Director (CHaRT)
- About
-
- Email Address
- g.maclennan@abdn.ac.uk
- Telephone Number
- +44 (0)1224 438147
- Office Address
Health Services Research Unit
2nd Floor Health Sciences Building
Foresterhill
Aberdeen
AB25 2ZD- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT.
My undergrad degree is in Mathematics from the University of Aberdeen, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.
Qualifications
- BSc Mathematics1997 - University of Aberdeen
- MSc Applied Statistics2004 - Sheffield Hallam University
- Research
-
Research Overview
The application of statistical methods to clinical trials. Recent example is JCE paper available here on using instrumental variables in a surgery trial to address non-compliance. Collaborators were Jonathan Cook (Oxford), Tom Palmer (Lancaster), and Richard Emesley (Manchester).
Research on making trials more efficient, collaborating with Trial Forge.
Current Research
A complete list of the CHaRT RCT portolio is available by clicking here
- Teaching
-
Teaching Responsibilities
I teach on our MPH course module PU5031: EVIDENCE-BASED HEALTH.
- Publications
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Page 2 of 6 Results 51 to 100 of 278
Development of an intervention to manage benzodiazepine dependence and high-risk use in the context of escalating drug related deaths in Scotland: an application of the MRC framework
BMC Health Services Research, vol. 23, no. 1, 1205Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s12913-023-10201-7
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/a80cea8a-44d6-4171-98b8-9e567282cdbd/download
- [ONLINE] View publication in Scopus
Emergency Department Resuscitative Endovascular Balloon Occlusion of the Aorta in Trauma Patients with Exsanguinating Hemorrhage: The UK-REBOA Randomized Clinical Trial
JAMA, vol. 330, no. 19, pp. 1862-1871Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1001/jama.2023.20850
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/d02970db-a58f-47ad-bcd5-8ec32213aafa/download
- [ONLINE] View publication in Scopus
Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma
British Journal of Ophthalmology, vol. 107, no. 10, pp. 1452-1457Contributions to Journals: ArticlesPatient preferences for stress urinary incontinence treatments: a discrete choice experiment
BMJ Open, vol. 13, no. 8, pp. e066157Contributions to Journals: ArticlesPROSPECT: 4- and 6-year follow-up of a randomised trial of surgery for vaginal prolapse
International Urogynecology Journal, vol. 34, pp. 67-78Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s00192-022-05308-0
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/1cb93e0d-7bb2-40f0-a2f5-3e7aad3fa8e3/download
- [ONLINE] View publication in Scopus
Cost utility analysis of shockwave lithotripsy versus ureteroscopic stone treatment in adults
BJU International, vol. 131, no. 2, pp. 253-261Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/bju.15862
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/53a7b43b-beac-436b-b040-11d7a661c5da/download
Correction to: Pulpotomy for the Management of Irreversible Pulpitis in Mature Teeth (PIP): a feasibility study (Pilot and Feasibility Studies, (2022), 8, 1, (77), 10.1186/s40814-022-01029-9)
Pilot and Feasibility Studies, vol. 8, 82Contributions to Journals: Comments and Debates- [ONLINE] DOI: https://doi.org/10.1186/s40814-022-01045-9
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/f696cee2-7b69-4a57-85a8-a4b1f45e3bf0/download
- [ONLINE] View publication in Scopus
Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial
The Lancet. Respiratory medicine, vol. 10, no. 12, pp. 1119-1128Contributions to Journals: ArticlesSingle-incision mini-slings versus standard synthetic mid-urethral slings for surgical treatment of stress urinary incontinence in women: The SIMS RCT
Health technology assessment (Winchester, England), vol. 26, no. 47, pp. 1-190Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/BTSA6148
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/22532954-ebac-42b0-8b86-986f75481d64/download
Randomised controlled trial comparing the clinical and cost-effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long-term catheters: study protocol for the CATHETER II study
Trials, vol. 23, no. 1, 630Contributions to Journals: ArticlesDeveloping a Diagnostic Multivariable Prediction Model for Urinary Tract Cancer in Patients Referred with Haematuria: results from the IDENTIFY Collaborative Study
European Urology Focus, vol. 8, no. 6, pp. 1673-1682Contributions to Journals: ArticlesPhotodynamic versus white-light-guided resection of first-diagnosis non-muscle-invasive bladder cancer: PHOTO RCT
Health technology assessment (Winchester, England), vol. 26, no. 40, pp. 1-144Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/PLPU1526
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/b7c3540b-9d3e-410b-912f-a513bb3d6c08/download
- [ONLINE] View publication in Scopus
A Randomized Trial of PHOTOdynamic Surgery in Non-Muscle-Invasive Bladder Cancer
NEJM evidence, vol. 1, no. 10, EVIDoa2200092Contributions to Journals: ArticlesThe Achieving Self-directed Integrated Cancer Aftercare Intervention for Detection of Recurrent and Second Primary Melanoma in Survivors of Melanoma: Pilot Randomized Controlled Trial
JMIR cancer, vol. 8, no. 3, e37539Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.2196/37539
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/c6f51a95-1926-4a98-9b8d-61fb63aabd86/download
Remotely delivered cognitive behavioural and personalised exercise interventions for fatigue severity and impact in inflammatory rheumatic diseases: a multi-centre randomised controlled parallel open-label group trial (LIFT)
The Lancet Rheumatology, vol. 4, no. 8, pp. e534-e545Contributions to Journals: ArticlesSynthetic sling or artificial urinary sphincter for men with urodynamic stress incontinence after prostate surgery: the MASTER non-inferiority RCT
Health Technology Assessment, vol. 26, no. 36, 184Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/TBFZ0277
Effectiveness and cost-effectiveness of text messages with or without endowment incentives for weight management in men with obesity (Game of Stones): study protocol for a randomised controlled trial
Trials, vol. 23, no. 1, 582Contributions to Journals: ArticlesReducing asthma attacks in children using exhaled nitric oxide (RAACENO) as a biomarker to inform treatment strategy: a multicentre, parallel, randomised, controlled, phase 3 trial
The Lancet. Respiratory medicine, vol. 10, no. 6, pp. 584-592Contributions to Journals: ArticlesTreatment guided by fractional exhaled nitric oxide in addition to standard care in 6- to 15-year-olds with asthma: the RAACENO RCT
Efficacy and Mechanism Evaluation, vol. 9, no. 4Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/AWOI5587
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/56f5855f-523f-470e-b91b-5b143227048a/download
The EMPOWER blended digital intervention for relapse prevention in schizophrenia: a feasibility cluster randomised controlled trial in Scotland and Australia
The Lancet Psychiatry, vol. 9, no. 6, pp. 477-486Contributions to Journals: ArticlesA randomized double-blind placebo-controlled trial of Dipeptidyl Peptidase-1 inhibition in hospitalized patients with COVID-19: the STOP-COVID19 trial
American Thoracic Society International Conference, A5055Contributions to Journals: AbstractsVisualising harms in publications of randomised controlled trials: consensus and recommendations
BMJ (Clinical research ed.), vol. 377, e068983Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmj-2021-068983
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/0bb10bbb-8cc1-47fe-99c9-a7b006597dca/download
- [ONLINE] View publication in Scopus
The effectiveness and cost-effectiveness of resuscitative endovascular balloon occlusion of the aorta (REBOA) for trauma patients with uncontrolled torso haemorrhage: study protocol for a randomised clinical trial (the UK-REBOA trial)
Trials, vol. 23, no. 1, 384Contributions to Journals: ArticlesDigital smartphone intervention to recognise and manage early warning signs in schizophrenia to prevent relapse: the EMPOWER feasibility cluster RCT
Health Technology Assessment, vol. 26, no. 27, pp. v-122Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/HLZE0479
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/a2040758-572a-4d62-912e-133885d5ea05/download
- [ONLINE] View publication in Scopus
ScotCap - A large observational cohort study
Colorectal Disease, vol. 24, no. 4, pp. 411-421Contributions to Journals: ArticlesUse of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial. (BICS)
Trials, vol. 23, no. 1, 307Contributions to Journals: ArticlesThe development of theory-informed participant-centred interventions to maximise participant retention in randomised controlled trials
Trials, vol. 23, no. 1, 268Contributions to Journals: ArticlesPulpotomy for the Management of Irreversible Pulpitis in Mature Teeth (PIP): a feasibility study
Pilot and Feasibility Studies, vol. 8, 77Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s40814-022-01029-9
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/ccd87ab3-6359-4f1f-a733-55582766b2ed/download
- [ONLINE] View publication in Scopus
Single-Incision Mini-Slings for Stress Urinary Incontinence in Women
The New England Journal of Medicine, vol. 386, no. 13, pp. 1230-1243Contributions to Journals: ArticlesShockwave lithotripsy compared with ureteroscopic stone treatment for adults with ureteric stones: the TISU non-inferiority RCT
Health technology assessment (Winchester, England), vol. 26, no. 19, pp. 1-70Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/WUZW9042
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/2deb2914-52a5-4304-84cd-d2e0b52b9e34/download
- [ONLINE] View publication in Scopus
A peer-delivered intervention to reduce harm and improve the well-being of homeless people with problem substance use: the SHARPS feasibility mixed-methods study
Health technology assessment (Winchester, England), vol. 26, no. 14, pp. 1-128Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/WVVL4786
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/3dce9662-ec2e-4652-ba0d-d5bf13a5ca03/download
- [ONLINE] View publication in Scopus
Assessing the feasibility, acceptability and accessibility of a peer-delivered intervention to reduce harm and improve the well-being of people who experience homelessness with problem substance use: the SHARPS study
Harm Reduction Journal, vol. 19, 10Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s12954-021-00582-5
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/9d940eba-1468-460d-9dea-6302adc8f088/download
- [ONLINE] View publication in Scopus
The ALLEGRO trial: a placebo controlled randomised trial of intravenous lidocaine in accelerating gastrointestinal recovery after colorectal surgery
Trials, vol. 23, no. 1, 84Contributions to Journals: ArticlesEye Movement Patterns Can Distinguish Schizophrenia From the Major Affective Disorders and Healthy Control Subjects
Schizophrenia Bulletin Open, vol. 3, no. 1, sgac032Contributions to Journals: ArticlesHow common are complications following polypropylene mesh, biological xenograft and native tissue surgery for pelvic organ prolapse?: A secondary analysis from the PROSPECT trial
BJOG: An International Journal of Obstetrics and Gynaecology, vol. 128, no. 13, pp. 2180-2189Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/1471-0528.16897
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/6547da43-36ab-475c-819a-35d9c5dfd092/download
- [ONLINE] View publication in Scopus
Primary trabeculectomy versus primary glaucoma eye drops for newly diagnosed advanced glaucoma: TAGS RCT
Health Technology Assessment, vol. 25, no. 72, pp. 1-194Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/hta25720
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/15202edc-0bb4-4171-b577-a3a7f6ed785d/download
Primary trabeculectomy versus primary glaucoma eye drops for newly diagnosed advanced glaucoma: TAGS RCT
Health Technology Assessment, vol. 25, no. 72, pp. i-158Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/hta25720
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/b2c5fc82-bafc-4852-8435-bdcc80131c5f/download
- [ONLINE] View publication in Scopus
Female Urgency, Trial of Urodynamics as Routine Evaluation (FUTURE study): a superiority randomised clinical trial to evaluate the effectiveness and cost-effectiveness of invasive urodynamic investigations in management of women with refractory overactive bladder symptoms
Trials, vol. 22, no. 1, 745Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s13063-021-05661-3
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/18914737-e6fd-4769-a075-de51727da633/download
- [ONLINE] View publication in Scopus
The IDENTIFY Study: The Investigation and Detection of Urological Neoplasia in Patients Referred with Suspected Urinary Tract Cancer; A multicentre observational study
BJU International, vol. 128, no. 4, pp. 440-450Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/bju.15483
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/83e52003-58ad-4569-87b8-2d1444966e7e/download
Why trials lose participants: a multi-trial investigation of participants’ perspectives using the theoretical domains framework
Journal of Clinical Epidemiology, vol. 137, pp. P1-13Contributions to Journals: ArticlesSelective Caries Removal in Permanent Teeth (SCRiPT) for the treatment of deep carious lesions: a randomised controlled clinical trial in primary care
BMC Oral Health, vol. 21, 336Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s12903-021-01637-6
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/fbfb2c1e-44ad-4010-8df6-a0cc6ff59058/download
- [ONLINE] View publication in Scopus
Have you had bleeding from your gums?: Self-report to Identify giNGival inflammation (The SING diagnostic accuracy and diagnostic model development study)
Journal of Journal of Clinical Periodontology, vol. 48, no. 7, pp. 919-928Contributions to Journals: ArticlesShockwave Lithotripsy Versus Ureteroscopic Treatment as Therapeutic Interventions for Stones of the Ureter (TISU): A Multicentre Randomised Controlled Non-inferiority Trial
European Urology, vol. 80, no. 1, pp. 46-54Contributions to Journals: ArticlesThe arabin pessary to prevent preterm birth in women with a twin pregnancy and a short cervix: The STOPPIT 2 RCT
NIHR Health Technology Assessment programme. 94 pagesBooks and Reports: Other Reports- [ONLINE] DOI: https://doi.org/10.3310/hta25440
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/789219c4-4bb7-4b95-a1c7-e07af54bd142/download
- [ONLINE] View publication in Scopus
Outcomes of a non-inferiority randomised controlled trial of surgery for men with urodynamic stress incontinence after prostate surgery (MASTER)
European Urology, vol. 79, no. 6, pp. 812-823Contributions to Journals: ArticlesTibial nerve stimulation compared with sham to reduce incontinence in care home residents: ELECTRIC RCT
Health technology assessment (Winchester, England), vol. 25, no. 41, pp. 1-109Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/hta25410
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/9016aebe-b641-4c2f-a466-08fb667e66c0/download
- [ONLINE] View publication in Scopus
TISU (Therepeutic Intervention for Stones in the Ureter): ESWL versus Ureteroscopy, a multicentre RCT
European Urology, vol. 79, no. S1, pp. S390-S390Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1016/S0302-2838(21)00660-6
Primary trabeculectomy for advanced glaucoma: pragmatic multicentre randomised controlled trial (TAGS)
BMJ, vol. 373, n1014Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmj.n1014
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/e196e827-92de-4234-964b-67203deacfe9/download
Equity of access to critical care services in Scotland: A Bayesian spatial analysis
Journal of the Intensive Care Society, vol. 22, no. 2, pp. 127-135Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1177/1751143720914462
- [ONLINE] View publication in Scopus
Evaluation of the Arabin cervical pessary for prevention of preterm birth in women with a twin pregnancy and short cervix (STOPPIT-2): An open-label randomised trial and updated meta-analysis
PLoS Medicine, vol. 18, no. 3, e1003506Contributions to Journals: Articles