Professor Graeme MacLennan | The University of Aberdeen

Professor Graeme MacLennan

Director (CHaRT)

Email Address: g.maclennan@abdn.ac.uk
Telephone Number: +44 (0)1224 438147
Office Address: Health Services Research Unit
2nd Floor Health Sciences Building
Foresterhill
Aberdeen
AB25 2ZD
School/Department: School of Medicine, Medical Sciences and Nutrition

Biography

I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT.

My undergrad degree is in Mathematics from the University of Aberdeen, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.

Qualifications

BSc Mathematics
1997 - University of Aberdeen
MSc Applied Statistics
2004 - Sheffield Hallam University

Research

Research Overview

The application of statistical methods to clinical trials. Recent example is JCE paper available here on using instrumental variables in a surgery trial to address non-compliance. Collaborators were Jonathan Cook (Oxford), Tom Palmer (Lancaster), and Richard Emesley (Manchester).

Research on making trials more efficient, collaborating with Trial Forge.

Current Research

A complete list of the CHaRT RCT portolio is available by clicking here

Teaching

Teaching Responsibilities

I teach on our MPH course module PU5031: EVIDENCE-BASED HEALTH.

Publications

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Protocol for a randomised controlled trial comparing laparoscopic cholecystectomy with observation/conservative management for preventing recurrent symptoms and complications in adults with uncomplicated symptomatic gallstones (C-Gall trial)
2021 - Published
Ahmed, I., Innes, K., Brazzelli, M., Gillies, K., Newlands, R., Avenell, A., Hernández, R., Blazeby, J., Croal, B., Hudson, J., MacLennan, G., McCormack, K., McDonald, A., Murchie, P., Ramsay, C.
BMJ Open, vol. 11, no. 3, e039781
Contributions to Journals: Articles
- [ONLINE] https://pubmed.ncbi.nlm.nih.gov/33766835/
- [ONLINE] DOI: https://doi.org/10.1136/bmjopen-2020-039781
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/05bad4b0-812e-4ce0-9110-3740234ddc0a/download
- [ONLINE] https://abdn.pure.elsevier.com/en/en/researchoutput/protocol-for-a-randomised-controlled-trial-comparing-laparoscopic-cholecystectomy-with-observationconservative-management-for-preventing-recurrent-symptoms-and-complications-in-adults-with-uncomplica(a66000bc-ddf4-4d6b-9167-7efd1556eace).html
Survey on ureTEric draiNage post uncomplicaTed ureteroscopy (STENT)
2021 - Published
Bhatt, N. R., MacKenzie, K., Shah, T. T., Gallagher, K., Clement, K., Cambridge, W. A., Kulkarni, M., MacLennan, G., Manecksha, R. P., Wiseman, O. J., Mcclinton, S., Smith, D., Kasivisvanathan, V.
BJUI Compass, vol. 2, no. 2, pp. 115-125
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1002/bco2.48
- [ONLINE] View publication in Scopus
Psychological intervention, antipsychotic medication or a combined treatment for adolescents with a first episode of psychosis: the MAPS feasibility three-arm RCT
2021 - Published
Morrison, A. P., Pyle, M., Byrne, R., Broome, M., Freeman, D., Johns, L., James, A., Husain, N., Whale, R., MacLennan, G., Norrie, J., Hudson, J., Peters, S., Davies, L., Bowe, S., Smith, J., Shiers, D., Joyce, E., Jones, W., Hollis, C., Maughan, D.
Health technology assessment (Winchester, England), vol. 25, no. 4, pp. 1-124
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3310/hta25040
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/3bb32462-eae0-4b5f-843d-5706afa668e3/download
- [ONLINE] View publication in Scopus
- [ONLINE] https://www.journalslibrary.nihr.ac.uk/hta/hta25040#/full-report
Open urethroplasty versus endoscopic urethrotomy for recurrent urethral stricture in men: the OPEN RCT
2020 - Published
Pickard, R., Goulao, B., Carnell, S., Shen, J., MacLennan, G., Norrie, J., Breckons, M., Vale, L., Whybrow, P., Rapley, T., Forbes, R., Currer, S., Forrest, M., Wilkinson, J., McColl, E., Andrich, D., Barclay, S., Cook, J., Mundy, A., N'Dow, J., Payne, S., Watkin, N.
Contributions to Journals: Registered Reports
- [ONLINE] DOI: https://doi.org/10.3310/hta24610
Surgical Treatment for Recurrent Bulbar Urethral Stricture: A Randomised Open-label Superiority Trial of Open Urethroplasty Versus Endoscopic Urethrotomy (the OPEN Trial)
2020 - Published
Goulao, B., Carnell, S., Shen, J., MacLennan, G., Norrie, J., Cook, J., McColl, E., Breckons, M., Vale, L., Whybrow, P., Rapley, T., Forbes, R., Currer, S., Forrest, M., Wilkinson, J., Andrich, D., Barclay, S., Mundy, A., N'Dow, J., Payne, S., Watkin, N., Pickard, R.
European Urology, vol. 78, no. 4, pp. 572-580
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.eururo.2020.06.003
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/29a5c02a-4dce-4b3c-9228-c3803de089f7/download
- [ONLINE] View publication in Scopus
Antipsychotic medication versus psychological intervention versus a combination of both in adolescents with first-episode psychosis (MAPS): a multicentre, three-arm, randomised controlled pilot and feasibility study
2020 - Published
Morrison, A. P., Pyle, M., Maughan, D., Johns, L., Freeman, D., Broome, M. R., Husain, N., Fowler, D., Hudson, J., MacLennan, G., Norrie, J., Shiers, D., Hollis, C., James, A., MAPS group
The lancet. Psychiatry, vol. 7, no. 9, pp. 788-800
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/S2215-0366(20)30248-0
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/aa6b7654-8677-40d2-bafe-73accebfb152/download
- [ONLINE] View publication in Scopus
Mesh inlay, mesh kit or native tissue repair for women having repeat anterior or posterior prolapse surgery: randomised controlled trial (PROSPECT)
2020 - Published
Glazener, C., Breeman, S., Elders, A., Hemming, C., Cooper, K. G., Freeman, R. M., Smith, A., Hagen, S., Montgomery, I., Kilonzo, M., Boyers, D., McDonald, A., McPherson, G., MacLennan, G., Norrie, J., Reid, F. M., PROSPECT study group
BJOG-An International Journal of Obstetrics and Gynaecology, vol. 127, no. 8, pp. 1002-1013
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1111/1471-0528.16197
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/5580854b-b2ab-4f10-9874-9aed97901dea/download
- [ONLINE] View publication in Scopus
The clinical and cost effectiveness of surgical interventions for stones in the lower pole of the kidney: the percutaneous nephrolithotomy, flexible ureterorenoscopy and extracorporeal shockwave lithotripsy for lower pole kidney stones randomised controlled trial (PUrE RCT) protocol
2020 - Published
McClinton, S., Starr, K., Thomas, R., MacLennan, G., Lam, T., Hernandez, R., Pickard, R., Anson, K., Clark, T., MacLennan, S., Thomas, D., Smith, D., Turney, B., McDonald, A., Cameron, S., Wiseman, O.
Trials, vol. 21, 479
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1186/s13063-020-04326-x
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/c99c199b-bb59-4173-9673-e9e840250c2e/download
- [ONLINE] View publication in Scopus
Total versus partial knee replacement in patients with medial compartment knee osteoarthritis: the TOPKAT RCT
2020 - Published
Beard, D. J., Davies, L. J., Cook, J. A., MacLennan, G., Price, A., Kent, S., Hudson, J., Carr, A., Leal, J., Campbell, H., Fitzpatrick, R., Arden, N., Murray, D., Campbell, M. K.
Health technology assessment (Winchester, England), vol. 24, no. 20, pp. 1-98
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3310/hta24200
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/00d4fc6e-f1b2-45fa-aee1-133cb5ee5798/download
- [ONLINE] View publication in Scopus
Baseline Characteristics of Participants in the Treatment of Advanced Glaucoma Study: A Multicenter Randomized Controlled Trial
2020 - Published
King, A. J., Hudson, J., Fernie, G., Burr, J., Azuara-Blanco, A., Sparrow, J. M., Barton, K., Garway-Heath, D., Kernohan, A., MacLennan, G., TAGS Research Group
American Journal of Ophthalmology, vol. 213, pp. 186-194
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.ajo.2020.01.026
- [ONLINE] View publication in Scopus
Surgical treatments for women with stress urinary incontinence: a systematic review of economic evidence
2020 - Published
Javanbakht, M., Moloney, E., Brazzelli, M., Wallace, S., Omar, M. I., Monga, A., Saraswat, L., Mackie, P., Imamura, M., Hudson, J., MacLennan, G., Vale, L., Craig, D.
Systematic reviews , vol. 9, 85
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1186/s13643-020-01352-3
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/e65857e8-084a-4e5b-b073-678335db735f/download
- [ONLINE] View publication in Scopus
Effect of hands-on interprofessional simulation training for local emergencies in Scotland: the THISTLE stepped-wedge design randomised controlled trial
2020 - Published
Lenguerrand, E., Winter, C., Siassakos, D., MacLennan, G., Innes, K., Lynch, P., Cameron, A., Crofts, J., McDonald, A., McCormack, K., Forrest, M., Norrie, J., Bhattacharya, S., Draycott, T.
BMJ Quality & Safety, vol. 29, no. 2, pp. 122-134
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1136/bmjqs-2018-008625
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/8db99b50-ee00-49a5-bd11-19228efeb95f/download
- [ONLINE] http://www.ncbi.nlm.nih.gov/pubmed/31302601
- [ONLINE] View publication in Mendeley
- [ONLINE] View publication in Scopus
Early signs monitoring to prevent relapse in psychosis and promote well-being, engagement, and recovery: Protocol for a feasibility cluster randomized controlled trial harnessing mobile phone technology blended with peer support
2020 - Published
Gumley, A., Bradstreet, S., Ainsworth, J., Allan, S., Alvarez-Jimenez, M., Beattie, L., Bell, I., Birchwood, M., Briggs, A., Bucci, S., Castagnini, E., Clark, A., Cotton, S. M., Engel, L., French, P., Lederman, R., Lewis, S., Machin, M., MacLennan, G., Matrunola, C., McLeod, H., McMeekin, N., Mihalopoulos, C., Morton, E., Norrie, J., Reilly, F., Schwannauer, M., Singh, S. P., Smith, L., Sundram, S., Thomson, D., Thompson, A., Whitehill, H., Wilson-Kay, A., Williams, C., Yung, A., Farhall, J., Gleeson, J.
JMIR Research Protocols, vol. 9, no. 1, pp. e15058
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.2196/15058
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/b0a7287a-d4fa-48ee-80e5-baae50b9ded2/download
- [ONLINE] View publication in Scopus
Economic evaluation of surgical treatments for women with stress urinary incontinence: a cost-utility and value of information analysis
2020 - Published
Javanbakht, M., Moloney, E., Brazzelli, M., Wallace, S., Ternent, L., Omar, M. I., Monga, A., Saraswat, L., Mackie, P., Becker, F., Imamura, M., Hudson, J., Shimonovich, M., MacLennan, G., Vale, L., Craig, D.
BMJ Open, vol. 10, no. 6, 035555
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1136/bmjopen-2019-035555
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/f864e52f-076f-47f9-8671-a3c8574cad03/download
- [ONLINE] View publication in Scopus
IDENTIFY: The investigation and detection of urological neoplasia in patients referred with suspected urinary tract cancer: A multicentre cohort study
2020 - Published
Khadhouri, S., Gallagher, K. M., MacKenzie, K., Shah, T. T., Gao, C., Moore, S., Zimmermann, E., Edison, E., Jefferies, M., Nambiar, A., MacLennan, G., McGrath, J. S., Kasivisvanathan, V., IDENTIFY Protocol Collaborators Group
International Journal of Surgery Protocols, vol. 21, pp. 8-12
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.isjp.2020.02.002
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/70c563fb-4678-43c3-8d95-eb45232db7d7/download
- [ONLINE] View publication in Scopus
ELECtric Tibial nerve stimulation to Reduce Incontinence in Care homes: protocol for the ELECTRIC randomised trial
2019 - Published
Booth, J., Aucott, L., Cotton, S., Goodman, C., Hagen, S., Harari, D., Lawrence, M., Lowndes, A., Macaulay, L., MacLennan, G., Mason, H., McClurg, D., Norrie, J., Norton, C., O'Dolan, C., Skelton, D. A., Surr, C., Treweek, S.
Trials, vol. 20, 723
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1186/s13063-019-3723-7
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/503182ef-ed58-41df-a26a-325e61b41b10/download
Practical help for specifying the target difference in sample size calculations for RCTs: The DELTA² five-stage study, including a workshop
2019 - Published
Cook, J. A., Julious, S. A., Sones, W., Hampson, L. V., Hewitt, C., Berlin, J. A., Ashby, D., Emsley, R., Fergusson, D. A., Walters, S. J., Wilson, E. C., Maclennan, G., Stallard, N., Rothwell, J. C., Bland, M., Brown, L., Ramsay, C. R., Cook, A., Armstrong, D., Altman, D., Vale, L. D.
Health Technology Assessment, vol. 23, no. 60
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3310/hta23600
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/d5eef883-abe3-4665-b255-2e33ade90221/download
- [ONLINE] View publication in Scopus
Methods to deal with missing data in area under the curve outcomes in randomised controlled trials: the OPEN trial case
2019 - Published
Goulao, B., MacLennan, G.
5th International Clinical Trials Methodology Conference, pp. 141-141
Contributions to Journals: Abstracts
- [ONLINE] DOI: https://doi.org/10.1186/s13063-019-3688-6
Laparoscopic supracervical hysterectomy versus endometrial ablation for women with heavy menstrual bleeding (HEALTH): a parallel-group, open-label, randomised controlled trial
2019 - Published
Cooper, K., Breeman, S., Scott, N. W., Scotland, G., Clark, J., Hawe, J., Hawthorn, R., Phillips, K., MacLennan, G., Wileman, S., McCormack, K., Hernández, R. A., Norrie, J., Bhattacharya, S., HEALTH Study Group
The Lancet, vol. 394, no. 10207, pp. 1425-1436
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/S0140-6736(19)31790-8
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/9a2d7459-f82e-45dd-8543-206b19f58bf9/download
- [ONLINE] https://abdn.pure.elsevier.com/en/en/researchoutput/laparoscopic-supracervical-hysterectomy-versus-endometrial-ablation-for-women-with-heavy-menstrual-bleeding-health(20b3fd84-6e08-4603-beaf-87c88732a17a).html
- [ONLINE] View publication in Scopus
Five-Year Outcomes of a Randomized Trial of Treatments for Varicose Veins
2019 - Published
Brittenden, J., Cooper, D., Dimitrova, M., Scotland, G., Cotton, S. C., Elders, A., MacLennan, G., Ramsay, C. R., Norrie, J., Burr, J. M., Campbell, B., Bachoo, P., Chetter, I., Gough, M., Earnshaw, J., Lees, T., Scott, J., Baker, S. A., Tassie, E., Francis, J., Campbell, M. K.
The New England Journal of Medicine, vol. 381, no. 10, pp. 912-922
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1056/NEJMoa1805186
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/31fbd86b-abc3-4ec2-8127-3532a0bcdf42/download
- [ONLINE] Publisher permissions
- [ONLINE] http://www.ncbi.nlm.nih.gov/pubmed/31483962
- [ONLINE] View publication in Mendeley
- [ONLINE] View publication in Scopus
Photodynamic versus white light-guided treatment of non-muscle invasive bladder cancer: A study protocol for a randomised trial of clinical and cost-effectiveness
2019 - Published
Tandogdu, Z., Lewis, R., Duncan, A., Penegar, S., McDonald, A., Vale, L., Shen, J., Kelly, J. D., Pickard, R., N Dow, J., Ramsay, C., Mostafid, H., Mariappan, P., Nabi, G., Creswell, J., Lazarowicz, H., McGrath, J., Taylor, E., Clark, E., Maclennan, G., Norrie, J., Hall, E., Heer, R.
BMJ Open, vol. 9, no. 9, e22268
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1136/bmjopen-2018-022268
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/d0fca6ed-54b1-4d5a-b929-8b1eb4a83bc8/download
- [ONLINE] View publication in Scopus
The clinical and cost-effectiveness of total versus partial knee replacement in patients with medial compartment osteoarthritis (TOPKAT): 5-year outcomes of a randomised controlled trial
2019 - Published
Beard, D. J., Davies, L. J., Cook, J. A., MacLennan, G., Price, A., Kent, S., Hudson, J., Carr, A., Leal, J., Campbell, H., Fitzpatrick, R., Arden, N., Murray, D., Campbell, M. K., TOPKAT Study Group
The Lancet, vol. 394, no. 10200, pp. 746-756
Contributions to Journals: Articles
- [ONLINE] https://www.journalslibrary.nihr.ac.uk/programmes/hta/081408/#/
- [ONLINE] DOI: https://doi.org/10.1016/S0140-6736(19)31281-4
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/9bb71eb7-9d41-4ae2-9a8a-f2009d514c6a/download
Study protocol for a randomised controlled trial of CBT vs antipsychotics vs both in 14-18-year-olds: Managing Adolescent first episode Psychosis: a feasibility study (MAPS)
2019 - Published
Pyle, M., Broome, M. R., Joyce, E., MacLennan, G., Norrie, J., Freeman, D., Fowler, D., Haddad, P. M., Shiers, D., Hollis, C., Smith, J., Liew, A., Byrne, R. E., French, P., Peters, S., Hudson, J., Davies, L., Emsley, R., Yung, A., Birchwood, M., Longden, E., Morrison, A. P.
Trials, vol. 20, 395
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1186/s13063-019-3506-1
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/2a1d5be1-35b1-4c25-86d7-43d483f83857/download
- [ONLINE] View publication in Scopus
- [ONLINE] https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-019-3506-1
- [ONLINE] View publication in Mendeley
Surgical interventions for women with stress urinary incontinence: systematic review and network meta-analysis of randomised controlled trials
2019 - Published
Imamura, M., Hudson, J., Wallace, S. A., MacLennan, G., Shimonovich, M., Omar, M. I., Javanbakht, M., Moloney, E., Becker, F., Ternent, L., Montgomery, I., Mackie, P., Saraswat, L., Monga, A., Vale, L., Craig, D., Brazzelli, M.
BMJ, vol. 365, l1842
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1136/bmj.l1842
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/8f342978-7396-4469-b56f-dfa38520e47e/download
- [ONLINE] View publication in Scopus
- [ONLINE] http://www.bmj.com/lookup/doi/10.1136/bmj.l1842
- [ONLINE] View publication in Mendeley
Supporting Harm Reduction through Peer Support (SHARPS): Testing the feasibility and acceptability of a peer-delivered, relational intervention for people with problem substance use who are homeless, to improve health outcomes, quality of life and social functioning and reduce harms: Study protocol
2019 - Published
Parkes, T., Matheson, C., Carver, H., Budd, J., Liddell, D., Wallace, J., Pauly, B., Fotopoulou, M., Burley, A., Anderson, I., MacLennan, G., Foster, R.
Pilot and Feasibility Studies, vol. 5, 64
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1186/s40814-019-0447-0
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/a7d5e267-cc92-48d7-8934-9d1d9cc35c69/download
- [ONLINE] View publication in Scopus
Surgical treatments for women with stress urinary incontinence: the ESTER systematic review and economic evaluation
2019 - Published
Brazzelli, M., Javanbakht, M., Imamura, M., Hudson, J., Moloney, E., Becker, F., Wallace, S., Omar, M. I., Shimonovich, M., MacLennan, G., Ternent, L., Vale, L., Montgomery, I., Mackie, P., Saraswat, L., Monga, A., Craig, D.
Health Technology Assessment, vol. 23, no. 14, pp. 1-306
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3310/hta23140
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/1c38008e-4ccb-48ad-82bb-ded9521d7c8c/download
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
- [ONLINE] Pubmed Publication
399 - Surgical treatment for recurrent bulbar urethral stricture: A randomised open label superiority trial of open urethroplasty versus endoscopic urethrotomy (The OPEN Trial): Abstracts EAU19 – 34th Annual EAU Congress
2019 - Published
Goulao, B., Carnell, S., Shen, J., MacLennan, G., Norrie, J., Cook, J., McColl, E., Breckons, M., Vale, L., Forbes, R., Currer, S., Forrest, M., Wilkinson, J., Andrich, D., Barclay, S., Munday, A., N’Dow, J., Payne, S., Watkin, N., Pickard, R.
European Urology Supplements, vol. 18, no. 1, pp. e523
Contributions to Journals: Articles
- [ONLINE] http://www.sciencedirect.com/science/article/pii/S1569905619303884
- [ONLINE] DOI: https://doi.org/10.1016/S1569-9056
Cognitive-behavioural therapy for clozapine-resistant schizophrenia: the FOCUS RCT
2019 - Published
Morrison, A. P., Pyle, M., Gumley, A., Schwannauer, M., Turkington, D., MacLennan, G., Norrie, J., Hudson, J., Bowe, S., French, P., Hutton, P., Byrne, R., Syrett, S., Dudley, R., McLeod, H. J., Griffiths, H., Barnes, T. R., Davies, L., Shields, G., Buck, D., Tully, S., Kingdon, D.
Health Technology Assessment, vol. 23, no. 7, pp. 1-144
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3310/hta23070
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/8730f44c-8860-4d40-8474-1c943975d91c/download
- [ONLINE] View publication in Scopus
Open randomised trial of the (Arabin) pessary to prevent preterm birth in twin pregnancy with health economics and acceptability: STOPPIT-2-a study protocol
2019 - Published
Norman, J. E., Norrie, J., Maclennan, G., Cooper, D., Whyte, S., Burley, S. C., Smith, J. B., Shennan, A., Robson, S. C., Thornton, S., Kilby, M. D., Marlow, N., Stock, S. J., Bennett, P. R., Denton, J.
BMJ Open, vol. 8, no. 12, e026430
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1136/bmjopen-2018-026430
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/373fb9c1-56ee-4720-a859-030cbc8f01c5/download
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Protocol for a multicentre randomised controlled parallel-group trial to compare the effectiveness of remotely delivered cognitive-behavioural and graded exercise interventions with usual care alone to lessen the impact of fatigue in inflammatory rheumatic diseases (LIFT)
2019 - Published
Martin, K. R., Bachmair, E., Aucott, L., Dures, E., Emsley, R., Gray, S. R., Hewlett, S., Kumar, V., Lovell, K., Macfarlane, G. J., MacLennan, G., McNamee, P., Norrie, J., Paul, L., Ralston, S., Siebert, S., Wearden, A., White, P. D., Basu, N.
BMJ Open, vol. 9, no. 1, e026793
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1136/bmjopen-2018-026793
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/587cbd31-f290-4639-877b-fa6332594783/download
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Bariatric surgery, lifestyle interventions and orlistat for severe obesity: the REBALANCE mixed-methods systematic review and economic evaluation
2018 - Published
Avenell, A., Robertson, C., Skea, Z., Jacobsen, E., Boyers, D., Cooper, D., Aceves-Martins, M., Retat, L., Fraser, C., Aveyard, P., Stewart, F., MacLennan, G., Webber, L., Corbould, E., Xu, B., Jaccard, A., Boyle, B., Duncan, E., Shimonovich, M., de Bruin, M.
Health Technology Assessment, vol. 22, no. 68, pp. 1-286
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3310/hta22680
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/f63b64d2-2255-4278-8a47-11d19f5d7af5/download
- [ONLINE] Corrigendum
Contrast-enhanced ultrasound and/or colour duplex ultrasound for surveillance after endovascular abdominal aortic aneurysm repair: a systematic review and economic evaluation
2018 - Published
Brazzelli, M., Hernández, R., Sharma, P., Robertson, C., Shimonovich, M., MacLennan, G., Fraser, C., Jamieson, R., Vallabhaneni, S. R.
Health Technology Assessment, vol. 22, no. 72, pp. 1-220
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3310/hta22720
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/45c019a3-d922-4e4d-8688-2d93407882a7/download
DELTA² guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial
2018 - Published
Cook, J. A., Julious, S. A., Sones, W., Hampson, L. V., Hewitt, C., Berlin, J. A., Ashby, D., Emsley, R., Fergusson, D. A., Walters, S. J., Wilson, E. C., MacLennan, G., Stallard, N., Rothwell, J. C., Bland, M., Brown, L., Ramsay, C. R., Cook, A., Armstrong, D., Altman, D., Vale, L. D.
BMJ, vol. 363, k3750
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1136/bmj.k3750
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/28cb0c7c-e8f1-48ab-8862-da91e37be8d0/download
- [ONLINE] View publication in Scopus
DELTA² guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial
2018 - Published
Cook, J. A., Julious, S. A., Sones, W., Hampson, L. V., Hewitt, C., Berlin, J. A., Ashby, D., Emsley, R., Fergusson, D. A., Walters, S. J., Wilson, E. C., Maclennan, G., Stallard, N., Rothwell, J. C., Bland, M., Brown, L., Ramsay, C. R., Cook, A., Armstrong, D., Altman, D., Vale, L. D.
Trials, vol. 19, 606
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1186/s13063-018-2884-0
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/7b6cb244-78df-4985-aac8-9edfc3d1960f/download
- [ONLINE] View publication in Scopus
COMPARISON OF NINE SURGICAL TREATMENTS FOR WOMEN WITH STRESS URINARY INCONTINENCE: A COST-EFFECTIVENESS AND VALUE OF INFORMATION ANALYSIS
2018 - Published
Javanbakht, M., Moloney, E., Brazzelli, M., Wallace, S. A., Ternent, L., Omar, M. I., Monga, A., Saraswat, L., Mackie, P., Imamura, M., Hudson, J., Shimonovich, M., MacLennan, G., Vale, L., Craig, D.
11th Annual European UroGynaecological Association Congress
Contributions to Conferences: Abstracts
- [ONLINE] https://www.eugaoffice.org/wp-content/uploads/2021/02/11th_EUGA_Congress_2018-abstract_book.pdf
A Systematic Review of Health Economic Evaluations of Surgical Treatments for Women with Stress Urinary Incontinence
2018 - Published
Javanbakht, M., Moloney, E., Craig, D., Brazzelli, M., Wallace, S., Omar, M. I., Monga, A., Saraswat, L., Mackie, P., Imamura, M., Hudson, J., Shimonovich, M., MacLennan, G., Vale, L.
ICS 2018
Contributions to Conferences: Abstracts
Partial factorial trials: comparing methods for statistical analysis and economic evaluation
2018 - Published
Dakin, H. A., Gray, A. M., MacLennan, G. S., Morris, R. W., Murray, D. W.
Trials, vol. 19, 442
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1186/s13063-018-2818-x
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/d9c28ccb-3708-4a04-8f39-c7d61a2fe752/download
Cognitive behavioural therapy in clozapine-resistant schizophrenia (FOCUS): an assessor-blinded, randomised controlled trial
2018 - Published
Morrison, A. P., Pyle, M., Gumley, A., Schwannauer, M., Turkington, D., MacLennan, G., Norrie, J., Hudson, J., Bowe, S. E., French, P., Byrne, R., Syrett, S., Dudley, R., McLeod, H. J., Griffiths, H., Barnes, T. R. E., Davies, L., Kingdon, D., FOCUS trial group
The lancet. Psychiatry, vol. 5, no. 8, pp. 633-643
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/S2215-0366(18)30184-6
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/783f2246-3264-4aa9-855c-55ff360068a7/download
Treatment of Advanced Glaucoma Study: a multicentre randomised controlled trial comparing primary medical treatment with primary trabeculectomy for people with newly diagnosed advanced glaucoma—study protocol
2018 - Published
King, A. J., Fernie, G., Azuara-Blanco, A., Burr, J. M., Garway-Heath, T., Sparrow, J. M., Vale, L., Hudson, J., MacLennan, G., McDonald, A. M., Barton, K., Norrie, J.
British Journal of Ophthalmology, vol. 102, no. 7, pp. 922-928
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1136/bjophthalmol-2017-310902
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/a70258ab-5250-4e1d-b031-42e2e6f12d97/download
A Systematic Review of Health Economic Evaluations of Surgical Treatments for Women with Stress Urinary Incontinence
2018 - Published
Javanbakht, M., Moloney, E., Craig, D., Brazzelli, M., Wallace, S., Omar, M. I., Monga, A., Saraswat, L., Mackie, P., Imamura, M., Hudson, J., Shimonovich, M., MacLennan, G., Vale, L.
Health Technology Assessment international 2018 Annual Meeting
Contributions to Conferences: Abstracts
TISU: Extracorporeal shockwave lithotripsy, as first treatment option, compared with direct progression to ureteroscopic treatment, for ureteric stones: study protocol for a randomised controlled trial
2018 - Published
McClinton, S., Cameron, S., Starr, K., Thomas, R., MacLennan, G., McDonald, A., Lam, T., N’Dow, J., Kilonzo, M., Pickard, R., Anson, K., Keeley, F., Burgess, N., Clark, C. T., MacLennan, S., Norrie, J., TISU Study Group
Trials, vol. 19, no. 1, pp. 1-11
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1186/s13063-018-2652-1
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/80458851-070c-42e2-b2fd-5b56bb31a049/download
Cancer and vitamin D supplementation: a systematic review and meta-analysis
2018 - Published
Goulao, B., Stewart, F., Ford, J. A., MacLennan, G., Avenell, A.
The American Journal of Clinical Nutrition, vol. 107, no. 4, pp. 652-663
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1093/ajcn/nqx047
- [ONLINE] http://nutrition.org/publications/guidelines-and-policies/permissions/
Instrumental variable methods for a binary outcome were used to informatively address non-compliance in a randomised trial in surgery
2018 - Published
Cook, J. A., Maclennan, G. S., Palmer, T., Lois, N., Emsley, R.
Journal of Clinical Epidemiology, vol. 96, pp. 126-132
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.jclinepi.2017.11.011
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/b09f549c-cacb-4a0b-9aab-cfadc46b5fc8/download
The split-plot design was useful for evaluating complex, multi-level interventions but there is need for improvement in its design and report
2018 - Published
Goulão, B., MacLennan, G., Ramsay, C.
Journal of Clinical Epidemiology, vol. 96, pp. 120-125
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.jclinepi.2017.10.019
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/702cbc71-71c4-42f7-9512-bd1ff9a89e8b/download
Systematic Techniques to Enhance rEtention in Randomised controlled trials: the STEER study protocol
2018 - Published
Gillies, K., Bower, P., Elliott, J., MacLennan, G., Newlands, R. S. N., Ogden, M., Treweek, S. P., Wells, M., Witham, M. D., Young, B., Francis, J. J.
Trials, vol. 19, 197
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1186/s13063-018-2572-0
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/d601707c-1477-4eb2-ae21-2da7302bfcd5/download
How to resolve discrepancies when findings from randomized controlled trials and meta-analyses disagree?
2018 - Published
Sylvester, R., Canfield, S. E., Lam, T., Marconi, L., MacLennan, S., Yuan, Y., MacLennan, G., Norrie, J., Omar, M. I., Bruins, H. M., Hernández, V., Plass, K., Van Poppel, H., N'Dow, J.
33rd Annual EAU Congress 2018
Contributions to Conferences: Posters
- [ONLINE] https://urosource.uroweb.org/resource-centres/eau18/6024/abstract
Male synthetic sling versus artificial urinary sphincter trial for men with urodynamic stress incontinence after prostate surgery (MASTER): Study protocol for a randomised controlled trial
2018 - Published
Constable, L., Cotterill, N., Cooper, D., Glazener, C., Drake, M. J., Forrest, M., Harding, C., Kilonzo, M., MacLennan, G., McCormack, K., McDonald, A., Mundy, A., Norrie, J., Pickard, R., Ramsay, C., Smith, R., Wileman, S., Abrams, P., The MASTER Study Group
Trials, vol. 19, pp. 1-17
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1186/s13063-018-2501-2
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/cec8b694-8bbc-455c-b707-5e40ed835cdb/download
- [ONLINE] View publication in Scopus
Effects of weight loss interventions for adults who are obese on mortality, cardiovascular disease and cancer: a systematic review and meta-analysis
2017 - Published
Ma, C., Avenell, A., Bolland, M., Hudson, J., Stewart, F., Robertson, C., Sharma, P., Fraser, C., MacLennan, G.
BMJ, vol. 359, j4849
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1136/bmj.j4849
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/8dc10a48-1324-4e78-bd27-dd9394a20cb9/download
Bayesian clinical trial designs: Another option for trauma trials?
2017 - Published
Jansen, J. O., Pallmann, P., MacLennan, G., Campbell, M. K., UK-REBOA Trial Investigators
The journal of trauma and acute care surgery, vol. 83, no. 4, pp. 736-741
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1097/TA.0000000000001638
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/4134d8c8-8ed8-47db-9d87-e9b8a26c29c3/download
THISTLE: trial of hands-on Interprofessional simulation training for local emergencies: a research protocol for a stepped-wedge clustered randomised controlled trial
2017 - Published
Lenguerrand, E., Winter, C., Innes, K., MacLennan, G., Siassakos, D., Lynch, P., Cameron, A., Crofts, J., McDonald, A., McCormack, K., Forrest, M., Norrie, J., Bhattacharya, S., Draycott, T., Thistle group
BMC Pregnancy and Childbirth, vol. 17, 294
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1186/s12884-017-1455-9
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/b9354e79-cd09-484e-99fa-2be8f92d4280/download

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Biography

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Current Research

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Protocol for a randomised controlled trial comparing laparoscopic cholecystectomy with observation/conservative management for preventing recurrent symptoms and complications in adults with uncomplicated symptomatic gallstones (C-Gall trial)

Survey on ureTEric draiNage post uncomplicaTed ureteroscopy (STENT)

Psychological intervention, antipsychotic medication or a combined treatment for adolescents with a first episode of psychosis: the MAPS feasibility three-arm RCT

Open urethroplasty versus endoscopic urethrotomy for recurrent urethral stricture in men: the OPEN RCT

Surgical Treatment for Recurrent Bulbar Urethral Stricture: A Randomised Open-label Superiority Trial of Open Urethroplasty Versus Endoscopic Urethrotomy (the OPEN Trial)

Antipsychotic medication versus psychological intervention versus a combination of both in adolescents with first-episode psychosis (MAPS): a multicentre, three-arm, randomised controlled pilot and feasibility study

Mesh inlay, mesh kit or native tissue repair for women having repeat anterior or posterior prolapse surgery: randomised controlled trial (PROSPECT)

The clinical and cost effectiveness of surgical interventions for stones in the lower pole of the kidney: the percutaneous nephrolithotomy, flexible ureterorenoscopy and extracorporeal shockwave lithotripsy for lower pole kidney stones randomised controlled trial (PUrE RCT) protocol

Total versus partial knee replacement in patients with medial compartment knee osteoarthritis: the TOPKAT RCT

Baseline Characteristics of Participants in the Treatment of Advanced Glaucoma Study: A Multicenter Randomized Controlled Trial

Surgical treatments for women with stress urinary incontinence: a systematic review of economic evidence

Effect of hands-on interprofessional simulation training for local emergencies in Scotland: the THISTLE stepped-wedge design randomised controlled trial

Early signs monitoring to prevent relapse in psychosis and promote well-being, engagement, and recovery: Protocol for a feasibility cluster randomized controlled trial harnessing mobile phone technology blended with peer support

Economic evaluation of surgical treatments for women with stress urinary incontinence: a cost-utility and value of information analysis

IDENTIFY: The investigation and detection of urological neoplasia in patients referred with suspected urinary tract cancer: A multicentre cohort study

ELECtric Tibial nerve stimulation to Reduce Incontinence in Care homes: protocol for the ELECTRIC randomised trial

Practical help for specifying the target difference in sample size calculations for RCTs: The DELTA2 five-stage study, including a workshop

Methods to deal with missing data in area under the curve outcomes in randomised controlled trials: the OPEN trial case

Laparoscopic supracervical hysterectomy versus endometrial ablation for women with heavy menstrual bleeding (HEALTH): a parallel-group, open-label, randomised controlled trial

Five-Year Outcomes of a Randomized Trial of Treatments for Varicose Veins

Photodynamic versus white light-guided treatment of non-muscle invasive bladder cancer: A study protocol for a randomised trial of clinical and cost-effectiveness

The clinical and cost-effectiveness of total versus partial knee replacement in patients with medial compartment osteoarthritis (TOPKAT): 5-year outcomes of a randomised controlled trial

Study protocol for a randomised controlled trial of CBT vs antipsychotics vs both in 14-18-year-olds: Managing Adolescent first episode Psychosis: a feasibility study (MAPS)

Surgical interventions for women with stress urinary incontinence: systematic review and network meta-analysis of randomised controlled trials

Supporting Harm Reduction through Peer Support (SHARPS): Testing the feasibility and acceptability of a peer-delivered, relational intervention for people with problem substance use who are homeless, to improve health outcomes, quality of life and social functioning and reduce harms: Study protocol

Surgical treatments for women with stress urinary incontinence: the ESTER systematic review and economic evaluation

399 - Surgical treatment for recurrent bulbar urethral stricture: A randomised open label superiority trial of open urethroplasty versus endoscopic urethrotomy (The OPEN Trial): Abstracts EAU19 – 34th Annual EAU Congress

Cognitive-behavioural therapy for clozapine-resistant schizophrenia: the FOCUS RCT

Open randomised trial of the (Arabin) pessary to prevent preterm birth in twin pregnancy with health economics and acceptability: STOPPIT-2-a study protocol

Protocol for a multicentre randomised controlled parallel-group trial to compare the effectiveness of remotely delivered cognitive-behavioural and graded exercise interventions with usual care alone to lessen the impact of fatigue in inflammatory rheumatic diseases (LIFT)

Bariatric surgery, lifestyle interventions and orlistat for severe obesity: the REBALANCE mixed-methods systematic review and economic evaluation

Contrast-enhanced ultrasound and/or colour duplex ultrasound for surveillance after endovascular abdominal aortic aneurysm repair: a systematic review and economic evaluation

DELTA 2 guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial

DELTA2 guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial

COMPARISON OF NINE SURGICAL TREATMENTS FOR WOMEN WITH STRESS URINARY INCONTINENCE: A COST-EFFECTIVENESS AND VALUE OF INFORMATION ANALYSIS

A Systematic Review of Health Economic Evaluations of Surgical Treatments for Women with Stress Urinary Incontinence

Partial factorial trials: comparing methods for statistical analysis and economic evaluation

Cognitive behavioural therapy in clozapine-resistant schizophrenia (FOCUS): an assessor-blinded, randomised controlled trial

Treatment of Advanced Glaucoma Study: a multicentre randomised controlled trial comparing primary medical treatment with primary trabeculectomy for people with newly diagnosed advanced glaucoma—study protocol

A Systematic Review of Health Economic Evaluations of Surgical Treatments for Women with Stress Urinary Incontinence

TISU: Extracorporeal shockwave lithotripsy, as first treatment option, compared with direct progression to ureteroscopic treatment, for ureteric stones: study protocol for a randomised controlled trial

Cancer and vitamin D supplementation: a systematic review and meta-analysis

Instrumental variable methods for a binary outcome were used to informatively address non-compliance in a randomised trial in surgery

The split-plot design was useful for evaluating complex, multi-level interventions but there is need for improvement in its design and report

Systematic Techniques to Enhance rEtention in Randomised controlled trials: the STEER study protocol

How to resolve discrepancies when findings from randomized controlled trials and meta-analyses disagree?

Male synthetic sling versus artificial urinary sphincter trial for men with urodynamic stress incontinence after prostate surgery (MASTER): Study protocol for a randomised controlled trial

Effects of weight loss interventions for adults who are obese on mortality, cardiovascular disease and cancer: a systematic review and meta-analysis

Bayesian clinical trial designs: Another option for trauma trials?

THISTLE: trial of hands-on Interprofessional simulation training for local emergencies: a research protocol for a stepped-wedge clustered randomised controlled trial

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Books and Reports

Chapters in Books, Reports and Conference Proceedings

Contributions to Conferences

Contributions to Journals

Practical help for specifying the target difference in sample size calculations for RCTs: The DELTA² five-stage study, including a workshop

DELTA² guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial

DELTA² guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial