We are using our Bruker/NanoString GeoMx and nCounter instruments in collaboration with groups around the University to examine spatial patterns of gene and protein expression in the context of a number of disease states, including the diseases mentioned above. These spatial technologies provide unprecedented opportunities to examine how adjacent cells and tissues respond to one another in the context of health and disease, and this can be done even on banked FFPE tissue samples.
Exploiting spatial 'omics to explore breast cancer, heart disease, developmental biology and neurode