People

Dr Fergal Waldron

Dr Fergal Waldron
Dr Fergal Waldron
Dr Fergal Waldron

BSc MSc MRes PhD (Cantab.)

Advanced Research Fellow

About
Office Address
5.15.5 Institute of Medical Sciences
Foresterhill Campus
Ashgrove Road West
AB25 2ZD

View on Map

School/Department
School of Medicine, Medical Sciences and Nutrition
ORCiD
Linkedin
Google Scholar
Pure

Biography

My research focuses on the roles of immunity, inflammation, and the gut-brain axis in ALS. I also work on biomarker developement in neurodegenerative disease but for ALS in particular. I am interested in heterogeneity, and early detection of disease, and my work involves a combination of experimental, molecular, histological, bioinformatics and meta-analytical approaches to answer fundamental questions in ALS research.

I obtained my PhD in Evolutionary Genetics from the University of Cambridge before undertaking postdoctoral work at the Institute of Evolutionary Biology at the University of Edinburgh. 

Qualifications

  • BSc Zoology 
    2003 - National University of Ireland, Galway 
  • MRes Zoology 
    2006 - National University of Ireland, Galway 
  • MSc Evolutionary Genetics and Genome Analysis 
    2008 - University of Edinburgh 
  • PhD Evolutionary Genetics 
    2013 - University of Cambridge 

Internal Memberships

The Genetics Society

The Pathological Society of Great Britain and Ireland

Latest Publications

  • Protein misfolding enteropathy predicts and prognosticates neurodegenerative disease years before symptom onset

    Langerová, T., MacVicar, E., Press, R., Read, F. L., Piana, M., Murdoch, S., Innes, J., Wilson, J., Watson, A. J., Waldron, F. M., Ramsay, G., Gregory, J. M.
    Gastroenterology
    Contributions to Journals: Articles

  • Metabolic signatures of ferritin and TDP-43 co-pathology provide a mechanistic basis for stratified therapeutic approaches in ALS

    Spence, H., Read, F., Waldron, F., Gregory, J.
    Working Papers: Preprint Papers

  • Genotype-specific interferon signatures in amyotrophic lateral sclerosis relate to disease severity

    Carletta, O., Perfetto, C., Rifai, O. M., Manganelli, F., Waldron, F., Maniatis, T., Gregory, J., Gerbino, V.
    Brain, vol. 149, no. 2, pp. 489-501
    Contributions to Journals: Articles

  • Amygdala TDP-43 pathology is associated with behavioural dysfunction and ferritin accumulation in amyotrophic lateral sclerosis

    Rifai, O. M., Waldron, F., O'shaughnessy, J., Read, F. L., Gilodi, M., Pastore, A., Shneider, N., Tartaglia, G. G., Zacco, E., Spence, H., Gregory, J.
    Brain Communications, vol. 8, no. 2, fcag104
    Contributions to Journals: Articles

  • Quantitative Profiling of Nanoscopic Protein Aggregates Reveals Specific Fingerprint of TDP-43-Positive Assemblies in Motor Neuron Disease

    Cox, D., Burke, M., Milani, S., White, M. A., Waldron, F. M., Böken, D., Lobanova, E., Sreedharan, J., Gregory, J. M., Klenerman, D.
    Advanced Science, vol. 12, no. 44, e05484
    Contributions to Journals: Articles

View My Publications

Research

Funding and Grants

A Laboratory Model for Antiviral Immunity in Molluscs (co-writer); £201,732 | 2018-06 to 2021-10 | Grant | The Leverhulme Trust (London, GB)

Establishment of a Laboratory Model for Antiviral Immunity in Molluscs (co-writer); £44,364 | 2017-04 to 2017-12 | Grant | Wellcome Trust ISSF (London, GB)

Antiviral immune expression in the mollusc Lymnaea stagnalis (co-writer); £1,791 | 2017-02 to 2017-06 | Grant | University of Edinburgh Moray Endowement Fund (Edinburgh, GB)

Next Generation Sequencing workshop hosted by the Vienna Graduate School of Population Genetics Registration and Travel Award; €1,000 | 2011-05 to 2011-06 | AwardEuropean Science Foundation (Strasbourg, FR)

St. John’s College, Cambridge Learning and Research Fund; £1,000 | 2010-06 to 2010-07 | Award | St. John's College, University of Cambridge (Cambridge, GB)

Summer Institute in Statistics and Modelling in Infectious Diseases workshop hosted by The University of Washington Registration and Travel Award; $4,000 | 2010-06 to 2010-07 | Award | National Institutes of Health (Bethesda, Maryland, US)

Marie Curie Early Stage Research Fellowship; £24,055 | 2007-09 to 2008-08 | Salary award | Marie Curie (London, GB)

Embark Initiative Thermadapt Programme Research Fellowship; €38,012 | 2003-09 to 2005-08 | Salary award | Irish Research Council (Dublin, IE)

Publications

Page 3 of 5 Results 21 to 30 of 47

  • RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS

    Spence, H., Waldron, F., Saleeb, R. S., Brown, A., Rifai, O. M., Gilodi, M., Read, F., Nellany, K., Milne, G., Wilkinson, D., O'shaughnessy, J., Pastore, A., Fratta, P., Shneider, N., Tartaglia, G. G., Zacco, E., Horrocks, M. H., Gregory, J.
    Acta Neuropathologica, vol. 147, 50
    Contributions to Journals: Articles

  • SOP and tick-sheet for using TDP-43 RNA aptamer (TDP-43APT) to detect pathological TDP-43 in FFPE-preserved human tissue, as described in Spence and Waldron et al., 2024 (Acta Neuropathologica) v1

    Waldron, F. M., Gregory, J., Spence, H.
    protocols.io.
    Other Contributions: Other Contributions

  • TDP-43 RNA aptamer staining to detect pathological TDP-43 in FFPE human tissue, as described in Spence and Waldron et al., 2024 (Acta Neuropathologica):: A SOP and tick-sheet. v2

    Waldron, F. M., Spence, H., Gregory, J.
    protocols.io (article).
    Other Contributions: Other Contributions

  • Distinct neuroinflammatory signatures exist across genetic and sporadic amyotrophic lateral sclerosis cohorts

    Rifai, O. M., O'shaughnessy, J., Dando, O. R., Munro, A. F., Sewell, M. D., Abrahams, S., Waldron, F. M., Sibley, C. R., Gregory, J. M.
    Brain, vol. 146, no. 12, pp. 5124-5138
    Contributions to Journals: Articles

  • RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides withSTMN-2cryptic splicing and precedes clinical manifestation in ALS

    Spence, H., Waldron, F. M., Saleeb, R. S., Brown, A., Rifai, O. M., Gilodi, M., Read, F., Roberts, K., Milne, G., Wilkinson, D., O’Shaughnessy, J., Pastore, A., Fratta, P., Shneider, N., Tartaglia, G. G., Zacco, E., Horrocks, M. H., Gregory, J. M.
    Working Papers: Preprint Papers

  • Systematic, comprehensive, evidence-based approach to identify neuroprotective interventions for motor neuron disease: Using systematic reviews to inform expert consensus

    Wong, C., Gregory, J. M., Liao, J., Egan, K., Vesterinen, H. M., Ahmad Khan, A., Anwar, M., Beagan, C., Brown, F. S., Cafferkey, J., Cardinali, A., Chiam, J. Y., Chiang, C., Collins, V., Dormido, J., Elliott, E., Foley, P., Foo, Y. C., Fulton-Humble, L., Gane, A. B., Glasmacher, S. A., Heffernan, ?., Jayaprakash, K., Jayasuriya, N., Kaddouri, A., Kiernan, J., Langlands, G., Leighton, D., Liu, J., Lyon, J., Mehta, A. R., Meng, A., Nguyen, V., Park, N. H., Quigley, S., Rashid, Y., Salzinger, A., Shiell, B., Singh, A., Soane, T., Thompson, A., Tomala, O., Waldron, F. M., Selvaraj, B. T., Chataway, J., Swingler, R., Connick, P., Pal, S., Chandran, S., Macleod, M.
    BMJ Open, vol. 13, no. 2, e064169
    Contributions to Journals: Articles

  • ALS and the Gut-Brain Axis: A protocol for a systematic review and meta-analysis assessing the relationship between amyotrophic lateral sclerosis, the gut and its microbiome.

    Jackson, A. T., Press, R. G., Waldron, F., Gregory, J.
    protocols.io.
    Other Contributions: Other Contributions

  • Distinct neuroinflammatory signatures exist across genetic and sporadic ALS cohorts

    Rifai, O. M., O'shaughnessy, J., Dando, O., Munro, A. F., Sewell, M. D., Abrahams, S., Waldron, F., Sibley, C. R., Gregory, J.
    Working Papers: Preprint Papers

  • pTDP-43 aggregates accumulate in non-central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis: a case series linking archival surgical biopsies with clinical phenotypic data

    Pattle, S. B., O'shaughnessy, J., Kantelberg, O., Rifai, O. M., Pate, J., Nellany, K., Hays, N., Arends, M. J., Horrocks, M., Waldron, F. M., Gregory, J.
    Journal of Pathology: Clinical Research, vol. 9, no. 1, pp. 44-55
    Contributions to Journals: Articles

  • A Systematic Approach to Identify Neuroprotective Interventions for Motor Neuron Disease

    Wong, C., Gregory, J., Liao, J., Egan, K., Vesterinen, H. M., Khan, A. A., Anwar, M., Beagan, C., Brown, F., Cafferkey, J., Cardinali, A., Chiam, J. Y., Chiang, C., Collins, V., Dormido, J., Elliott, E., Foley, P., Foo, Y. C., Fulton-Humble, L., Gane, A. B., Glasmacher, S., Heffernan, ?., Jayaprakash, K., Jayasuriya, N., Kaddouri, A., Kiernan, J., Langlands, G., Leighton, D., Liu, J., Lyon, J., Mehta, A. R., Meng, A., Nguyen, V., Park, K. H., Quigley, S., Rashid, Y., Salzinger, A., Shiell, B., Singh, A., Soane, T., Thompson, A., Tomala, O., Waldron, F. M., Selvaraj, B. T., Chataway, J., Swingler, R., Connick, P., Pal, S., Chandran, S., Macleod, M. R.
    Working Papers: Preprint Papers
Show 10 | 25 | 50 | 100 results per page

Refine

Contributions to Journals

Working Papers

Other Contributions

Update