FAS, FRSB
Regius Chair of Anatomy
- About
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- Email Address
- simon.parson@abdn.ac.uk
- Telephone Number
- +44 (0)1224 274328
- Office Address
Anatomy Rm 324 Suttie Centre Foresterhill University of Aberdeen Aberdeen AB24 3HF
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
BSc Zoology, University of Durham, 1987
PhD Neuroscience, University of Edinburgh, 1990
Lecturer in Anatomy, University of Leeds, 1995
Senior Lecturer in Anatomy, University of Edinburgh, 2006
Professor of Anatomy, University of Aberdeen, 2013
Regius Chair of Anatomy, 2018
Memberships and Affiliations
- Internal Memberships
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All aspects relating to Home Office legislation of anatomical teaching and research
College Teaching and Learning Committee
Division of Medical and Dental Education Executive Committee
Year 1-3 Medical Executive Committees
Medicine Curriculum Steering Group
- External Memberships
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Elected Councillor, Anatomical Society: 2010-2016
Meetings Officer, Anatomical Society: 2011- 2016
IFAA Programme Secretary: 2018 - 2019
President, Anatomical Society 2019-2022
- Research
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Research Overview
Spinal Muscular Atrophy
Systemic involvement in neurodegeneration, especially of the cardiovascular system
Effects of Hypoxia and ischaemia on the nervous system
Current Research
Spinal muscular Atrophy (SMA) is a childhood form of Motor Neurone Disease. It is caused by a defect in a gene which 1:35 of us carry. When two carriers come together there is a 1:4 chance of producing an affected child. SMA is the second most common genetic cause of infant death, affecting between 1:6-10,000 live births Worldwide. The most severely affected children will never sit unaided and will die before their second birthday. The disease is characterised by a loss of motor neurones and resultant muscle weakness and inability to carry out co-ordinated motor tasks including breathing. The genetic defect is well-characterised and attempts to replace or reduce the severe depletion of the key Survival of Motor Neurone (SMN) protein are ongoing. However, even when protein levels in motor neurones are increased and improvements in motor parameters are reported, survival is not increased.
There is an increasing appreciation that this is not a classical motor neurone disease, but rather a systemic disease in which motor neurones are either most vulnerable or that defects in them are most clinically relevant.
Our research has pioneered significant pre and early symptomatic defects in the cardiovascular system, where the heart, blood vessels and circulating cells are all defective in SMA. We are now particularly interested to determine how this impacts on SMA disease development and progression. This is particularly relevant in the new post- therapeutic landscape, as these were designed to target neuronal defects.
We are currently exploring the extent to which the non-neuronal pathologies described in animal models are also seen in human post-mortem material and are using cellular models to determine the vulnerabilities of SMA cells to hypoxic environments. These will help us to understand and develop novel combinatorial therapies to treat the entirety of SMA pathology in patients.
Most recently, we are exploring similar non-motor pathologies in ALS/ MNDs.
Collaborations
Professor Tom Gillingwater: University of Edinburgh
Dr Tom Wishart: Roslin Institute Edinburgh
Dr Lyndsay Murray: University of Edinburgh
Dr's Francesco Muntoni and Haiyan Zhou: UCL, London
Prof Rashmi Kothary: University of Ottawa, Canada
Prof Charlotte Sumner: John Hopkins University, USA
Funding and Grants
SMA Europe
Anatomical Society
Tenovus Scotland
- Teaching
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Teaching Responsibilities
All aspects of Anatomy teaching to Medical and Science students
- Publications
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SMN Depleted Mice Offer a Robust and Rapid Onset Model of Nonalcoholic Fatty Liver Disease
CMGH Cellular and Molecular Gastroenterology and Hepatology, vol. 12, no. 1, pp. 354-377Contributions to Journals: ArticlesExploring shared surgical decision-making from the patient’s perspective: is the personality of the surgeon important?
Colorectal Disease, vol. 22, no. 12, pp. 2214-2221Contributions to Journals: ArticlesAnatomical Evaluation of a Conventional Pectoralis II Versus a Subserratus Plane Block for Breast Surgery
Anesthesia and Analgesia, vol. 131, no. 3, pp. 928-934Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1213/ANE.0000000000005039
- [ONLINE] View publication in Scopus
COVID-19 and Anatomy: Stimulus and Initial Response
Journal of Anatomy, vol. 237, no. 3, pp. 393-403Contributions to Journals: Review articlesWidespread tissue hypoxia dysregulates cell and metabolic pathways in SMA
Annals of Clinical and Translational Neurology, vol. 7, no. 9, pp. 1580-1593Contributions to Journals: ArticlesRenal pathology in a mouse model of severe Spinal Muscular Atrophy is associated with downregulation of Glial Cell-Line Derived Neurotrophic Factor (GDNF)
Human Molecular Genetics, vol. 29, no. 14, pp. 2365-2378Contributions to Journals: ArticlesA role for spinal cord hypoxia in neurodegeneration
Cell Death & Disease, vol. 10, 861Contributions to Journals: Review articlesLamin A/C dysregulation contributes to cardiac pathology in a mouse model of severe spinal muscular atrophy
Human Molecular Genetics, vol. 28, no. 21, pp. 3515–3527Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/hmg/ddz195
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/14887/1/HMG_2019_D_00455.R1_Proof_hi.pdf
- [ONLINE] View publication in Mendeley
Abnormal fatty acid metabolism is a core component of spinal muscular atrophy
Annals of Clinical and Translational Neurology, vol. 6, no. 8, pp. 1519-1532Contributions to Journals: ArticlesIs the Conventional Ultrasound Guided Pectoralis II or Sub-serratus Plane Superior for Brest Surgery: A Cadaveric Study
Europian Society of Regional Anesthesia, Congress (ESRA 2018)Contributions to Journals: Abstracts