Director (CHaRT)
- About
-
- Email Address
- g.maclennan@abdn.ac.uk
- Telephone Number
- +44 (0)1224 438147
- Office Address
Health Services Research Unit
2nd Floor Health Sciences Building
Foresterhill
Aberdeen
AB25 2ZD- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT.
My undergrad degree is in Mathematics from the University of Aberdeen, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.
Qualifications
- BSc Mathematics1997 - University of Aberdeen
- MSc Applied Statistics2004 - Sheffield Hallam University
- Research
-
Research Overview
The application of statistical methods to clinical trials. Recent example is JCE paper available here on using instrumental variables in a surgery trial to address non-compliance. Collaborators were Jonathan Cook (Oxford), Tom Palmer (Lancaster), and Richard Emesley (Manchester).
Research on making trials more efficient, collaborating with Trial Forge.
Current Research
A complete list of the CHaRT RCT portolio is available by clicking here
- Teaching
-
Teaching Responsibilities
I teach on our MPH course module PU5031: EVIDENCE-BASED HEALTH.
- Publications
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Page 1 of 6 Results 1 to 50 of 278
Effectiveness and cost-effectiveness of a peer-delivered, relational, harm reduction intervention to improve mental health, quality of life, and related outcomes, for people experiencing homelessness and substance use problems: protocol for the ‘SHARPS’ cluster randomised controlled trial
TrialsContributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s13063-025-09364-x
ColoCap: determining the diagnostic accuracy of colon capsule endoscopy compared with standard colonoscopy in patients at risk of colorectal disease: a study protocol
BMJ Open, vol. 15, no. 9, e104661Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmjopen-2025-104661
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/93fd9194-f4d8-4efd-acd8-bf1827c927d0/download
- [ONLINE] View publication in Scopus
Spirometry to manage asthma in children: a study protocol for a randomised controlled trial (SPIROMAC)
Trials, vol. 26, 373Contributions to Journals: ArticlesPUrE Randomised Controlled Trial 2: Clinical and Cost Effectiveness of Flexible Ureterorenoscopy and Percutaneous Nephrolithotomy for Lower-pole Stones of 10–25 mm
European Urology FocusContributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.euf.2025.08.010
- [ONLINE] View publication in Scopus
Updated Systematic Review and Meta-analysis of Extracorporeal Shock Wave Lithotripsy, Flexible Ureterorenoscopy, and Percutaneous Nephrolithotomy for Lower Pole Renal Stones
European Urology, vol. 88, no. 3, pp. 231-239Contributions to Journals: Review articlesTen Year Follow-Up of a Multicentre Randomised Controlled Trial Assessing Clinical and Cost Effectiveness of Total Versus Partial Knee Replacement
The Lancet RheumatologyContributions to Journals: ArticlesClinical and cost-effectiveness of percutaneous nephrolithotomy, flexible ureterorenoscopy and extracorporeal shockwave lithotripsy for lower pole stones: the PUrE RCTs
Health Technology Assessment, vol. 29, no. 40Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/WFRE6844
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/1e346e4d-5542-4f65-b03b-92928315c58a/download
- [ONLINE] View publication in Scopus
Secondary analysis of the Game of Stones trial for men with obesity: Examining moderator effects and exploratory outcomes
Obesity, vol. 33, no. 8, pp. 1432-1446Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/oby.24316
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/9168a290-bb3e-412d-8d66-9b51eb1bf39b/download
The PUrE Randomised Controlled Trial (RCT) 1: Clinical and cost-effectiveness of Flexible Ureterorenoscopy and Extracorporeal Shockwave Lithotripsy for lower pole stones ≤10mm.
European Urology, vol. 88, no. 2, pp. 179-189Contributions to Journals: ArticlesInvasive urodynamic investigations in the management of women with refractory overactive bladder symptoms: FUTURE, a superiority RCT and economic evaluation
Health Technology Assessment, vol. 29, no. 27Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/UKYW4923
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/d13cca15-e1ae-437d-ae1c-7f6c2bcc2f73/download
Long-term cost-effectiveness of invasive urodynamic studies for overactive bladder in women
BJU International, vol. 136, no. 1, pp. 82-94Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/bju.16703
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/bd6457f7-1f71-4a82-8254-ef8bd8a7f774/download
Text messaging with or without financial incentives versus a waitlist control for weight loss in men: cost-effectiveness analysis of the Game of Stones randomised controlled trial
The Lancet Regional Health - Europe, vol. 54, 101328Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.lanepe.2025.101328
CATHETER II, a Randomised Controlled Trial Comparing the Clinical and Cost Effectiveness of Various Washout Policies versus No Washout Policy in Preventing Catheter Associated Complications in Adults Living with Long Term Catheters
45th Congress of the Société Internationale d'UrologieContributions to Conferences: PostersBisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT
Health Technology Assessment, vol. 29, no. 17, pp. i-xvi, 1-97Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/TNDG8641
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/51f34404-049e-4f07-99e1-f687f97bcd82/download
Patients and health care professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: Qualitative Study of the CATHETER II Trial
BMJ Open, vol. 15, no. 4, e087206Contributions to Journals: ArticlesInvasive urodynamic investigations in the management of women with refractory overactive bladder symptoms (FUTURE) in the UK: a multicentre, superiority, parallel, open-label, randomised controlled trial
The Lancet, vol. 405, no. 10484, pp. 1057-1068Contributions to Journals: ArticlesCATHETER II, a randomised controlled trial comparing the clinical and cost effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long term catheters
European Association of Urology Annual Congress 2025, pp. A0090Contributions to Conferences: Abstracts- [ONLINE] http://300500960
Intravenous Lidocaine for Gut Function Recovery in Colonic Surgery: A Health Economic Evaluation of the ALLEGRO Randomised Clinical Trial
BMJ Open, vol. 15, no. 2, e088298Contributions to Journals: ArticlesICANEQUAL multi-stakeholder partnership: Reducing inequalities in liver cancer (HCC) diagnosis, treatment and care across the UK
NIHR Open Research, vol. 5, no. 5Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/nihropenres.13723.1
Intravenous lidocaine for gut function recovery in colonic surgery: A Randomized Clinical Trial
JAMA, vol. 333, no. 1, pp. 39-48Contributions to Journals: ArticlesComplexity of Trials on Pain Management in Acute Pancreatitis: An Ongoing Challenge
Clinical Gastroenterology and Hepatology, vol. 23, no. 1Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1016/j.cgh.2024.03.031
- [ONLINE] View publication in Scopus
Laparoscopic cholecystectomy versus conservative management for uncomplicated symptomatic gallstones: economic evaluation based on the C-GALL trial
British Journal of Surgery, vol. 112, no. 1, znae293Contributions to Journals: ArticlesA feasibility randomized controlled trial of an individually delivered, peer support intervention to reduce the impact of psychosis stigma and discrimination for people with psychosis: the let's talk study
Psychological Medicine, vol. 54, no. 16, pp. 1-12Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1017/S0033291724002605
A randomised, double-blind placebo controlled trial of the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease
Health Technology AssessmentContributions to Journals: ArticlesCATHETER II: a randomised controlled trial comparing the clinical and cost effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long term catheters
BMJ Open, vol. 14, no. 12, e087203Contributions to Journals: ArticlesClinical and cost-effectiveness of parenting intervention for mothers experiencing psychosocial stress: insights from the early closure of the Mellow Babies RCT
Public Health Research, vol. 12, no. 17Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/KCVL7125
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/4fd18ef2-35b1-401e-82a4-44712b5ca18b/download
Which glaucoma patients should be monitored at home and exploration of clinician perceptions on home monitoring? a survey of glaucoma specialists in the UK
BMJ Open, vol. 14, no. 11, pp. e080873Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmjopen-2023-080873
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/e426019e-b77a-4711-8289-f0442179d03a/download
- [ONLINE] View publication in Scopus
RCT comparing the clinical and cost effectiveness of various catheter washout policies
RCOG World Congress 2024, MTeP-42Contributions to Journals: AbstractsCATHETER II, a randomised controlled trial comparing the clinical and cost effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long term catheters
The International Continence Society, 101602Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1016/j.cont.2024.101602
Patient and health care professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: Qualitative Study of the CATHETER II Trial
RCOG World Congress 2024, pp. 171Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1111/1471-0528.17946
- [ONLINE] Conference Poster
The UK resuscitative endovascular balloon occlusion of the aorta in trauma patients with life-threatening torso haemorrhage: The (UK-REBOA) multicentre RCT
Health Technology Assessment, vol. 28, no. 54Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/LTYV4082
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/7b808c00-2292-4817-9f30-8081c995abe8/download
- [ONLINE] View publication in Scopus
Patient and health care professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: Qualitative Study of the CATHETER II Trial
The International Continence SocietyContributions to Conferences: PostersPublic perspective on potential treatment intervention harm in clinical trials-terminology and communication
Trials, vol. 25, no. 1, 573Contributions to Journals: ArticlesFeasibility of in-home monitoring for people with glaucoma: the I-TRAC mixed-methods study
Health technology assessment (Winchester, England), vol. 28, no. 44, pp. 1-163Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/GTWD6802
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/4d5e74e6-c44c-4c62-95ef-c8e79bb22d2e/download
- [ONLINE] View publication in Scopus
Text Messages With Financial Incentives for Men With Obesity: A Randomized Clinical Trial
JAMA, vol. 332, no. 1, pp. 31-40Contributions to Journals: ArticlesEvaluating Primary Treatment for People with Advanced Glaucoma: Five-Year Results of the Treatment of Advanced Glaucoma Study
Ophthalmology, vol. 131, no. 7, pp. 759-770Contributions to Journals: ArticlesAssessment of depth of sedation using Bispectral Index™ monitoring in patients with severe traumatic brain injury in UK intensive care units
BJA Open, vol. 10, 100287Contributions to Journals: ArticlesLaparoscopic cholecystectomy versus conservative management for adults with uncomplicated symptomatic gallstones: the C-GALL RCT
Health Technology Assessment, vol. 28, no. 26, pp. 1-151Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/MNBY3104
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/90f6837d-ef24-4bfc-8f00-5cb51bea0db9/download
Bisoprolol in Patients With Chronic Obstructive Pulmonary Disease at High Risk of Exacerbation: The BICS Randomized Clinical Trial
JAMA, vol. 332, no. 6, pp. 462-470Contributions to Journals: ArticlesPrevalencia del cáncer del tracto urinario. Análisis de la cohorte española del estudio IDENTIFY
Actas Urologicas Espanolas, vol. 48, no. 3, pp. 228-237Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.acuro.2023.06.004
- [ONLINE] View publication in Scopus
Resuscitative Endovascular Balloon Occlusion of the Aorta in Patients With Exsanguinating Hemorrhage-Reply
JAMA, vol. 331, no. 11, pp. 981-982Contributions to Journals: Comments and Debates- [ONLINE] DOI: https://doi.org/10.1001/jama.2024.0285
PUrE RCT 1: Clinical and cost-effectiveness of flexible ureterorenoscopy and extracorporeal shockwave lithotripsy for lower pole stones ≤10 mm
39th Annual EAU Congress, pp. S529Contributions to Journals: AbstractsPUrE RCT 2: Clinical and cost-effectiveness of FURS and percutaneous nephrolithotomy for lower pole stones 10-25mm
39th Annual EAU Congress, pp. S537Contributions to Journals: AbstractsReply to Arnulf Stenzl, Morgan Rouprêt, J. Alfred Witjes, Paolo Gontero. High-quality Transurethral Resection of Bladder Tumour Needs Additional Forms of Tumour Delineation. Eur Urol 2023;83:193–4
European Urology, vol. 85, no. 3, pp. 309-312Contributions to Journals: Comments and Debates- [ONLINE] DOI: https://doi.org/10.1016/j.eururo.2023.05.040
- [ONLINE] View publication in Scopus
SFX-01 in hospitalised patients with community-acquired pneumonia during the COVID-19 pandemic: a double-blind, randomised, placebo-controlled trial
ERJ Open Research, vol. 10, no. 2, 00917-2023Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1183/23120541.00917-2023
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/cf422e88-0e63-453c-a592-46db53adae5f/download
- [ONLINE] View publication in Scopus
Three-year cost utility analysis of mini versus standard slings: A trial based economic evaluation
BJUI Compass, vol. 5, no. 2, pp. 230-239Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/bco2.303
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/2851c33a-8826-4803-9b15-5b9bfde4eedf/download
- [ONLINE] View publication in Scopus
Effects of socioeconomic status on baseline values and outcomes at 24 months in the Treatment of Advanced Glaucoma Study randomised controlled Trial
British Journal of Ophthalmology, vol. 108, no. 2, pp. 203-210Contributions to Journals: ArticlesHow surgical Trainee Research Collaboratives achieve success: a mixed methods study to develop trainee engagement strategies
BMJ Open, vol. 13, no. 12, e072851Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmjopen-2023-072851
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstreams/c69b87b1-13d5-420e-95ff-8a59a522988c/download
- [ONLINE] View publication in Scopus
Effectiveness of conservative management versus laparoscopic cholecystectomy in the prevention of recurrent symptoms and complications in adults with uncomplicated symptomatic gallstone disease (C-GALL trial): pragmatic, multicentre randomised controlled trial
BMJ, vol. 383, e075383Contributions to Journals: ArticlesCost-effectiveness of cognitive behavioural and personalised exercise interventions for reducing fatigue in inflammatory rheumatic diseases
Rheumatology, vol. 62, no. 12, pp. 3819-3827Contributions to Journals: Articles