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The School of Natural and Computing Sciences

Dr Thomas Baddeley

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Dr Thomas Baddeley
Dr Thomas Baddeley
Dr Thomas Baddeley

PhD, BSc Hons

Senior Research Fellow

About
Telephone Number
+44 (0)1224 274238
School/Department
School of Natural and Computing Sciences
Linkedin
Google Scholar
Pure

North East Analytical Research (NEAR) Symposium

Link to the NEAR Symposium Website

NEAR Symposium

Qualifications

  • PhD Chemistry 
    2002 - University of Aberdeen 
  • BSc Hons Chemistry 
    1998 - University of Aberdeen 

External Memberships

  • Head of DMPK / Analytical Chemistry for TauRx Therapeutics
  • Cofounder of the North East Analytical Research (NEAR) Symposium

Latest Publications

View My Publications

Research

Research Overview

My focus is on the analytical pathways involved in pharmaceutical drug development.

  • This starts early during R and D looking at physical chemical testing of novel compounds and early analytical development to determine material purity and its impurities.
  • As the candidates progress further, bioanalytical methods, initial metabolism and material characterisation are developed.
  • Once into non clinical and clinical development validation according to ICH Q3 is required for material assays and ICH M7 for bioanalytical methods

 

 

Current Research

The development and use of new analytical methods in the study of small organic molecules undergoing clinical evaluation.

The development and use of bioanalytical methods used in clinical and non clinical studies

DMPK studies supporting novel pharmaceutical development

Past Research

The synthesis and study of novel organic compounds for use as potential drug candidates and excipients.

The study of the physical properties of novel oligosaccharides

Knowledge Exchange

Speaker at NEAR Symposium 2024 in Aberdeen

Speaker at REID bioanalytical Forum 2019, Cambridge

Speaker at INFORM 2018 in Copenhagen

 

Publications

Page 3 of 4 Results 21 to 30 of 35

  • (Pyrazinecarbonyl)hydrazone halobenzaldehydes: Supramolecular arrays generated by face to face stacking of ribbons, formed from C-H-O interactions

    Baddeley, T. C., Alan Howie, R., Da Silva Lima, C. H., Kaiser, C. R., De Souza, M. V., Wardell, J. L., Wardell, S. M.
    Zeitschrift fur Kristallographie, vol. 224, no. 10, pp. 506-514
    Contributions to Journals: Articles

  • 2-Hydroxyacetophenone arylhydrazones. Supramolecular arrangements based on C–H · · · O(H), CH · · · O(NO), N–H · · · O(H), N–H · · · O(NO), C–H · · · π or π · · · π interactions

    Baddeley, T. C., Franca, L. d. S., Howie, R. A., de Lima, G. M., Skakle, J., de Souza, J. D., Wardell, J. L., Wardell, S. M. S. V.
    Zeitschrift für Kristallographie, vol. 224, no. 4, pp. 213-224
    Contributions to Journals: Articles

  • Synthesis of Per- and Poly Substituted Trehalose Derivatives: Studies of Properties Relevant to Their Use as Excipients for Controlled Drug Release

    Baddeley, T. C., Wardell, J. L.
    Journal of Carbohydrate Chemistry, vol. 28, no. 4, pp. 198-221
    Contributions to Journals: Articles

  • Methods of synthesis and/or purification of diaminophenothiazinium compounds

    Wischik, C. M., Storey, J. M. D., Marshall, C., Sinclair, J. P., Baddeley, T.
    Patents: Patents

  • Studies of distannylated-1,2-dithiolato compounds: Synthesis of 4,5-bis[(triorganostannylmethyl)thiolato]-1,3-dithiole-2-thiones, (R3SnCH2)(2)(dmit), and 4,5-bis[(triorganostannylmethyl)thiolato]-1,3-dithiole-2-ones, (R3SnCH2)(2)(dmio) - Crystal structures of (Ph3SnCH2)(2)(dmit) and (Ph3SnCH2)(2)(dmio)

    Baddeley, T. C., Bordinhão, J., Comerlato, N. M., Cortás, L. d. C., Ferreira, G. B., Howie, R. A., Wardell, J. L.
    Journal of Organometallic Chemistry, vol. 692, no. 25, pp. 5583-5588
    Contributions to Journals: Articles

  • Co-crystallised alpha- and beta-Anomers of 2,3,4,6-Tetra-acetyl-D-glucopyranose, in which the alpha- and beta-Anomers are Randomly Distributed in the Hydrogen-bonded Chains of Molecules

    Baddeley, T. C., Harrison, W. T. A., Howie, R. A., Skakle, J. M. S., Wardell, J. L.
    Journal of Chemical Crystallography, vol. 37, no. 12, pp. 853-858
    Contributions to Journals: Articles

  • A homologous series of eunicellin-based diterpenes from Acalycigorgia sp. characterised by tandem mass spectrometry

    Kyeremeh, K., Baddeley, T., Stein, B. K., Jaspars, M.
    Tetrahedron, vol. 62, pp. 8770-8778
    Contributions to Journals: Articles

  • 1,2,3,4-Tetra-O-acetyl-beta-D-glucopyranuronic acid monohydrate at 120 K and anhydrous 1,2,3,4-tetra-O-acetyl-beta-D-glucopyranose at 292 K

    Baddeley, T. C., Howie, R. A., Skakle, J. M. S., Wardell, J. L.
    Acta Crystallographica Section C, Crystal Structure Communications, vol. 61, no. 12, pp. o711-o714
    Contributions to Journals: Articles

  • Supramolecular structures of substituted a,a'-trehalose derivatives

    Baddeley, T., Wardell, J. L., Skakle, J., Low, J., Glidewell, C., Davidson, I.
    Acta Crystallographica Section B, Structural Science, vol. B60, no. 4, pp. 461-471
    Contributions to Journals: Articles

  • Disordered 2,2 ',3,3 ',4,6,6 '-hepta-O-pivaloyl-alpha,alpha '-trehalose

    Baddeley, T. C., Clow, S. M., Cox, P. J., Davidson, I. G., Murdoch, A. M., Wardell, J. L.
    Acta Crystallographica Section E: Structure Reports Online, vol. 59, pp. 753-755
    Contributions to Journals: Articles
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