal weight change

    Barrett, P., Wilson, D. L., Mercer, J., Ross, A., Bell, L., Ebling, F. J. P., Schuhler, A., Morgan, P. J.
    Frontiers in Neuroendocrinology, vol. 27, no. 1, pp. 7-8
    Contributions to Journals: Articles

  • The suppressor of cytokine signalling 3, SOCS3, may be one critical modulator of seasonal body weight changes in the Siberian hamster, Phodopus sungorus

    Tups, A., Barrett, P., Ross, A., Morgan, P. J., Klingenspor, M., Mercer, J.
    Journal of Neuroendocrinology, vol. 18, no. 2, pp. 139-145
    Contributions to Journals: Articles

  • What can we learn from seasonal animals about the regulation of energy balance?

    Morgan, P. J., Ross, A., Mercer, J., Barrett, P.
    Progress in Brain Research, vol. 153, pp. 325-337
    Contributions to Journals: Articles

  • Photoperiodic regulation of histamine H3 receptor and VGF messenger ribonucleic acid in the arcuate nucleus of the Siberian hamster

    Barrett, P., Ross, A., Balik, A., Littlewood, P. A., Mercer, J., Moar, K., Sallmen, T., Kaslin, J., Panula, P., Schuhler, S., Ebling, F. J., Ubeaud, C., Morgan, P. J.
    Endocrinology, vol. 146, no. 4, pp. 1930-1939
    Contributions to Journals: Articles

  • Temporal changes in gene expression in the arcuate nucleus precede seasonal responses in adiposity and reproduction

    Ross, A., Bell, L., Littlewood, P. A., Mercer, J., Barrett, P., Morgan, P. J.
    Endocrinology, vol. 146, no. 4, pp. 1940-1947
    Contributions to Journals: Articles

  • Photoperiodic regulation of hypothalamic retinoid signaling: Association of retinoid X receptor gamma with body weight

    Ross, A., Webster, C. A., Mercer, J., Moar, K., Ebling, F. J., Schuhler, S., Barrett, P., Morgan, P. J.
    Endocrinology, vol. 145, no. 1, pp. 13-20
    Contributions to Journals: Articles
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