People

Dr Fergal Waldron

Dr Fergal Waldron
Dr Fergal Waldron
Dr Fergal Waldron

BSc MSc MRes PhD (Cantab.)

Advanced Research Fellow

About
Office Address
5.15.5 Institute of Medical Sciences
Foresterhill Campus
Ashgrove Road West
AB25 2ZD

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School/Department
School of Medicine, Medical Sciences and Nutrition
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Biography

My research focuses on the roles of immunity, inflammation, and the gut-brain axis in ALS. I also work on biomarker developement in neurodegenerative disease but for ALS in particular. I am interested in heterogeneity, and early detection of disease, and my work involves a combination of experimental, molecular, histological, bioinformatics and meta-analytical approaches to answer fundamental questions in ALS research.

I obtained my PhD in Evolutionary Genetics from the University of Cambridge before undertaking postdoctoral work at the Institute of Evolutionary Biology at the University of Edinburgh. 

Qualifications

  • BSc Zoology 
    2003 - National University of Ireland, Galway 
  • MRes Zoology 
    2006 - National University of Ireland, Galway 
  • MSc Evolutionary Genetics and Genome Analysis 
    2008 - University of Edinburgh 
  • PhD Evolutionary Genetics 
    2013 - University of Cambridge 

Internal Memberships

The Genetics Society

The Pathological Society of Great Britain and Ireland

Latest Publications

  • Protein misfolding enteropathy predicts and prognosticates neurodegenerative disease years before symptom onset

    Langerová, T., MacVicar, E., Press, R., Read, F. L., Piana, M., Murdoch, S., Innes, J., Wilson, J., Watson, A. J., Waldron, F. M., Ramsay, G., Gregory, J. M.
    Gastroenterology
    Contributions to Journals: Articles

  • Metabolic signatures of ferritin and TDP-43 co-pathology provide a mechanistic basis for stratified therapeutic approaches in ALS

    Spence, H., Read, F., Waldron, F., Gregory, J.
    Working Papers: Preprint Papers

  • Genotype-specific interferon signatures in amyotrophic lateral sclerosis relate to disease severity

    Carletta, O., Perfetto, C., Rifai, O. M., Manganelli, F., Waldron, F., Maniatis, T., Gregory, J., Gerbino, V.
    Brain, vol. 149, no. 2, pp. 489-501
    Contributions to Journals: Articles

  • Amygdala TDP-43 pathology is associated with behavioural dysfunction and ferritin accumulation in amyotrophic lateral sclerosis

    Rifai, O. M., Waldron, F., O'shaughnessy, J., Read, F. L., Gilodi, M., Pastore, A., Shneider, N., Tartaglia, G. G., Zacco, E., Spence, H., Gregory, J.
    Brain Communications, vol. 8, no. 2, fcag104
    Contributions to Journals: Articles

  • Quantitative Profiling of Nanoscopic Protein Aggregates Reveals Specific Fingerprint of TDP-43-Positive Assemblies in Motor Neuron Disease

    Cox, D., Burke, M., Milani, S., White, M. A., Waldron, F. M., Böken, D., Lobanova, E., Sreedharan, J., Gregory, J. M., Klenerman, D.
    Advanced Science, vol. 12, no. 44, e05484
    Contributions to Journals: Articles

View My Publications

Research

Funding and Grants

A Laboratory Model for Antiviral Immunity in Molluscs (co-writer); £201,732 | 2018-06 to 2021-10 | Grant | The Leverhulme Trust (London, GB)

Establishment of a Laboratory Model for Antiviral Immunity in Molluscs (co-writer); £44,364 | 2017-04 to 2017-12 | Grant | Wellcome Trust ISSF (London, GB)

Antiviral immune expression in the mollusc Lymnaea stagnalis (co-writer); £1,791 | 2017-02 to 2017-06 | Grant | University of Edinburgh Moray Endowement Fund (Edinburgh, GB)

Next Generation Sequencing workshop hosted by the Vienna Graduate School of Population Genetics Registration and Travel Award; €1,000 | 2011-05 to 2011-06 | AwardEuropean Science Foundation (Strasbourg, FR)

St. John’s College, Cambridge Learning and Research Fund; £1,000 | 2010-06 to 2010-07 | Award | St. John's College, University of Cambridge (Cambridge, GB)

Summer Institute in Statistics and Modelling in Infectious Diseases workshop hosted by The University of Washington Registration and Travel Award; $4,000 | 2010-06 to 2010-07 | Award | National Institutes of Health (Bethesda, Maryland, US)

Marie Curie Early Stage Research Fellowship; £24,055 | 2007-09 to 2008-08 | Salary award | Marie Curie (London, GB)

Embark Initiative Thermadapt Programme Research Fellowship; €38,012 | 2003-09 to 2005-08 | Salary award | Irish Research Council (Dublin, IE)

Publications

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  • Fingerprinting disease-derived protein aggregates reveals unique signature of Motor Neuron Disease

    Cox, D., Burke, M., Milani, S., White, M. A., Waldron, F., Böken, D., Lobanova, E., Sreedharan, J., Gregory, J., Klenerman, D.
    Working Papers: Preprint Papers

  • Improving ALS detection and cognitive impairment stratification with attention-enhanced deep learning models

    Xia, Y., Gregory, J. M., Waldron, F. M., Spence, H., Vallejo, M.
    Scientific Reports, vol. 15, no. 1, 7045
    Contributions to Journals: Articles

  • Organellomics: AI-driven deep organellar phenotyping reveals novel ALS mechanisms in human neurons

    Krispin, S., van Zuiden, W., Danino, Y. M., Molitor, L., Rudberg, N., Bar, C., Coyne, A., Meimoun, T., Waldron, F., Gregory, J., Fisher, T., Nachshon, A., Stern-Ginossar, N., Yacovzada, N., Horstein, E.
    Working Papers: Preprint Papers

  • Machine learning identifies routine blood tests as accurate predictive measures of pollution-dependent poor cognitive function

    Johnson, H., Longden, J., Cameron, G., Waiter, G. D., Waldron, F. M., Gregory, J. M., Spence, H.
    Working Papers: Preprint Papers

  • Clinicopathological analysis of NEK1 variants in amyotrophic lateral sclerosis

    Rifai, O. M., Waldron, F., Sleibi, D., O'shaughnessy, J., Leighton, D. J., Gregory, J.
    Brain Pathology, vol. 35, no. 1, e13287
    Contributions to Journals: Articles

  • Integrating Transfer Learning and Attention Mechanisms for Accurate ALS Diagnosis and Cognitive Impairment Detection

    Xia, Y., Gregory, J. M., Waldron, F. M., Spence, H., Vallejo, M.
    Working Papers: Preprint Papers

  • An adaptable protocol for antibody & TDP-43 RNA aptamer dual immunohistochemical staining for FFPE-preserved human tissue: with SOP and tick-sheet

    Waldron, F., Gregory, J.
    Working Papers: Preprint Papers

  • Antibody and TDP-43 RNA aptamer dual staining to detect patterns of co-pathology in FFPE-preserved human tissue, as described in Rifai et al., 2024 (Brain Pathology): A SOP and tick-sheet. V1

    Waldron, F., Rifai, O. M., Gregory, J.
    Working Papers: Preprint Papers

  • Understanding the influence of altered lipid metabolism on TDP-43 pathology: a protocol for a systematic review and meta-analysis v1

    Langerova, T., Spence, H., Waldron, F. M., Gregory, J.
    protocols.io.
    Other Contributions: Other Contributions

  • Amygdala TDP-43 pathology is associated with behavioural dysfunction and ferritin accumulation in amyotrophic lateral sclerosis

    Rifai, O. M., Waldron, F., O'Shaughnessy, J., Read, F., Gilodi, M., Pastore, A., Tartaglia, G. G., Zacco, E., Spence, H., Gregory, J.
    Working Papers: Preprint Papers
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